IL126856A0 - 1-Deoxy baccatin iii 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof - Google Patents
1-Deoxy baccatin iii 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereofInfo
- Publication number
- IL126856A0 IL126856A0 IL12685697A IL12685697A IL126856A0 IL 126856 A0 IL126856 A0 IL 126856A0 IL 12685697 A IL12685697 A IL 12685697A IL 12685697 A IL12685697 A IL 12685697A IL 126856 A0 IL126856 A0 IL 126856A0
- Authority
- IL
- Israel
- Prior art keywords
- deoxy
- taxol
- preparation
- baccatin iii
- analogs
- Prior art date
Links
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title 2
- OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical compound O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 title 1
- 229930012538 Paclitaxel Natural products 0.000 title 1
- 229960001592 paclitaxel Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
- C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
- C07C49/733—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
- C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
- C07C49/737—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having three rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1692796P | 1996-05-06 | 1996-05-06 | |
PCT/US1997/007569 WO1997042181A1 (fr) | 1996-05-06 | 1997-05-05 | 1-deoxy baccatine iii, 1-deoxy taxol, analogues de 1-deoxy taxol, et procedes de fabrication correspondants |
Publications (1)
Publication Number | Publication Date |
---|---|
IL126856A0 true IL126856A0 (en) | 1999-09-22 |
Family
ID=21779772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12685697A IL126856A0 (en) | 1996-05-06 | 1997-05-05 | 1-Deoxy baccatin iii 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof |
Country Status (8)
Country | Link |
---|---|
US (3) | US6545168B1 (fr) |
EP (1) | EP0927175A4 (fr) |
JP (1) | JP2000510470A (fr) |
CN (1) | CN1221412A (fr) |
AU (1) | AU724499B2 (fr) |
CA (1) | CA2253513A1 (fr) |
IL (1) | IL126856A0 (fr) |
WO (1) | WO1997042181A1 (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1221412A (zh) * | 1996-05-06 | 1999-06-30 | 佛罗里达州立大学 | 1-脱氧浆果赤霉素ⅲ,1-脱氧紫杉醇和1-脱氧紫杉醇类似物及其制备方法 |
US5739359A (en) * | 1997-01-24 | 1998-04-14 | Virginia Tech Intellectual Properties, Inc. | Methods for preparing 1-deoxy paclitaxels |
WO1999008986A1 (fr) | 1997-08-21 | 1999-02-25 | Florida State University | Procede de synthese de taxanes |
AU776767B2 (en) | 2000-02-02 | 2004-09-23 | Florida State University Research Foundation, Inc. | C10 heterosubstituted acetate taxanes as antitumor agents |
US6649632B2 (en) | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
GEP20043239B (en) | 2000-02-02 | 2004-05-25 | Florida State Univ Research Foundation Us | C10 Carbonate Substituted Taxanes as Antitumor Agents |
BR0104355A (pt) | 2000-02-02 | 2002-01-02 | Univ Florida State Res Found | Taxanos substituìdos por c7 carbamoilóxi como agentes antitumor |
CZ20013519A3 (cs) | 2000-02-02 | 2002-04-17 | Florida State University Research Foundation, Inc. | Taxany s C7 heterosubstituovaným acetátem jako protinádorové látky |
US6596737B2 (en) | 2000-02-02 | 2003-07-22 | Fsu Research Foundation, Inc. | C10 carbamoyloxy substituted taxanes |
CO5280224A1 (es) | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
MXPA01009906A (es) | 2000-02-02 | 2003-07-28 | Univ Florida State Res Found | Taxanos sustituidos con carbonato en c7 como agentes. |
HN2005000054A (es) | 2004-02-13 | 2009-02-18 | Florida State University Foundation Inc | Taxanos sustituidos con esteres de ciclopentilo en c10 |
US7160919B2 (en) | 2004-03-05 | 2007-01-09 | Florida State University Research Foundation, Inc. | C7 lactyloxy-substituted taxanes |
US8242166B2 (en) | 2008-03-31 | 2012-08-14 | Florida State University Research Foundation, Inc. | C(10) ethyl ester and C(10) cyclopropyl ester substituted taxanes |
CN102093315A (zh) * | 2010-12-23 | 2011-06-15 | 上海大学 | C7,c10修饰的1-去羟基紫杉醇类似物及其制备方法 |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4680391A (en) | 1983-12-01 | 1987-07-14 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
CA1256444A (fr) | 1986-04-30 | 1989-06-27 | Kazunori Kan | Methode de preparation de derives de 4-acetoxy- 3-hydroxyethylazetidin-2-one |
FR2601675B1 (fr) | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2601676B1 (fr) | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Procede de preparation du taxol et du desacetyl-10 taxol |
US4876399A (en) * | 1987-11-02 | 1989-10-24 | Research Corporation Technologies, Inc. | Taxols, their preparation and intermediates thereof |
US4942184A (en) | 1988-03-07 | 1990-07-17 | The United States Of America As Represented By The Department Of Health And Human Services | Water soluble, antineoplastic derivatives of taxol |
FR2629819B1 (fr) | 1988-04-06 | 1990-11-16 | Rhone Poulenc Sante | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii |
FR2629818B1 (fr) | 1988-04-06 | 1990-11-16 | Centre Nat Rech Scient | Procede de preparation du taxol |
US4960790A (en) | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
MY110249A (en) | 1989-05-31 | 1998-03-31 | Univ Florida State | Method for preparation of taxol using beta lactam |
US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
US5136060A (en) | 1989-11-14 | 1992-08-04 | Florida State University | Method for preparation of taxol using an oxazinone |
US5015744A (en) | 1989-11-14 | 1991-05-14 | Florida State University | Method for preparation of taxol using an oxazinone |
US5059699A (en) | 1990-08-28 | 1991-10-22 | Virginia Tech Intellectual Properties, Inc. | Water soluble derivatives of taxol |
FR2669631B1 (fr) | 1990-11-23 | 1994-09-09 | Rhone Poulenc Rorer Sa | Nouveaux derives de l'oxazolidine, leur preparation et leur emploi. |
MX9102128A (es) | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
US5481010A (en) | 1991-07-16 | 1996-01-02 | Centre National De La Recherche Scientifique | 7-deacetoxy beccatine IV derivative and preparation and use thereof |
FR2679230B1 (fr) | 1991-07-16 | 1993-11-19 | Rhone Poulenc Rorer Sa | Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent. |
US5229526A (en) * | 1991-09-23 | 1993-07-20 | Florida State University | Metal alkoxides |
US5274124A (en) | 1991-09-23 | 1993-12-28 | Florida State University | Metal alkoxides |
US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
US5654447A (en) * | 1991-09-23 | 1997-08-05 | Florida State University | Process for the preparation of 10-desacetoxybaccatin III |
US5728850A (en) | 1991-09-23 | 1998-03-17 | Florida State University | Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them |
US5350866A (en) | 1991-09-23 | 1994-09-27 | Bristol-Myers Squibb Company | 10-desacetoxytaxol derivatives |
US5284865A (en) | 1991-09-23 | 1994-02-08 | Holton Robert A | Cyclohexyl substituted taxanes and pharmaceutical compositions containing them |
US5399726A (en) * | 1993-01-29 | 1995-03-21 | Florida State University | Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups |
US5990325A (en) | 1993-03-05 | 1999-11-23 | Florida State University | Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof |
US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
US5489601A (en) | 1991-09-23 | 1996-02-06 | Florida State University | Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them |
US5250683A (en) | 1991-09-23 | 1993-10-05 | Florida State University | Certain substituted taxanes and pharmaceutical compositions containing them |
US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
US5338872A (en) | 1993-01-15 | 1994-08-16 | Florida State University | Process for the preparation of 10-desacetoxybaccatin III and 10-desacetoxytaxol and derivatives thereof |
US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
US5254703A (en) | 1992-04-06 | 1993-10-19 | Florida State University | Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones |
US5440056A (en) | 1992-04-17 | 1995-08-08 | Abbott Laboratories | 9-deoxotaxane compounds |
PT1146043E (pt) * | 1992-11-13 | 2006-06-30 | Univ Florida State | Taxanos com uma cadeia alquilica lateral substituida e composicoes farmaceuticas que os contem |
PT679156E (pt) * | 1993-01-15 | 2000-11-30 | Univ Florida State | Processo para a preparacao de 10-desacetoxibacatina iii e 10-desacetoxitaxol e seus derivados |
ES2193154T3 (es) | 1993-03-05 | 2003-11-01 | Univ Florida State | Procedimiento para la preparacion de 9-desoxotaxanos. |
US5703247A (en) * | 1993-03-11 | 1997-12-30 | Virginia Tech Intellectual Properties, Inc. | 2-Debenzoyl-2-acyl taxol derivatives and methods for making same |
DE69432141T2 (de) * | 1993-03-22 | 2003-07-31 | Florida State University, Tallahassee | Taxane mit furyl-oder thienyl substituierten seitenketten |
US5405972A (en) * | 1993-07-20 | 1995-04-11 | Florida State University | Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes |
CN1221412A (zh) * | 1996-05-06 | 1999-06-30 | 佛罗里达州立大学 | 1-脱氧浆果赤霉素ⅲ,1-脱氧紫杉醇和1-脱氧紫杉醇类似物及其制备方法 |
-
1997
- 1997-05-05 CN CN97195321A patent/CN1221412A/zh active Pending
- 1997-05-05 IL IL12685697A patent/IL126856A0/xx unknown
- 1997-05-05 WO PCT/US1997/007569 patent/WO1997042181A1/fr not_active Application Discontinuation
- 1997-05-05 AU AU29966/97A patent/AU724499B2/en not_active Ceased
- 1997-05-05 US US08/850,942 patent/US6545168B1/en not_active Expired - Fee Related
- 1997-05-05 CA CA002253513A patent/CA2253513A1/fr not_active Abandoned
- 1997-05-05 EP EP97924581A patent/EP0927175A4/fr not_active Withdrawn
- 1997-05-05 JP JP09540115A patent/JP2000510470A/ja not_active Ceased
-
2002
- 2002-09-06 US US10/236,798 patent/US6620950B2/en not_active Expired - Fee Related
-
2003
- 2003-08-07 US US10/636,017 patent/US7019150B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6620950B2 (en) | 2003-09-16 |
CA2253513A1 (fr) | 1997-11-13 |
AU724499B2 (en) | 2000-09-21 |
EP0927175A1 (fr) | 1999-07-07 |
WO1997042181A1 (fr) | 1997-11-13 |
US20040029976A1 (en) | 2004-02-12 |
JP2000510470A (ja) | 2000-08-15 |
CN1221412A (zh) | 1999-06-30 |
EP0927175A4 (fr) | 2002-05-22 |
US20030028039A1 (en) | 2003-02-06 |
US7019150B2 (en) | 2006-03-28 |
AU2996697A (en) | 1997-11-26 |
US6545168B1 (en) | 2003-04-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0928803A4 (fr) | Composes organosilicies fluores et leur procede de preparation | |
IL124316A0 (en) | Water-stabilized organosilane compounds and method for using the same | |
GB9716439D0 (en) | Combusution for gas-or-liquid-fuelled turbine | |
HUP0500044A3 (en) | Process for prepare oxazolidinones | |
GB2298680B (en) | Stator for turbomachines | |
IL126856A0 (en) | 1-Deoxy baccatin iii 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof | |
IL134025A (en) | Process for converting 9-dihydro-13-acetylbaccatin iii into taxol and derivatives thereof | |
IL122555A0 (en) | Water-stabilized organosilane compounds and methods for using the same | |
GB9406854D0 (en) | Antiperspirants | |
ZA984538B (en) | Method for the preparation of carbamates | |
GB2311826B (en) | Turbomachines | |
HUP9903318A3 (en) | Intermediates for prepare taxol | |
IL139218A0 (en) | 2-aroyl-4-acyl-paclitaxel (taxol) analogs | |
GB9405400D0 (en) | Taxane derivatives | |
EP0693485A3 (fr) | Dérivés de la baccatine et procédés pour les préparer | |
GB9614114D0 (en) | New packages | |
ZA984534B (en) | Method for the preparation of carbamates | |
GB2296239B (en) | Taxane derivatives | |
EP0745632A3 (fr) | Composés organosilicone et méthode de préparation | |
GB2332556B (en) | Editing apparatus | |
GB9409131D0 (en) | Unsaturated taxane compounds | |
EP1087678A4 (fr) | Appareil ameliore de production d'art decoratif | |
GB9422245D0 (en) | Taxane derivatives | |
GB9422246D0 (en) | Taxane derivatives | |
GB9625984D0 (en) | Navigators aid |