IL132991A - Substituted pyrazoles, pharmaceutical compositionscomprising them and their use as p38 inase inhibi tors - Google Patents
Substituted pyrazoles, pharmaceutical compositionscomprising them and their use as p38 inase inhibi torsInfo
- Publication number
- IL132991A IL132991A IL13299198A IL13299198A IL132991A IL 132991 A IL132991 A IL 132991A IL 13299198 A IL13299198 A IL 13299198A IL 13299198 A IL13299198 A IL 13299198A IL 132991 A IL132991 A IL 132991A
- Authority
- IL
- Israel
- Prior art keywords
- inase
- substituted pyrazoles
- inhibi tors
- compositionscomprising
- pharmaceutical
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4757097P | 1997-05-22 | 1997-05-22 | |
| PCT/US1998/010436 WO1998052940A1 (en) | 1997-05-22 | 1998-05-22 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL132991A0 IL132991A0 (en) | 2001-03-19 |
| IL132991A true IL132991A (en) | 2005-11-20 |
Family
ID=21949743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13299198A IL132991A (en) | 1997-05-22 | 1998-05-22 | Substituted pyrazoles, pharmaceutical compositionscomprising them and their use as p38 inase inhibi tors |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1000055A1 (bg) |
| JP (1) | JP2002508754A (bg) |
| KR (1) | KR20010012854A (bg) |
| CN (1) | CN1264377A (bg) |
| AP (1) | AP1246A (bg) |
| AU (1) | AU754830C (bg) |
| BG (1) | BG64313B1 (bg) |
| BR (1) | BR9809147A (bg) |
| CA (1) | CA2291115A1 (bg) |
| EA (1) | EA003925B1 (bg) |
| EE (1) | EE9900527A (bg) |
| GE (1) | GEP20033053B (bg) |
| HU (1) | HUP0001880A3 (bg) |
| ID (1) | ID22982A (bg) |
| IL (1) | IL132991A (bg) |
| IS (1) | IS5257A (bg) |
| NO (1) | NO995695L (bg) |
| NZ (1) | NZ501112A (bg) |
| OA (1) | OA12981A (bg) |
| PL (1) | PL337020A1 (bg) |
| SK (1) | SK157899A3 (bg) |
| TR (1) | TR200000235T2 (bg) |
| WO (1) | WO1998052940A1 (bg) |
| ZA (1) | ZA984358B (bg) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW289752B (bg) * | 1994-03-11 | 1996-11-01 | Ciba Geigy Ag | |
| US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
| US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
| AU7726898A (en) | 1997-05-22 | 1998-12-11 | G.D. Searle & Co. | Pyrazole derivatives as p38 kinase inhibitors |
| US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
| EP1023066A4 (en) | 1997-06-13 | 2001-05-23 | Smithkline Beecham Corp | NEW PYRAZOLE AND PYRAZOLINE SUBSTITUTED COMPOUND |
| US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| WO2000019824A1 (en) | 1998-10-07 | 2000-04-13 | Smithkline Beecham Corporation | Novel treatment for stroke management |
| DE69903976T2 (de) | 1998-12-16 | 2003-07-24 | Aventis Pharma Ltd | Heteroaryl-zyklische acetale |
| US6191147B1 (en) | 1998-12-24 | 2001-02-20 | Ppd Discovery, Inc. | Pyrazole compounds and uses thereof |
| DE69926542T2 (de) * | 1998-12-25 | 2006-04-27 | Teikoku Hormone Mfg. Co., Ltd. | Aminopyrazolderivate |
| TW502019B (en) | 1999-03-26 | 2002-09-11 | Cocensys Inc | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof |
| ES2239596T3 (es) | 1999-06-03 | 2005-10-01 | Teikoku Hormone Mfg. Co., Ltd. | Compuestos de pirazol sustituidos. |
| US7122666B2 (en) | 1999-07-21 | 2006-10-17 | Sankyo Company, Limited | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses |
| KR20020030791A (ko) * | 1999-08-12 | 2002-04-25 | 버텍스 파마슈티칼스 인코포레이티드 | ｃ－ＪＵＮ Ｎ-말단 키나제(ＪＮＫ) 및 기타의 단백질키나제 억제제 |
| WO2001030154A2 (de) * | 1999-10-25 | 2001-05-03 | Basf Aktiengesellschaft | Pyrazole enthaltende agrochemische zusammensetzungen und ihre verwendung als fungizide flanzenschutzmittel |
| DE19952147A1 (de) | 1999-10-29 | 2001-05-03 | Boehringer Ingelheim Pharma | Neue Cyclopropane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US7053099B1 (en) | 1999-11-23 | 2006-05-30 | Smithkline Beecham Corporation | 3,4-dihydro-(1H)quinazolin-2-one compounds as CSBP/p38 kinase inhibitors |
| JP4911864B2 (ja) | 2000-08-14 | 2012-04-04 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 置換ピラゾール |
| WO2002062792A1 (fr) * | 2001-02-02 | 2002-08-15 | Takeda Chemical Industries, Ltd. | Inhibiteur de jnk |
| GB0102687D0 (en) | 2001-02-02 | 2001-03-21 | Pharmacia & Upjohn Spa | Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them |
| EP2048142A3 (en) | 2001-04-26 | 2009-04-22 | Eisai R&D Management Co., Ltd. | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof |
| EP1397364B1 (en) | 2001-05-24 | 2007-07-25 | Eli Lilly And Company | Novel pyrrole derivatives as pharmaceutical agents |
| US7057049B2 (en) | 2001-09-25 | 2006-06-06 | Pharmacia Corporation | Process for making substituted pyrazoles |
| WO2003026663A1 (en) | 2001-09-25 | 2003-04-03 | Pharmacia Corporation | Process for making substituted pyrazoles |
| BR0311619A (pt) * | 2002-06-05 | 2005-03-08 | Pharmacia Corp | Derivados de pirazol como inibidores de cinase p38 |
| GB0215844D0 (en) | 2002-07-09 | 2002-08-14 | Novartis Ag | Organic compounds |
| ATE349210T1 (de) | 2002-07-09 | 2007-01-15 | Boehringer Ingelheim Pharma | Pharazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege |
| GB0217786D0 (en) * | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Compounds |
| AU2003265395A1 (en) | 2002-08-14 | 2004-03-03 | Ppd Discovery, Inc. | Prenylation inhibitors and methods of their synthesis and use |
| US6649638B1 (en) | 2002-08-14 | 2003-11-18 | Ppd Discovery, Inc. | Prenylation inhibitors and methods of their synthesis and use |
| WO2004026302A1 (en) * | 2002-09-19 | 2004-04-01 | Eli Lilly And Company | Methods of inhibiting tgf beta with substituted pyrazoles |
| GB0229618D0 (en) | 2002-12-19 | 2003-01-22 | Cancer Rec Tech Ltd | Pyrazole compounds |
| US7622471B2 (en) | 2003-02-07 | 2009-11-24 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivatives having a pyridazine and pyridine functionality |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| PT1778686E (pt) | 2004-08-12 | 2008-12-26 | Pfizer | Derivados de triazolopiridinilsufanilo como inibidores da p38 map-cinase |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| CA2591912C (en) | 2004-12-28 | 2013-06-25 | Aska Pharmaceutical Co., Ltd. | Pyrimidinylisoxazole derivatives |
| EP2024353A2 (en) * | 2006-03-16 | 2009-02-18 | Pfizer Products Inc. | Pyrazole compounds |
| CA2655999A1 (en) * | 2006-06-28 | 2008-01-03 | Aska Pharmaceutical Co., Ltd. | Treating agent of inflammatory bowel disease |
| ES2396251T3 (es) | 2006-06-28 | 2013-02-20 | Aska Pharmaceutical Co., Ltd. | Derivado de piridilisoxazol |
| EP2123255B1 (en) | 2007-02-16 | 2013-05-15 | ASKA Pharmaceutical Co., Ltd. | Pharmaceutical composition containing fine particle oil-based suspension |
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| AU2008277730B2 (en) * | 2007-07-13 | 2013-01-31 | Addex Pharma S.A. | Pyrazole derivatives as modulators of metabotropic glutamate receptors |
| EP2220048B1 (en) | 2007-11-16 | 2017-01-25 | Boehringer Ingelheim International GmbH | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| CL2009000904A1 (es) * | 2008-04-21 | 2010-04-30 | Shionogi & Co | Compuestos derivados de ciclohexil sulfonamidas que tienen actividad antagonista en el receptor npy y5, composicion farmaceutica y formulacion farmaceutica que los comprende. |
| US8765780B2 (en) | 2008-05-13 | 2014-07-01 | Boehringer Ingelheim International Gmbh | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use |
| PL2324008T3 (pl) | 2008-07-24 | 2012-09-28 | Nerviano Medical Sciences Srl | 3,4-diarylopirazole jako inhibitory kinazy białkowej |
| US8609690B2 (en) * | 2008-08-25 | 2013-12-17 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use |
| JP2012506388A (ja) * | 2008-10-23 | 2012-03-15 | ロンザ リミテッド | 置換されたピラゾールの合成方法 |
| US8252790B2 (en) * | 2008-11-21 | 2012-08-28 | Raqualia Pharma Inc. | Pyrazole-3-carboxamide derivative having 5-HT2B receptor antagonist activity |
| US8703765B2 (en) | 2009-06-02 | 2014-04-22 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| EP2440537A1 (en) | 2009-06-11 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
| US20120149661A1 (en) * | 2009-08-26 | 2012-06-14 | Novartis Ag | Tetra-substituted heteroaryl compounds and their use as mdm2 and/or mdm4 modulators |
| JO3002B1 (ar) | 2009-08-28 | 2016-09-05 | Irm Llc | مركبات و تركيبات كمثبطات كيناز بروتين |
| EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
| BR112012018358A2 (pt) | 2009-12-21 | 2016-08-09 | Bayer Cropscience Ag | tienilpiri(mi)dinilazol e seu uso para controlar fungos fitopatogênicos |
| WO2011092088A1 (en) | 2010-01-27 | 2011-08-04 | Nerviano Medical Sciences S.R.L. | Sulfonamido derivatives of 3,4-diarylpyrazoles as protein kinase inhibitors |
| AR081810A1 (es) | 2010-04-07 | 2012-10-24 | Bayer Cropscience Ag | Piridinilpirazoles biciclicos |
| WO2011159760A1 (en) | 2010-06-16 | 2011-12-22 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| WO2012016993A1 (en) | 2010-08-03 | 2012-02-09 | Nerviano Medical Sciences S.R.L. | Derivatives of pyrazolophenyl-benzenesulfonamide compounds and use thereof as antitumor agents |
| DK3181133T3 (da) * | 2010-12-20 | 2019-08-26 | Pfizer | Nye kondenserede pyridinforbindelser som casein-kinasehæmmere |
| WO2012175513A1 (en) | 2011-06-20 | 2012-12-27 | Bayer Intellectual Property Gmbh | Thienylpyri(mi)dinylpyrazole |
| EP2744783A1 (en) | 2011-08-17 | 2014-06-25 | Boehringer Ingelheim International GmbH | Indenopyridine derivatives |
| EP2763993B1 (en) | 2011-10-06 | 2017-04-19 | Bayer Intellectual Property GmbH | Heterocyclylpyri(mi)dinylpyrazole |
| WO2013050437A1 (en) | 2011-10-06 | 2013-04-11 | Bayer Intellectual Property Gmbh | Heterocyclylpyri (mi) dinylpyrazole as fungicidals |
| DE102011115525A1 (de) | 2011-10-11 | 2013-04-11 | Boehringer Ingelheim International Gmbh | Zweiteilige Flasche mit einem darin angeordneten Trockenmittel |
| BR112014011223A8 (pt) | 2011-11-11 | 2023-01-31 | Novartis Ag | Método de tratar uma doença proliferativa |
| CA2856406C (en) | 2011-11-23 | 2020-06-23 | Novartis Ag | Pharmaceutical formulations |
| US9452170B2 (en) | 2013-03-15 | 2016-09-27 | The California Institute For Biomedical Research | Compounds and methods for inducing chondrogenesis |
| WO2015088038A1 (ja) * | 2013-12-12 | 2015-06-18 | 住友化学株式会社 | 芳香族化合物及びその用途 |
| CN104829536B (zh) * | 2015-05-04 | 2017-12-29 | 陕西科技大学 | 一种具抗肿瘤活性的苯基吡唑羧酸类化合物及其合成方法 |
| CN107848962B (zh) * | 2015-05-27 | 2021-04-09 | 杏林制药株式会社 | 脲衍生物或其药理学上可接受的盐 |
| CN112480079B (zh) * | 2017-11-08 | 2022-03-11 | 北京嘉林药业股份有限公司 | 化合物及其治疗癌症的用途 |
| US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| AU2020417293A1 (en) | 2020-01-03 | 2022-09-01 | Berg Llc | Polycyclic amides as UBE2K modulators for treating cancer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
| US5486534A (en) * | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
-
1998
- 1998-05-22 TR TR2000/00235T patent/TR200000235T2/xx unknown
- 1998-05-22 WO PCT/US1998/010436 patent/WO1998052940A1/en not_active Application Discontinuation
- 1998-05-22 CN CN98807369A patent/CN1264377A/zh active Pending
- 1998-05-22 HU HU0001880A patent/HUP0001880A3/hu unknown
- 1998-05-22 ZA ZA984358A patent/ZA984358B/xx unknown
- 1998-05-22 EE EEP199900527A patent/EE9900527A/xx unknown
- 1998-05-22 IL IL13299198A patent/IL132991A/xx not_active IP Right Cessation
- 1998-05-22 BR BR9809147-6A patent/BR9809147A/pt not_active Application Discontinuation
- 1998-05-22 GE GEAP19985095A patent/GEP20033053B/en unknown
- 1998-05-22 NZ NZ501112A patent/NZ501112A/xx unknown
- 1998-05-22 SK SK1578-99A patent/SK157899A3/sk unknown
- 1998-05-22 EA EA199900953A patent/EA003925B1/ru not_active IP Right Cessation
- 1998-05-22 AU AU75883/98A patent/AU754830C/en not_active Ceased
- 1998-05-22 EP EP98923642A patent/EP1000055A1/en not_active Withdrawn
- 1998-05-22 AP APAP/P/1999/001715A patent/AP1246A/en active
- 1998-05-22 ID IDW991425A patent/ID22982A/id unknown
- 1998-05-22 KR KR19997010820A patent/KR20010012854A/ko not_active Application Discontinuation
- 1998-05-22 JP JP55065098A patent/JP2002508754A/ja not_active Withdrawn
- 1998-05-22 CA CA002291115A patent/CA2291115A1/en not_active Abandoned
- 1998-05-22 PL PL98337020A patent/PL337020A1/xx unknown
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1999
- 1999-11-19 NO NO995695A patent/NO995695L/no not_active Application Discontinuation
- 1999-11-19 IS IS5257A patent/IS5257A/is unknown
- 1999-11-22 OA OA9900252A patent/OA12981A/en unknown
- 1999-12-08 BG BG103964A patent/BG64313B1/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2291115A1 (en) | 1998-11-26 |
| EP1000055A1 (en) | 2000-05-17 |
| HUP0001880A2 (en) | 2001-03-28 |
| JP2002508754A (ja) | 2002-03-19 |
| NO995695L (no) | 2000-01-21 |
| IL132991A0 (en) | 2001-03-19 |
| CN1264377A (zh) | 2000-08-23 |
| AU754830B2 (en) | 2002-11-28 |
| HUP0001880A3 (en) | 2002-03-28 |
| TR200000235T2 (tr) | 2000-05-22 |
| EE9900527A (et) | 2000-06-15 |
| GEP20033053B (en) | 2003-08-25 |
| PL337020A1 (en) | 2000-07-31 |
| IS5257A (is) | 1999-11-19 |
| KR20010012854A (ko) | 2001-02-26 |
| NO995695D0 (no) | 1999-11-19 |
| EA003925B1 (ru) | 2003-10-30 |
| BG103964A (bg) | 2000-08-31 |
| ZA984358B (en) | 1999-05-24 |
| BG64313B1 (bg) | 2004-09-30 |
| WO1998052940A1 (en) | 1998-11-26 |
| SK157899A3 (en) | 2000-08-14 |
| AU754830C (en) | 2004-02-12 |
| AP9901715A0 (en) | 1999-12-31 |
| OA12981A (en) | 2006-10-13 |
| EA199900953A1 (ru) | 2000-10-30 |
| ID22982A (id) | 1999-12-23 |
| AP1246A (en) | 2004-02-07 |
| AU7588398A (en) | 1998-12-11 |
| NZ501112A (en) | 2002-10-25 |
| BR9809147A (pt) | 2000-08-01 |
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