IL123761A - גורמים נוירוטרופים קטועים שמקורם מקו תאי גליאה, ותכשירים רפואיים המכילים אותם - Google Patents

גורמים נוירוטרופים קטועים שמקורם מקו תאי גליאה, ותכשירים רפואיים המכילים אותם

Info

Publication number
IL123761A
IL123761A IL12376196A IL12376196A IL123761A IL 123761 A IL123761 A IL 123761A IL 12376196 A IL12376196 A IL 12376196A IL 12376196 A IL12376196 A IL 12376196A IL 123761 A IL123761 A IL 123761A
Authority
IL
Israel
Prior art keywords
seq
gdnf
rrgqrgknrg
truncated gdnf
truncated
Prior art date
Application number
IL12376196A
Other languages
English (en)
Other versions
IL123761A0 (en
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Priority to IL14401896A priority Critical patent/IL144018A0/xx
Priority to IL14448896A priority patent/IL144488A0/xx
Publication of IL123761A0 publication Critical patent/IL123761A0/xx
Publication of IL123761A publication Critical patent/IL123761A/he

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL12376196A 1995-09-28 1996-09-16 גורמים נוירוטרופים קטועים שמקורם מקו תאי גליאה, ותכשירים רפואיים המכילים אותם IL123761A (he)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL14401896A IL144018A0 (en) 1995-09-28 1996-09-16 Truncated glial cell line-derived neurotrophic factor
IL14448896A IL144488A0 (en) 1995-09-28 1996-09-16 Truncated glial cell line-derived neurotrophic factor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/535,681 US6184200B1 (en) 1995-09-28 1995-09-28 Truncated glial cell line-derived neurotrophic factor
PCT/US1996/014915 WO1997011964A1 (en) 1995-09-28 1996-09-16 Truncated glial cell line-derived neurotrophic factor

Publications (2)

Publication Number Publication Date
IL123761A0 IL123761A0 (en) 1998-10-30
IL123761A true IL123761A (he) 2005-12-18

Family

ID=24135310

Family Applications (6)

Application Number Title Priority Date Filing Date
IL14401896A IL144018A0 (en) 1995-09-28 1996-09-16 Truncated glial cell line-derived neurotrophic factor
IL14448896A IL144488A0 (en) 1995-09-28 1996-09-16 Truncated glial cell line-derived neurotrophic factor
IL12376196A IL123761A (he) 1995-09-28 1996-09-16 גורמים נוירוטרופים קטועים שמקורם מקו תאי גליאה, ותכשירים רפואיים המכילים אותם
IL144018A IL144018A (he) 1995-09-28 2001-06-26 פולינוקליוטידים המקודדים לגורמים נוירוטרופים קטועים שמקורם מקו תאי גליאה ודרכי שימוש של הפוליניוקליוטידים
IL144488A IL144488A (he) 1995-09-28 2001-07-23 השימוש בגורם נוירוטרופי קוטע הנגזר משורת תאים גליאלי להכין הרכב תרופתי
IL218336A IL218336A0 (en) 1995-09-28 2012-02-27 Polynucleotides encoding truncated glial derived neurotrophic factors and methods of using said polynucleotides

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IL14401896A IL144018A0 (en) 1995-09-28 1996-09-16 Truncated glial cell line-derived neurotrophic factor
IL14448896A IL144488A0 (en) 1995-09-28 1996-09-16 Truncated glial cell line-derived neurotrophic factor

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL144018A IL144018A (he) 1995-09-28 2001-06-26 פולינוקליוטידים המקודדים לגורמים נוירוטרופים קטועים שמקורם מקו תאי גליאה ודרכי שימוש של הפוליניוקליוטידים
IL144488A IL144488A (he) 1995-09-28 2001-07-23 השימוש בגורם נוירוטרופי קוטע הנגזר משורת תאים גליאלי להכין הרכב תרופתי
IL218336A IL218336A0 (en) 1995-09-28 2012-02-27 Polynucleotides encoding truncated glial derived neurotrophic factors and methods of using said polynucleotides

Country Status (24)

Country Link
US (5) US6184200B1 (he)
EP (1) EP0920448B1 (he)
JP (3) JP4153036B2 (he)
KR (1) KR100334739B1 (he)
CN (1) CN1283659C (he)
AT (1) ATE314389T1 (he)
AU (1) AU707528B2 (he)
CA (1) CA2232749C (he)
CZ (1) CZ297326B6 (he)
DE (1) DE69635675T2 (he)
DK (1) DK0920448T3 (he)
EA (1) EA001204B1 (he)
ES (1) ES2255713T3 (he)
HU (1) HU226220B1 (he)
IL (6) IL144018A0 (he)
MX (1) MX9802278A (he)
NO (1) NO322521B1 (he)
NZ (1) NZ318697A (he)
SI (1) SI0920448T1 (he)
SK (1) SK288094B6 (he)
TW (1) TW570926B (he)
UA (1) UA66339C2 (he)
WO (1) WO1997011964A1 (he)
ZA (1) ZA968087B (he)

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US6184200B1 (en) * 1995-09-28 2001-02-06 Amgen Inc. Truncated glial cell line-derived neurotrophic factor
US6677135B1 (en) 1996-05-08 2004-01-13 Biogen, Inc. Ret ligand (RetL) for stimulating neutral and renal growth
DE19816186A1 (de) * 1998-04-14 1999-10-21 Univ Muenchen L Maximilians GDNF-kodierende DNA, Teile davon und GDNF-Varianten
US20020055467A1 (en) * 1998-07-06 2002-05-09 Johansen Teit E. Novel neurotrophic factors
US6507788B1 (en) * 1999-02-25 2003-01-14 Société de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.) Rational selection of putative peptides from identified nucleotide, or peptide sequences, of unknown function
US6897061B1 (en) 2000-06-16 2005-05-24 Spinal Cord Society Transdifferentiation of glial cells
US7442370B2 (en) 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
US7276580B2 (en) 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
US8946151B2 (en) 2003-02-24 2015-02-03 Northern Bristol N.H.S. Trust Frenchay Hospital Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
US7245117B1 (en) 2004-11-01 2007-07-17 Cardiomems, Inc. Communicating with implanted wireless sensor
US20060239966A1 (en) * 2003-10-20 2006-10-26 Tornoee Jens In vivo gene therapy of parkinson's disease
EP1677833B1 (en) 2003-10-20 2010-03-10 Nsgene A/S Virus vector for use in in vivo gene therapy of Parkinson's disease
BRPI0514409A (pt) 2004-08-19 2008-06-10 Biogen Idec Inc redobra de proteìnas da famìlia de fator de crescimento transformante beta
TWI501774B (zh) 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
CA2659990C (en) * 2006-08-04 2016-03-22 Prolong Pharmaceuticals, Inc. Polyethylene glycol erythropoietin conjugates
WO2008100966A1 (en) * 2007-02-12 2008-08-21 The Research Foundation Of State University Of New York Gdnf-derived peptides
TWI445544B (zh) 2007-05-01 2014-07-21 Biogen Idec Inc 增進血管形成之組合物及方法
US8446454B2 (en) 2007-05-21 2013-05-21 Polycom, Inc. Dynamic adaption of a continuous presence videoconferencing layout based on video content
FI20070808A0 (fi) 2007-10-25 2007-10-25 Mart Saarma GDNF:n silmukointivariantit ja niiden käytöt
UA112981C2 (uk) * 2011-04-11 2016-11-25 Елі Ліллі Енд Компані Варіант людського gdnf
US10376562B2 (en) 2013-03-15 2019-08-13 The Jackson Laboratory Methods for promoting wound healing and hair growth comprising GDNF administration
RU2561050C2 (ru) * 2013-08-28 2015-08-20 Федеральное государственное бюджетное учреждение науки Институт биофизики клетки Российской академии наук (ИБК РАН) Применение белка yb-1 и его фрагментов для изготовления лекарственных средств при лечении болезни альцгеймера
JP2019535267A (ja) 2016-11-10 2019-12-12 ケロス セラピューティクス インコーポレイテッドKeros Therapeutics,Inc. Gdnf融合ポリペプチド及びその使用方法
JP7665215B2 (ja) * 2019-12-19 2025-04-21 トランスフェルト・プラス・ソシエテ・アン・コマンディテ 腸のニューロパチーを治療するためのグリア細胞株由来神経栄養因子(gdnf)の使用
EP4442830A4 (en) 2021-11-29 2025-04-30 Shanghai Regenelead Therapies Co., Ltd. AADC/GDNF polynucleotide and use thereof in the treatment of Parkinson's disease

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US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
US4518584A (en) 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
DE3572982D1 (en) 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
US5106627A (en) 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5158881A (en) 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US4892538A (en) 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
DE68925966T2 (de) 1988-12-22 1996-08-29 Kirin Amgen Inc Chemisch modifizierte granulocytenkolonie erregender faktor
WO1990014363A1 (en) 1989-05-19 1990-11-29 Amgen Inc. Metalloproteinase inhibitor
US5229500A (en) 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
CA1332433C (en) 1989-09-29 1994-10-11 Robert L. Sutherland Ski structure and binding therefor
EP0423980B1 (en) 1989-10-16 2000-07-12 Amgen Inc. Stem cell factor
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
WO1991010470A1 (en) 1990-01-08 1991-07-25 Brown University Research Foundation Devices and methods for enhanced delivery of active factors
US5202428A (en) 1990-06-20 1993-04-13 The Salk Institute For Biological Studies DNA encoding neurotropic growth factor
US5252714A (en) 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
MX9205293A (es) 1991-09-20 1993-05-01 Syntex Sinergen Neuroscience J Factores neurotrofico derivado del glial
AU1443095A (en) 1993-12-22 1995-07-10 University Of Medicine And Dentistry Of New Jersey Novel nucleic acid sequences isolated from glial cells
FR2717824B1 (fr) 1994-03-25 1996-04-26 Rhone Poulenc Rorer Sa Virus recombinants, préparation et utilisation en thérapie génique.
US5733875A (en) * 1994-11-15 1998-03-31 Amgen Inc. Methods of using GDNF as a neuroprotective agent
US5739307A (en) * 1995-08-28 1998-04-14 Washington University Polynucleotide encoding neurturin neurotrophic factor
US6184200B1 (en) 1995-09-28 2001-02-06 Amgen Inc. Truncated glial cell line-derived neurotrophic factor
US5731284A (en) * 1995-09-28 1998-03-24 Amgen Inc. Method for treating Alzheimer's disease using glial line-derived neurotrophic factor (GDNF) protein product
US5641749A (en) * 1995-11-29 1997-06-24 Amgen Inc. Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product
US5641750A (en) * 1995-11-29 1997-06-24 Amgen Inc. Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product
US5929041A (en) * 1996-02-23 1999-07-27 Amgen Inc. Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor(GDNF) protein product
US5837681A (en) * 1996-02-23 1998-11-17 Amgen Inc. Method for treating sensorineural hearing loss using glial cell line-derived neurotrophic factor (GDNF) protein product
US5741778A (en) * 1996-03-19 1998-04-21 Amgen Inc. Method for treating Huntington's disease using glial cell line-derived neurotrophic factor (GDNF) protein product

Also Published As

Publication number Publication date
ATE314389T1 (de) 2006-01-15
JP5241037B2 (ja) 2013-07-17
AU7074696A (en) 1997-04-17
ZA968087B (en) 1997-06-12
US20040127419A1 (en) 2004-07-01
EA199800301A1 (ru) 1998-10-29
ES2255713T3 (es) 2006-07-01
WO1997011964A1 (en) 1997-04-03
NO981430L (no) 1998-03-30
UA66339C2 (uk) 2004-05-17
NZ318697A (en) 1999-09-29
JPH11512709A (ja) 1999-11-02
NO981430D0 (no) 1998-03-30
SK38998A3 (en) 1999-07-12
EP0920448B1 (en) 2005-12-28
SI0920448T1 (sl) 2006-04-30
CA2232749C (en) 2003-03-25
JP2010279360A (ja) 2010-12-16
HU226220B1 (hu) 2008-06-30
US20040214776A1 (en) 2004-10-28
CA2232749A1 (en) 1997-04-03
DK0920448T3 (da) 2006-04-10
CN1197461A (zh) 1998-10-28
HUP9802262A3 (en) 2001-01-29
NO322521B1 (no) 2006-10-16
CZ297326B6 (cs) 2006-11-15
US20040254114A1 (en) 2004-12-16
MX9802278A (es) 1998-08-30
IL144488A0 (en) 2002-05-23
DE69635675T2 (de) 2006-07-06
EP0920448A1 (en) 1999-06-09
HK1021823A1 (en) 2000-07-07
IL218336A0 (en) 2012-04-30
JP4153036B2 (ja) 2008-09-17
US7611865B2 (en) 2009-11-03
US6184200B1 (en) 2001-02-06
HUP9802262A2 (hu) 1999-01-28
CZ88298A3 (cs) 1999-02-17
KR19990063825A (ko) 1999-07-26
US20110251267A1 (en) 2011-10-13
JP4909843B2 (ja) 2012-04-04
JP2008067699A (ja) 2008-03-27
SK288094B6 (sk) 2013-07-02
CN1283659C (zh) 2006-11-08
KR100334739B1 (ko) 2002-09-17
AU707528B2 (en) 1999-07-15
IL144018A (he) 2012-04-30
IL123761A0 (en) 1998-10-30
IL144488A (he) 2006-12-31
EA001204B1 (ru) 2000-12-25
US7390781B2 (en) 2008-06-24
IL144018A0 (en) 2002-04-21
DE69635675D1 (de) 2006-02-02
TW570926B (en) 2004-01-11

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