IL128597A - An electrochemical detector integrated on tiny capillary chips with insulating parts movement in a charged solution - Google Patents

An electrochemical detector integrated on tiny capillary chips with insulating parts movement in a charged solution

Info

Publication number
IL128597A
IL128597A IL12859797A IL12859797A IL128597A IL 128597 A IL128597 A IL 128597A IL 12859797 A IL12859797 A IL 12859797A IL 12859797 A IL12859797 A IL 12859797A IL 128597 A IL128597 A IL 128597A
Authority
IL
Israel
Prior art keywords
channel
thin film
electrode
capillary electrophoresis
electrophoresis chip
Prior art date
Application number
IL12859797A
Other languages
English (en)
Hebrew (he)
Other versions
IL128597A0 (en
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/703,394 external-priority patent/US5906723A/en
Application filed by Univ California filed Critical Univ California
Publication of IL128597A0 publication Critical patent/IL128597A0/xx
Publication of IL128597A publication Critical patent/IL128597A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/4473—Arrangements for investigating the separated zones, e.g. localising zones by electric means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
IL12859797A 1996-08-26 1997-08-26 An electrochemical detector integrated on tiny capillary chips with insulating parts movement in a charged solution IL128597A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/703,394 US5906723A (en) 1996-08-26 1996-08-26 Electrochemical detector integrated on microfabricated capillary electrophoresis chips
US08/916,557 US6045676A (en) 1996-08-26 1997-08-22 Electrochemical detector integrated on microfabricated capilliary electrophoresis chips
PCT/US1997/015006 WO1998009161A1 (fr) 1996-08-26 1997-08-26 Detecteur electrochimique integre a des puces pour electrophorese capillaire fabriquees par micro-usinage

Publications (2)

Publication Number Publication Date
IL128597A0 IL128597A0 (en) 2000-01-31
IL128597A true IL128597A (en) 2001-11-25

Family

ID=27107131

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12859797A IL128597A (en) 1996-08-26 1997-08-26 An electrochemical detector integrated on tiny capillary chips with insulating parts movement in a charged solution

Country Status (10)

Country Link
US (1) US6045676A (fr)
EP (1) EP0922218A1 (fr)
JP (1) JP3474581B2 (fr)
KR (1) KR100316437B1 (fr)
CN (1) CN1235674A (fr)
AU (1) AU714163B2 (fr)
CA (1) CA2263859C (fr)
IL (1) IL128597A (fr)
NZ (1) NZ334181A (fr)
WO (1) WO1998009161A1 (fr)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6641708B1 (en) 1996-01-31 2003-11-04 Board Of Regents, The University Of Texas System Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
US6045676A (en) * 1996-08-26 2000-04-04 The Board Of Regents Of The University Of California Electrochemical detector integrated on microfabricated capilliary electrophoresis chips
US6110354A (en) * 1996-11-01 2000-08-29 University Of Washington Microband electrode arrays
JP3394262B2 (ja) 1997-02-06 2003-04-07 セラセンス、インク． 小体積インビトロ被検体センサー
US6281006B1 (en) 1998-08-24 2001-08-28 Therasense, Inc. Electrochemical affinity assay
US6638716B2 (en) 1998-08-24 2003-10-28 Therasense, Inc. Rapid amperometric verification of PCR amplification of DNA
FR2783919A1 (fr) * 1998-09-25 2000-03-31 Suisse Electronique Microtech Capteur optique integre pour detecter les composants d'un fluide
US6338790B1 (en) * 1998-10-08 2002-01-15 Therasense, Inc. Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
GB9822185D0 (en) 1998-10-13 1998-12-02 Zeneca Ltd Device
US6361671B1 (en) * 1999-01-11 2002-03-26 The Regents Of The University Of California Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels
WO2000054041A1 (fr) * 1999-03-05 2000-09-14 Ce Resources Pte Ltd. Appareil distributeur haute performance
US6682887B1 (en) 1999-04-30 2004-01-27 Aclara Biosciences, Inc. Detection using degradation of a tagged sequence
US20040248150A1 (en) * 1999-04-02 2004-12-09 Sharat Singh Methods employing oligonucleotide-binding e-tag probes
US6627400B1 (en) 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US6322980B1 (en) * 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
US6514700B1 (en) * 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US6673550B2 (en) 1999-04-30 2004-01-06 Aclara Biosciences, Inc. Electrophoretic tag reagents comprising fluorescent compounds
US20030235832A1 (en) * 2000-06-21 2003-12-25 Ahmed Chenna Multiplexed analysis by chromatographic separation of molecular tags
US7037654B2 (en) 1999-04-30 2006-05-02 Aclara Biosciences, Inc. Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
US7001725B2 (en) 1999-04-30 2006-02-21 Aclara Biosciences, Inc. Kits employing generalized target-binding e-tag probes
DE19927533B4 (de) * 1999-06-16 2004-03-04 Merck Patent Gmbh Miniaturisiertes Analysensystem
DE19927535B4 (de) * 1999-06-16 2004-06-17 Merck Patent Gmbh Miniaturisiertes Analysensystem mit Vorrichtung zum Ausschleusen von Substanzen
WO2002048673A2 (fr) * 2000-11-17 2002-06-20 University Of Virginia Patent Foundation Procede convenant pour des systemes de tassement/injection orthogonaux d'analytes dans une electrophorese
US6878255B1 (en) 1999-11-05 2005-04-12 Arrowhead Center, Inc. Microfluidic devices with thick-film electrochemical detection
US20040067498A1 (en) * 2000-04-28 2004-04-08 Ahmed Chenna Detection of nucleic acid sequences by cleavage and separation of tag-containing structures
US7160735B2 (en) * 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
US7537938B2 (en) * 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
US20030207300A1 (en) * 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
US7771929B2 (en) * 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
WO2002000100A2 (fr) * 2000-06-23 2002-01-03 Daniel Armstrong Methode de separation, d'identification et d'evaluation de microbes et de cellules
US20020029203A1 (en) * 2000-09-01 2002-03-07 Pelland David M. Electronic personal assistant with personality adaptation
US7114541B2 (en) * 2000-09-07 2006-10-03 Gesim Gesselschaft Fur Silizium-Mikrosysteme Mbh Method for producing a 3-D micro flow cell and a 3-D micro flow cell
WO2002029402A2 (fr) * 2000-10-02 2002-04-11 Sophion Bioscience A/S Systeme permettant de proceder a des mesures electrophysiologiques
US6596140B2 (en) * 2001-05-01 2003-07-22 Applera Corporation Multi-channel capillary electrophoresis device and method
AU2002305658A1 (en) 2001-05-21 2002-12-03 Aclara Biosciences, Inc. Analyzing phosphorylated proteins
JP2005505749A (ja) 2001-05-21 2005-02-24 アクララ バイオサイエンシーズ， インコーポレイテッド タンパク質を分析するための方法および組成物
WO2002097112A2 (fr) * 2001-05-26 2002-12-05 Aclara Biosciences, Inc. Amplification catalytique de signaux de dosage multiplexe
US6896778B2 (en) 2001-06-04 2005-05-24 Epocal Inc. Electrode module
KR100455661B1 (ko) * 2001-07-20 2004-11-12 학교법인 포항공과대학교 아민 화합물 분석용 랩온어칩
KR100442412B1 (ko) * 2001-07-20 2004-07-30 학교법인 포항공과대학교 모세관으로 연결된 랩온어칩 시스템
US6890409B2 (en) * 2001-08-24 2005-05-10 Applera Corporation Bubble-free and pressure-generating electrodes for electrophoretic and electroosmotic devices
CN1166422C (zh) * 2001-11-05 2004-09-15 北京源德生物医学工程股份有限公司 用于体外高能聚焦超声波治疗机的坐位架
US20050053939A1 (en) * 2001-11-09 2005-03-10 Ahmed Chenna Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
CN1164939C (zh) * 2001-11-30 2004-09-01 清华大学 检测核苷酸和单核苷酸多态性用的毛细管电泳芯片装置
AU2003219733A1 (en) 2002-02-08 2003-09-02 University Of Louisville Research Foundation, Inc.Belknap Campus A capillary electrophoresis-electrochemical detection microchip device and supporting circuits
US7060798B2 (en) 2002-05-13 2006-06-13 State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University Modified protein adhesives and lignocellulosic composites made from the adhesives
NL1021269C2 (nl) * 2002-08-14 2004-02-17 Lionix B V Elektrodesysteem en werkwijze voor het aanleggen van elektrische spanningen en het teweegbrengen van elektrische stromen.
US20040112751A1 (en) * 2002-08-26 2004-06-17 Jongyoon Han Multidimensional electrophoresis and methods of making and using thereof
WO2004027379A2 (fr) * 2002-09-20 2004-04-01 Novus Molecular, Inc. Procedes et dispositifs pour epreuve biologique active
US20040091850A1 (en) * 2002-11-08 2004-05-13 Travis Boone Single cell analysis of membrane molecules
US7402398B2 (en) * 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
JP2007502417A (ja) * 2003-08-11 2007-02-08 モノグラム バイオサイエンシズ，インコーポレーテッド 分子複合体の検出および特徴づけ
US8012328B2 (en) * 2003-08-21 2011-09-06 Colorado State University Research Foundation Non-fluidic micro-detection device and uses thereof
US20060194306A1 (en) * 2003-08-25 2006-08-31 Herr Amy E System for gel electrophoretic immunoassay
EP1680666A4 (fr) * 2003-10-27 2008-03-26 Monogram Biosciences Inc Detection d'anticorps anti-therapeutique humain
ES2432040T3 (es) * 2004-01-28 2013-11-29 454 Life Sciences Corporation Amplificación de ácido nucleico con emulsión de flujo continuo
US7211184B2 (en) * 2004-08-04 2007-05-01 Ast Management Inc. Capillary electrophoresis devices
CN100417937C (zh) * 2005-01-13 2008-09-10 清华大学 芯片式电容耦合非接触型电导检测器
JP2006224014A (ja) * 2005-02-18 2006-08-31 Yokogawa Electric Corp マイクロ流路デバイス
US7417418B1 (en) * 2005-06-14 2008-08-26 Ayliffe Harold E Thin film sensor
CN100437106C (zh) * 2005-08-12 2008-11-26 浙江大学 一种可应用于毛细管电泳的电化学电流测量装置
US7988839B2 (en) 2005-09-20 2011-08-02 University Of Louisville Research Foundation, Inc. Capillary electrophoresis systems and methods
EP1963817A2 (fr) * 2005-12-22 2008-09-03 Honeywell International Inc. Cartouche pour analyseur d'echantillons portatif
US9452429B2 (en) 2006-02-02 2016-09-27 E. I. Spectra, Llc Method for mutiplexed microfluidic bead-based immunoassay
US8616048B2 (en) * 2006-02-02 2013-12-31 E I Spectra, LLC Reusable thin film particle sensor
US8171778B2 (en) * 2006-05-05 2012-05-08 E I Spectra, LLC Thin film particle sensor
US9293311B1 (en) 2006-02-02 2016-03-22 E. I. Spectra, Llc Microfluidic interrogation device
US20110189714A1 (en) * 2010-02-03 2011-08-04 Ayliffe Harold E Microfluidic cell sorter and method
KR100883775B1 (ko) * 2007-03-22 2009-02-18 명지대학교 산학협력단 모세관 전기영동 칩상에 집적된 전기화학적 검출기 및 이의제조방법
US8025776B2 (en) * 2007-10-29 2011-09-27 Korea Institute Of Science And Technology Glass electrophoresis microchip and method of manufacturing the same by MEMS fabrication
WO2011108333A1 (fr) * 2010-03-05 2011-09-09 コニカミノルタオプト株式会社 Procédé de fabrication d'une puce de détection microfluidique
US8804105B2 (en) 2012-03-27 2014-08-12 E. I. Spectra, Llc Combined optical imaging and electrical detection to characterize particles carried in a fluid
WO2013168835A1 (fr) * 2012-05-09 2013-11-14 서울대학교산학협력단 Puce électrophorétique pour une détection électrochimique
US9217179B2 (en) 2012-05-24 2015-12-22 The Governing Council Of The University Of Toronto Systems and methods for multiplexed electrochemical detection
WO2015112635A1 (fr) 2014-01-21 2015-07-30 The Board Of Trustees Of The University Of Illinois Substrats présentant des motifs de mouillabilité pour transport et drainage de liquides sans pompe
GB2531615B (en) 2015-02-02 2017-11-22 Atlas Genetics Ltd Instrument for performing a diagnostic test on a fluidic cartridge
GB201501705D0 (en) 2015-02-02 2015-03-18 Atlas Genetics Ltd Instrument for performing a diagnostic test on a fluidic cartridge
JP6912112B2 (ja) * 2015-10-05 2021-07-28 株式会社タカゾノテクノロジー 微生物検出装置
JP6641146B2 (ja) * 2015-10-05 2020-02-05 株式会社タカゾノテクノロジー 電圧印加装置
US10976282B2 (en) * 2016-03-16 2021-04-13 The University Of Notre Dame Du Lac Voltammetry in high-voltage fields
CN110044680B (zh) * 2019-04-28 2024-02-23 宁波大学 一种毛细管电泳的样品浓缩装置和方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2191110B (en) * 1986-06-06 1989-12-06 Plessey Co Plc Chromatographic separation device
US5071531A (en) * 1989-05-01 1991-12-10 Soane Technologies, Inc. Casting of gradient gels
US5126022A (en) * 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
GB2244135B (en) * 1990-05-04 1994-07-13 Gen Electric Co Plc Sensor devices
DE4314755C2 (de) * 1993-05-05 1995-03-02 Meinhard Prof Dr Knoll Kapillarelektrophoretisches Trennverfahren sowie Vorrichtung zur Durchführung von chemischen oder biochemischen Analysen
GB9320286D0 (en) * 1993-10-01 1993-11-17 Drew Scient Ltd Electro-chemical detector
US5429734A (en) * 1993-10-12 1995-07-04 Massachusetts Institute Of Technology Monolithic capillary electrophoretic device
US5580435A (en) * 1994-06-10 1996-12-03 The Board Of Trustees Of The Leland Stanford Junior University System for detecting components of a sample in electrophoretic separation
US6045676A (en) * 1996-08-26 2000-04-04 The Board Of Regents Of The University Of California Electrochemical detector integrated on microfabricated capilliary electrophoresis chips

Also Published As

Publication number Publication date
KR100316437B1 (ko) 2001-12-12
IL128597A0 (en) 2000-01-31
JP3474581B2 (ja) 2003-12-08
CN1235674A (zh) 1999-11-17
EP0922218A1 (fr) 1999-06-16
WO1998009161A1 (fr) 1998-03-05
AU714163B2 (en) 1999-12-23
NZ334181A (en) 2000-09-29
KR20000035802A (ko) 2000-06-26
US6045676A (en) 2000-04-04
JP2001527637A (ja) 2001-12-25
CA2263859A1 (fr) 1998-03-05
AU4090597A (en) 1998-03-19
CA2263859C (fr) 2003-07-01

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