BR9815445A - Complexos lipìdicos e lipossomas de complexos de platina altamente insolúveis - Google Patents

Complexos lipìdicos e lipossomas de complexos de platina altamente insolúveis

Info

Publication number
BR9815445A
BR9815445A BR9815445-1A BR9815445A BR9815445A BR 9815445 A BR9815445 A BR 9815445A BR 9815445 A BR9815445 A BR 9815445A BR 9815445 A BR9815445 A BR 9815445A
Authority
BR
Brazil
Prior art keywords
complexes
liposomes
lipid
highly insoluble
insoluble platinum
Prior art date
Application number
BR9815445-1A
Other languages
English (en)
Inventor
Mathew Cherian
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of BR9815445A publication Critical patent/BR9815445A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"COMPLEXOS LIPìDICOS E LIPOSSOMAS DE COMPLEXOS DE PLATINA ALTAMENTE INSOLúVEIS". Descreve-se uma composição farmacêutica que compreende um complexo lipídico ou lipossoma de um fosfolipídio com um dicarboxilato de platina insolúvel em água, e método para a preparação dessas composições.
BR9815445-1A 1997-02-05 1998-01-28 Complexos lipìdicos e lipossomas de complexos de platina altamente insolúveis BR9815445A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3737797P 1997-02-05 1997-02-05
PCT/US1998/000035 WO1998033481A1 (en) 1997-02-05 1998-01-28 Lipid complexes and liposomes of highly insoluble platinum complexes

Publications (1)

Publication Number Publication Date
BR9815445A true BR9815445A (pt) 2001-09-25

Family

ID=21894020

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9815445-1A BR9815445A (pt) 1997-02-05 1998-01-28 Complexos lipìdicos e lipossomas de complexos de platina altamente insolúveis

Country Status (22)

Country Link
US (1) US6287593B2 (pt)
EP (1) EP0975329B1 (pt)
JP (1) JP2002513396A (pt)
KR (1) KR100578705B1 (pt)
CN (2) CN1191067C (pt)
AT (1) ATE284204T1 (pt)
AU (1) AU749220B2 (pt)
BR (1) BR9815445A (pt)
CA (1) CA2279279C (pt)
DE (1) DE69828038T2 (pt)
DK (1) DK0975329T3 (pt)
EA (1) EA002630B1 (pt)
ES (1) ES2234094T3 (pt)
HK (2) HK1029059A1 (pt)
HU (1) HUP0001266A3 (pt)
IL (1) IL131008A (pt)
NO (1) NO993750L (pt)
NZ (1) NZ337502A (pt)
PL (1) PL192633B1 (pt)
PT (1) PT975329E (pt)
UA (1) UA71540C2 (pt)
WO (1) WO1998033481A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0102521A3 (en) 1998-04-03 2003-08-28 Ajinomoto Kk Antitumor agents comprising a stilbene derivative and a platinum coordination compound
US6476068B1 (en) 2001-12-06 2002-11-05 Pharmacia Italia, S.P.A. Platinum derivative pharmaceutical formulations
US9186322B2 (en) * 2002-08-02 2015-11-17 Insmed Incorporated Platinum aggregates and process for producing the same
CA2524478A1 (en) * 2003-05-02 2004-11-18 Aronex Pharmaceuticals, Inc. Lipid platinum complexes and methods of use thereof
WO2004105747A1 (en) * 2003-05-20 2004-12-09 Aronex Pharmaceuticals, Inc Combination chemotherapy comprising capecitabine and a liposomal platinum complex
WO2004103382A1 (en) * 2003-05-20 2004-12-02 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising 5-fluorouracil or a derivative thereof and a liposomal platinum complex
EP1631258A1 (en) * 2003-05-20 2006-03-08 Aronex Pharmaceuticals Inc. Combination chemotherapy comprising gemcitabine and a liposomal platinum complex
JP2007504177A (ja) * 2003-09-02 2007-03-01 プリヴァ−ラケマ，エー．エス． 医薬組成物、その製造方法及び治療上の使用
US7611733B2 (en) * 2004-03-26 2009-11-03 Cell Therapeutics Europe S.R.L. Nanoparticle formulations of platinum compounds
WO2006084248A2 (en) * 2005-02-04 2006-08-10 Antigenics, Inc. Compositions comprising a platinum complex, lipid, and surfactant
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
BRPI0619565A2 (pt) * 2005-12-08 2011-10-04 Wyeth Corp composições lipossÈmicas
CZ300424B6 (cs) * 2006-06-20 2009-05-13 Pliva - Lachema A. S. Farmaceutická kompozice pro perorální podání
WO2011034394A2 (ko) * 2009-09-21 2011-03-24 주식회사 중외제약 옥살리플라틴의 나노 입자 및 이를 제조하는 방법
US9387152B2 (en) 2010-06-28 2016-07-12 The General Hospital Corporation Blood substitutes and uses thereof
CN102286050A (zh) * 2011-06-24 2011-12-21 天津大学 用于肿瘤靶向治疗的含葡萄糖铂配合物及其制备方法
CN102286049A (zh) * 2011-06-24 2011-12-21 天津谷堆生物医药科技有限公司 用于肿瘤治疗的水溶性铂配合物及其制备方法
CN102276674A (zh) * 2011-06-24 2011-12-14 天津大学 用于肿瘤靶向治疗的含半乳糖铂配合物及其制备方法
CN102716145A (zh) * 2012-06-20 2012-10-10 天津谷堆生物医药科技有限公司 含糖铂配合物在制备防治肿瘤药物的用途
MX363455B (es) 2012-07-18 2019-03-25 Onyx Therapeutics Inc Composiciones liposómicas de inhibidores de proteasoma basadas en epoxicetona.
EP2892524B1 (en) 2012-09-04 2020-11-25 Eleison Pharmaceuticals, LLC Preventing pulmonary recurrence of cancer with lipid-complexed cisplatin
EP2968142A1 (en) 2013-03-13 2016-01-20 Mallinckrodt LLC Liposomal cisplatin compositions for cancer therapy
CN104546722B (zh) * 2015-02-10 2017-05-24 中国医学科学院医药生物技术研究所 米铂脂质体和制法
CN110590855B (zh) * 2016-01-25 2023-05-12 沈阳药科大学 铂类配合物的制备方法及其含有该铂类配合物的脂质体与制备方法
US11339209B2 (en) 2016-11-14 2022-05-24 Novartis Ag Compositions, methods, and therapeutic uses related to fusogenic protein minion
CN114652680A (zh) * 2020-12-24 2022-06-24 沈阳药科大学 制备脂质体的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0113508A1 (en) * 1982-11-04 1984-07-18 Inco Research & Development Center, Inc. Hydrophobic platinum compounds and their preparation
US5384127A (en) * 1985-10-18 1995-01-24 Board Of Regents, The University Of Texas System Stable liposomal formulations of lipophilic platinum compounds
US4927571A (en) * 1987-05-18 1990-05-22 Liposome Technology, Inc. Preparation of injectable doxorubicin/liposome suspension
CA1339034C (en) * 1988-08-22 1997-04-01 Paul A. Tremblay Platinum complexes of single isomer neoalkyl acids
US5393909A (en) 1988-11-22 1995-02-28 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
JPH03200795A (ja) * 1989-12-28 1991-09-02 Nippon Kayaku Co Ltd 脂質親和性白金錯体及びそれを含有する製剤
US5843475A (en) * 1996-12-06 1998-12-01 Board Of Regents, The University Of Texas System Delivery and activation through liposome incorporation of diaminocyclohexane platinum (II) complexes

Also Published As

Publication number Publication date
DK0975329T3 (da) 2005-03-14
CA2279279A1 (en) 1998-08-06
US20010010822A1 (en) 2001-08-02
CN1191067C (zh) 2005-03-02
CN1422619A (zh) 2003-06-11
HK1054201B (zh) 2005-09-09
NO993750D0 (no) 1999-08-03
CA2279279C (en) 2008-10-14
NZ337502A (en) 2001-02-23
US6287593B2 (en) 2001-09-11
UA71540C2 (uk) 2004-12-15
IL131008A (en) 2003-06-24
ES2234094T3 (es) 2005-06-16
DE69828038D1 (de) 2005-01-13
ATE284204T1 (de) 2004-12-15
IL131008A0 (en) 2001-01-28
KR20000070771A (ko) 2000-11-25
EP0975329B1 (en) 2004-12-08
PL334940A1 (en) 2000-03-27
CN1264295A (zh) 2000-08-23
EA002630B1 (ru) 2002-08-29
KR100578705B1 (ko) 2006-05-12
JP2002513396A (ja) 2002-05-08
HK1054201A1 (en) 2003-11-21
NO993750L (no) 1999-08-03
HK1029059A1 (en) 2001-03-23
EP0975329A1 (en) 2000-02-02
PT975329E (pt) 2005-03-31
HUP0001266A2 (hu) 2000-11-28
HUP0001266A3 (en) 2001-02-28
DE69828038T2 (de) 2005-11-03
PL192633B1 (pl) 2006-11-30
EA199900715A1 (ru) 2000-04-24
AU749220B2 (en) 2002-06-20
WO1998033481A1 (en) 1998-08-06
AU6015498A (en) 1998-08-25
CN1096263C (zh) 2002-12-18

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.

B15K Others concerning applications: alteration of classification

Ipc: A61K 9/127 (2006.01), A61K 31/555 (2006.0