IL132099A0 - Methods for assessing cardiovascular status and compositions for use therein - Google Patents
Methods for assessing cardiovascular status and compositions for use thereinInfo
- Publication number
- IL132099A0 IL132099A0 IL13209998A IL13209998A IL132099A0 IL 132099 A0 IL132099 A0 IL 132099A0 IL 13209998 A IL13209998 A IL 13209998A IL 13209998 A IL13209998 A IL 13209998A IL 132099 A0 IL132099 A0 IL 132099A0
- Authority
- IL
- Israel
- Prior art keywords
- cardiovascular status
- methods
- compositions
- agt
- nucleic acid
- Prior art date
Links
- 230000002526 effect on cardiovascular system Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 3
- 102000004881 Angiotensinogen Human genes 0.000 abstract 3
- 108090001067 Angiotensinogen Proteins 0.000 abstract 3
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 3
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 3
- 108050000824 Angiotensin II receptor Proteins 0.000 abstract 2
- 102000008873 Angiotensin II receptor Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 108020004711 Nucleic Acid Probes Proteins 0.000 abstract 1
- 102100026803 Type-1 angiotensin II receptor Human genes 0.000 abstract 1
- 101710096334 Type-1 angiotensin II receptor Proteins 0.000 abstract 1
- 239000002327 cardiovascular agent Substances 0.000 abstract 1
- 229940125692 cardiovascular agent Drugs 0.000 abstract 1
- 239000002853 nucleic acid probe Substances 0.000 abstract 1
- 102000054765 polymorphisms of proteins Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4293097P | 1997-04-04 | 1997-04-04 | |
| PCT/IB1998/000475 WO1998045477A2 (en) | 1997-04-04 | 1998-04-01 | Methods for assessing cardiovascular status and compositions for use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL132099A0 true IL132099A0 (en) | 2001-03-19 |
Family
ID=21924511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13209998A IL132099A0 (en) | 1997-04-04 | 1998-04-01 | Methods for assessing cardiovascular status and compositions for use therein |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6197505B1 (da) |
| EP (1) | EP0972075B1 (da) |
| JP (1) | JP2001519660A (da) |
| AT (1) | ATE335844T1 (da) |
| AU (1) | AU741750B2 (da) |
| CA (1) | CA2285671A1 (da) |
| CY (1) | CY1106158T1 (da) |
| DE (1) | DE69835509T2 (da) |
| DK (1) | DK0972075T3 (da) |
| ES (1) | ES2270510T3 (da) |
| IL (1) | IL132099A0 (da) |
| NZ (1) | NZ337878A (da) |
| WO (1) | WO1998045477A2 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197505B1 (en) | 1997-04-04 | 2001-03-06 | Pyrosequencing Ab | Methods for assessing cardiovascular status and compositions for use thereof |
| KR100523112B1 (ko) * | 1997-10-17 | 2005-10-19 | 유로진 리미티드 | 레닌-안지오텐신계 억제제의 사용 |
| AU6116399A (en) * | 1998-10-14 | 2000-05-01 | Pyrosequencing Ab | Genes for assessing cardiovascular status and compositions for use thereof |
| US6280994B1 (en) * | 1998-11-25 | 2001-08-28 | Zymogenetics, Inc. | Zace 1: a human metalloenzyme |
| WO2000056922A2 (en) * | 1999-03-23 | 2000-09-28 | Gemini Genomics Ab | Genetic polymorphism and polymorphic pattern for assessing disease status, and compositions for use thereof |
| GB9914440D0 (en) * | 1999-06-22 | 1999-08-18 | Zeneca Ltd | Chemical compounds |
| US20030113330A1 (en) * | 1999-11-08 | 2003-06-19 | Uhal Bruce D. | Methods for treating pulmonary fibrosis |
| EP1415004A4 (en) * | 2001-07-03 | 2005-01-19 | Univ Leland Stanford Junior | BIOLUMINESCENCE REGENERATING CIRCULATION (BRC) FOR NUCLEIC ACID QUANTIFICATION |
| EP1394267A1 (en) * | 2002-08-19 | 2004-03-03 | Bayer HealthCare AG | Single nucleotide polymorphisms predictive for cardiovascular disease, adverse drug reactions, and drug efficacy |
| US20040197793A1 (en) * | 2002-08-30 | 2004-10-07 | Arjang Hassibi | Methods and apparatus for biomolecule detection, identification, quantification and/or sequencing |
| WO2005083127A2 (en) * | 2004-02-27 | 2005-09-09 | Applera Corporation | Genetic polymorphisms associated with stroke, methods of detection and uses thereof |
| CN100540678C (zh) * | 2004-04-15 | 2009-09-16 | 香港中文大学 | 应用遗传标记和芯片预测糖尿病肾病危险的方法 |
| WO2006123885A1 (en) * | 2005-05-18 | 2006-11-23 | Samsung Electronics Co., Ltd. | Methods and compositions for diagnosing cardiovascular disease |
| WO2008136995A1 (en) * | 2007-04-30 | 2008-11-13 | The Ohio State University Research Foundation | Polymorphisms in genes affecting dopamine transporter disorders and uses thereof |
| WO2010096680A2 (en) | 2009-02-20 | 2010-08-26 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Protein structural biomarkers to guide targeted chemotherapies |
| US9938576B1 (en) | 2012-09-21 | 2018-04-10 | Ohio State Innovation Foundation | Materials and methods for determining metabolizer status in humans |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1987002709A1 (en) | 1985-10-24 | 1987-05-07 | Biotechnology Research Partners, Ltd. | Blood tests diagnostic for hypertension |
| AU1728088A (en) | 1987-04-30 | 1988-12-02 | Biotechnology Research Partners Limited | Hypertension-related blood tests useful as genetic markers |
| FR2678285A1 (fr) * | 1991-06-27 | 1992-12-31 | Inst Nat Sante Rech Med | Moyens et procedes pour l'etude du polymorphisme genetique de l'enzyme de conversion de l'angiotensine 1. |
| US5374525A (en) | 1992-09-30 | 1994-12-20 | University Of Utah Research Foundation | Methods to determine predisposition to hypertension and association of variant angiotensinogen gene and hypertension |
| US5243652A (en) * | 1992-09-30 | 1993-09-07 | Gte Laboratories Incorporated | Location-sensitive remote database access control |
| FR2723590B1 (fr) * | 1994-08-09 | 1996-10-25 | Inst Nat Sante Rech Med | Procede de detection et trousse de diagnostic in vitro d'une predisposition a l'infarctus du myocarde |
| US5800990A (en) | 1995-12-06 | 1998-09-01 | Regents Of The University Of Colorado | Angiotensin-converting enzyme genetic variant screens |
| US6197505B1 (en) | 1997-04-04 | 2001-03-06 | Pyrosequencing Ab | Methods for assessing cardiovascular status and compositions for use thereof |
| WO1999037761A1 (de) | 1997-12-30 | 1999-07-29 | Max-Delbrück-Centrum für Molekulare Medizin | Neue sequenzvarianten des menschlichen beta2-adrenergen rezeptorgens und ihre verwendung |
-
1998
- 1998-03-27 US US09/050,159 patent/US6197505B1/en not_active Expired - Fee Related
- 1998-04-01 AT AT98908252T patent/ATE335844T1/de not_active IP Right Cessation
- 1998-04-01 CA CA002285671A patent/CA2285671A1/en not_active Abandoned
- 1998-04-01 DK DK98908252T patent/DK0972075T3/da active
- 1998-04-01 AU AU66329/98A patent/AU741750B2/en not_active Ceased
- 1998-04-01 JP JP54253098A patent/JP2001519660A/ja active Pending
- 1998-04-01 IL IL13209998A patent/IL132099A0/xx not_active IP Right Cessation
- 1998-04-01 DE DE69835509T patent/DE69835509T2/de not_active Expired - Fee Related
- 1998-04-01 NZ NZ337878A patent/NZ337878A/en unknown
- 1998-04-01 WO PCT/IB1998/000475 patent/WO1998045477A2/en not_active Ceased
- 1998-04-01 ES ES98908252T patent/ES2270510T3/es not_active Expired - Lifetime
- 1998-04-01 EP EP98908252A patent/EP0972075B1/en not_active Expired - Lifetime
-
2006
- 2006-11-08 CY CY20061101603T patent/CY1106158T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69835509D1 (de) | 2006-09-21 |
| ES2270510T3 (es) | 2007-04-01 |
| WO1998045477A2 (en) | 1998-10-15 |
| ATE335844T1 (de) | 2006-09-15 |
| DK0972075T3 (da) | 2006-12-11 |
| US6197505B1 (en) | 2001-03-06 |
| CY1106158T1 (el) | 2011-06-08 |
| JP2001519660A (ja) | 2001-10-23 |
| WO1998045477A3 (en) | 1999-01-28 |
| AU6632998A (en) | 1998-10-30 |
| EP0972075B1 (en) | 2006-08-09 |
| DE69835509T2 (de) | 2007-04-05 |
| AU741750B2 (en) | 2001-12-06 |
| CA2285671A1 (en) | 1998-10-15 |
| EP0972075A2 (en) | 2000-01-19 |
| NZ337878A (en) | 2001-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |