IL123805A - Pharmaceutical components containing derivatives of hydroxymic acid to protect the mitochondrial genome and / or mitochondria from damage or to treat diseases related to these damages - Google Patents
Pharmaceutical components containing derivatives of hydroxymic acid to protect the mitochondrial genome and / or mitochondria from damage or to treat diseases related to these damagesInfo
- Publication number
- IL123805A IL123805A IL12380596A IL12380596A IL123805A IL 123805 A IL123805 A IL 123805A IL 12380596 A IL12380596 A IL 12380596A IL 12380596 A IL12380596 A IL 12380596A IL 123805 A IL123805 A IL 123805A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- compound
- group
- acid addition
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/539—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more oxygen atoms in the same ring, e.g. dioxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9502843A HU9502843D0 (en) | 1995-09-29 | 1995-09-29 | Pharmaceutical composition |
PCT/HU1996/000053 WO1997013504A1 (en) | 1995-09-29 | 1996-09-26 | Pharmaceutical compositions containing hydroximic acid derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
IL123805A0 IL123805A0 (en) | 1998-10-30 |
IL123805A true IL123805A (en) | 2001-10-31 |
Family
ID=10987259
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12380596A IL123805A (en) | 1995-09-29 | 1996-09-26 | Pharmaceutical components containing derivatives of hydroxymic acid to protect the mitochondrial genome and / or mitochondria from damage or to treat diseases related to these damages |
Country Status (14)
Country | Link |
---|---|
US (1) | US6306878B1 (ja) |
EP (2) | EP1020187A1 (ja) |
JP (2) | JP3932559B2 (ja) |
KR (1) | KR100363069B1 (ja) |
CN (2) | CN1104894C (ja) |
AT (1) | ATE321543T1 (ja) |
AU (1) | AU7092296A (ja) |
CA (1) | CA2233315C (ja) |
DE (1) | DE69635996T2 (ja) |
HU (1) | HU9502843D0 (ja) |
IL (1) | IL123805A (ja) |
RU (1) | RU2191005C2 (ja) |
UA (1) | UA57712C2 (ja) |
WO (1) | WO1997013504A1 (ja) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
HU9701081D0 (en) | 1997-06-23 | 1997-08-28 | Gene Research Lab Inc N | Pharmaceutical composition of antitumoral activity |
HUP9701080A3 (en) | 1997-06-23 | 1999-05-28 | Gene Res Lab Inc New York N | Pharmaceutical composition containing a compound of antiviral activity and a hydroximic acid ester derivative |
CA2319131A1 (en) | 1998-01-26 | 1999-07-29 | Walter H. Moos | Mitochondria protecting agents for treating mitochondria associated diseases |
US6268398B1 (en) | 1998-04-24 | 2001-07-31 | Mitokor | Compounds and methods for treating mitochondria-associated diseases |
WO2000007580A2 (en) * | 1998-08-03 | 2000-02-17 | N-Gene Kutató Kft. | Pharmaceutical compositions against autoimmune diseases |
HUP0001583A2 (hu) | 2000-04-18 | 2002-11-28 | BIOREX Kutató és Fejlesztő Rt. | Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké |
HU228783B1 (en) * | 2001-07-26 | 2013-05-28 | Greenearth Cleaning | Dry cleaning apparatus and method capable of utilizing a siloxane solvent |
PL371251A1 (en) | 2002-01-11 | 2005-06-13 | Biorex Kutato Es Fejlesztö Rt. | Carboxamidine derivatives and their use in the treatment of vascular diseases |
BRPI0410805A (pt) | 2003-09-09 | 2006-06-27 | Fumapharm Ag | uso de derivados do ácido fumárico para tratamento da insuficiência cardìaca e asma |
HUP0303584A3 (en) * | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
HUP0401177A2 (en) * | 2004-06-14 | 2007-09-28 | N Gene Res Lab Inc | Pharmaceutical composition for increasing the mitochondrial genesis |
HUP0500145A2 (en) * | 2005-01-28 | 2006-11-28 | Gene Res Lab N | Use of o-(3-piperidino-2-hydroxy-1-propyl)-nicotinic amidoxime for preparation of medicaments against oral diseases |
US7763601B2 (en) * | 2006-11-02 | 2010-07-27 | N-Gene Research Laboratories, Inc. | Prevention and treatment of obesity |
US20080108602A1 (en) * | 2006-11-02 | 2008-05-08 | N-Gene Research Laboratories, Inc. | Prevention of obesity in antipsychotic, antidepressant and antiepileptic medication |
PT2653873T (pt) | 2007-02-08 | 2022-07-26 | Biogen Ma Inc | Composições e utilizações para o tratamento de esclerose múltipla |
US20090281143A1 (en) * | 2007-12-10 | 2009-11-12 | N-Gene Research Laboratories, Inc. | Dose Reduction of a Cannabinoid CB1 Receptor Antagonist in the Treatment of Overweight or Obesity |
HUP1100444A2 (en) | 2011-08-17 | 2013-02-28 | Pharma Gene Sa | Pharmaceutical composition |
HUP1100445A2 (en) * | 2011-08-17 | 2013-02-28 | Pharma Gene Sa | Pharmaceutical composition |
CN102408411B (zh) * | 2011-09-19 | 2014-10-22 | 北京康辰药业股份有限公司 | 一种含喹啉基的羟肟酸类化合物及其制备方法、以及含有该化合物的药物组合物及其应用 |
EP3263105A1 (en) | 2016-07-01 | 2018-01-03 | Montana State University | Use of bgp15 to treat familial dysautonomia |
EP3263104A1 (en) * | 2016-07-01 | 2018-01-03 | N-Gene Research Laboratories Inc. | Use of bgp15 to stimulate mitochondrial fusion |
EP3634411B1 (en) | 2017-06-08 | 2023-09-20 | N-Gene Research Laboratories Inc. | Methods for treating nash and for preventing nash-induced hcc |
HUP1800298A1 (hu) | 2018-08-30 | 2020-05-28 | N Gene Res Laboratories Inc | Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére |
CA3202568A1 (en) | 2020-11-19 | 2022-05-27 | Zevra Denmark A/S | Processes for preparing arimoclomol citrate and intermediates thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4308399A (en) * | 1977-08-30 | 1981-12-29 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | O-(3-Amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same |
HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
PL179032B1 (pl) * | 1994-05-06 | 2000-07-31 | Biorex Kutato Fejlesztoe Kft | kwasu hydroksamowego oraz kompozycje farmaceutyczne zawierajace nowe pochodnekwasu hydroksamowego PL PL |
-
1995
- 1995-09-29 HU HU9502843A patent/HU9502843D0/hu unknown
-
1996
- 1996-09-26 EP EP99122692A patent/EP1020187A1/en not_active Withdrawn
- 1996-09-26 IL IL12380596A patent/IL123805A/en not_active IP Right Cessation
- 1996-09-26 CA CA002233315A patent/CA2233315C/en not_active Expired - Fee Related
- 1996-09-26 AU AU70922/96A patent/AU7092296A/en not_active Abandoned
- 1996-09-26 EP EP96931924A patent/EP0852495B1/en not_active Expired - Lifetime
- 1996-09-26 JP JP51484497A patent/JP3932559B2/ja not_active Expired - Fee Related
- 1996-09-26 DE DE69635996T patent/DE69635996T2/de not_active Expired - Fee Related
- 1996-09-26 CN CN96197805A patent/CN1104894C/zh not_active Expired - Fee Related
- 1996-09-26 WO PCT/HU1996/000053 patent/WO1997013504A1/en active IP Right Grant
- 1996-09-26 UA UA98041714A patent/UA57712C2/uk unknown
- 1996-09-26 RU RU98108553/14A patent/RU2191005C2/ru not_active IP Right Cessation
- 1996-09-26 AT AT96931924T patent/ATE321543T1/de not_active IP Right Cessation
- 1996-09-26 KR KR10-1998-0702380A patent/KR100363069B1/ko not_active IP Right Cessation
- 1996-09-27 US US08/722,499 patent/US6306878B1/en not_active Expired - Fee Related
-
1999
- 1999-11-12 CN CN99124308A patent/CN1263763A/zh active Pending
- 1999-12-03 JP JP11344653A patent/JP2000302676A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU7092296A (en) | 1997-04-30 |
RU2191005C2 (ru) | 2002-10-20 |
EP0852495A1 (en) | 1998-07-15 |
EP1020187A1 (en) | 2000-07-19 |
CA2233315A1 (en) | 1997-04-17 |
HU9502843D0 (en) | 1995-11-28 |
JP2000302676A (ja) | 2000-10-31 |
WO1997013504A1 (en) | 1997-04-17 |
CN1104894C (zh) | 2003-04-09 |
DE69635996D1 (de) | 2006-05-18 |
CN1200670A (zh) | 1998-12-02 |
KR19990063907A (ko) | 1999-07-26 |
ATE321543T1 (de) | 2006-04-15 |
CA2233315C (en) | 2007-12-04 |
KR100363069B1 (ko) | 2003-01-29 |
JP3932559B2 (ja) | 2007-06-20 |
IL123805A0 (en) | 1998-10-30 |
DE69635996T2 (de) | 2007-03-15 |
CN1263763A (zh) | 2000-08-23 |
EP0852495B1 (en) | 2006-03-29 |
JP2001519756A (ja) | 2001-10-23 |
US6306878B1 (en) | 2001-10-23 |
UA57712C2 (uk) | 2003-07-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |