AR005535A1 - El uso de anticuerpos anti-cd18 para la manufactura de un medicamento para tratar ataques focales isquemicos, articulo de manufactura y equipo que loscomprenden - Google Patents
El uso de anticuerpos anti-cd18 para la manufactura de un medicamento para tratar ataques focales isquemicos, articulo de manufactura y equipo que loscomprendenInfo
- Publication number
- AR005535A1 AR005535A1 ARP970100281A ARP970100281A AR005535A1 AR 005535 A1 AR005535 A1 AR 005535A1 AR P970100281 A ARP970100281 A AR P970100281A AR P970100281 A ARP970100281 A AR P970100281A AR 005535 A1 AR005535 A1 AR 005535A1
- Authority
- AR
- Argentina
- Prior art keywords
- manufacture
- article
- equipment
- antibodies
- medicinal product
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Uso de un anticuerpo anti-CD18 para la manufactura de un medicamento útil para tratar ataques isquémicos focales causados por obstrucción de unaarteria cerebral principal en un mamífero, que comprende administrar una cantidad deanticue rpo anti-CD18 al mamífero que es eficaz para aumentar elflujo de sangre cerebral o para reducir el tamano del infarto, en ausencia de remoción de la obstrucción arterial; artículo de manufactura y equipo que loscomprende.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58998296A | 1996-01-23 | 1996-01-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR005535A1 true AR005535A1 (es) | 1999-06-23 |
Family
ID=24360401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970100281A AR005535A1 (es) | 1996-01-23 | 1997-01-23 | El uso de anticuerpos anti-cd18 para la manufactura de un medicamento para tratar ataques focales isquemicos, articulo de manufactura y equipo que loscomprenden |
Country Status (13)
Country | Link |
---|---|
EP (2) | EP1297847A3 (es) |
JP (1) | JP4864175B2 (es) |
AR (1) | AR005535A1 (es) |
AT (1) | ATE222774T1 (es) |
AU (1) | AU724449B2 (es) |
CA (1) | CA2242414C (es) |
DE (1) | DE69714966T2 (es) |
DK (1) | DK0877626T3 (es) |
ES (1) | ES2183131T3 (es) |
IL (1) | IL125255A (es) |
PT (1) | PT877626E (es) |
WO (1) | WO1997026912A2 (es) |
ZA (1) | ZA97257B (es) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020081294A1 (en) | 1996-01-23 | 2002-06-27 | Genentech, Inc. | Co-administration of a thrombolytic and an anti-CD18 antibody in stroke |
US7122636B1 (en) | 1997-02-21 | 2006-10-17 | Genentech, Inc. | Antibody fragment-polymer conjugates and uses of same |
JP3521382B2 (ja) | 1997-02-27 | 2004-04-19 | 日本たばこ産業株式会社 | 細胞間接着及びシグナル伝達を媒介する細胞表面分子 |
US7112655B1 (en) | 1997-02-27 | 2006-09-26 | Japan Tobacco, Inc. | JTT-1 protein and methods of inhibiting lymphocyte activation |
WO2000048681A2 (en) * | 1999-02-17 | 2000-08-24 | Genentech, Inc. | Co-administration of a thrombolytic and an anti-cd18 antibody |
JP3871503B2 (ja) | 1999-08-30 | 2007-01-24 | 日本たばこ産業株式会社 | 免疫性疾患治療剤 |
JP4210454B2 (ja) | 2001-03-27 | 2009-01-21 | 日本たばこ産業株式会社 | 炎症性腸疾患治療剤 |
WO2001070266A2 (en) | 2000-03-17 | 2001-09-27 | Millennium Pharmaceuticals, Inc. | Method of inhibiting stenosis and restenosis with a mixture of antibodies anti cd18 and anti ccr2 |
JP2004507448A (ja) * | 2000-03-18 | 2004-03-11 | ミレニアム・フアーマシユーチカルズ・インコーポレーテツド | 狭窄症関連疾患を抑制するcd−18結合抗体 |
JP3597140B2 (ja) | 2000-05-18 | 2004-12-02 | 日本たばこ産業株式会社 | 副刺激伝達分子ailimに対するヒトモノクローナル抗体及びその医薬用途 |
JP4212278B2 (ja) | 2001-03-01 | 2009-01-21 | 日本たばこ産業株式会社 | 移植片拒絶反応抑制剤 |
US6870034B2 (en) | 2002-02-05 | 2005-03-22 | Genentech, Inc. | Protein purification |
JP4319979B2 (ja) | 2002-04-26 | 2009-08-26 | ジェネンテック・インコーポレーテッド | タンパク質の非アフィニティ精製 |
AU2004265253B2 (en) | 2003-07-28 | 2011-09-01 | Genentech, Inc. | Reducing protein A leaching during protein A affinity chromatography |
CA2550155C (en) | 2003-12-15 | 2015-03-17 | Dendreon Corporation | Hla-dr-specific antibodies, compositions and methods |
US20060099203A1 (en) | 2004-11-05 | 2006-05-11 | Pease Larry R | B7-DC binding antibody |
JP5902367B2 (ja) * | 2004-06-30 | 2016-04-13 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 抗体 |
US7501119B2 (en) | 2004-06-30 | 2009-03-10 | Mayo Foundation For Medical Education And Research | Methods and molecules for modulating an immune response |
US7662926B2 (en) | 2004-09-02 | 2010-02-16 | Genentech, Inc. | Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor |
US7655229B2 (en) | 2004-09-02 | 2010-02-02 | Chan Andrew C | Anti-FC-gamma RIIB receptor antibody and uses therefor |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
FR2902799B1 (fr) | 2006-06-27 | 2012-10-26 | Millipore Corp | Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide |
US8362217B2 (en) | 2006-12-21 | 2013-01-29 | Emd Millipore Corporation | Purification of proteins |
US8163886B2 (en) | 2006-12-21 | 2012-04-24 | Emd Millipore Corporation | Purification of proteins |
US8569464B2 (en) | 2006-12-21 | 2013-10-29 | Emd Millipore Corporation | Purification of proteins |
EP2120915B1 (en) | 2007-01-22 | 2011-09-28 | Genentech, Inc. | Polyelectrolyte precipitation and purification of antibodies |
LT3597659T (lt) | 2007-07-09 | 2023-05-10 | Genentech, Inc. | Disulfidinės jungties redukcijos prevencijos būdas gaminant polipeptidą rekombinantiniu būdu |
PL2840090T3 (pl) | 2007-10-30 | 2018-07-31 | Genentech, Inc. | Oczyszczanie przeciwciał za pomocą chromatografii kationowymiennej |
WO2009151514A1 (en) | 2008-06-11 | 2009-12-17 | Millipore Corporation | Stirred tank bioreactor |
SI2848625T1 (sl) | 2008-08-14 | 2019-11-29 | Genentech Inc | Postopki za odstranjevanje kontaminanta z uporabo ionskoizmenjevalne membranske kromatografije z izpodrinjenjem nativnega proteina |
EP2334323A2 (en) | 2008-09-10 | 2011-06-22 | F. Hoffmann-La Roche AG | Compositions and methods for the prevention of oxidative degradation of proteins |
US20110020327A1 (en) | 2008-12-16 | 2011-01-27 | Millipore Corporation | Purification of proteins |
CN105037535A (zh) | 2008-12-16 | 2015-11-11 | Emd密理博公司 | 搅拌槽反应器及方法 |
CA2752884A1 (en) | 2009-02-27 | 2010-09-02 | Genentech, Inc. | Methods and compositions for protein labelling |
PT2464725T (pt) | 2009-08-11 | 2020-05-21 | Hoffmann La Roche | Produção de proteínas em meios de cultura celular isentos de glutamina |
WO2011028753A1 (en) | 2009-09-01 | 2011-03-10 | Genentech, Inc. | Enhanced protein purification through a modified protein a elution |
ES2722201T3 (es) | 2010-03-22 | 2019-08-08 | Hoffmann La Roche | Composiciones y procedimientos útiles para estabilizar formulaciones que contienen proteínas |
BR112012027828A2 (pt) | 2010-05-03 | 2016-08-09 | Genentech Inc | composição de matéria, artigo de fabricação e método de redução da viscosidade de uma formulação contendo proteína e de preparação de uma formulação aquosa contendo proteína |
EP3597671B1 (en) | 2010-05-17 | 2022-09-21 | EMD Millipore Corporation | Stimulus responsive polymers for the purification of biomolecules |
ES2599412T3 (es) | 2010-05-28 | 2017-02-01 | F. Hoffmann-La Roche Ag | Disminución del nivel de lactato y aumento de la producción de polipéptidos regulando por disminución la expresión de la lactato deshidrogenasa y de la piruvato deshidrogenasa quinasa |
MY184736A (en) | 2010-06-24 | 2021-04-20 | Genentech Inc | Compositions and methods containing alkylglycosides for stabilizing protein-containing formulations |
EP2603525A1 (en) | 2010-08-13 | 2013-06-19 | F.Hoffmann-La Roche Ag | Antibodies to il-1beta and il-18, for treatment of disease |
WO2012030512A1 (en) | 2010-09-03 | 2012-03-08 | Percivia Llc. | Flow-through protein purification process |
EP2732021B1 (en) | 2011-07-08 | 2020-05-27 | EMD Millipore Corporation | Improved depth filters for disposable biotechnological processes |
BR112014015101A8 (pt) | 2011-12-22 | 2021-06-08 | Genentech Inc | métodos para intensificar eficiência de etapas de cromatografia a jusante para purificação de anticorpos |
MX365947B (es) | 2012-03-27 | 2019-06-19 | Genentech Inc | Operaciones de cosecha mejoradas para proteinas recombinadas. |
CA2873646C (en) | 2012-05-18 | 2022-04-26 | Genentech, Inc. | High-concentration monoclonal antibody formulations |
CN104994885B (zh) | 2012-12-19 | 2017-09-29 | 基因泰克公司 | 用于放射性卤素蛋白质标记的方法和组合物 |
KR102355306B1 (ko) | 2014-07-09 | 2022-01-24 | 제넨테크, 인크. | 세포 은행의 해동 회수를 개선하는 ph 조정 |
AU2017242031B2 (en) | 2016-03-29 | 2023-07-27 | Geltor, Inc. | Expression of proteins in gram-negative bacteria wherein the ratio of periplasmic volume to cytoplasmic volume is between 0.5:1 and 10:1 |
AU2017382281A1 (en) | 2016-12-22 | 2019-06-13 | Genentech, Inc. | Methods and formulations for reducing reconstitution time of lyophilized polypeptides |
US11180541B2 (en) | 2017-09-28 | 2021-11-23 | Geltor, Inc. | Recombinant collagen and elastin molecules and uses thereof |
BR112020025623A2 (pt) | 2018-07-03 | 2021-03-23 | Bristol-Myers Squibb Company | métodos de produção de proteínas recombinantes |
EP3864127A1 (en) | 2018-10-10 | 2021-08-18 | Boehringer Ingelheim International GmbH | Method for membrane gas transfer in high density bioreactor culture |
MX2021012032A (es) | 2019-04-01 | 2021-11-03 | Genentech Inc | Composiciones y metodos para estabilizar formulaciones que contienen proteinas. |
WO2020210440A1 (en) | 2019-04-12 | 2020-10-15 | Geltor, Inc. | Recombinant elastin and production thereof |
US20220315887A1 (en) | 2019-08-01 | 2022-10-06 | Bristol-Myers Squibb Company | Methods of improving protein productivity in fed-batch cell cultures |
WO2022066595A1 (en) | 2020-09-22 | 2022-03-31 | Bristol-Myers Squibb Company | Methods for producing therapeutic proteins |
WO2023015234A1 (en) | 2021-08-05 | 2023-02-09 | Bristol-Myers Squibb Company | Cell culture methods for producing therapeutic proteins |
WO2023049687A1 (en) | 2021-09-21 | 2023-03-30 | Bristol-Myers Squibb Company | Methods of controlling the level of dissolved oxygen (do) in a solution comprising a recombinant protein in a storage container |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
CA2119128C (en) * | 1992-07-16 | 2000-05-30 | Lynn M. Rose | Alleviation of symptoms associated with inflammatory disease states |
AU5732694A (en) * | 1992-12-01 | 1994-06-22 | Protein Design Labs, Inc. | Humanized antibodies reactive with cd18 |
-
1997
- 1997-01-11 DK DK97903790T patent/DK0877626T3/da active
- 1997-01-11 EP EP02078486A patent/EP1297847A3/en not_active Withdrawn
- 1997-01-11 WO PCT/US1997/000492 patent/WO1997026912A2/en active IP Right Grant
- 1997-01-11 EP EP97903790A patent/EP0877626B1/en not_active Expired - Lifetime
- 1997-01-11 IL IL12525597A patent/IL125255A/en not_active IP Right Cessation
- 1997-01-11 JP JP52689497A patent/JP4864175B2/ja not_active Expired - Lifetime
- 1997-01-11 ES ES97903790T patent/ES2183131T3/es not_active Expired - Lifetime
- 1997-01-11 AT AT97903790T patent/ATE222774T1/de active
- 1997-01-11 DE DE69714966T patent/DE69714966T2/de not_active Expired - Lifetime
- 1997-01-11 AU AU18273/97A patent/AU724449B2/en not_active Expired
- 1997-01-11 CA CA2242414A patent/CA2242414C/en not_active Expired - Lifetime
- 1997-01-11 PT PT97903790T patent/PT877626E/pt unknown
- 1997-01-13 ZA ZA97257A patent/ZA97257B/xx unknown
- 1997-01-23 AR ARP970100281A patent/AR005535A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
DE69714966D1 (de) | 2002-10-02 |
DE69714966T2 (de) | 2003-04-24 |
WO1997026912A3 (en) | 1997-10-09 |
AU1827397A (en) | 1997-08-20 |
ATE222774T1 (de) | 2002-09-15 |
DK0877626T3 (da) | 2002-12-30 |
WO1997026912A2 (en) | 1997-07-31 |
IL125255A (en) | 2002-02-10 |
PT877626E (pt) | 2003-01-31 |
JP2000517289A (ja) | 2000-12-26 |
AU724449B2 (en) | 2000-09-21 |
CA2242414A1 (en) | 1997-07-31 |
EP1297847A2 (en) | 2003-04-02 |
CA2242414C (en) | 2012-01-03 |
EP0877626B1 (en) | 2002-08-28 |
JP4864175B2 (ja) | 2012-02-01 |
EP1297847A3 (en) | 2003-05-07 |
ZA97257B (en) | 1998-07-14 |
ES2183131T3 (es) | 2003-03-16 |
EP0877626A2 (en) | 1998-11-18 |
IL125255A0 (en) | 1999-03-12 |
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