IL127214A0 - Inhibition of serotonin reuptake - Google Patents
Inhibition of serotonin reuptakeInfo
- Publication number
- IL127214A0 IL127214A0 IL12721497A IL12721497A IL127214A0 IL 127214 A0 IL127214 A0 IL 127214A0 IL 12721497 A IL12721497 A IL 12721497A IL 12721497 A IL12721497 A IL 12721497A IL 127214 A0 IL127214 A0 IL 127214A0
- Authority
- IL
- Israel
- Prior art keywords
- inhibition
- serotonin reuptake
- reuptake
- serotonin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1975196P | 1996-06-14 | 1996-06-14 | |
PCT/US1997/010243 WO1997047302A1 (fr) | 1996-06-14 | 1997-06-12 | Inhibition de la reabsorption de la serotonine |
Publications (1)
Publication Number | Publication Date |
---|---|
IL127214A0 true IL127214A0 (en) | 1999-09-22 |
Family
ID=21794846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12721497A IL127214A0 (en) | 1996-06-14 | 1997-06-12 | Inhibition of serotonin reuptake |
Country Status (9)
Country | Link |
---|---|
US (2) | US5846982A (fr) |
EP (1) | EP0812826A1 (fr) |
JP (1) | JP2000512296A (fr) |
KR (1) | KR20000016624A (fr) |
AU (1) | AU3390797A (fr) |
BR (1) | BR9709726A (fr) |
CA (1) | CA2256649A1 (fr) |
IL (1) | IL127214A0 (fr) |
WO (1) | WO1997047302A1 (fr) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6128537A (en) * | 1997-05-01 | 2000-10-03 | Medtronic, Inc | Techniques for treating anxiety by brain stimulation and drug infusion |
CA2299286A1 (fr) | 1997-08-09 | 1999-02-18 | Laramie Mary Gaster | Composes bicycliques servant de ligands pour les recepteurs 5-ht1 |
AR013669A1 (es) * | 1997-10-07 | 2001-01-10 | Smithkline Beecham Corp | Compuestos y metodos |
US6133287A (en) * | 1998-03-24 | 2000-10-17 | Allelix Biopharmaceuticals Inc. | Piperidine-indole compounds having 5-HT6 affinity |
US6150533A (en) * | 1998-04-08 | 2000-11-21 | American Home Products Corp. | N-aryloxyethyl-indoly-alkylamines for the treatment of depression |
DE69903930T2 (de) * | 1998-04-08 | 2003-07-17 | Wyeth, Madison | N-aryloxyethyl-indolyl-alkylamine zur behandlung von depressionen |
CA2330577A1 (fr) * | 1998-04-29 | 1999-11-04 | American Home Products Corporation | Agents serotoninergiques |
US6303627B1 (en) | 1998-06-19 | 2001-10-16 | Eli Lilly And Company | Inhibitors of serotonin reuptake |
WO2000044376A1 (fr) * | 1999-01-28 | 2000-08-03 | Bristol-Myers Squibb Company | Composes antidepresseurs heterocycliques |
MXPA01010655A (es) * | 1999-04-21 | 2002-11-04 | Allelix Biopharma | Compuestos de piperidin-indol que tienen afinidad por 5-ht6. |
AR021155A1 (es) * | 1999-07-08 | 2002-06-12 | Lundbeck & Co As H | Tratamiento de desordenes neuroticos |
US6686374B1 (en) | 1999-08-12 | 2004-02-03 | Nps Allelix Corp. | Azaindoles having serotonin receptor affinity |
JP4969004B2 (ja) * | 1999-08-12 | 2012-07-04 | エヌピーエス ファーマシューティカルズ,インク. | セロトニン受容体親和性を有するアザインドール |
ATE318135T1 (de) * | 1999-09-03 | 2006-03-15 | Apbi Holdings Llc | Verwendung von dapoxetin, a selektiver serotonin- aufnahme inhibitor mit schnellem wirkungseintritt,zur behandlung von sexueller dysfunction |
US6664274B1 (en) | 1999-09-29 | 2003-12-16 | Eli Lilly And Company | Piperidine derivatives as serotonine reuptake inhibitors |
US6828332B1 (en) | 1999-09-29 | 2004-12-07 | Eli Lilly And Company | Piperidine derivatives as reuptake inhibitors |
EP1244622A1 (fr) * | 1999-12-20 | 2002-10-02 | Eli Lilly And Company | Procede de preparation de piperidines trans-2,4-disubstituees |
WO2001046179A1 (fr) * | 1999-12-20 | 2001-06-28 | Eli Lilly And Company | Derives de piperidine et leur utilisation comme antagonistes du recepteur de la serotonine |
IL152894A0 (en) * | 2000-05-18 | 2003-06-24 | Daiichi Seiyaku Co | Novel benzothiophene derivatives |
PL361887A1 (en) * | 2000-10-20 | 2004-10-04 | Biovitrum Ab | 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy |
YU85303A (sh) * | 2001-05-01 | 2006-05-25 | H. Lundbeck A/S | Upotreba enantiomerno čistog escitaloprama |
EP1408976B3 (fr) * | 2001-07-20 | 2010-08-25 | Psychogenics Inc. | Traitement des troubles de deficit de l'attention/hyperactivite |
EP1539742B1 (fr) * | 2002-06-24 | 2006-11-08 | Schering Corporation | Derives d'indole utilises en tant qu'antagonistes h3 d'histamine |
CN1980917B (zh) * | 2004-05-03 | 2014-02-12 | 詹森药业有限公司 | 作为选择性雄激素受体调节剂(sarms)的新的吲哚衍生物 |
PE20060373A1 (es) | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 |
PE20060748A1 (es) | 2004-09-21 | 2006-10-01 | Smithkline Beecham Corp | Derivados de indolcarboxamida como inhibidores de quinasa ikk2 |
KR100678277B1 (ko) * | 2004-11-30 | 2007-02-02 | 삼성전자주식회사 | 멀티미디어 데이터 송수신 시스템에서 지연 시간에 대한측정값을 제공하는 지연 시간 측정 장치와 그 방법 |
KR20130136010A (ko) | 2005-04-13 | 2013-12-11 | 네우렉슨 인코포레이티드 | Nos 저해 활성을 갖는 치환된 인돌 화합물 |
TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
JP5094394B2 (ja) * | 2005-04-20 | 2012-12-12 | 武田薬品工業株式会社 | 縮合複素環化合物 |
ATE531706T1 (de) * | 2005-04-30 | 2011-11-15 | Boehringer Ingelheim Int | Neue piperidin-substituierte indole und ihre verwendung als ccr-3-modulatoren |
US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
WO2007098418A1 (fr) | 2006-02-17 | 2007-08-30 | Memory Pharmaceuticals Corporation | Composes ayant une affinite pour le recepteur 5-ht6 |
JP5350219B2 (ja) | 2006-04-13 | 2013-11-27 | ニューラクソン,インコーポレーテッド | Nos阻害活性を有する1,5および3,6−置換インドール化合物 |
PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
AU2008310883A1 (en) * | 2007-10-09 | 2009-04-16 | Hamann, Mark T | Method to use compositions having antidepressant anxiolytic and other neurological activity and compositions of matter |
KR20100103799A (ko) | 2007-11-16 | 2010-09-28 | 네우렉슨 인코포레이티드 | 내장통을 치료하기 위한 인돌 화합물 및 방법 |
WO2010102968A1 (fr) | 2009-03-10 | 2010-09-16 | Glaxo Group Limited | Dérivés d'indole comme inhibiteurs de ikk2 |
TWI429652B (zh) | 2011-08-05 | 2014-03-11 | Ind Tech Res Inst | 有機金屬化合物及包含其之有機電激發光裝置 |
MX2023006652A (es) * | 2020-12-07 | 2023-09-21 | Mindset Pharma Inc | Derivados de amina-indol-3-ciclica como agentes serotonergicos para el tratamiento de trastornos del snc. |
IL314361A (en) | 2022-01-29 | 2024-09-01 | Suven Life Sciences Ltd | Benzoisothiazole and benzoisoxazole compounds for the treatment of mental disorders |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4856687A (fr) * | 1971-11-18 | 1973-08-09 | ||
DK574274A (fr) * | 1973-12-06 | 1975-07-28 | Ciba Geigy Ag | |
FR2362628A1 (fr) * | 1976-08-26 | 1978-03-24 | Roussel Uclaf | Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments |
FR2426465B1 (fr) * | 1978-01-16 | 1983-04-29 | Roussel Uclaf | |
FR2421899A1 (fr) * | 1978-01-16 | 1979-11-02 | Roussel Uclaf | Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits |
FR2444678A2 (fr) * | 1978-12-22 | 1980-07-18 | Roussel Uclaf | Nouveau procede de preparation de derives du piperidyl-indole et de leurs sels |
FR2486081A2 (fr) * | 1979-06-12 | 1982-01-08 | Roussel Uclaf | Le (-) 4-(3-piperidinyl) 1h-indole et ses sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
SE8004129L (sv) * | 1979-07-13 | 1981-01-14 | Roussel Uclaf | Nya tetrahydropyridin-4-yl-indolderivat samt salter derav, framstellning och anvendning derav sasom lekemedel samt kompositioner innehallande dessa foreningar |
FR2460947A1 (fr) * | 1979-07-13 | 1981-01-30 | Roussel Uclaf | Nouveau derives n-substitues du tetrahydropyridinyl-indole, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
TW222631B (fr) * | 1991-07-15 | 1994-04-21 | Duphar Int Res | |
US5532240A (en) * | 1991-12-26 | 1996-07-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Condensed thiophene compound and pharmaceutical use thereof |
JPH06234633A (ja) * | 1993-02-10 | 1994-08-23 | Ajinomoto Co Inc | アミン誘導体およびこれを含有する抗血小板剤 |
AU679045B2 (en) * | 1993-03-18 | 1997-06-19 | Merck Sharp & Dohme Limited | Benzimidazole derivatives |
IL114026A (en) * | 1994-06-08 | 1999-06-20 | Lundbeck & Co As H | 4-aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzo thiophenemethyl) piperidines tetrahydropyridines or piperazines and pharmaceutical compositions containing them |
US5521196A (en) * | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
US5521197A (en) * | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
US5576321A (en) * | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
WO1996041633A1 (fr) * | 1995-06-08 | 1996-12-27 | Eli Lilly And Company | Methodes de traitement des rhumes et des rhinites allergiques |
-
1997
- 1997-05-22 US US08/862,208 patent/US5846982A/en not_active Expired - Fee Related
- 1997-06-12 CA CA002256649A patent/CA2256649A1/fr not_active Abandoned
- 1997-06-12 JP JP10501836A patent/JP2000512296A/ja not_active Ceased
- 1997-06-12 AU AU33907/97A patent/AU3390797A/en not_active Abandoned
- 1997-06-12 EP EP97304125A patent/EP0812826A1/fr not_active Withdrawn
- 1997-06-12 KR KR1019980710220A patent/KR20000016624A/ko not_active Application Discontinuation
- 1997-06-12 BR BR9709726A patent/BR9709726A/pt not_active Application Discontinuation
- 1997-06-12 IL IL12721497A patent/IL127214A0/xx unknown
- 1997-06-12 WO PCT/US1997/010243 patent/WO1997047302A1/fr not_active Application Discontinuation
-
1998
- 1998-07-30 US US09/126,572 patent/US6046215A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1997047302A1 (fr) | 1997-12-18 |
US6046215A (en) | 2000-04-04 |
BR9709726A (pt) | 1999-08-10 |
EP0812826A1 (fr) | 1997-12-17 |
AU3390797A (en) | 1998-01-07 |
CA2256649A1 (fr) | 1997-12-18 |
JP2000512296A (ja) | 2000-09-19 |
US5846982A (en) | 1998-12-08 |
KR20000016624A (ko) | 2000-03-25 |
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