IL123999A - שימוש של תולדה של אימידאזול בייצור תרופה - Google Patents
שימוש של תולדה של אימידאזול בייצור תרופהInfo
- Publication number
- IL123999A IL123999A IL12399996A IL12399996A IL123999A IL 123999 A IL123999 A IL 123999A IL 12399996 A IL12399996 A IL 12399996A IL 12399996 A IL12399996 A IL 12399996A IL 123999 A IL123999 A IL 123999A
- Authority
- IL
- Israel
- Prior art keywords
- adrenergic
- medicament
- receptors
- manufacture
- formula
- Prior art date
Links
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- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical class CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N para-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 239000012165 plant wax Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000059 polyethylene glycol stearate Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical group CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Epoxy Resins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9521680.0A GB9521680D0 (en) | 1995-10-23 | 1995-10-23 | New use of imidazole derivatives |
| PCT/FI1996/000560 WO1997015302A1 (en) | 1995-10-23 | 1996-10-23 | Pharmaceutical compositions of levo-enantiomers of medetomidine derivatives and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL123999A true IL123999A (he) | 2002-09-12 |
Family
ID=10782758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12399996A IL123999A (he) | 1995-10-23 | 1996-10-23 | שימוש של תולדה של אימידאזול בייצור תרופה |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5994384A (he) |
| EP (1) | EP0858338B1 (he) |
| JP (1) | JP2000503298A (he) |
| KR (1) | KR19990067008A (he) |
| CN (1) | CN1200035A (he) |
| AT (1) | ATE218340T1 (he) |
| AU (1) | AU707728B2 (he) |
| BG (1) | BG102396A (he) |
| CA (1) | CA2232336A1 (he) |
| CZ (1) | CZ120498A3 (he) |
| DE (1) | DE69621633T2 (he) |
| EE (1) | EE9800131A (he) |
| ES (1) | ES2178717T3 (he) |
| GB (1) | GB9521680D0 (he) |
| HU (1) | HUP9900027A3 (he) |
| IL (1) | IL123999A (he) |
| NO (1) | NO981799L (he) |
| NZ (1) | NZ320289A (he) |
| PL (1) | PL326562A1 (he) |
| RU (1) | RU2193404C2 (he) |
| SK (1) | SK48698A3 (he) |
| WO (1) | WO1997015302A1 (he) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6841684B2 (en) | 1997-12-04 | 2005-01-11 | Allergan, Inc. | Imidiazoles having reduced side effects |
| US6329369B1 (en) | 1997-12-04 | 2001-12-11 | Allergan Sales, Inc. | Methods of treating pain and other conditions |
| AU5331200A (en) * | 1999-06-11 | 2001-01-02 | Ohio State University Research Foundation, The | Methods and compositions for treating raynaud's phenomenon and scleroderma |
| US6444681B1 (en) | 2000-06-09 | 2002-09-03 | The Ohio State University Research Foundation | Methods and compositions for treating Raynaud's Phenomenon and scleroderma |
| NZ527142A (en) * | 2003-07-23 | 2006-03-31 | Douglas Pharmaceuticals Ltd | A stable suspension formulation |
| JP2009524616A (ja) | 2006-01-27 | 2009-07-02 | エフ．ホフマン−ラ ロシュ アーゲー | Ｃｎｓ疾患のための４−イミダゾール誘導体の使用 |
| CN101671305A (zh) * | 2009-09-29 | 2010-03-17 | 北京华禧联合科技发展有限公司 | 一种拆分美托咪定的左旋及右旋对映体的方法 |
| WO2013078151A1 (en) * | 2011-11-21 | 2013-05-30 | Allergan, Inc. | Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases |
| WO2015011177A1 (en) * | 2013-07-24 | 2015-01-29 | I-Tech Ab | Use of the enantiomer levomedetomidine as inhibitor for marine biofouling of surfaces |
| WO2015054059A2 (en) | 2013-10-07 | 2015-04-16 | Teikoku Pharma Usa, Inc. | Methods and compositions for treating attention deficit hyperactivity disorder, anxiety and insomnia using dexmedetomidine transdermal compositions |
| CN105764494A (zh) | 2013-10-07 | 2016-07-13 | 帝国制药美国公司 | 右旋美托咪啶经皮递送装置及其使用方法 |
| EP3054930B1 (en) | 2013-10-07 | 2020-12-02 | Teikoku Pharma USA, Inc. | Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine |
| EP3054934B1 (en) * | 2013-10-07 | 2024-05-22 | Teikoku Pharma USA, Inc. | Methods and compositions for treating withdrawal syndromes using non-sedative dexmedetomidine transdermal compositions |
| CN106442765A (zh) * | 2016-08-31 | 2017-02-22 | 辰欣药业股份有限公司 | 一种盐酸右美托咪定粗品中异构体的检测方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2101114B (en) * | 1981-07-10 | 1985-05-22 | Farmos Group Ltd | Substituted imidazole derivatives and their preparation and use |
| GB8626287D0 (en) * | 1986-11-04 | 1986-12-03 | Ucb Sa | Substituted 1h-imidazoles |
| GB2206880B (en) * | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
| GB8810067D0 (en) * | 1988-04-28 | 1988-06-02 | Ucb Sa | Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides |
| US5124157A (en) * | 1989-08-18 | 1992-06-23 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
| AU671071B2 (en) * | 1990-08-30 | 1996-08-15 | State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University, Portland, Oregon, and The University of Oregon, Eugene, Oregon, Johnson Hall, | Substituted amidines having high binding to the sigma receptor and the use thereof |
| GB9111732D0 (en) * | 1991-05-31 | 1991-07-24 | Orion Yhtymae Oy | The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs |
| GB9310965D0 (en) * | 1993-05-27 | 1993-07-14 | Ucb Sa | 2-hydroxy-3-(1h-imidazol-4-yl)alkyl)benzenecarboximidamides |
-
1995
- 1995-10-23 GB GBGB9521680.0A patent/GB9521680D0/en active Pending
-
1996
- 1996-10-23 EE EE9800131A patent/EE9800131A/xx unknown
- 1996-10-23 US US09/043,107 patent/US5994384A/en not_active Expired - Fee Related
- 1996-10-23 ES ES96934847T patent/ES2178717T3/es not_active Expired - Lifetime
- 1996-10-23 EP EP96934847A patent/EP0858338B1/en not_active Expired - Lifetime
- 1996-10-23 CZ CZ981204A patent/CZ120498A3/cs unknown
- 1996-10-23 HU HU9900027A patent/HUP9900027A3/hu unknown
- 1996-10-23 DE DE69621633T patent/DE69621633T2/de not_active Expired - Fee Related
- 1996-10-23 PL PL96326562A patent/PL326562A1/xx unknown
- 1996-10-23 KR KR1019980702944A patent/KR19990067008A/ko not_active Application Discontinuation
- 1996-10-23 AU AU73019/96A patent/AU707728B2/en not_active Ceased
- 1996-10-23 RU RU98109949/14A patent/RU2193404C2/ru not_active IP Right Cessation
- 1996-10-23 JP JP9516319A patent/JP2000503298A/ja active Pending
- 1996-10-23 SK SK486-98A patent/SK48698A3/sk unknown
- 1996-10-23 NZ NZ320289A patent/NZ320289A/xx unknown
- 1996-10-23 CA CA002232336A patent/CA2232336A1/en not_active Abandoned
- 1996-10-23 IL IL12399996A patent/IL123999A/he not_active IP Right Cessation
- 1996-10-23 CN CN96197793A patent/CN1200035A/zh active Pending
- 1996-10-23 AT AT96934847T patent/ATE218340T1/de not_active IP Right Cessation
- 1996-10-23 WO PCT/FI1996/000560 patent/WO1997015302A1/en not_active Application Discontinuation
-
1998
- 1998-04-21 BG BG102396A patent/BG102396A/xx unknown
- 1998-04-22 NO NO981799A patent/NO981799L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2232336A1 (en) | 1997-05-01 |
| SK48698A3 (en) | 1999-03-12 |
| NO981799D0 (no) | 1998-04-22 |
| ES2178717T3 (es) | 2003-01-01 |
| DE69621633T2 (de) | 2003-02-06 |
| CN1200035A (zh) | 1998-11-25 |
| JP2000503298A (ja) | 2000-03-21 |
| US5994384A (en) | 1999-11-30 |
| KR19990067008A (ko) | 1999-08-16 |
| RU2193404C2 (ru) | 2002-11-27 |
| AU707728B2 (en) | 1999-07-15 |
| DE69621633D1 (de) | 2002-07-11 |
| ATE218340T1 (de) | 2002-06-15 |
| BG102396A (en) | 1999-01-29 |
| CZ120498A3 (cs) | 1998-09-16 |
| GB9521680D0 (en) | 1996-01-03 |
| WO1997015302A1 (en) | 1997-05-01 |
| HUP9900027A2 (hu) | 1999-04-28 |
| EE9800131A (et) | 1998-10-15 |
| NO981799L (no) | 1998-04-22 |
| PL326562A1 (en) | 1998-09-28 |
| AU7301996A (en) | 1997-05-15 |
| NZ320289A (en) | 1999-08-30 |
| EP0858338A1 (en) | 1998-08-19 |
| EP0858338B1 (en) | 2002-06-05 |
| HUP9900027A3 (en) | 1999-11-29 |
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| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |