IL130062A - Formation process - Google Patents
Formation processInfo
- Publication number
- IL130062A IL130062A IL13006297A IL13006297A IL130062A IL 130062 A IL130062 A IL 130062A IL 13006297 A IL13006297 A IL 13006297A IL 13006297 A IL13006297 A IL 13006297A IL 130062 A IL130062 A IL 130062A
- Authority
- IL
- Israel
- Prior art keywords
- organic compound
- melting point
- process according
- emulsion
- dispersion medium
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 23
- 238000002425 crystallisation Methods 0.000 title claims description 14
- 150000002894 organic compounds Chemical class 0.000 claims abstract description 38
- 238000002844 melting Methods 0.000 claims abstract description 35
- 230000008018 melting Effects 0.000 claims abstract description 35
- 239000007788 liquid Substances 0.000 claims abstract description 27
- 239000000839 emulsion Substances 0.000 claims abstract description 22
- 239000000155 melt Substances 0.000 claims abstract description 18
- 239000002612 dispersion medium Substances 0.000 claims abstract description 16
- 239000013078 crystal Substances 0.000 claims abstract description 12
- 239000000725 suspension Substances 0.000 claims abstract description 12
- 238000001816 cooling Methods 0.000 claims abstract description 8
- 238000004519 manufacturing process Methods 0.000 claims abstract description 3
- 150000001875 compounds Chemical class 0.000 claims description 12
- 230000004927 fusion Effects 0.000 claims description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 239000012736 aqueous medium Substances 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 3
- 239000007764 o/w emulsion Substances 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 description 21
- 239000002609 medium Substances 0.000 description 11
- RZJRJXONCZWCBN-UHFFFAOYSA-N octadecane Chemical compound CCCCCCCCCCCCCCCCCC RZJRJXONCZWCBN-UHFFFAOYSA-N 0.000 description 8
- 238000000527 sonication Methods 0.000 description 8
- LQERIDTXQFOHKA-UHFFFAOYSA-N nonadecane Chemical compound CCCCCCCCCCCCCCCCCCC LQERIDTXQFOHKA-UHFFFAOYSA-N 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 239000012071 phase Substances 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000000654 additive Substances 0.000 description 4
- 239000008346 aqueous phase Substances 0.000 description 4
- DCAYPVUWAIABOU-UHFFFAOYSA-N hexadecane Chemical compound CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 description 4
- CBFCDTFDPHXCNY-UHFFFAOYSA-N icosane Chemical compound CCCCCCCCCCCCCCCCCCCC CBFCDTFDPHXCNY-UHFFFAOYSA-N 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000006911 nucleation Effects 0.000 description 4
- 238000010899 nucleation Methods 0.000 description 4
- 229940038384 octadecane Drugs 0.000 description 4
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 4
- 238000002604 ultrasonography Methods 0.000 description 4
- 229940126062 Compound A Drugs 0.000 description 3
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000003905 agrochemical Substances 0.000 description 3
- 239000002270 dispersing agent Substances 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000000417 fungicide Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000005730 Azoxystrobin Substances 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- WFDXOXNFNRHQEC-GHRIWEEISA-N azoxystrobin Chemical compound CO\C=C(\C(=O)OC)C1=CC=CC=C1OC1=CC(OC=2C(=CC=CC=2)C#N)=NC=N1 WFDXOXNFNRHQEC-GHRIWEEISA-N 0.000 description 2
- 239000000374 eutectic mixture Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000000575 pesticide Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 238000007711 solidification Methods 0.000 description 2
- 230000008023 solidification Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000004546 suspension concentrate Substances 0.000 description 2
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000002528 anti-freeze Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
- 238000010296 bead milling Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 238000000113 differential scanning calorimetry Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- -1 for example Substances 0.000 description 1
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 1
- 239000004009 herbicide Substances 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 238000004626 scanning electron microscopy Methods 0.000 description 1
- 235000011067 sorbitan monolaureate Nutrition 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B01F23/411—Emulsifying using electrical or magnetic fields, heat or vibrations
- B01F23/4111—Emulsifying using electrical or magnetic fields, heat or vibrations using vibrations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/90—Heating or cooling systems
- B01F2035/98—Cooling
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/48—Mixing liquids with liquids; Emulsifying characterised by the nature of the liquids
- B01F23/482—Mixing liquids with liquids; Emulsifying characterised by the nature of the liquids using molten solids
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Saccharide Compounds (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Pyridine Compounds (AREA)
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Liquid Crystal (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Colloid Chemistry (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9624615.2A GB9624615D0 (en) | 1996-11-26 | 1996-11-26 | Chrystallisation process |
| PCT/GB1997/002927 WO1998023350A1 (en) | 1996-11-26 | 1997-10-23 | Crystallisation process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL130062A0 IL130062A0 (en) | 2000-02-29 |
| IL130062A true IL130062A (en) | 2002-08-14 |
Family
ID=10803536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13006297A IL130062A (en) | 1996-11-26 | 1997-10-23 | Formation process |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6338742B1 (da) |
| EP (1) | EP0946232B2 (da) |
| JP (2) | JP4605826B2 (da) |
| KR (1) | KR100463340B1 (da) |
| CN (1) | CN1091623C (da) |
| AT (1) | ATE204501T1 (da) |
| AU (1) | AU4716997A (da) |
| BR (1) | BR9714307A (da) |
| DE (1) | DE69706312T3 (da) |
| DK (1) | DK0946232T4 (da) |
| ES (1) | ES2163137T5 (da) |
| GB (1) | GB9624615D0 (da) |
| IL (1) | IL130062A (da) |
| WO (1) | WO1998023350A1 (da) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9810859D0 (en) * | 1998-05-20 | 1998-07-22 | Zeneca Ltd | Crystallisation process |
| UA70327C2 (uk) * | 1998-06-08 | 2004-10-15 | Баєр Акціенгезельшафт | Спосіб боротьби з фітопатогенними хворобами сільськогосподарських рослин та фунгіцидна композиція |
| US6369083B1 (en) | 1998-09-16 | 2002-04-09 | Dow Agrosciences Llc | 2-methoxyimino-2 (pyrinyloxymethyl) phenyl acetamides with polyether derivatives on the pyridine ring |
| WO2000015616A1 (en) | 1998-09-16 | 2000-03-23 | Dow Agrosciences Llc | 2-methoxyimino-2-(pyridinyloxymethyl)phenyl acetamides with (derivatised) hydroxyalkyl derivatives on the pyridine ring |
| KR20010079852A (ko) * | 1998-09-16 | 2001-08-22 | 케네쓰 엘. 로에르트셔 | 살진균제로서 피리딘 환 상에 5원 헤테로사이클릭 환을갖는 2-메톡시이미노-2-(피리디닐옥시메틸)페닐아세트아미드 |
| GB9828721D0 (en) | 1998-12-24 | 1999-02-17 | Glaxo Group Ltd | Novel apparatus and process |
| US6541426B1 (en) * | 1999-06-18 | 2003-04-01 | Rohm And Haas Company | Method to produce pesticide suspension concentrates |
| CN1409705A (zh) | 1999-12-15 | 2003-04-09 | 美国陶氏益农公司 | 具有杀真菌活性的吡啶衍生物和其制备方法及使用方法 |
| CZ20011726A3 (cs) | 2000-05-26 | 2002-02-13 | Pfizer Products Inc. | Způsob reakční krystalizace, který umoľňuje řídit velikost částic |
| GB0126144D0 (en) * | 2001-10-31 | 2002-01-02 | Syngenta Ltd | Pesticidal formulations |
| AU2003225101A1 (en) * | 2002-05-10 | 2003-11-11 | Bristol-Myers Squibb Company | Crystallization system using homogenization |
| GB0216700D0 (en) | 2002-07-18 | 2002-08-28 | Astrazeneca Ab | Process |
| EP1575895A1 (en) * | 2002-11-26 | 2005-09-21 | Ciba SC Holding AG | Phenolic antioxidants in crystalline form |
| GB0302673D0 (en) | 2003-02-06 | 2003-03-12 | Astrazeneca Ab | Pharmaceutical formulations |
| TWI436988B (zh) * | 2007-03-05 | 2014-05-11 | Transform Pharmaceuticals Inc | ７-〔（３-氯-６，１１-二氫-６-甲基二苯并〔ｃ，ｆ〕〔１，２〕噻氮呯-１１-基）胺〕庚酸ｓ，ｓ二氧化物之多晶型及其製造與使用方法 |
| EA020180B1 (ru) † | 2009-07-14 | 2014-09-30 | Басф Се | Способ получения водной суспензии органического пестицидного соединения |
| WO2012142927A1 (zh) * | 2011-04-18 | 2012-10-26 | 合肥贝霓医药科技有限公司 | 一种纯化二氢吡啶类钙通道阻滞剂并制备其纳米的方法 |
| CN102746215A (zh) * | 2011-04-18 | 2012-10-24 | 张兆勇 | 一种制备高纯度盐酸贝尼地平的方法 |
| KR20160040522A (ko) * | 2013-06-21 | 2016-04-14 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유리 염기 결정 |
| GB2548117B (en) | 2016-03-08 | 2022-10-26 | Lewtas Science & Tech Ltd | Use of ultrasound and acoustics to control crystallisation |
| TWI809148B (zh) * | 2018-07-13 | 2023-07-21 | 印度商Ｕｐｌ有限公司 | 包含白克列及嗜球果傘素殺真菌劑之共熔混合物的組成物、其製備程序及對抗或控制真菌方法 |
| CN116143803B (zh) * | 2023-01-29 | 2024-11-08 | 山东省分析测试中心 | 一种大颗粒头孢哌酮钠球形晶体的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH558659A (fr) | 1969-11-26 | 1975-02-14 | Orsymonde | Procede pour la preparation d'une composition lyophilisee a usage hygienique. |
| DE2551841A1 (de) * | 1975-11-19 | 1977-05-26 | Bayer Ag | Verfahren zur herstellung konzentrierter suspensionen |
| FR2413928A1 (fr) * | 1978-01-05 | 1979-08-03 | Rhone Poulenc Ind | Procede continu de mise en dispersion aqueuse finement divisee d'une phase homogene d'au moins un ingredient solide fusible |
| DE3421468A1 (de) | 1984-06-08 | 1985-12-19 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung |
| DE3538751A1 (de) † | 1985-10-31 | 1987-05-07 | Henkel Kgaa | Verfahren zur herstellung von perlglanzdispersionen |
| CN1020391C (zh) * | 1987-02-09 | 1993-05-05 | 帝国化学工业公司 | 制备杀菌化合物的方法 |
| EP0278595B2 (en) | 1987-02-09 | 2000-01-12 | Zeneca Limited | Fungicides |
| JP2718505B2 (ja) * | 1988-03-08 | 1998-02-25 | 花王株式会社 | 油脂類の晶析法 |
| DE3916465A1 (de) * | 1989-05-20 | 1990-11-22 | Bayer Ag | Herstellung kugelfoermiger dispersionen durch kristallisation von emulsionen |
| WO1992020420A1 (en) † | 1991-05-03 | 1992-11-26 | Elizabeth Acton | Method and apparatus for the control of solidification in liquids |
| DE4226850A1 (de) | 1992-03-23 | 1993-09-30 | Roiner Franz | Verfahren zur Behandlung und/oder Herstellung einer Emulsion, insbesondere einer Fettemulsion |
| CA2091152C (en) * | 1993-03-05 | 2005-05-03 | Kirsten Westesen | Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof |
| US5471001A (en) | 1994-12-15 | 1995-11-28 | E. I. Du Pont De Nemours And Company | Crystallization of adipic acid |
| GB9810859D0 (en) * | 1998-05-20 | 1998-07-22 | Zeneca Ltd | Crystallisation process |
-
1996
- 1996-11-26 GB GBGB9624615.2A patent/GB9624615D0/en active Pending
-
1997
- 1997-10-23 EP EP97909494A patent/EP0946232B2/en not_active Expired - Lifetime
- 1997-10-23 IL IL13006297A patent/IL130062A/en not_active IP Right Cessation
- 1997-10-23 KR KR10-1999-7004603A patent/KR100463340B1/ko not_active Expired - Fee Related
- 1997-10-23 US US09/308,741 patent/US6338742B1/en not_active Expired - Fee Related
- 1997-10-23 AU AU47169/97A patent/AU4716997A/en not_active Abandoned
- 1997-10-23 ES ES97909494T patent/ES2163137T5/es not_active Expired - Lifetime
- 1997-10-23 JP JP52438498A patent/JP4605826B2/ja not_active Expired - Fee Related
- 1997-10-23 DE DE69706312T patent/DE69706312T3/de not_active Expired - Lifetime
- 1997-10-23 BR BR9714307-3A patent/BR9714307A/pt not_active IP Right Cessation
- 1997-10-23 WO PCT/GB1997/002927 patent/WO1998023350A1/en not_active Ceased
- 1997-10-23 CN CN97199941A patent/CN1091623C/zh not_active Expired - Fee Related
- 1997-10-23 DK DK97909494T patent/DK0946232T4/da active
- 1997-10-23 AT AT97909494T patent/ATE204501T1/de not_active IP Right Cessation
-
2010
- 2010-01-08 JP JP2010003305A patent/JP2010100646A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GB9624615D0 (en) | 1997-01-15 |
| BR9714307A (pt) | 2000-05-02 |
| KR20000069123A (ko) | 2000-11-25 |
| AU4716997A (en) | 1998-06-22 |
| ATE204501T1 (de) | 2001-09-15 |
| DE69706312D1 (de) | 2001-09-27 |
| CN1091623C (zh) | 2002-10-02 |
| JP2010100646A (ja) | 2010-05-06 |
| EP0946232B1 (en) | 2001-08-22 |
| IL130062A0 (en) | 2000-02-29 |
| ES2163137T3 (es) | 2002-01-16 |
| JP4605826B2 (ja) | 2011-01-05 |
| KR100463340B1 (ko) | 2005-01-07 |
| DE69706312T3 (de) | 2005-03-17 |
| DK0946232T3 (da) | 2001-10-08 |
| CN1238708A (zh) | 1999-12-15 |
| JP2001504758A (ja) | 2001-04-10 |
| ES2163137T5 (es) | 2005-03-01 |
| DK0946232T4 (da) | 2004-11-08 |
| EP0946232A1 (en) | 1999-10-06 |
| US6338742B1 (en) | 2002-01-15 |
| WO1998023350A1 (en) | 1998-06-04 |
| EP0946232B2 (en) | 2004-07-07 |
| DE69706312T2 (de) | 2002-02-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |