IL126701A - Inhaler system for inhalation of a dry powder drug - Google Patents
Inhaler system for inhalation of a dry powder drugInfo
- Publication number
- IL126701A IL126701A IL12670197A IL12670197A IL126701A IL 126701 A IL126701 A IL 126701A IL 12670197 A IL12670197 A IL 12670197A IL 12670197 A IL12670197 A IL 12670197A IL 126701 A IL126701 A IL 126701A
- Authority
- IL
- Israel
- Prior art keywords
- inhaler
- drug
- microns
- dry powder
- inhalation
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims abstract description 31
- 229940079593 drug Drugs 0.000 title claims abstract description 30
- 239000000843 powder Substances 0.000 title claims abstract description 25
- 239000002245 particle Substances 0.000 claims abstract description 30
- 239000000203 mixture Substances 0.000 claims abstract description 14
- 238000012384 transportation and delivery Methods 0.000 claims abstract description 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 230000009885 systemic effect Effects 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 208000006673 asthma Diseases 0.000 claims description 3
- 229940088597 hormone Drugs 0.000 claims description 3
- 239000005556 hormone Substances 0.000 claims description 3
- 229920001184 polypeptide Polymers 0.000 claims description 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 230000000699 topical effect Effects 0.000 claims description 3
- 230000008021 deposition Effects 0.000 description 14
- 210000004072 lung Anatomy 0.000 description 11
- 125000003003 spiro group Chemical group 0.000 description 8
- 229940071648 metered dose inhaler Drugs 0.000 description 5
- 230000002093 peripheral effect Effects 0.000 description 5
- 229940112141 dry powder inhaler Drugs 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 102000055006 Calcitonin Human genes 0.000 description 3
- 108060001064 Calcitonin Proteins 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 229960004015 calcitonin Drugs 0.000 description 3
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 3
- 230000003434 inspiratory effect Effects 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 229940092705 beclomethasone Drugs 0.000 description 2
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical group CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 229940023485 nasal product Drugs 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000012385 systemic delivery Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1642896P | 1996-04-29 | 1996-04-29 | |
| PCT/US1997/006621 WO1997040819A1 (en) | 1996-04-29 | 1997-04-21 | Methods of dry powder inhalation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL126701A0 IL126701A0 (en) | 1999-08-17 |
| IL126701A true IL126701A (en) | 2001-08-08 |
Family
ID=21777075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12670197A IL126701A (en) | 1996-04-29 | 1997-04-21 | Inhaler system for inhalation of a dry powder drug |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6116237A (ja) |
| EP (1) | EP0896525B1 (ja) |
| JP (2) | JP2000510109A (ja) |
| AT (1) | ATE247948T1 (ja) |
| AU (1) | AU724503B2 (ja) |
| BR (1) | BR9709748A (ja) |
| CA (1) | CA2252814A1 (ja) |
| CZ (1) | CZ343798A3 (ja) |
| DE (1) | DE69724420T2 (ja) |
| DK (1) | DK0896525T3 (ja) |
| ES (1) | ES2205210T3 (ja) |
| HU (1) | HUP9901575A3 (ja) |
| IL (1) | IL126701A (ja) |
| NO (1) | NO984999D0 (ja) |
| NZ (1) | NZ332669A (ja) |
| WO (1) | WO1997040819A1 (ja) |
Families Citing this family (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6060069A (en) * | 1991-05-20 | 2000-05-09 | Dura Pharmaceuticals, Inc. | Pulmonary delivery of pharmaceuticals |
| US6681767B1 (en) * | 1991-07-02 | 2004-01-27 | Nektar Therapeutics | Method and device for delivering aerosolized medicaments |
| ATE189124T1 (de) * | 1991-07-02 | 2000-02-15 | Inhale Inc | Verfahren und vorrichtung zum abgeben von medikamenten in aerosolform |
| ES2302332T3 (es) | 1994-09-21 | 2008-07-01 | Nektar Therapeutics | Aparato y metodos para dispersar medicamentos en polvo seco. |
| WO1997040819A1 (en) * | 1996-04-29 | 1997-11-06 | Dura Pharmaceuticals, Inc. | Methods of dry powder inhalation |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6565885B1 (en) * | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| SK13632000A3 (sk) | 1998-03-16 | 2001-03-12 | Inhale Therapeutic Systems, Inc. | Spôsob podávania aktívnej látky do pľúc ľudského pacienta a zariadenie na jeho vykonávanie |
| US6257233B1 (en) | 1998-06-04 | 2001-07-10 | Inhale Therapeutic Systems | Dry powder dispersing apparatus and methods for their use |
| US7056504B1 (en) | 1998-08-27 | 2006-06-06 | Massachusetts Institute Of Technology | Rationally designed heparinases derived from heparinase I and II |
| UA73924C2 (en) | 1998-10-09 | 2005-10-17 | Nektar Therapeutics | Device for delivering active agent formulation to lungs of human patient |
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| JP4824170B2 (ja) | 1999-04-23 | 2011-11-30 | マサチューセッツ インスティテュート オブ テクノロジー | ポリマーを表記するためのシステムおよび方法 |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
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| US7305986B1 (en) * | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
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| CA2402160C (en) * | 2000-03-08 | 2012-02-14 | Massachusetts Institute Of Technology | Heparinase iii and uses thereof |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| AU6124601A (en) | 2000-05-10 | 2001-11-20 | Alliance Pharmaceutical Corporation | Phospholipid-based powders for drug delivery |
| AU2001283546A1 (en) | 2000-08-14 | 2002-02-25 | Advanced Inhalation Research, Inc. | Inhalation device and method |
| DE60138115D1 (de) | 2000-09-12 | 2009-05-07 | Massachusetts Inst Technology | Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind |
| AU2002224408B2 (en) | 2000-10-18 | 2007-08-23 | Massachusetts Institute Of Technology | Methods and products related to pulmonary delivery of polysaccharides |
| AU2002336246B8 (en) | 2001-03-15 | 2006-02-02 | Creare Incorporated | Nebulizer having cooling chamber |
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| SI1458360T1 (sl) | 2001-12-19 | 2011-08-31 | Novartis Ag | Pulmonalno dajanje aminoglikozidov |
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| IT1220979B (it) * | 1981-06-04 | 1990-06-21 | Lofarma Farma Lab | Capsule contenenti un allergene e procedimento per la loro preparazione |
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1997
- 1997-04-21 WO PCT/US1997/006621 patent/WO1997040819A1/en active IP Right Grant
- 1997-04-21 DE DE69724420T patent/DE69724420T2/de not_active Expired - Lifetime
- 1997-04-21 AU AU27371/97A patent/AU724503B2/en not_active Ceased
- 1997-04-21 EP EP97921298A patent/EP0896525B1/en not_active Revoked
- 1997-04-21 ES ES97921298T patent/ES2205210T3/es not_active Expired - Lifetime
- 1997-04-21 JP JP09538984A patent/JP2000510109A/ja active Pending
- 1997-04-21 IL IL12670197A patent/IL126701A/en not_active IP Right Cessation
- 1997-04-21 NZ NZ332669A patent/NZ332669A/xx unknown
- 1997-04-21 CA CA002252814A patent/CA2252814A1/en not_active Abandoned
- 1997-04-21 BR BR9709748-9A patent/BR9709748A/pt not_active IP Right Cessation
- 1997-04-21 HU HU9901575A patent/HUP9901575A3/hu unknown
- 1997-04-21 DK DK97921298T patent/DK0896525T3/da active
- 1997-04-21 AT AT97921298T patent/ATE247948T1/de active
- 1997-04-21 CZ CZ983437A patent/CZ343798A3/cs unknown
- 1997-04-24 US US08/847,287 patent/US6116237A/en not_active Expired - Lifetime
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1998
- 1998-10-27 NO NO984999A patent/NO984999D0/no not_active Application Discontinuation
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2009
- 2009-02-24 JP JP2009040744A patent/JP2009148586A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0896525A4 (en) | 2001-01-10 |
| JP2000510109A (ja) | 2000-08-08 |
| HUP9901575A2 (hu) | 1999-08-30 |
| AU2737197A (en) | 1997-11-19 |
| DK0896525T3 (da) | 2003-12-01 |
| EP0896525B1 (en) | 2003-08-27 |
| US6116237A (en) | 2000-09-12 |
| ATE247948T1 (de) | 2003-09-15 |
| EP0896525A1 (en) | 1999-02-17 |
| DE69724420T2 (de) | 2004-06-09 |
| AU724503B2 (en) | 2000-09-21 |
| IL126701A0 (en) | 1999-08-17 |
| HUP9901575A3 (en) | 1999-11-29 |
| CA2252814A1 (en) | 1997-11-06 |
| NO984999L (no) | 1998-10-27 |
| JP2009148586A (ja) | 2009-07-09 |
| DE69724420D1 (de) | 2003-10-02 |
| NO984999D0 (no) | 1998-10-27 |
| CZ343798A3 (cs) | 1999-02-17 |
| WO1997040819A1 (en) | 1997-11-06 |
| ES2205210T3 (es) | 2004-05-01 |
| NZ332669A (en) | 1999-02-25 |
| BR9709748A (pt) | 2000-01-11 |
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