IL129016A - Crystalline substance of cefditoren pivoxyl and the production of the same - Google Patents
Crystalline substance of cefditoren pivoxyl and the production of the sameInfo
- Publication number
- IL129016A IL129016A IL12901697A IL12901697A IL129016A IL 129016 A IL129016 A IL 129016A IL 12901697 A IL12901697 A IL 12901697A IL 12901697 A IL12901697 A IL 12901697A IL 129016 A IL129016 A IL 129016A
- Authority
- IL
- Israel
- Prior art keywords
- production
- same
- crystalline substance
- cefditoren pivoxyl
- pivoxyl
- Prior art date
Links
- 229960002142 cefditoren pivoxil Drugs 0.000 title 1
- AFZFFLVORLEPPO-UVYJNCLZSA-N cefditoren pivoxil Chemical group S([C@@H]1[C@@H](C(N1C=1C(=O)OCOC(=O)C(C)(C)C)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1\C=C/C=1SC=NC=1C AFZFFLVORLEPPO-UVYJNCLZSA-N 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Liquid Crystal Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24956196 | 1996-09-20 | ||
| PCT/JP1997/003340 WO1998012200A1 (en) | 1996-09-20 | 1997-09-19 | A crystalline substance of cefditoren pivoxyl and the production of the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL129016A0 IL129016A0 (en) | 2000-02-17 |
| IL129016A true IL129016A (en) | 2003-01-12 |
Family
ID=17194838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12901697A IL129016A (en) | 1996-09-20 | 1997-09-19 | Crystalline substance of cefditoren pivoxyl and the production of the same |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US6294669B1 (cs) |
| EP (1) | EP0937083B1 (cs) |
| JP (1) | JP3403206B2 (cs) |
| KR (1) | KR100441907B1 (cs) |
| CN (1) | CN1116299C (cs) |
| AR (1) | AR008483A1 (cs) |
| AT (1) | ATE238310T1 (cs) |
| AU (1) | AU714735B2 (cs) |
| BR (1) | BR9712072A (cs) |
| CA (1) | CA2265686C (cs) |
| CZ (1) | CZ295199B6 (cs) |
| DE (1) | DE69721290T2 (cs) |
| EA (1) | EA001526B1 (cs) |
| ES (1) | ES2198593T3 (cs) |
| HU (1) | HU224196B1 (cs) |
| ID (1) | ID22064A (cs) |
| IL (1) | IL129016A (cs) |
| NZ (1) | NZ334883A (cs) |
| PL (1) | PL189548B1 (cs) |
| PT (1) | PT937083E (cs) |
| RO (1) | RO120196B1 (cs) |
| SK (1) | SK284973B6 (cs) |
| TR (1) | TR199900614T2 (cs) |
| UA (1) | UA55426C2 (cs) |
| WO (1) | WO1998012200A1 (cs) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA55426C2 (uk) * | 1996-09-20 | 2003-04-15 | Мейджі Сейка Кайша Лтд. | Кристалічний цефдиторен півоксилу і способи його одержання |
| HU230295B1 (hu) * | 1998-01-07 | 2015-12-28 | Meiji Seika Pharma Co., Ltd. | Kristálytanilag stabil, amorf, cephalosporin tartalmú készítmény és eljárás előállítására |
| ATE285821T1 (de) * | 1999-10-08 | 2005-01-15 | Affinium Pharm Inc | Fab i inhibitoren |
| HU226640B1 (en) * | 1999-10-18 | 2009-05-28 | Egis Gyogyszergyar Nyilvanosan | Process for producing amorphous atorvastatin calcium salt |
| JP2001131071A (ja) * | 1999-10-29 | 2001-05-15 | Meiji Seika Kaisha Ltd | 非晶質および非晶質を含有する医薬組成物 |
| ES2320984T3 (es) * | 2001-04-06 | 2009-06-01 | Affinium Pharmaceuticals, Inc. | Inhibidores de fab i. |
| JP2006500364A (ja) * | 2002-08-16 | 2006-01-05 | イムノージェン インコーポレーテッド | 高い反応性と溶解度を有する架橋剤および小分子薬物の標的化送達用コンジュゲートの調製におけるそれらの使用 |
| ATE482710T1 (de) * | 2002-10-02 | 2010-10-15 | Meiji Seika Kaisha | Antibakterielle medizinische zusammensetzung mit erhöhtem oralem absorptionsvermögen |
| US7244842B2 (en) * | 2002-11-15 | 2007-07-17 | Orchid Chemicals & Pharmaceuticals Ltd. | Amorphous hydrate of a cephalosporin antibiotic |
| AU2003298937A1 (en) | 2002-12-06 | 2004-06-30 | Affinium Pharmaceuticals, Inc. | Heterocyclic compounds, methods of making them and their use in therapy |
| JP4880448B2 (ja) * | 2003-03-17 | 2012-02-22 | アフィナム ファーマシューティカルズ，インコーポレーテッド | 複数の抗生物質を含む組成物、及びそれを用いる方法 |
| US7531650B2 (en) * | 2003-03-27 | 2009-05-12 | Basilea Pharmaceutica Ag | Cephalosporin salts in crystalline form |
| US8088387B2 (en) * | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| EP1660505A2 (en) * | 2003-08-14 | 2006-05-31 | Ranbaxy Laboratories Limited | Process for selective preparation of z-isomer of cefditoren and pharmaceutically acceptable salts and esters thereof |
| CN1863535A (zh) | 2003-10-08 | 2006-11-15 | 明治制果株式会社 | 含有头孢托仑匹伏酯的非晶性抗菌组合物 |
| EP1689755A2 (en) * | 2003-11-07 | 2006-08-16 | Ranbaxy Laboratories Limited | Processes for the preparation of highly pure 3-(2-substituted vinyl) cephalosporin |
| JP2005162696A (ja) * | 2003-12-04 | 2005-06-23 | Nichiko Pharmaceutical Co Ltd | 溶出性に優れたセフジトレンピボキシル製剤 |
| KR101299399B1 (ko) * | 2004-06-04 | 2013-08-22 | 아피늄 파마슈티컬스, 인크. | 치료제, 및 그의 제조 및 사용 방법 |
| WO2006024900A1 (en) * | 2004-08-31 | 2006-03-09 | Ranbaxy Laboratories Limited | Highly pure cefditoren pivoxil |
| WO2007067416A2 (en) * | 2005-12-05 | 2007-06-14 | Affinium Pharmaceuticals, Inc. | Heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents |
| US20080069879A1 (en) * | 2006-05-02 | 2008-03-20 | Ravishekhar Bhiwgade | Stable solid dosage form containing amorphous cefditoren pivoxil and process for preparation thereof |
| US8318720B2 (en) | 2006-07-20 | 2012-11-27 | Affinium Pharmaceuticals, Inc. | Acrylamide derivatives as Fab I inhibitors |
| EP2125802A4 (en) | 2007-02-16 | 2014-08-20 | Debiopharm Int Sa | SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS |
| EP2520578A1 (en) | 2011-05-06 | 2012-11-07 | Lupin Limited | Process for purification of cephalosporins |
| CN103421025B (zh) * | 2012-05-21 | 2016-05-11 | 上海医药工业研究院 | 制备7α-甲氧基头孢菌素C的方法 |
| ME03392B (me) | 2012-06-19 | 2020-01-20 | Debiopharm Int Sa | Prolek derivati (e)-n-meтil-n-( (з-метi lbenzofuran-2-il)meтil)-3-(7 -okso-5 ,6, 7,8-тетrанidr0-1,8-nafтiridin-3-il)akrilamida |
| KR101561963B1 (ko) * | 2013-05-23 | 2015-10-22 | 영진약품공업 주식회사 | 세프디토렌 피복실의 신규 결정 형태 및 이의 제조 방법 |
| CN103665002B (zh) * | 2013-12-18 | 2016-02-03 | 成都医路康医学技术服务有限公司 | 一种头孢妥仑匹酯的制备方法 |
| EP3244879A1 (en) | 2015-01-16 | 2017-11-22 | Ögün, Yusuf Toktamis | Cefditoren pivoxil compositions with improved stability and production methods thereof |
| ES2842443T3 (es) | 2016-02-26 | 2021-07-14 | Debiopharm Int Sa | Medicamento para el tratamiento de infecciones del pie diabético |
| MA54009B1 (fr) | 2019-02-14 | 2022-10-31 | Debiopharm Int Sa | Formulation d'afabicine et son procédé de préparation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE58487B1 (en) * | 1984-09-07 | 1993-09-22 | Kaisha Maiji Seika | New cephalosporin compounds and the production thereof |
| US5827845A (en) * | 1993-09-29 | 1998-10-27 | Meiji Seika Kaisha, Ltd. | Cephalosporin derivative |
| ATE198892T1 (de) * | 1993-11-17 | 2001-02-15 | Biochemie Gmbh | Trennung von cephalosporinisomeren |
| UA55426C2 (uk) * | 1996-09-20 | 2003-04-15 | Мейджі Сейка Кайша Лтд. | Кристалічний цефдиторен півоксилу і способи його одержання |
-
1997
- 1997-09-19 UA UA99042171A patent/UA55426C2/uk unknown
- 1997-09-19 BR BR9712072A patent/BR9712072A/pt not_active Application Discontinuation
- 1997-09-19 US US09/269,109 patent/US6294669B1/en not_active Expired - Lifetime
- 1997-09-19 EP EP97940434A patent/EP0937083B1/en not_active Expired - Lifetime
- 1997-09-19 PT PT97940434T patent/PT937083E/pt unknown
- 1997-09-19 CZ CZ1999975A patent/CZ295199B6/cs not_active IP Right Cessation
- 1997-09-19 CA CA002265686A patent/CA2265686C/en not_active Expired - Lifetime
- 1997-09-19 AU AU42222/97A patent/AU714735B2/en not_active Expired
- 1997-09-19 NZ NZ334883A patent/NZ334883A/xx not_active IP Right Cessation
- 1997-09-19 RO RO99-00280A patent/RO120196B1/ro unknown
- 1997-09-19 WO PCT/JP1997/003340 patent/WO1998012200A1/en active IP Right Grant
- 1997-09-19 PL PL97332314A patent/PL189548B1/pl unknown
- 1997-09-19 JP JP51452298A patent/JP3403206B2/ja not_active Expired - Lifetime
- 1997-09-19 TR TR1999/00614T patent/TR199900614T2/xx unknown
- 1997-09-19 HU HU9903454A patent/HU224196B1/hu active IP Right Grant
- 1997-09-19 ID IDW990100A patent/ID22064A/id unknown
- 1997-09-19 EA EA199900311A patent/EA001526B1/ru not_active IP Right Cessation
- 1997-09-19 CN CN97199098A patent/CN1116299C/zh not_active Expired - Lifetime
- 1997-09-19 DE DE69721290T patent/DE69721290T2/de not_active Expired - Lifetime
- 1997-09-19 IL IL12901697A patent/IL129016A/xx not_active IP Right Cessation
- 1997-09-19 SK SK354-99A patent/SK284973B6/sk not_active IP Right Cessation
- 1997-09-19 AT AT97940434T patent/ATE238310T1/de active
- 1997-09-19 ES ES97940434T patent/ES2198593T3/es not_active Expired - Lifetime
- 1997-09-19 KR KR10-1999-7002385A patent/KR100441907B1/ko not_active Expired - Lifetime
- 1997-09-22 AR ARP970104349A patent/AR008483A1/es active IP Right Grant
-
2001
- 2001-05-15 US US09/854,462 patent/US6441162B2/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |