IL133809A0 - Steroidal alkaloids and pharmaceutical compositions comprising them - Google Patents

Steroidal alkaloids and pharmaceutical compositions comprising them

Info

Publication number
IL133809A0
IL133809A0 IL13380999A IL13380999A IL133809A0 IL 133809 A0 IL133809 A0 IL 133809A0 IL 13380999 A IL13380999 A IL 13380999A IL 13380999 A IL13380999 A IL 13380999A IL 133809 A0 IL133809 A0 IL 133809A0
Authority
IL
Israel
Prior art keywords
steroidal alkaloids
steroidal
pharmaceutical compositions
families
alkaloids
Prior art date
Application number
IL13380999A
Other languages
English (en)
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Priority to IL13380999A priority Critical patent/IL133809A0/xx
Priority to AT00983471T priority patent/ATE304360T1/de
Priority to CA002395642A priority patent/CA2395642A1/en
Priority to PCT/IL2000/000866 priority patent/WO2001049279A2/en
Priority to AU20229/01A priority patent/AU2022901A/en
Priority to JP2001549647A priority patent/JP2003519178A/ja
Priority to EP00983471A priority patent/EP1274445B1/en
Priority to IL14991300A priority patent/IL149913A0/xx
Priority to US10/169,353 priority patent/US20030114393A1/en
Priority to DE60022687T priority patent/DE60022687T2/de
Publication of IL133809A0 publication Critical patent/IL133809A0/xx
Priority to IL149913A priority patent/IL149913A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL13380999A 1999-12-30 1999-12-30 Steroidal alkaloids and pharmaceutical compositions comprising them IL133809A0 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IL13380999A IL133809A0 (en) 1999-12-30 1999-12-30 Steroidal alkaloids and pharmaceutical compositions comprising them
JP2001549647A JP2003519178A (ja) 1999-12-30 2000-12-28 多剤耐性を転換するためのステロイドアルカロイドの使用
CA002395642A CA2395642A1 (en) 1999-12-30 2000-12-28 Use of steroidal alkaloids to reverse multidrug resistance
PCT/IL2000/000866 WO2001049279A2 (en) 1999-12-30 2000-12-28 Use of steroidal alkaloids to reverse multidrug resistance
AU20229/01A AU2022901A (en) 1999-12-30 2000-12-28 Use of steroidal alkaloids to reverse multidrug resistance
AT00983471T ATE304360T1 (de) 1999-12-30 2000-12-28 Verwendung von steroid-alkaloidderivaten zur umkehrung multipler medikamentenresistenz
EP00983471A EP1274445B1 (en) 1999-12-30 2000-12-28 Use of steroidal alkaloids to reverse multidrug resistance
IL14991300A IL149913A0 (en) 1999-12-30 2000-12-28 Use of steroidal alkaloids to reverse multidrug resistance
US10/169,353 US20030114393A1 (en) 1999-12-30 2000-12-28 Use of steroidal alkaloids to reverse multidrug resistance
DE60022687T DE60022687T2 (de) 1999-12-30 2000-12-28 Verwendung von steroid-alkaloidderivaten zur umkehrung multipler medikamentenresistenz
IL149913A IL149913A (en) 1999-12-30 2004-01-01 Use of steroidal alkaloids for the manufacture of a composition for reverse of multi-drug resistance

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL13380999A IL133809A0 (en) 1999-12-30 1999-12-30 Steroidal alkaloids and pharmaceutical compositions comprising them

Publications (1)

Publication Number Publication Date
IL133809A0 true IL133809A0 (en) 2001-04-30

Family

ID=11073663

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13380999A IL133809A0 (en) 1999-12-30 1999-12-30 Steroidal alkaloids and pharmaceutical compositions comprising them
IL149913A IL149913A (en) 1999-12-30 2004-01-01 Use of steroidal alkaloids for the manufacture of a composition for reverse of multi-drug resistance

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL149913A IL149913A (en) 1999-12-30 2004-01-01 Use of steroidal alkaloids for the manufacture of a composition for reverse of multi-drug resistance

Country Status (9)

Country Link
US (1) US20030114393A1 (xx)
EP (1) EP1274445B1 (xx)
JP (1) JP2003519178A (xx)
AT (1) ATE304360T1 (xx)
AU (1) AU2022901A (xx)
CA (1) CA2395642A1 (xx)
DE (1) DE60022687T2 (xx)
IL (2) IL133809A0 (xx)
WO (1) WO2001049279A2 (xx)

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BRPI0514444A (pt) * 2004-08-27 2008-06-10 Infinity Pharmaceuticals Inc análogos de ciclopamina e métodos de uso destes
WO2006039569A1 (en) * 2004-09-30 2006-04-13 The University Of Chicago Combination therapy of hedgehog inhibitors, radiation and chemotherapeutic agents
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
CN101687877B (zh) 2007-03-07 2014-07-23 无限发现股份有限公司 杂环环杷明类似物及其使用方法
EP2134719B1 (en) 2007-03-07 2013-07-17 Infinity Discovery, Inc. Cyclopamine lactam analogs and methods of use thereof
EP3190121B1 (en) 2007-12-27 2019-02-20 Infinity Pharmaceuticals, Inc. Methods for stereoselective reduction of cyclopamine 4-en-3-one derivative
US20100297118A1 (en) * 2007-12-27 2010-11-25 Macdougall John Therapeutic Cancer Treatments
JP2011522773A (ja) * 2007-12-27 2011-08-04 インフィニティ ファーマスーティカルズ、インク． 治療剤での癌の処置方法
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
CN102574791A (zh) 2009-08-05 2012-07-11 无限药品股份有限公司 环杷明类似物的酶促转氨基反应
WO2011057222A1 (en) * 2009-11-06 2011-05-12 Infinity Pharmaceuticals, Inc. Oral formulations of a hedgehog pathway inhibitor
WO2011088404A1 (en) * 2010-01-15 2011-07-21 Infinity Pharmaceuticals , Inc Treatment of fibrotic conditions using hedgehog inhibitors
ES2593256T3 (es) 2010-05-21 2016-12-07 Infinity Pharmaceuticals, Inc. Compuestos químicos, composiciones y métodos para las modulaciones de cinasas
WO2012037217A1 (en) 2010-09-14 2012-03-22 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
EP2637669A4 (en) 2010-11-10 2014-04-02 Infinity Pharmaceuticals Inc Heterocyclic compounds and their use
ES2637113T3 (es) 2011-01-10 2017-10-10 Infinity Pharmaceuticals, Inc. Procedimientos para preparar isoquinolinonas y formas sólidas de isoquinolinonas
US9457033B2 (en) 2011-02-15 2016-10-04 Socpra Sciences Et Genie, S.E.C. Steroid alkaloids and uses thereof as antimicrobial agents against electron transport-deficient microbes and as potentiators for antimicrobial agents against pathogenic bacteria
CA2838275C (en) * 2011-06-06 2021-08-10 University Of Iowa Research Foundation Methods for inhibiting muscle atrophy
TWI565709B (zh) 2011-07-19 2017-01-11 英菲尼提製藥股份有限公司 雜環化合物及其用途
CN103930422A (zh) 2011-07-19 2014-07-16 无限药品股份有限公司 杂环化合物及其用途
WO2013032591A1 (en) 2011-08-29 2013-03-07 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
US9630979B2 (en) 2011-09-29 2017-04-25 Infinity Pharmaceuticals, Inc. Inhibitors of monoacylglycerol lipase and methods of their use
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX2020009849A (es) 2012-11-01 2021-09-13 Infinity Pharmaceuticals Inc Tratamiento de canceres utilizando moduladores de las isoformas de pi3 cinasa.
EP2925363A4 (en) 2012-11-29 2016-11-09 Strasspharma Llc METHOD FOR MODULATING FOLLICLE-STIMULATING HORMONACTIVITY
CN103043635B (zh) * 2012-12-25 2015-04-22 浙江大学 一种抗耐药性的顺铂矿化液及其制备方法和应用
EP2970194A1 (en) 2013-03-15 2016-01-20 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
US9192609B2 (en) 2013-04-17 2015-11-24 Hedgepath Pharmaceuticals, Inc. Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors
US20140377258A1 (en) 2013-05-30 2014-12-25 Infinity Pharmaceuticals, Inc. Treatment Of Cancers Using PI3 Kinase Isoform Modulators
CN104224815A (zh) * 2013-06-18 2014-12-24 复旦大学 澳洲茄胺在制备抗肿瘤药物中的应用
FR3008699B1 (fr) 2013-07-19 2015-08-21 Univ Picardie Nouveaux composes derives de la solanidine
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
ES2900806T3 (es) 2013-10-04 2022-03-18 Infinity Pharmaceuticals Inc Compuestos heterocíclicos y usos de los mismos
US20160244452A1 (en) 2013-10-21 2016-08-25 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US10137137B2 (en) 2013-12-23 2018-11-27 Socpra Sciences Et Genie S.E.C. ATP synthase inhibitors and steroid alkaloids and uses thereof as antimicrobial agents and as potentiators for aminoglycosides against pathogenic bacteria
JP6701088B2 (ja) 2014-03-19 2020-05-27 インフィニティー ファーマシューティカルズ， インコーポレイテッド Ｐｉ３ｋ−ガンマ媒介障害の治療で使用するための複素環式化合物
WO2015160986A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
WO2015168079A1 (en) 2014-04-29 2015-11-05 Infinity Pharmaceuticals, Inc. Pyrimidine or pyridine derivatives useful as pi3k inhibitors
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
BR112017026103B1 (pt) 2015-06-04 2023-10-03 Sol-Gel Technologies Ltd Composições tópicas com composto inibidor de hedgehog, sistema de entrega tópica e seus usos
CN105911176A (zh) * 2016-04-15 2016-08-31 广西壮族自治区梧州食品药品检验所 一种浙贝母中贝母素甲、贝母素乙的测定方法
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP3474856B1 (en) 2016-06-24 2022-09-14 Infinity Pharmaceuticals, Inc. Combination therapies
CN108853120B (zh) * 2018-07-23 2021-02-19 华南农业大学 贝母辛在制备抗白色念珠菌药物中的应用
CN110613720B (zh) * 2019-09-24 2022-06-03 华南农业大学 蒜藜芦碱用于制备防治白色念珠菌感染的药物中的应用
CN112138066B (zh) * 2020-09-09 2022-02-25 中南大学湘雅医院 龙葵或龙葵提取物在增加抗生素或抗肿瘤药物敏感性中的应用
CN112121059B (zh) * 2020-09-28 2022-02-11 郑州大学第一附属医院 一种中药单体组合物及用于治疗食管癌的用途

Family Cites Families (8)

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NZ193564A (en) * 1979-05-02 1985-01-31 Aruba Pty Ltd Steroid alkaloids from solanum sodomeum and pharmaceutical compositions
US5104858A (en) * 1988-09-29 1992-04-14 Yale University Sensitizing multidrug resistant cells to antitumor agents
US5005588A (en) * 1989-10-13 1991-04-09 David Rubin Method for increasing tumor sensitivity to chemotherapy
SE9600229D0 (sv) * 1996-01-23 1996-01-23 Pharmacia Ab Novel potentiating agents
WO1998058543A1 (en) * 1997-06-20 1998-12-30 Gubarev Michael J Method to enhance innate immunity defense mechanisms by treatment with plant-derived alkaloids
US6616925B1 (en) * 1998-04-02 2003-09-09 I.D.M. Immuno-Designed Molecules Combined preparation for the treatment of neoplasic diseases or of infectious diseases
EP1067939B1 (en) * 1998-04-09 2015-09-16 The Johns Hopkins University Use of steroidal alkaloid derivatives as inhibitors of hedgehog protein signaling pathways
US6291516B1 (en) * 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto

Also Published As

Publication number Publication date
WO2001049279A2 (en) 2001-07-12
CA2395642A1 (en) 2001-07-12
DE60022687T2 (de) 2006-07-06
WO2001049279A3 (en) 2002-10-17
EP1274445A2 (en) 2003-01-15
JP2003519178A (ja) 2003-06-17
DE60022687D1 (de) 2005-10-20
EP1274445B1 (en) 2005-09-14
US20030114393A1 (en) 2003-06-19
IL149913A (en) 2006-08-01
AU2022901A (en) 2001-07-16
ATE304360T1 (de) 2005-09-15

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