IL127603A - A process for preparing rapidly dissolving solid dosage forms and the dosage forms obtained in this process - Google Patents
A process for preparing rapidly dissolving solid dosage forms and the dosage forms obtained in this processInfo
- Publication number
- IL127603A IL127603A IL12760397A IL12760397A IL127603A IL 127603 A IL127603 A IL 127603A IL 12760397 A IL12760397 A IL 12760397A IL 12760397 A IL12760397 A IL 12760397A IL 127603 A IL127603 A IL 127603A
- Authority
- IL
- Israel
- Prior art keywords
- mold
- process according
- foam
- dosage forms
- water
- Prior art date
Links
- 239000002552 dosage form Substances 0.000 title claims abstract description 73
- 238000000034 method Methods 0.000 title claims abstract description 62
- 239000007787 solid Substances 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000000463 material Substances 0.000 claims abstract description 48
- 239000000203 mixture Substances 0.000 claims abstract description 41
- 239000011159 matrix material Substances 0.000 claims abstract description 28
- 239000002904 solvent Substances 0.000 claims abstract description 25
- 230000005499 meniscus Effects 0.000 claims abstract description 22
- 238000004108 freeze drying Methods 0.000 claims abstract description 12
- 238000007710 freezing Methods 0.000 claims abstract description 8
- 230000008014 freezing Effects 0.000 claims abstract description 8
- 238000004090 dissolution Methods 0.000 claims abstract description 6
- 239000004480 active ingredient Substances 0.000 claims description 24
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- 235000011852 gelatine desserts Nutrition 0.000 claims description 14
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- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 12
- 229940024606 amino acid Drugs 0.000 claims description 11
- 150000001413 amino acids Chemical class 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 11
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- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 4
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- 241001465754 Metazoa Species 0.000 description 2
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 2
- 239000012736 aqueous medium Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000005336 cracking Methods 0.000 description 2
- 238000004807 desolvation Methods 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
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- 238000011068 loading method Methods 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 239000005033 polyvinylidene chloride Substances 0.000 description 2
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- 239000000454 talc Substances 0.000 description 2
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- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 1
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- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
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- GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 description 1
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- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2025996P | 1996-06-17 | 1996-06-17 | |
| PCT/EP1997/003065 WO1997048383A1 (en) | 1996-06-17 | 1997-06-10 | Biconvex rapidly disintegrating dosage forms |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL127603A0 IL127603A0 (en) | 1999-10-28 |
| IL127603A true IL127603A (en) | 2001-08-08 |
Family
ID=21797599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12760397A IL127603A (en) | 1996-06-17 | 1997-06-10 | A process for preparing rapidly dissolving solid dosage forms and the dosage forms obtained in this process |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6224905B1 (xx) |
| EP (1) | EP0910345B1 (xx) |
| JP (1) | JP4371435B2 (xx) |
| CN (1) | CN1191824C (xx) |
| AT (1) | ATE213154T1 (xx) |
| AU (1) | AU713062B2 (xx) |
| BR (1) | BR9709829A (xx) |
| CA (1) | CA2257303C (xx) |
| CY (1) | CY2288B1 (xx) |
| CZ (1) | CZ297261B6 (xx) |
| DE (1) | DE69710460T2 (xx) |
| DK (1) | DK0910345T3 (xx) |
| EE (1) | EE03549B1 (xx) |
| ES (1) | ES2172793T3 (xx) |
| HK (1) | HK1019200A1 (xx) |
| HU (1) | HU225819B1 (xx) |
| IL (1) | IL127603A (xx) |
| NO (1) | NO321510B1 (xx) |
| NZ (1) | NZ332832A (xx) |
| PL (1) | PL188231B1 (xx) |
| PT (1) | PT910345E (xx) |
| SI (1) | SI0910345T1 (xx) |
| SK (1) | SK282868B6 (xx) |
| TR (1) | TR199802616T2 (xx) |
| TW (1) | TW402561B (xx) |
| WO (1) | WO1997048383A1 (xx) |
| ZA (1) | ZA975277B (xx) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9815064A (pt) * | 1997-11-26 | 2001-11-20 | Procter & Gamble | Tablete detergente |
| US6270790B1 (en) * | 1998-08-18 | 2001-08-07 | Mxneil-Ppc, Inc. | Soft, convex shaped chewable tablets having reduced friability |
| DE19860189C1 (de) * | 1998-12-24 | 2000-03-30 | Henkel Kgaa | Formoptimierter Waschmittelformkörper |
| GB0020964D0 (en) * | 2000-08-25 | 2000-10-11 | Reckitt & Colmann Prod Ltd | Improvements in or relating to containers |
| WO2002083194A1 (en) * | 2001-04-12 | 2002-10-24 | Therics, Inc. | Method and apparatus for engineered regenerative biostructures |
| WO2003024428A1 (en) * | 2001-09-14 | 2003-03-27 | Scolr, Inc. | Amino acid modulated extended release dosage form |
| TW200400055A (en) * | 2002-02-22 | 2004-01-01 | Pharmacia Corp | Ophthalmic formulation with novel gum composition |
| EP1487419A2 (en) | 2002-03-20 | 2004-12-22 | Elan Pharma International Limited | Fast dissolving dosage forms having reduced friability |
| US20040109889A1 (en) | 2002-12-04 | 2004-06-10 | Bunick Frank J. | Surface treatment composition for soft substrates |
| US20050036977A1 (en) * | 2003-08-11 | 2005-02-17 | Dilip Gole | Taste-masked resinate and preparation thereof |
| CA2540040C (en) * | 2003-10-07 | 2012-09-11 | Andrx Pharmaceuticals Llc | Rapidly disintegrating formulation |
| US20050085922A1 (en) * | 2003-10-17 | 2005-04-21 | Shappley Ben R. | Shaped filler for implantation into a bone void and methods of manufacture and use thereof |
| DE102004028940A1 (de) * | 2004-06-15 | 2006-01-12 | Krka Tovarna Zdravil, D.D. | Oral zerfallende pharmazeutische Zusammensetzung, die Risperidon enthält |
| US20070048369A1 (en) * | 2005-08-26 | 2007-03-01 | National Starch And Chemical Investment Holding Corporation | Mucosal delivery tablet |
| US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
| MX354603B (es) | 2007-05-25 | 2018-03-13 | Indivior Uk Ltd | Formulaciones de transferencia sostenida de compuestos de risperidona. |
| US20090060983A1 (en) * | 2007-08-30 | 2009-03-05 | Bunick Frank J | Method And Composition For Making An Orally Disintegrating Dosage Form |
| BRPI0819231B8 (pt) * | 2007-10-31 | 2021-05-25 | Mcneil Ppc Inc | processo para preparo de forma farmacêutica de desintegração rápida por moldagem a quente na presença de sal inorgânico hidratado |
| JP2011527607A (ja) | 2008-07-08 | 2011-11-04 | ハイパーブランチ メディカル テクノロジー， インコーポレイテッド | 多成分処方のための独立式医療用アプリケータおよびその使用方法 |
| KR20100023538A (ko) * | 2008-08-22 | 2010-03-04 | 삼성전자주식회사 | 고상 시약의 제조방법 및 고상 시약을 수용하는 미세유동장치 |
| TWI468157B (zh) * | 2009-04-29 | 2015-01-11 | Intervet Int Bv | 形成錠劑的方法，進行該方法的系統及包含該錠劑的包裝物 |
| TWI471127B (zh) | 2009-04-29 | 2015-02-01 | Intervet Int Bv | 供人類使用之口服崩解錠劑的製備方法、所製得之口服崩解錠劑、以及含有該口服崩解錠劑的包裝物 |
| WO2012039788A1 (en) | 2010-09-22 | 2012-03-29 | Mcneil-Ppc, Inc. | Multi-layered orally disintegrating tablet and the manufacture thereof |
| US8313768B2 (en) | 2009-09-24 | 2012-11-20 | Mcneil-Ppc, Inc. | Manufacture of tablet having immediate release region and sustained release region |
| US20110318411A1 (en) | 2010-06-24 | 2011-12-29 | Luber Joseph R | Multi-layered orally disintegrating tablet and the manufacture thereof |
| US8343533B2 (en) | 2009-09-24 | 2013-01-01 | Mcneil-Ppc, Inc. | Manufacture of lozenge product with radiofrequency |
| US20110070286A1 (en) * | 2009-09-24 | 2011-03-24 | Andreas Hugerth | Process for the manufacture of nicotine-comprising chewing gum and nicotine-comprising chewing gum manufactured according to said process |
| GB2481017B (en) | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
| US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
| EP2618813A1 (en) | 2010-09-22 | 2013-07-31 | McNeil-PPC, Inc. | Manufacture of tablets from energy-applied powder blend |
| CN102462665B (zh) * | 2010-11-18 | 2016-12-07 | 董玲 | 冻干赋形制剂的制备方法 |
| JP2013053135A (ja) * | 2011-08-09 | 2013-03-21 | Taisho Pharmaceutical Co Ltd | 内服製剤 |
| JP2013053136A (ja) * | 2011-08-09 | 2013-03-21 | Taisho Pharmaceutical Co Ltd | 内服液剤 |
| EP2858495A4 (en) * | 2012-04-30 | 2016-06-01 | Dow Agrosciences Llc | VEHICLES FOR ADMINISTERING A PESTICIDE COMPOSITION |
| US9511028B2 (en) | 2012-05-01 | 2016-12-06 | Johnson & Johnson Consumer Inc. | Orally disintegrating tablet |
| US9445971B2 (en) | 2012-05-01 | 2016-09-20 | Johnson & Johnson Consumer Inc. | Method of manufacturing solid dosage form |
| US9233491B2 (en) | 2012-05-01 | 2016-01-12 | Johnson & Johnson Consumer Inc. | Machine for production of solid dosage forms |
| US20140141078A1 (en) * | 2012-09-15 | 2014-05-22 | Jeffery K. Slaboden | Dissolvable TableT |
| CN103431411A (zh) * | 2013-09-17 | 2013-12-11 | 张国庆 | 一种便于婴幼儿服用的乳钙口腔速溶片及其生产方法 |
| MX368159B (es) | 2014-01-10 | 2019-09-20 | Johnson & Johnson Consumer Inc | Proceso para elaborar tabletas con el uso de radiofrecuencia y partículas disipativas revestidas. |
| GB201404139D0 (en) | 2014-03-10 | 2014-04-23 | Rb Pharmaceuticals Ltd | Sustained release buprenorphine solution formulations |
| NZ731309A (en) | 2014-11-07 | 2022-02-25 | Indivior Uk Ltd | Buprenorphine dosing regimens |
| CN106466228A (zh) * | 2015-08-14 | 2017-03-01 | 董玲 | 一种多模具制备任意形状的冻干赋形制剂的方法及其产品 |
| CN110225745A (zh) | 2016-11-28 | 2019-09-10 | 强生消费者公司 | 用于制备包衣剂型的方法 |
| US10493026B2 (en) | 2017-03-20 | 2019-12-03 | Johnson & Johnson Consumer Inc. | Process for making tablet using radiofrequency and lossy coated particles |
| US10646484B2 (en) | 2017-06-16 | 2020-05-12 | Indivior Uk Limited | Methods to treat opioid use disorder |
| EP3646856B1 (en) * | 2017-06-27 | 2023-11-22 | Daiichi Sankyo Company, Limited | Tablet |
| USD821683S1 (en) * | 2017-07-26 | 2018-07-03 | Wm. Wrigley Jr. Company | Confectionary piece |
| CN114867496A (zh) | 2019-12-17 | 2022-08-05 | 9286-3620 魁北克有限公司 | 基于原位形成蛋白质/多糖凝聚体的口服递送系统 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE53696B1 (en) * | 1981-12-02 | 1989-01-18 | Wyeth John & Brother Ltd | Solid shaped articles |
| GB2111423B (en) | 1981-12-02 | 1985-06-26 | Wyeth John & Brother Ltd | Making quick-dissolving pills |
| US4792448A (en) | 1987-06-11 | 1988-12-20 | Pfizer Inc. | Generic zero order controlled drug delivery system |
| JP2614409B2 (ja) * | 1991-12-20 | 1997-05-28 | ファイザー・インコーポレーテッド | 多孔質の付形された放出製剤およびその製造方法 |
| IL105553A (en) * | 1992-05-06 | 1998-01-04 | Janssen Pharmaceutica Inc | Solid dosage forms consisting of a porous network of matrix that releases a substance that dissipates rapidly in water |
| US5457895A (en) * | 1993-10-01 | 1995-10-17 | R. P. Scherer Corporation | Method of identifying freeze-dried dosage forms |
-
1997
- 1997-06-10 US US09/194,808 patent/US6224905B1/en not_active Expired - Lifetime
- 1997-06-10 HU HU9903654A patent/HU225819B1/hu unknown
- 1997-06-10 PT PT97927176T patent/PT910345E/pt unknown
- 1997-06-10 EP EP97927176A patent/EP0910345B1/en not_active Expired - Lifetime
- 1997-06-10 CN CNB971956030A patent/CN1191824C/zh not_active Expired - Lifetime
- 1997-06-10 PL PL97330530A patent/PL188231B1/pl unknown
- 1997-06-10 JP JP50221898A patent/JP4371435B2/ja not_active Expired - Lifetime
- 1997-06-10 AU AU31757/97A patent/AU713062B2/en not_active Expired
- 1997-06-10 SI SI9730313T patent/SI0910345T1/xx unknown
- 1997-06-10 WO PCT/EP1997/003065 patent/WO1997048383A1/en active IP Right Grant
- 1997-06-10 BR BR9709829-9A patent/BR9709829A/pt not_active IP Right Cessation
- 1997-06-10 AT AT97927176T patent/ATE213154T1/de active
- 1997-06-10 DE DE69710460T patent/DE69710460T2/de not_active Expired - Lifetime
- 1997-06-10 TR TR1998/02616T patent/TR199802616T2/xx unknown
- 1997-06-10 EE EE9800428A patent/EE03549B1/xx unknown
- 1997-06-10 NZ NZ332832A patent/NZ332832A/xx not_active IP Right Cessation
- 1997-06-10 CA CA002257303A patent/CA2257303C/en not_active Expired - Lifetime
- 1997-06-10 DK DK97927176T patent/DK0910345T3/da active
- 1997-06-10 ES ES97927176T patent/ES2172793T3/es not_active Expired - Lifetime
- 1997-06-10 IL IL12760397A patent/IL127603A/en not_active IP Right Cessation
- 1997-06-10 CZ CZ0412498A patent/CZ297261B6/cs not_active IP Right Cessation
- 1997-06-10 SK SK1737-98A patent/SK282868B6/sk not_active IP Right Cessation
- 1997-06-13 ZA ZA975277A patent/ZA975277B/xx unknown
- 1997-06-16 TW TW086108287A patent/TW402561B/zh not_active IP Right Cessation
-
1998
- 1998-12-15 NO NO19985876A patent/NO321510B1/no not_active IP Right Cessation
-
1999
- 1999-10-02 HK HK99104282A patent/HK1019200A1/xx not_active IP Right Cessation
-
2002
- 2002-07-18 CY CY0200046A patent/CY2288B1/xx unknown
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