IL127850A - Method for the acetylation of 10 - dacetylbacatin III at position C-10 - Google Patents

Method for the acetylation of 10 - dacetylbacatin III at position C-10

Info

Publication number
IL127850A
IL127850A IL12785097A IL12785097A IL127850A IL 127850 A IL127850 A IL 127850A IL 12785097 A IL12785097 A IL 12785097A IL 12785097 A IL12785097 A IL 12785097A IL 127850 A IL127850 A IL 127850A
Authority
IL
Israel
Prior art keywords
solution
iii
baccatin iii
residue
acylating agent
Prior art date
Application number
IL12785097A
Other languages
English (en)
Hebrew (he)
Other versions
IL127850A0 (en
Original Assignee
Napro Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Napro Biotherapeutics Inc filed Critical Napro Biotherapeutics Inc
Publication of IL127850A0 publication Critical patent/IL127850A0/xx
Publication of IL127850A publication Critical patent/IL127850A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
IL12785097A 1996-07-11 1997-07-09 Method for the acetylation of 10 - dacetylbacatin III at position C-10 IL127850A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/678,759 US5750736A (en) 1996-07-11 1996-07-11 Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
PCT/US1997/012307 WO1998002427A1 (en) 1996-07-11 1997-07-09 Method for acylating 10-deacetylbaccatin iii selectively at the c-10 position

Publications (2)

Publication Number Publication Date
IL127850A0 IL127850A0 (en) 1999-10-28
IL127850A true IL127850A (en) 2001-11-25

Family

ID=24724151

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12785097A IL127850A (en) 1996-07-11 1997-07-09 Method for the acetylation of 10 - dacetylbacatin III at position C-10

Country Status (16)

Country Link
US (1) US5750736A (de)
EP (1) EP0918764B1 (de)
JP (1) JP2000514458A (de)
KR (1) KR20000023649A (de)
CN (1) CN1096453C (de)
AT (1) ATE266650T1 (de)
AU (1) AU731651B2 (de)
BR (1) BR9710234A (de)
CA (1) CA2259906A1 (de)
DE (1) DE69729100D1 (de)
EA (1) EA002001B1 (de)
HK (1) HK1019596A1 (de)
IL (1) IL127850A (de)
NO (1) NO986066L (de)
NZ (1) NZ333889A (de)
WO (1) WO1998002427A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6005120A (en) 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US5914411A (en) * 1998-01-21 1999-06-22 Napro Biotherapeutics, Inc. Alternate method for acylating 10-deacetylbaccatin III selectively at the C-10 position
US6066749A (en) * 1998-05-01 2000-05-23 Napro Biotherapeutics, Inc. Method for conversion of C-2'-O-protected-10-hydroxy taxol to c-2'-O-protected taxol:useful intermediates in paclitaxel synthesis
US6448417B1 (en) * 1998-05-01 2002-09-10 Napro Biotherapeutics, Inc. Methods and useful intermediates for paclitaxel synthesis from C-7, C-10 di-cbz 10-deacetylbaccatin III
US6136999A (en) * 1999-06-21 2000-10-24 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-n-acyl (2R,3S)-3-phenylisoserine substituted phenyl activated esters and method for production thereof
US6143902A (en) * 1999-06-21 2000-11-07 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-N-acyl (2R,3S)-3-phenylisoserine N-imido activated esters and method for production thereof
US6281368B1 (en) 2000-03-16 2001-08-28 Napro Biotherapeutics, Inc. Simple and efficient hydrazinolysis of C-10 and C-13 ester functionalities of taxanes to obtain 10-DAB III
US6495705B2 (en) 2000-03-16 2002-12-17 Napro Biotherapeutics, Inc. Efficient process for the production of 10-DAB III by selective hydrazinolysis of various taxanes
US6358996B1 (en) 2000-06-09 2002-03-19 Napro Biotherapeutics, Inc. Stable isotope labeling of paclitaxel
EP1562927B1 (de) * 2002-10-09 2009-05-13 Chatham Biotec Ltd. Thio-analoga von paclitaxel und deren vorprodukte
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
IT1254517B (it) * 1992-03-06 1995-09-25 Indena Spa 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
FR2696463B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
FR2750989B1 (fr) * 1996-07-09 1998-09-25 Rhone Poulenc Rorer Sa Procede de monoacylation d'hydroxy taxanes
EP0875508B1 (de) * 1997-05-02 2003-10-22 Pharmachemie B.V. Verfahren zur Herstellung von Baccatin III und seiner Derivate ausgehend von 10-Deacetylbaccatin III.
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes

Also Published As

Publication number Publication date
NO986066D0 (no) 1998-12-22
IL127850A0 (en) 1999-10-28
EA002001B1 (ru) 2001-10-22
HK1019596A1 (en) 2000-02-18
ATE266650T1 (de) 2004-05-15
JP2000514458A (ja) 2000-10-31
DE69729100D1 (de) 2004-06-17
EP0918764A4 (de) 1999-09-01
CN1225089A (zh) 1999-08-04
AU3800297A (en) 1998-02-09
BR9710234A (pt) 2000-01-11
EP0918764A1 (de) 1999-06-02
CA2259906A1 (en) 1998-01-22
NO986066L (no) 1999-03-05
WO1998002427A1 (en) 1998-01-22
EP0918764B1 (de) 2004-05-12
AU731651B2 (en) 2001-04-05
CN1096453C (zh) 2002-12-18
EA199900096A1 (ru) 1999-08-26
US5750736A (en) 1998-05-12
NZ333889A (en) 1999-03-29
KR20000023649A (ko) 2000-04-25

Similar Documents

Publication Publication Date Title
US5750736A (en) Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
WO1996040667A1 (en) Paclitaxel synthesis from precursor compounds and methods of producing the same
EP0847393B1 (de) Paclitaxelsynthese aus vorläufervebindungen und verfahren zu deren herstellung
US5684175A (en) C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor
US5914411A (en) Alternate method for acylating 10-deacetylbaccatin III selectively at the C-10 position
EP0941219B1 (de) Zwischenprodukt zur verwendung in der docetaxelsynthese und herstellungsverfahren davon
US6066749A (en) Method for conversion of C-2'-O-protected-10-hydroxy taxol to c-2'-O-protected taxol:useful intermediates in paclitaxel synthesis
US6048990A (en) Method for selective acylation of C-2'-O-protected-10-hydroxy-taxol at the C-10 position
EP1082316B1 (de) Verfahren und verwendbare zwischenprodukte für paclitaxel synthese von c-7,c-10 di-cbz baccatin iii
MXPA99000448A (es) Metodo para acilar selectivamente el 10-deacetilbaccatin iii en la posicion c-10
MXPA00006715A (es) Metodo alternativo para acilar 10-deacetilbaccatin iii selectivamente en la posicion c-10
MXPA00010678A (es) Metodos e intermediarios utiles para la sintesis de paclitaxel a partir de di-cbz bacatina iii de c-7, c-10

Legal Events

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KB Patent renewed
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