IL128900A0 - Beta-sulfonyl hydroxamic acids as matrix metalloproteinases inhibitor - Google Patents

Beta-sulfonyl hydroxamic acids as matrix metalloproteinases inhibitor

Info

Publication number
IL128900A0
IL128900A0 IL12890097A IL12890097A IL128900A0 IL 128900 A0 IL128900 A0 IL 128900A0 IL 12890097 A IL12890097 A IL 12890097A IL 12890097 A IL12890097 A IL 12890097A IL 128900 A0 IL128900 A0 IL 128900A0
Authority
IL
Israel
Prior art keywords
beta
matrix metalloproteinases
hydroxamic acids
sulfonyl hydroxamic
metalloproteinases inhibitor
Prior art date
Application number
IL12890097A
Other languages
English (en)
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of IL128900A0 publication Critical patent/IL128900A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/44Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72Two oxygen atoms, e.g. hydantoin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL12890097A 1996-09-27 1997-09-19 Beta-sulfonyl hydroxamic acids as matrix metalloproteinases inhibitor IL128900A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2684896P 1996-09-27 1996-09-27
PCT/US1997/016348 WO1998013340A1 (en) 1996-09-27 1997-09-19 β-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS

Publications (1)

Publication Number Publication Date
IL128900A0 true IL128900A0 (en) 2000-01-31

Family

ID=21834136

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12890097A IL128900A0 (en) 1996-09-27 1997-09-19 Beta-sulfonyl hydroxamic acids as matrix metalloproteinases inhibitor

Country Status (22)

Country Link
US (2) US5847153A (xx)
EP (1) EP0929519B1 (xx)
JP (1) JP2001516338A (xx)
KR (1) KR20000048639A (xx)
CN (1) CN1158254C (xx)
AT (1) ATE289590T1 (xx)
AU (1) AU726799B2 (xx)
BR (1) BR9712134A (xx)
CA (1) CA2266368A1 (xx)
CZ (1) CZ92399A3 (xx)
DE (1) DE69732571T2 (xx)
EA (1) EA001460B1 (xx)
ES (1) ES2236829T3 (xx)
HK (1) HK1022468A1 (xx)
HU (1) HUP0000145A3 (xx)
ID (1) ID21897A (xx)
IL (1) IL128900A0 (xx)
NO (1) NO312893B1 (xx)
NZ (1) NZ334729A (xx)
PL (1) PL332509A1 (xx)
UA (1) UA48262C2 (xx)
WO (1) WO1998013340A1 (xx)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566384B1 (en) * 1996-08-07 2003-05-20 Darwin Discovery Ltd. Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
CA2263154A1 (en) * 1996-08-07 1998-02-12 Darwin Discovery Limited Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity
CA2266368A1 (en) * 1996-09-27 1998-04-02 Pharmacia & Upjohn Company .beta.-sulfonyl hydroxamic acids as matrix metalloproteinases inhibitors
EP0960096B1 (en) 1997-01-22 2005-04-06 Aventis Pharmaceuticals Inc. Substituted beta-thiocarboxylic acids
GB9702088D0 (en) 1997-01-31 1997-03-19 Pharmacia & Upjohn Spa Matrix metalloproteinase inhibitors
US6172057B1 (en) * 1997-02-27 2001-01-09 American Cyanamid Company N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
KR20000075955A (ko) * 1997-03-04 2000-12-26 죤 에이치. 뷰센 방향족 술포닐 알파-히드록시 히드록삼산 화합물
US6362183B1 (en) 1997-03-04 2002-03-26 G. D. Searle & Company Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds
US6063786A (en) * 1997-11-12 2000-05-16 Darwin Discovery, Ltd. Heterocyclic compounds having MMP and TNF inhibitory activity
US6187924B1 (en) * 1997-11-12 2001-02-13 Darwin Discovery, Ltd. Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
UA66818C2 (uk) * 1997-11-21 2004-06-15 Фармація Енд Апджон Компані <font face="Symbol">a</font>-ГІДРОКСИ, АМІНО- ТА ГАЛОПОХІДНІ <font face="Symbol">b</font>-СУЛЬФОНІЛГІДРОКСАМОВИХ КИСЛОТ, ПОХІДНІ ПРОПІОНОВОЇ КИСЛОТИ, СПОСІБ ІНГІБУВАННЯ МАТРИЧНИХ МЕТАЛОПРОТЕЇНАЗ, СПОСІБ ЛІКУВАННЯ ЛЮДИНИ, ЩО СТРАЖДАЄ ВІД АБО ЧУТЛИВОЇ ДО ХВОРОБИ, ПОВ'ЯЗАНОЇ З РУЙНУВАННЯМ СПОЛУЧНОЇ ТКАНИНИ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ
EP1051395B1 (en) * 1998-01-30 2006-11-22 Darwin Discovery Limited N-hydroxyformamide derivatives
DK1357109T3 (da) 1998-06-18 2008-09-08 Hoffmann La Roche Fremgangsmåde til arylalkylsulfid
GB9916562D0 (en) 1999-07-14 1999-09-15 Pharmacia & Upjohn Spa 3-Arylsulfonyl-2-(substituted-methyl) propanoic acid derivatives as matrix metalloproteinase inhibitora
US6620823B2 (en) 2000-07-11 2003-09-16 Bristol-Myers Squibb Pharme Company Lactam metalloprotease inhibitors
GB0017435D0 (en) * 2000-07-14 2000-08-30 Pharmacia & Upjohn Spa 3-arylsulfonyl-2-hydroxy-2-methylpropanoic acid derivatives
WO2004060346A2 (en) 2002-12-30 2004-07-22 Angiotech International Ag Drug delivery from rapid gelling polymer composition
JP2009519349A (ja) * 2005-12-15 2009-05-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Cb2受容体を変調する化合物
WO2008014199A2 (en) 2006-07-28 2008-01-31 Boehringer Ingelheim International Gmbh Sulfonyl compounds which modulate the cb2 receptor
CA2664310A1 (en) 2006-09-25 2008-04-03 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
WO2009061652A1 (en) * 2007-11-07 2009-05-14 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
US8178568B2 (en) 2008-07-10 2012-05-15 Boehringer Ingelheim International Gmbh Sulfone compounds which modulate the CB2 receptor
CA2737639A1 (en) * 2008-09-25 2010-04-01 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the cb2 receptor
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
EP2443107B1 (en) 2009-06-16 2018-08-08 Boehringer Ingelheim International GmbH Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor
JP2013505295A (ja) * 2009-09-22 2013-02-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Cb2受容体を選択的に調節する化合物
JP2013517271A (ja) 2010-01-15 2013-05-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Cb2受容体を調節する化合物
EP2542539B1 (en) 2010-03-05 2014-02-26 Boehringer Ingelheim International GmbH Tetrazole compounds which selectively modulate the cb2 receptor
JP5746764B2 (ja) 2010-07-22 2015-07-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Cb2受容体を調節する化合物
EP2803668A1 (en) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB689608A (en) * 1950-04-13 1953-04-01 Basf Ag Improvements in the production of gamma-sulphonyl carboxylic acids
US2659752A (en) * 1951-08-09 1953-11-17 Goodrich Co B F Method for preparing beta-(arylsulfonyl) carboxylic acids and salts thereof
GB8827305D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds
WO1993020047A1 (en) * 1992-04-07 1993-10-14 British Bio-Technology Limited Hydroxamic acid based collagenase and cytokine inhibitors
DE4233099A1 (de) * 1992-10-01 1994-04-07 Hoechst Ag Verfahren zur stereoselektiven Synthese von 3-substituierten 2-Thiomethylpropionsäuren
DE4233100A1 (de) * 1992-10-01 1994-04-07 Hoechst Ag Verfahren zur stereoselektiven Synthese von 3-substituierten 2-Sulfonylmethylpropionsäuren sowie Zwischenprodukte
GB9223904D0 (en) * 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
EP0640594A1 (en) * 1993-08-23 1995-03-01 Fujirebio Inc. Hydantoin derivative as metalloprotease inhibitor
GB9320660D0 (en) * 1993-10-07 1993-11-24 British Bio Technology Inhibition of cytokine production
ES2183905T3 (es) * 1995-12-20 2003-04-01 Hoffmann La Roche Inhibidores de metaloproteasa de matriz.
EP0871439B1 (en) * 1996-01-02 2004-03-31 Aventis Pharmaceuticals Inc. Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds
TW448172B (en) * 1996-03-08 2001-08-01 Pharmacia & Upjohn Co Llc Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation
CA2266368A1 (en) * 1996-09-27 1998-04-02 Pharmacia & Upjohn Company .beta.-sulfonyl hydroxamic acids as matrix metalloproteinases inhibitors
US6362183B1 (en) 1997-03-04 2002-03-26 G. D. Searle & Company Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds

Also Published As

Publication number Publication date
CA2266368A1 (en) 1998-04-02
EA001460B1 (ru) 2001-04-23
DE69732571D1 (de) 2005-03-31
EP0929519A1 (en) 1999-07-21
PL332509A1 (en) 1999-09-13
CN1158254C (zh) 2004-07-21
JP2001516338A (ja) 2001-09-25
US5847153A (en) 1998-12-08
NO991494L (no) 1999-05-26
AU726799B2 (en) 2000-11-23
NO991494D0 (no) 1999-03-26
NO312893B1 (no) 2002-07-15
CN1230177A (zh) 1999-09-29
ATE289590T1 (de) 2005-03-15
DE69732571T2 (de) 2006-01-12
WO1998013340A1 (en) 1998-04-02
US6235928B1 (en) 2001-05-22
NZ334729A (en) 2001-01-26
EA199900332A1 (ru) 1999-12-29
KR20000048639A (ko) 2000-07-25
HUP0000145A2 (en) 2000-07-28
AU4645997A (en) 1998-04-17
ID21897A (id) 1999-08-05
ES2236829T3 (es) 2005-07-16
EP0929519B1 (en) 2005-02-23
HK1022468A1 (en) 2000-08-11
UA48262C2 (uk) 2002-08-15
CZ92399A3 (cs) 1999-07-14
HUP0000145A3 (en) 2001-12-28
BR9712134A (pt) 1999-08-31

Similar Documents

Publication Publication Date Title
IL128900A0 (en) Beta-sulfonyl hydroxamic acids as matrix metalloproteinases inhibitor
IL143545A (en) Thrombin inhibitors and pharmaceutical compositions containing them
CA2367017A1 (en) Inhibitors of impdh enzyme
AU2536995A (en) Arylsulfonamido-substituted hydroxamic acids as matrix metalloproteinase inhibitors
ES2052452A1 (es) Procedimiento de preparacion de inhibidores duales de no-sintasa y ciclooxigenasa.
NO20003018L (no) Triazinangiogenese-inhibitorer
RU95101048A (ru) Производные пролинамида, фармкомпозиция на их основе
NZ237023A (en) 17beta-substituted-4-aza-5alpha-androstan-3-ones and pharmaceutical compositions
EA200100804A1 (ru) Сульфоароматические производные гидроксамовой кислоты как ингибиторы металлопротеаз
UA37181C2 (uk) ГІДРОХЛОРИД 7-&lt;font face=&#34;Symbol&#34;&gt;b&lt;/font&gt;-[(Z)-2-(2-АМІНО-4-ТІАЗОЛІЛ)-3-ГІДРОКСИІМІНОАЦЕТА- МІДО]-3-(1,2,3-ТРИАЗОЛ-4-ІЛ)ТІОМЕТИЛТІО-3-ЦЕФЕМ-4-КАРБОНОВОЇ КИСЛОТИ АБО ЙОГО ГІДРАТИ, ЩО МАЮТЬ АНТИБАКТЕРІАЛЬНУ ДІЮ, ФАРМАЦЕВТИЧНА АНТИБАКТЕРІАЛЬНА КОМПОЗИЦІЯ, СПОСІБ ПРИГНІЧЕННЯ РОЗВИТКУ БАКТЕРІЙ, СПОСІБ ЛІКУВАННЯ БАКТЕРІАЛЬНИХ ІНФЕКЦІЙ
EA200101085A1 (ru) Гидроксамовые кислоты, производные ароматических сульфонов, - ингибиторы металлопротеаз
CO5261493A1 (es) Procedimiento y compuestos para la inhibicion de la mrp1
AU5090393A (en) Platelet aggregation inhibitors
TR200003252T2 (tr) Interleukın-1ß dönüştürme enzimi succınamıde inhibitörleri.
CA2266759A1 (en) 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
AU5710696A (en) Platelet aggregation inhibitors
NO983511L (no) Difenylstilbener som pro-legemidler til COX-2-inhibitorer
HUP0301010A2 (hu) A koleszteril-észter és a viaszészter szintézisét egyaránt gátló vegyületek faggyúmirigy-betegségek kezeléséhez és ezeket tartalmazó gyógyszerkészítmények