IL131008A - Lipid complexes and liposomes of highly insoluble platinum complex dicarboxylate - Google Patents

Lipid complexes and liposomes of highly insoluble platinum complex dicarboxylate

Info

Publication number
IL131008A
IL131008A IL13100898A IL13100898A IL131008A IL 131008 A IL131008 A IL 131008A IL 13100898 A IL13100898 A IL 13100898A IL 13100898 A IL13100898 A IL 13100898A IL 131008 A IL131008 A IL 131008A
Authority
IL
Israel
Prior art keywords
dicarboxylate
liposomes
platinum complex
lipid complexes
highly insoluble
Prior art date
Application number
IL13100898A
Other languages
English (en)
Other versions
IL131008A0 (en
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of IL131008A0 publication Critical patent/IL131008A0/xx
Publication of IL131008A publication Critical patent/IL131008A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL13100898A 1997-02-05 1998-01-28 Lipid complexes and liposomes of highly insoluble platinum complex dicarboxylate IL131008A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3737797P 1997-02-05 1997-02-05
PCT/US1998/000035 WO1998033481A1 (en) 1997-02-05 1998-01-28 Lipid complexes and liposomes of highly insoluble platinum complexes

Publications (2)

Publication Number Publication Date
IL131008A0 IL131008A0 (en) 2001-01-28
IL131008A true IL131008A (en) 2003-06-24

Family

ID=21894020

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13100898A IL131008A (en) 1997-02-05 1998-01-28 Lipid complexes and liposomes of highly insoluble platinum complex dicarboxylate

Country Status (22)

Country Link
US (1) US6287593B2 (pl)
EP (1) EP0975329B1 (pl)
JP (1) JP2002513396A (pl)
KR (1) KR100578705B1 (pl)
CN (2) CN1191067C (pl)
AT (1) ATE284204T1 (pl)
AU (1) AU749220B2 (pl)
BR (1) BR9815445A (pl)
CA (1) CA2279279C (pl)
DE (1) DE69828038T2 (pl)
DK (1) DK0975329T3 (pl)
EA (1) EA002630B1 (pl)
ES (1) ES2234094T3 (pl)
HK (1) HK1054201B (pl)
HU (1) HUP0001266A3 (pl)
IL (1) IL131008A (pl)
NO (1) NO993750L (pl)
NZ (1) NZ337502A (pl)
PL (1) PL192633B1 (pl)
PT (1) PT975329E (pl)
UA (1) UA71540C2 (pl)
WO (1) WO1998033481A1 (pl)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999051246A1 (en) 1998-04-03 1999-10-14 Ajinomoto Co., Inc. Antitumor agents
US6476068B1 (en) 2001-12-06 2002-11-05 Pharmacia Italia, S.P.A. Platinum derivative pharmaceutical formulations
US9186322B2 (en) * 2002-08-02 2015-11-17 Insmed Incorporated Platinum aggregates and process for producing the same
JP2006525368A (ja) * 2003-05-02 2006-11-09 アロネックス，ファーマシューティカルズ，インコーポレーテッド 脂質白金錯体およびその使用方法
WO2004105732A1 (en) * 2003-05-20 2004-12-09 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising gemcitabine and a liposomal platinum complex
CA2526289A1 (en) * 2003-05-20 2004-12-02 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising 5-fluorouracil or a derivative thereof and a liposomal platinum complex
EP1631278A4 (en) * 2003-05-20 2006-09-20 Aronex Pharmaceuticals Inc COMBINATION SCHEMOTHERAPY WITH CAPECITABIN AND A LIPOSOMAL PLATINUM COMPLEX
JP2007504177A (ja) * 2003-09-02 2007-03-01 プリヴァ−ラケマ，エー．エス． 医薬組成物、その製造方法及び治療上の使用
EP1734937A1 (en) * 2004-03-26 2006-12-27 Cell Therapeutics Europe S.R.L. Nanoparticle formulations of platinum compounds
WO2006084248A2 (en) * 2005-02-04 2006-08-10 Antigenics, Inc. Compositions comprising a platinum complex, lipid, and surfactant
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
CA2631243A1 (en) * 2005-12-08 2007-06-14 Wyeth Liposomal compositions
CZ300424B6 (cs) * 2006-06-20 2009-05-13 Pliva - Lachema A. S. Farmaceutická kompozice pro perorální podání
IN2012DN02576A (pl) * 2009-09-21 2015-08-28 Jw Pharmaceutical Corportion
WO2012006101A2 (en) 2010-06-28 2012-01-12 The General Hospital Corporation Blood substitutes and uses thereof
CN102276674A (zh) * 2011-06-24 2011-12-14 天津大学 用于肿瘤靶向治疗的含半乳糖铂配合物及其制备方法
CN102286049A (zh) * 2011-06-24 2011-12-21 天津谷堆生物医药科技有限公司 用于肿瘤治疗的水溶性铂配合物及其制备方法
CN102286050A (zh) * 2011-06-24 2011-12-21 天津大学 用于肿瘤靶向治疗的含葡萄糖铂配合物及其制备方法
CN102716145A (zh) * 2012-06-20 2012-10-10 天津谷堆生物医药科技有限公司 含糖铂配合物在制备防治肿瘤药物的用途
EP2874605A1 (en) 2012-07-18 2015-05-27 Onyx Therapeutics, Inc. Liposomal compositions of epoxyketone-based proteasome inhibitors
DK2892524T3 (da) 2012-09-04 2021-01-25 Eleison Pharmaceuticals LLC Forebyggelse af pulmonalt kræfttilbagefald med lipid-komplekseret cisplatin
US10039716B2 (en) 2013-03-13 2018-08-07 Mallinckrodt Llc Liposomal cisplatin compositions for cancer therapy
CN104546722B (zh) * 2015-02-10 2017-05-24 中国医学科学院医药生物技术研究所 米铂脂质体和制法
CN109678910B (zh) * 2016-01-25 2021-09-07 沈阳药科大学 一种化合物及其应用以及一种铂类配合物及其脂质体
JP2020500020A (ja) 2016-11-14 2020-01-09 ノバルティス アーゲー 融合誘導性タンパク質ｍｉｎｉｏｎに関連する組成物、方法、および治療上の使用
CN114652680A (zh) * 2020-12-24 2022-06-24 沈阳药科大学 制备脂质体的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0113508A1 (en) * 1982-11-04 1984-07-18 Inco Research & Development Center, Inc. Hydrophobic platinum compounds and their preparation
US5384127A (en) * 1985-10-18 1995-01-24 Board Of Regents, The University Of Texas System Stable liposomal formulations of lipophilic platinum compounds
US4927571A (en) * 1987-05-18 1990-05-22 Liposome Technology, Inc. Preparation of injectable doxorubicin/liposome suspension
CA1339034C (en) * 1988-08-22 1997-04-01 Paul A. Tremblay Platinum complexes of single isomer neoalkyl acids
US5393909A (en) * 1988-11-22 1995-02-28 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
JPH03200795A (ja) * 1989-12-28 1991-09-02 Nippon Kayaku Co Ltd 脂質親和性白金錯体及びそれを含有する製剤
US5843475A (en) * 1996-12-06 1998-12-01 Board Of Regents, The University Of Texas System Delivery and activation through liposome incorporation of diaminocyclohexane platinum (II) complexes

Also Published As

Publication number Publication date
AU749220B2 (en) 2002-06-20
AU6015498A (en) 1998-08-25
CN1191067C (zh) 2005-03-02
HK1029059A1 (zh) 2001-03-23
ATE284204T1 (de) 2004-12-15
KR100578705B1 (ko) 2006-05-12
CN1096263C (zh) 2002-12-18
NO993750D0 (no) 1999-08-03
CA2279279C (en) 2008-10-14
CN1264295A (zh) 2000-08-23
CN1422619A (zh) 2003-06-11
ES2234094T3 (es) 2005-06-16
HUP0001266A2 (hu) 2000-11-28
KR20000070771A (ko) 2000-11-25
NZ337502A (en) 2001-02-23
EA199900715A1 (ru) 2000-04-24
JP2002513396A (ja) 2002-05-08
DE69828038D1 (de) 2005-01-13
DK0975329T3 (da) 2005-03-14
EA002630B1 (ru) 2002-08-29
CA2279279A1 (en) 1998-08-06
DE69828038T2 (de) 2005-11-03
EP0975329B1 (en) 2004-12-08
NO993750L (no) 1999-08-03
EP0975329A1 (en) 2000-02-02
WO1998033481A1 (en) 1998-08-06
IL131008A0 (en) 2001-01-28
US20010010822A1 (en) 2001-08-02
HUP0001266A3 (en) 2001-02-28
PL334940A1 (en) 2000-03-27
US6287593B2 (en) 2001-09-11
HK1054201A1 (en) 2003-11-21
HK1054201B (zh) 2005-09-09
BR9815445A (pt) 2001-09-25
PL192633B1 (pl) 2006-11-30
UA71540C2 (uk) 2004-12-15
PT975329E (pt) 2005-03-31

Similar Documents

Publication Publication Date Title
IL131008A (en) Lipid complexes and liposomes of highly insoluble platinum complex dicarboxylate
AU4711296A (en) Method for loading lipid vesicles
MY112093A (en) Cosmetic delivery system for salicylic acid and process for preparation of the same.
HUP9801370A3 (en) Stable protein:phospholipid compositions and methods for production thereof
CA2305704A1 (en) Peptide/lipid complex formation by co-lyophilization
CA2186588A1 (en) Novel Cationic Phospholipids for Transfection
AU6527596A (en) Lipid vehicle drug delivery composition containing vitamin e
CA2201120A1 (en) Polyethylene glycol modified ceramide lipids and liposome uses thereof
IL123986A0 (en) Antithombotic agents process for their preparation and pharmaceutical compositions comprising them
AU7979491A (en) Intracellular delivery of biologically active substances by means of self-assembling lipid complexes
KR987000336A (en) Amphiphilic complexes, method for their preparation and compositions containing them
KR950700725A (ko) 리포솜 조성물(liposome composition)
ATE301709T1 (de) Lipidabkömmlinge von pentaerythritol
AU6165196A (en) Stable formulations of mhc-peptide complexes
GB2302505A (en) Stabilisation of photosensitive materials
CA2326348A1 (en) Liposomal bupivacaine compositions and methods of preparation
CA2177696A1 (en) Lipid vesicles containing avocado oil unsaponifiables
DE69520231D1 (de) Liposomzubereitungen enthaltend hybrid-interferon
AU632313B2 (en) New platinum complexes, their preparation and pharmaceutical compositions which contain them
IL122872A0 (en) Quinoxaline-and quinoxalinylalkane-phosphonic acids their preparation and pharmaceutical compositions containing them
GB2317562B (en) Lipid vehicle drug delivery composition containing vitamin E
UA5654C2 (uk) Спосіб одержання липосомального препарату
IL119136A0 (en) Heterocyclically substituted pseudopeptides their preparation and pharmaceutical compositions containing them
IL113713A0 (en) Pharmaceutical compositions comprising a processed natural lipid preparation and the production of such preparation

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees