IL126856A0 - 1-Deoxy baccatin iii 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof - Google Patents

1-Deoxy baccatin iii 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof

Info

Publication number
IL126856A0
IL126856A0 IL12685697A IL12685697A IL126856A0 IL 126856 A0 IL126856 A0 IL 126856A0 IL 12685697 A IL12685697 A IL 12685697A IL 12685697 A IL12685697 A IL 12685697A IL 126856 A0 IL126856 A0 IL 126856A0
Authority
IL
Israel
Prior art keywords
deoxy
taxol
preparation
baccatin iii
analogs
Prior art date
Application number
IL12685697A
Other languages
English (en)
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State filed Critical Univ Florida State
Publication of IL126856A0 publication Critical patent/IL126856A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C07C49/733Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having two rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C07C49/737Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having three rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL12685697A 1996-05-06 1997-05-05 1-Deoxy baccatin iii 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof IL126856A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1692796P 1996-05-06 1996-05-06
PCT/US1997/007569 WO1997042181A1 (en) 1996-05-06 1997-05-05 1-deoxy baccatin iii, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof

Publications (1)

Publication Number Publication Date
IL126856A0 true IL126856A0 (en) 1999-09-22

Family

ID=21779772

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12685697A IL126856A0 (en) 1996-05-06 1997-05-05 1-Deoxy baccatin iii 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof

Country Status (8)

Country Link
US (3) US6545168B1 (xx)
EP (1) EP0927175A4 (xx)
JP (1) JP2000510470A (xx)
CN (1) CN1221412A (xx)
AU (1) AU724499B2 (xx)
CA (1) CA2253513A1 (xx)
IL (1) IL126856A0 (xx)
WO (1) WO1997042181A1 (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2253513A1 (en) * 1996-05-06 1997-11-13 Florida State University 1-deoxy baccatin iii, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
US5739359A (en) * 1997-01-24 1998-04-14 Virginia Tech Intellectual Properties, Inc. Methods for preparing 1-deoxy paclitaxels
EP1019347B1 (en) 1997-08-21 2003-03-19 Florida State University Method for the synthesis of taxanes
CZ20013519A3 (cs) 2000-02-02 2002-04-17 Florida State University Research Foundation, Inc. Taxany s C7 heterosubstituovaným acetátem jako protinádorové látky
AR030188A1 (es) 2000-02-02 2003-08-13 Univ Florida State Res Found Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos
PL350331A1 (en) 2000-02-02 2002-12-02 Univ Florida State Res Found C10 carbamoyloxy substituted taxanes as antitumor agents
CN1362956A (zh) 2000-02-02 2002-08-07 佛罗里达州立大学研究基金有限公司 C7氨基甲酰氧基取代的紫衫烷抗肿瘤剂
RU2264400C2 (ru) 2000-02-02 2005-11-20 Флорида Стейт Юниверсити Рисерч Фаундейшн, Инк. Таксан, фармацевтическая композиция на его основе и способ ингибирования роста опухоли
WO2001056564A1 (en) 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. C10 heterosubstituted acetate taxanes as antitumor agents
CN1362958A (zh) 2000-02-02 2002-08-07 佛罗里达州立大学研究基金有限公司 用作抗肿瘤剂的c7碳酸酯取代的紫杉烷
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
PE20050693A1 (es) 2004-02-13 2005-09-27 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
TW200540164A (en) 2004-03-05 2005-12-16 Univ Florida State Res Found C7 lactyloxy-substituted taxanes
WO2009145981A1 (en) 2008-03-31 2009-12-03 Florida State University Research Foundation, Inc. C(10) ethyl ester and c(10) cyclopropyl ester substituted taxanes
CN102093315A (zh) * 2010-12-23 2011-06-15 上海大学 C7,c10修饰的1-去羟基紫杉醇类似物及其制备方法

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4680391A (en) 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
CA1256444A (en) 1986-04-30 1989-06-27 Kazunori Kan Process for preparing 4-acetoxy-3- hydroxyethylazetidin-2-one derivatives
FR2601675B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
US4876399A (en) * 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
US4942184A (en) 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
FR2629818B1 (fr) 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
MY110249A (en) 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5136060A (en) 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5015744A (en) 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5059699A (en) 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2669631B1 (fr) 1990-11-23 1994-09-09 Rhone Poulenc Rorer Sa Nouveaux derives de l'oxazolidine, leur preparation et leur emploi.
MX9102128A (es) 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5481010A (en) 1991-07-16 1996-01-02 Centre National De La Recherche Scientifique 7-deacetoxy beccatine IV derivative and preparation and use thereof
FR2679230B1 (fr) 1991-07-16 1993-11-19 Rhone Poulenc Rorer Sa Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent.
US5274124A (en) 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US5489601A (en) 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5990325A (en) 1993-03-05 1999-11-23 Florida State University Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof
US5728850A (en) 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5338872A (en) 1993-01-15 1994-08-16 Florida State University Process for the preparation of 10-desacetoxybaccatin III and 10-desacetoxytaxol and derivatives thereof
US5399726A (en) 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5250683A (en) 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5284864A (en) 1991-09-23 1994-02-08 Florida State University Butenyl substituted taxanes and pharmaceutical compositions containing them
US5350866A (en) 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5254703A (en) 1992-04-06 1993-10-19 Florida State University Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones
US5440056A (en) 1992-04-17 1995-08-08 Abbott Laboratories 9-deoxotaxane compounds
ES2259303T3 (es) * 1992-11-13 2006-10-01 Florida State University Taxanos que tienen una cadena lateral sustituida con alquilo y composiciones farmaceuticas que los contienen.
CA2153903C (en) * 1993-01-15 2004-11-02 Robert A. Holton Process for the preparation of 10-desacetoxybaccatin iii
ES2193154T3 (es) * 1993-03-05 2003-11-01 Univ Florida State Procedimiento para la preparacion de 9-desoxotaxanos.
US5703247A (en) * 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
DK1260223T3 (da) * 1993-03-22 2005-09-05 Univ Florida State Taxaner med furyl- eller thienylsubstituerede sidekæde
US5405972A (en) * 1993-07-20 1995-04-11 Florida State University Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
CA2253513A1 (en) * 1996-05-06 1997-11-13 Florida State University 1-deoxy baccatin iii, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof

Also Published As

Publication number Publication date
JP2000510470A (ja) 2000-08-15
WO1997042181A1 (en) 1997-11-13
AU724499B2 (en) 2000-09-21
AU2996697A (en) 1997-11-26
CN1221412A (zh) 1999-06-30
EP0927175A4 (en) 2002-05-22
US7019150B2 (en) 2006-03-28
US20030028039A1 (en) 2003-02-06
EP0927175A1 (en) 1999-07-07
US20040029976A1 (en) 2004-02-12
US6545168B1 (en) 2003-04-08
CA2253513A1 (en) 1997-11-13
US6620950B2 (en) 2003-09-16

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