IL125255A - Anti-cd18 antibodies for treating stroke - Google Patents
Anti-cd18 antibodies for treating strokeInfo
- Publication number
- IL125255A IL125255A IL12525597A IL12525597A IL125255A IL 125255 A IL125255 A IL 125255A IL 12525597 A IL12525597 A IL 12525597A IL 12525597 A IL12525597 A IL 12525597A IL 125255 A IL125255 A IL 125255A
- Authority
- IL
- Israel
- Prior art keywords
- antibody
- ser
- val
- thr
- leu
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58998296A | 1996-01-23 | 1996-01-23 | |
PCT/US1997/000492 WO1997026912A2 (en) | 1996-01-23 | 1997-01-11 | Anti-cd18 antibodies for use against stroke |
Publications (2)
Publication Number | Publication Date |
---|---|
IL125255A0 IL125255A0 (en) | 1999-03-12 |
IL125255A true IL125255A (en) | 2002-02-10 |
Family
ID=24360401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12525597A IL125255A (en) | 1996-01-23 | 1997-01-11 | Anti-cd18 antibodies for treating stroke |
Country Status (13)
Country | Link |
---|---|
EP (2) | EP0877626B1 (es) |
JP (1) | JP4864175B2 (es) |
AR (1) | AR005535A1 (es) |
AT (1) | ATE222774T1 (es) |
AU (1) | AU724449B2 (es) |
CA (1) | CA2242414C (es) |
DE (1) | DE69714966T2 (es) |
DK (1) | DK0877626T3 (es) |
ES (1) | ES2183131T3 (es) |
IL (1) | IL125255A (es) |
PT (1) | PT877626E (es) |
WO (1) | WO1997026912A2 (es) |
ZA (1) | ZA97257B (es) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020081294A1 (en) | 1996-01-23 | 2002-06-27 | Genentech, Inc. | Co-administration of a thrombolytic and an anti-CD18 antibody in stroke |
US7122636B1 (en) | 1997-02-21 | 2006-10-17 | Genentech, Inc. | Antibody fragment-polymer conjugates and uses of same |
JP3521382B2 (ja) | 1997-02-27 | 2004-04-19 | 日本たばこ産業株式会社 | 細胞間接着及びシグナル伝達を媒介する細胞表面分子 |
US7112655B1 (en) | 1997-02-27 | 2006-09-26 | Japan Tobacco, Inc. | JTT-1 protein and methods of inhibiting lymphocyte activation |
AU4000500A (en) * | 1999-02-17 | 2000-09-04 | Genentech Inc. | Co-administration of a thrombolytic and an anti-cd18 antibody |
JP4210454B2 (ja) | 2001-03-27 | 2009-01-21 | 日本たばこ産業株式会社 | 炎症性腸疾患治療剤 |
JP3871503B2 (ja) | 1999-08-30 | 2007-01-24 | 日本たばこ産業株式会社 | 免疫性疾患治療剤 |
US6663863B2 (en) | 2000-03-17 | 2003-12-16 | Millennium Pharmaceuticals, Inc. | Method of inhibiting stenosis and restenosis |
EP1278538A4 (en) * | 2000-03-18 | 2005-05-04 | Millennium Pharm Inc | ANTIBODIES BINDING TO CD18 AND INHIBITING STENOSE-RELATED DISORDERS |
JP3597140B2 (ja) | 2000-05-18 | 2004-12-02 | 日本たばこ産業株式会社 | 副刺激伝達分子ailimに対するヒトモノクローナル抗体及びその医薬用途 |
JP4212278B2 (ja) | 2001-03-01 | 2009-01-21 | 日本たばこ産業株式会社 | 移植片拒絶反応抑制剤 |
WO2003066662A2 (en) | 2002-02-05 | 2003-08-14 | Genentech, Inc. | Protein purification |
WO2003102132A2 (en) | 2002-04-26 | 2003-12-11 | Genetech, Inc. | Non-affinity purification of proteins |
SI1648940T1 (sl) | 2003-07-28 | 2016-08-31 | Genentech, Inc. | Zmanjševanje izluževanja proteina A med afinitetno kromatografijo proteina A |
EP1711527A4 (en) * | 2003-12-15 | 2008-09-03 | Dendreon Corp | HLA-DR SPECIFIC ANTIBODIES, COMPOSITIONS AND METHODS |
US7501119B2 (en) | 2004-06-30 | 2009-03-10 | Mayo Foundation For Medical Education And Research | Methods and molecules for modulating an immune response |
US20060099203A1 (en) | 2004-11-05 | 2006-05-11 | Pease Larry R | B7-DC binding antibody |
CA2572098C (en) * | 2004-06-30 | 2015-01-27 | Mayo Foundation For Medical Education And Research | B7-dc binding antibody |
US7655229B2 (en) | 2004-09-02 | 2010-02-02 | Chan Andrew C | Anti-FC-gamma RIIB receptor antibody and uses therefor |
US7662926B2 (en) | 2004-09-02 | 2010-02-16 | Genentech, Inc. | Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
FR2902799B1 (fr) | 2006-06-27 | 2012-10-26 | Millipore Corp | Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide |
US8569464B2 (en) | 2006-12-21 | 2013-10-29 | Emd Millipore Corporation | Purification of proteins |
US8362217B2 (en) | 2006-12-21 | 2013-01-29 | Emd Millipore Corporation | Purification of proteins |
US8163886B2 (en) | 2006-12-21 | 2012-04-24 | Emd Millipore Corporation | Purification of proteins |
MX2009007632A (es) | 2007-01-22 | 2009-07-24 | Genentech Inc | Precipitacion de polielectrolito y purificacion de proteinas. |
DE17196350T1 (de) | 2007-07-09 | 2018-12-27 | Genentech, Inc. | Verhindern der disulfid-bindungsreduktion während der rekombinanten herstellung von polypeptiden |
HUE037409T2 (hu) | 2007-10-30 | 2018-08-28 | Genentech Inc | Antitest-tisztítás kationcserés kromatográfiával |
WO2009151514A1 (en) | 2008-06-11 | 2009-12-17 | Millipore Corporation | Stirred tank bioreactor |
WO2010019148A1 (en) | 2008-08-14 | 2010-02-18 | Genentech, Inc. | Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography |
CN103599541A (zh) | 2008-09-10 | 2014-02-26 | 弗·哈夫曼-拉罗切有限公司 | 用于防止蛋白质氧化降解的组合物和方法 |
JP2012512244A (ja) | 2008-12-16 | 2012-05-31 | イー・エム・デイー・ミリポア・コーポレイシヨン | タンパク質の精製 |
EP2370561B1 (en) | 2008-12-16 | 2019-08-07 | EMD Millipore Corporation | Stirred tank reactor and method |
US8435488B2 (en) | 2009-02-27 | 2013-05-07 | Genentech, Inc. | Methods and compositions for protein labelling |
KR20180114966A (ko) | 2009-08-11 | 2018-10-19 | 제넨테크, 인크. | 글루타민-비함유 세포 배양 배지에서의 단백질의 생성 |
MX2012002565A (es) | 2009-09-01 | 2012-05-29 | Genentech Inc | Purificacion de proteina mejorada a traves de una elucion de proteina a modificada. |
CN106983862A (zh) | 2010-03-22 | 2017-07-28 | 弗·哈夫曼-拉罗切有限公司 | 对于稳定含有蛋白质的制剂有用的组合物和方法 |
WO2011123813A2 (en) | 2010-04-02 | 2011-10-06 | Amunix Operating Inc. | Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same |
MX2012012743A (es) | 2010-05-03 | 2012-11-23 | Genentech Inc | Composiciones y metodos utiles para reducir la viscosidad de formulaciones que contienen proteina. |
US8691918B2 (en) | 2010-05-17 | 2014-04-08 | Emd Millipore Corporation | Stimulus responsive polymers for the purification of biomolecules |
ES2599412T3 (es) | 2010-05-28 | 2017-02-01 | F. Hoffmann-La Roche Ag | Disminución del nivel de lactato y aumento de la producción de polipéptidos regulando por disminución la expresión de la lactato deshidrogenasa y de la piruvato deshidrogenasa quinasa |
KR101924653B1 (ko) | 2010-06-24 | 2018-12-03 | 제넨테크, 인크. | 단백질-함유 제제를 안정화시키기 위한 알킬글리코시드 함유 조성물 및 방법 |
WO2012021773A1 (en) | 2010-08-13 | 2012-02-16 | Genentech, Inc. | Antibodies to il-1beta and il-18, for treatment of disease |
WO2012030512A1 (en) | 2010-09-03 | 2012-03-08 | Percivia Llc. | Flow-through protein purification process |
US20130012689A1 (en) | 2011-07-08 | 2013-01-10 | Emd Millipore Corporation | Depth Filters For Disposable Biotechnological Processes |
MX360453B (es) | 2011-12-22 | 2018-11-01 | Genentech Inc | Cromatografia de membrana de intercambio ionico. |
AU2013240280A1 (en) | 2012-03-27 | 2014-10-16 | Genentech, Inc. | Improved harvest operations for recombinant proteins |
MY188825A (en) | 2012-05-18 | 2022-01-06 | Genentech Inc | High-concentration monoclonal antibody formulations |
US9393327B2 (en) | 2012-12-19 | 2016-07-19 | Genentech, Inc. | Methods and compositions for radiohalogen protein labeling |
ES2825574T3 (es) | 2014-07-09 | 2021-05-17 | Hoffmann La Roche | Ajuste del pH para mejorar la recuperación por descongelación de bancos de células |
AU2017242031B2 (en) | 2016-03-29 | 2023-07-27 | Geltor, Inc. | Expression of proteins in gram-negative bacteria wherein the ratio of periplasmic volume to cytoplasmic volume is between 0.5:1 and 10:1 |
KR102579836B1 (ko) | 2016-12-22 | 2023-09-15 | 제넨테크, 인크. | 동결건조된 폴리펩타이드의 재구성 시간을 감소시키기 위한 방법 및 제제 |
US11180541B2 (en) | 2017-09-28 | 2021-11-23 | Geltor, Inc. | Recombinant collagen and elastin molecules and uses thereof |
RS65472B1 (sr) | 2018-07-03 | 2024-05-31 | Bristol Myers Squibb Co | Postupak proizvodnje rekombinantnih proteina |
MA53859A (fr) | 2018-10-10 | 2022-01-19 | Boehringer Ingelheim Int | Procédé de transfert de gaz de membrane dans une culture de bioréacteur à haute densité |
CN113660953A (zh) | 2019-04-01 | 2021-11-16 | 豪夫迈·罗氏有限公司 | 用于稳定含蛋白质制剂的组合物和方法 |
WO2020210440A1 (en) | 2019-04-12 | 2020-10-15 | Geltor, Inc. | Recombinant elastin and production thereof |
EP4007808A1 (en) | 2019-08-01 | 2022-06-08 | Bristol-Myers Squibb Company | Methods of improving protein productivity in fed-batch cell cultures |
JP2023542924A (ja) | 2020-09-22 | 2023-10-12 | ブリストル-マイヤーズ スクイブ カンパニー | 治療タンパク質を生産するための方法 |
WO2023015234A1 (en) | 2021-08-05 | 2023-02-09 | Bristol-Myers Squibb Company | Cell culture methods for producing therapeutic proteins |
WO2023049687A1 (en) | 2021-09-21 | 2023-03-30 | Bristol-Myers Squibb Company | Methods of controlling the level of dissolved oxygen (do) in a solution comprising a recombinant protein in a storage container |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
WO1994002175A1 (en) * | 1992-07-16 | 1994-02-03 | Icos Corporation | Alleviation of symptoms associated with inflammatory disease states |
AU5732694A (en) * | 1992-12-01 | 1994-06-22 | Protein Design Labs, Inc. | Humanized antibodies reactive with cd18 |
-
1997
- 1997-01-11 WO PCT/US1997/000492 patent/WO1997026912A2/en active IP Right Grant
- 1997-01-11 EP EP97903790A patent/EP0877626B1/en not_active Expired - Lifetime
- 1997-01-11 ES ES97903790T patent/ES2183131T3/es not_active Expired - Lifetime
- 1997-01-11 DK DK97903790T patent/DK0877626T3/da active
- 1997-01-11 AU AU18273/97A patent/AU724449B2/en not_active Expired
- 1997-01-11 EP EP02078486A patent/EP1297847A3/en not_active Withdrawn
- 1997-01-11 IL IL12525597A patent/IL125255A/en not_active IP Right Cessation
- 1997-01-11 JP JP52689497A patent/JP4864175B2/ja not_active Expired - Lifetime
- 1997-01-11 AT AT97903790T patent/ATE222774T1/de active
- 1997-01-11 PT PT97903790T patent/PT877626E/pt unknown
- 1997-01-11 DE DE69714966T patent/DE69714966T2/de not_active Expired - Lifetime
- 1997-01-11 CA CA2242414A patent/CA2242414C/en not_active Expired - Lifetime
- 1997-01-13 ZA ZA97257A patent/ZA97257B/xx unknown
- 1997-01-23 AR ARP970100281A patent/AR005535A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
ATE222774T1 (de) | 2002-09-15 |
CA2242414C (en) | 2012-01-03 |
WO1997026912A3 (en) | 1997-10-09 |
AR005535A1 (es) | 1999-06-23 |
ES2183131T3 (es) | 2003-03-16 |
AU1827397A (en) | 1997-08-20 |
JP4864175B2 (ja) | 2012-02-01 |
AU724449B2 (en) | 2000-09-21 |
EP0877626B1 (en) | 2002-08-28 |
DK0877626T3 (da) | 2002-12-30 |
EP1297847A3 (en) | 2003-05-07 |
WO1997026912A2 (en) | 1997-07-31 |
DE69714966D1 (de) | 2002-10-02 |
IL125255A0 (en) | 1999-03-12 |
EP1297847A2 (en) | 2003-04-02 |
JP2000517289A (ja) | 2000-12-26 |
CA2242414A1 (en) | 1997-07-31 |
PT877626E (pt) | 2003-01-31 |
DE69714966T2 (de) | 2003-04-24 |
ZA97257B (en) | 1998-07-14 |
EP0877626A2 (en) | 1998-11-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0877626B1 (en) | Anti-cd18 antibodies for use against stroke | |
US5914112A (en) | Anti-CD18 antibodies in stroke | |
WO1997026912A9 (en) | Anti-cd18 antibodies for use against stroke | |
US7655230B2 (en) | Co-administration of a tissue plasminogen activator, anti-CD11b antibody and anti-CD18 antibody in stroke | |
US5840299A (en) | Humanized antibodies against leukocyte adhesion molecule VLA-4 | |
DK175491B1 (da) | Anvendelse af ICAM-1 og dets funktionelle derivater til behandling af ikke-specifik inflammation | |
US20090041785A1 (en) | Use of anti-integrin antibodies for reducing scar tissue formation | |
US6297049B1 (en) | Methods and compositions for ameliorating the symptoms of sepsis | |
US20150056205A1 (en) | Steroid sparing agents and methods of using same | |
BG66149B1 (bg) | Използване на антитяло хомолог като антагонист на интегрин алфа-4 субединица за получаване на фармацевтичен състав за лечение на фиброзни състояния | |
AU3605993A (en) | Treatment for inflammatory bowel disease | |
JP2007524605A5 (es) | ||
US6168790B1 (en) | Use of antibodies to block the effects of gram-positive bacteria and mycobacteria | |
US10087252B2 (en) | Methods and compositions for treating and preventing disease associated with αvβ5 integrin | |
AU7245800A (en) | Anti-CD18 antibodies for use against stroke | |
WO2000048681A2 (en) | Co-administration of a thrombolytic and an anti-cd18 antibody | |
US20210060161A1 (en) | Treatment of ovarian cancer in patients with ascites using a specific binding agent of human angiopoietin-2 in combination with a taxane | |
AU2011213878B2 (en) | Steroid sparing agents and methods of using same | |
AU719499B2 (en) | Use of antibodies to block the effects of Gram-positive bacteria and mycobacteria | |
MXPA99011741A (es) | Terapia de bloqueo de cd154 para el síndrome inhibidor de proteína terapéutica |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |