IL131849A - -7(((-5אמינו--1,2,4 תיאדיאזול- -3יל)- פלואורומתוקסיאימינו) אצטיל) אמינו--3 ((אימינו--1 פיפרזינילמתיל) הידרזונו מותמר) מתיל--3צפמ--4חומצה קרבוקסילית, אסטר או מלח שלו, הכנתו ותכשירים פרצבטיים המכילים אותו - Google Patents

-7(((-5אמינו--1,2,4 תיאדיאזול- -3יל)- פלואורומתוקסיאימינו) אצטיל) אמינו--3 ((אימינו--1 פיפרזינילמתיל) הידרזונו מותמר) מתיל--3צפמ--4חומצה קרבוקסילית, אסטר או מלח שלו, הכנתו ותכשירים פרצבטיים המכילים אותו

Info

Publication number
IL131849A
IL131849A IL13184998A IL13184998A IL131849A IL 131849 A IL131849 A IL 131849A IL 13184998 A IL13184998 A IL 13184998A IL 13184998 A IL13184998 A IL 13184998A IL 131849 A IL131849 A IL 131849A
Authority
IL
Israel
Prior art keywords
compound
formula
amino
methyl
group
Prior art date
Application number
IL13184998A
Other languages
English (en)
Other versions
IL131849A0 (en
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AT54797A external-priority patent/AT405180B/de
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Priority to IL15641798A priority Critical patent/IL156417A0/xx
Publication of IL131849A0 publication Critical patent/IL131849A0/xx
Publication of IL131849A publication Critical patent/IL131849A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL13184998A 1997-04-01 1998-04-01 -7(((-5אמינו--1,2,4 תיאדיאזול- -3יל)- פלואורומתוקסיאימינו) אצטיל) אמינו--3 ((אימינו--1 פיפרזינילמתיל) הידרזונו מותמר) מתיל--3צפמ--4חומצה קרבוקסילית, אסטר או מלח שלו, הכנתו ותכשירים פרצבטיים המכילים אותו IL131849A (he)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL15641798A IL156417A0 (en) 1997-04-01 1998-04-01 7-(5-amino-1, 2, 4-thiadiazol-3-yl)-amino-3-((imino-1-substituted piperazinylmethyl) substituted hydrazono) methyl-3-cephem-4-carboxylic acid, ester or salt thereof, its preparation and pharmaceutical compositions containing the same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AT54797A AT405180B (de) 1997-04-01 1997-04-01 Neue derivate von substituierten 3-cephem-4-carbonsäurederivaten und verfahren zu deren herstellung
AT54697 1997-04-01
AT54897 1997-04-01
PCT/EP1998/001890 WO1998043981A1 (en) 1997-04-01 1998-04-01 Antibacterial substituted 7-acylamino-3-(methylhydrazono)methyl -cephalosporins and intermediates

Publications (2)

Publication Number Publication Date
IL131849A0 IL131849A0 (en) 2001-03-19
IL131849A true IL131849A (he) 2004-05-12

Family

ID=27146440

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13184998A IL131849A (he) 1997-04-01 1998-04-01 -7(((-5אמינו--1,2,4 תיאדיאזול- -3יל)- פלואורומתוקסיאימינו) אצטיל) אמינו--3 ((אימינו--1 פיפרזינילמתיל) הידרזונו מותמר) מתיל--3צפמ--4חומצה קרבוקסילית, אסטר או מלח שלו, הכנתו ותכשירים פרצבטיים המכילים אותו

Country Status (21)

Country Link
EP (2) EP0973780B1 (he)
JP (2) JP3363157B2 (he)
KR (2) KR100481143B1 (he)
CN (1) CN1117095C (he)
AU (1) AU734897B2 (he)
BR (1) BR9807913A (he)
CA (1) CA2284501C (he)
DE (1) DE69816057T2 (he)
DK (1) DK0973780T3 (he)
ES (1) ES2203955T3 (he)
HK (1) HK1026692A1 (he)
ID (1) ID22441A (he)
IL (1) IL131849A (he)
NO (1) NO325687B1 (he)
NZ (1) NZ337732A (he)
PL (1) PL200130B1 (he)
PT (1) PT973780E (he)
RU (1) RU2201933C2 (he)
SK (1) SK133099A3 (he)
TR (1) TR199902387T2 (he)
WO (1) WO1998043981A1 (he)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT406772B (de) * 1998-03-23 2000-08-25 Biochemie Gmbh Antibakterielle 7-acylamino-3-iminomethyl- cephalosporine und verfahren zu deren herstellung
US6504025B2 (en) * 2000-05-24 2003-01-07 Basilea Pharmaceutica Ag Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives
AT413282B (de) * 2002-02-01 2006-01-15 Sandoz Ag Kristalline salze der 7-(((5-amino-1,2,4-thiadiazol-3-yl) (fluoromethoxy-imino)acetyl)amino)-3- ((imino-1-piperazinylmethyl)
CN114401970A (zh) 2019-09-06 2022-04-26 纳布里瓦治疗有限责任公司 铁载体头孢菌素缀合物及其用途
CN111187281B (zh) * 2020-02-11 2023-03-14 广西科技大学 含胍基的头孢菌素衍生物及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190639B (en) * 1983-12-12 1986-09-29 Gyogyszerkutato Intezet Kv,Hu Process for production of new aminoguanidin derivatives
FI851934L (fi) * 1984-05-30 1985-12-01 Ici Plc Kefalosporinderivat.
RU2183212C2 (ru) * 1995-05-11 2002-06-10 Биохеми Гезельшафт Мбх Антибактериальные цефалоспорины, фармацевтическая композиция на их основе и способ лечения

Also Published As

Publication number Publication date
CA2284501A1 (en) 1998-10-08
IL131849A0 (en) 2001-03-19
ID22441A (id) 1999-10-14
KR100481143B1 (ko) 2005-04-08
CN1251591A (zh) 2000-04-26
TR199902387T2 (xx) 2000-01-21
DE69816057D1 (de) 2003-08-07
RU2201933C2 (ru) 2003-04-10
NO994719L (no) 1999-09-28
CA2284501C (en) 2007-07-17
CN1117095C (zh) 2003-08-06
NO325687B1 (no) 2008-07-07
PL336004A1 (en) 2000-06-05
DK0973780T3 (da) 2003-10-27
NZ337732A (en) 2001-09-28
EP0973780A1 (en) 2000-01-26
BR9807913A (pt) 2000-02-22
KR20040000380A (ko) 2004-01-03
DE69816057T2 (de) 2004-04-15
WO1998043981A1 (en) 1998-10-08
HK1026692A1 (en) 2000-12-22
NO994719D0 (no) 1999-09-28
AU734897B2 (en) 2001-06-28
KR20000076288A (ko) 2000-12-26
AU7521398A (en) 1998-10-22
JP2002316992A (ja) 2002-10-31
EP0973780B1 (en) 2003-07-02
PL200130B1 (pl) 2008-12-31
JP2000514832A (ja) 2000-11-07
SK133099A3 (en) 2001-03-12
PT973780E (pt) 2003-11-28
ES2203955T3 (es) 2004-04-16
EP1300408A1 (en) 2003-04-09
JP3363157B2 (ja) 2003-01-08

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees