IL123553A0 - Cell-cycle checkpoint genes - Google Patents

Cell-cycle checkpoint genes

Info

Publication number
IL123553A0
IL123553A0 IL12355396A IL12355396A IL123553A0 IL 123553 A0 IL123553 A0 IL 123553A0 IL 12355396 A IL12355396 A IL 12355396A IL 12355396 A IL12355396 A IL 12355396A IL 123553 A0 IL123553 A0 IL 123553A0
Authority
IL
Israel
Prior art keywords
cell
cycle checkpoint
checkpoint genes
genes
cycle
Prior art date
Application number
IL12355396A
Other languages
English (en)
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Publication of IL123553A0 publication Critical patent/IL123553A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL12355396A 1995-09-06 1996-09-06 Cell-cycle checkpoint genes IL123553A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9518220.0A GB9518220D0 (en) 1995-09-06 1995-09-06 Checkpoint gene
PCT/GB1996/002197 WO1997009433A1 (en) 1995-09-06 1996-09-06 Cell-cycle checkpoint genes
CZ1998656A CZ292808B6 (cs) 1995-09-06 1996-09-06 ATR polypeptid, polynukleotid, který jej kóduje, způsoby jejich detekce, vektor a protilátka

Publications (1)

Publication Number Publication Date
IL123553A0 true IL123553A0 (en) 1998-10-30

Family

ID=25746866

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12355396A IL123553A0 (en) 1995-09-06 1996-09-06 Cell-cycle checkpoint genes

Country Status (13)

Country Link
EP (1) EP0856058B1 (de)
JP (1) JPH11511984A (de)
CN (1) CN1201492A (de)
AU (1) AU730220B2 (de)
BR (1) BR9610168A (de)
CA (1) CA2231190A1 (de)
CZ (1) CZ292808B6 (de)
GB (1) GB9518220D0 (de)
IL (1) IL123553A0 (de)
NO (1) NO980957L (de)
PL (1) PL325427A1 (de)
SK (1) SK30298A3 (de)
WO (1) WO1997009433A1 (de)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL322876A1 (en) * 1995-11-16 1998-03-02 Icos Corp Pik type kinase of cellular cycle control point: materials and methods
GB9718952D0 (en) * 1997-09-05 1997-11-12 Medical Res Council Mammalian chk1 effector cell cycle checkpoint protein kinase materials and methods
CA2321224A1 (en) 1998-02-23 1999-08-26 Icos Corporation Phosphodiesterase 10
US6479256B1 (en) 1998-03-04 2002-11-12 Icos Corporation Lectomedin materials and methods
US6071691A (en) * 1998-04-27 2000-06-06 Oregon Health Science University Materials and methods for modulating differentiation
WO2000061724A2 (en) 1999-04-09 2000-10-19 Pharmacia & Upjohn Company Anti-bacterial vaccine compositions
US6790950B2 (en) 1999-04-09 2004-09-14 Pharmacia & Upjohn Company Anti-bacterial vaccine compositions
US6670167B1 (en) * 1999-11-01 2003-12-30 Agouron Pharmaceuticals, Inc. Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof
US6344549B1 (en) 1999-10-14 2002-02-05 Icos Corporation ATR-2 cell cycle checkpoint
WO2001031005A2 (en) 1999-10-22 2001-05-03 Pharmacia & Upjohn Company Drosophila g protein coupled receptors, nucleic acids, and methods related to the same
WO2001038533A2 (en) 1999-11-24 2001-05-31 Pharmacia & Upjohn Company G protein-coupled receptor-like receptors and modulators thereof
US6498026B2 (en) 2000-02-25 2002-12-24 Hercules Incorporated Variant galactose oxidase, nucleic acid encoding same, and methods of using same
EP1297112A2 (de) 2000-05-22 2003-04-02 PHARMACIA & UPJOHN COMPANY Neue matrix-metalloproteasen
US6686449B2 (en) 2000-06-30 2004-02-03 Pharmacia & Upjohn Company Mutant presenilin 1 polypeptides
WO2002002639A2 (en) 2000-07-05 2002-01-10 Pharmacia & Upjohn Company Human ion channels
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US7098007B2 (en) 2001-08-22 2006-08-29 California Institute Of Technology Cloning and functional assays of Xenopus ATR
WO2003068929A2 (en) * 2002-02-13 2003-08-21 University Of Rochester Methods of inhibiting hiv-1 vpr activity and hiv-1 infectivity using atr or rad17 inhibitors
CN1787837A (zh) 2002-11-15 2006-06-14 希龙公司 防止和治疗癌转移以及与癌转移相关的骨质损失的方法
US20050266409A1 (en) * 2003-02-04 2005-12-01 Wyeth Compositions and methods for diagnosing, preventing, and treating cancers
US7541158B2 (en) 2004-04-14 2009-06-02 Monell Chemical Senses Center Taste receptors of the T1R family from domestic dog
EP2657251B1 (de) 2004-05-24 2018-03-21 The Government of The United States of America, as represented by The Secretary, Department of Health and Human Services Lebender, oraler Impfstoff gegen Shigella dysenteriae Serotyp 1
US20060134698A1 (en) 2004-12-20 2006-06-22 Evanston Northwestern Healthcare Research Institute Methods for treating cardiac disease by modifying an N-terminal domain of troponin I
EP2295080A3 (de) 2005-07-25 2011-06-22 Emergent Product Development Seattle, LLC B-Zell-Verringerung mit CD37-spezifischen und CD20-spezifischen Bindungsmolekülen
EP1984024A2 (de) 2006-01-05 2008-10-29 Novartis AG Methoden zur verhinderung und behandlung von krebs-metastasierung und mit krebs-metastasierung einhergehendem knochenverlust
CN105837690A (zh) 2006-06-12 2016-08-10 新兴产品开发西雅图有限公司 具有效应功能的单链多价结合蛋白
WO2009047567A1 (en) * 2007-10-10 2009-04-16 University Of Sheffield Assay for identifying agents which inhibit the atr and/or dna-pk pathways
PT2132228E (pt) 2008-04-11 2011-10-11 Emergent Product Dev Seattle Imunoterapia de cd37 e sua combinação com um quimioterápico bifuncional
EP3281955A1 (de) 2008-10-02 2018-02-14 Aptevo Research and Development LLC Multitarget-bindungsproteine mit cd86-antagonist
EP2516467A2 (de) 2009-12-23 2012-10-31 Emergent Product Development Seattle, LLC Zusammensetzungen mit tnf-alpha- und il-6-antagonisten und verwendungsverfahren dafür
SI2519543T1 (sl) 2009-12-29 2016-08-31 Emergent Product Development Seattle, Llc Beljakovine, ki se vežejo s heterodimeri in njihova uporaba
RU2447899C2 (ru) 2010-05-27 2012-04-20 Михаил Валентинович Филатов Композиция для лечения гепатита с и способ лечения гепатита с
MY172692A (en) 2012-07-13 2019-12-10 Calysta Inc Biorefinery system, methods and compositions thereof
US9909153B2 (en) 2012-11-09 2018-03-06 Calysta, Inc. Compositions and methods for biological production of fatty acid derivatives
CN105378077A (zh) 2013-06-18 2016-03-02 凯利斯塔公司 用于使用乳酸脱氢酶转化体从c1化合物以生物方式产生乳酸的组合物和方法
EP3027204B1 (de) 2013-07-29 2022-01-05 2seventy bio, Inc. Multilaterale signalisierungsproteine und verwendungen davon
US20170130211A1 (en) 2014-01-02 2017-05-11 Trelys, Inc. Compositions and methods for biological production of amino acids in hydrogenotrophic microorganisms
BR112016016539A2 (pt) 2014-01-16 2018-01-23 Calysta Inc micro-organismos recombinantes enriquecidos com carboidratos
US9993494B2 (en) 2014-02-07 2018-06-12 Effector Therapeutics, Inc. Compositions and methods for treating fibrotic disease
WO2015120334A2 (en) 2014-02-07 2015-08-13 Effector Therapeutics, Inc. Compositions and methods for treating neurological disorders
CN106459992A (zh) 2014-03-17 2017-02-22 塔皮穆内公司 核酸分子疫苗组合物及其用途
CA2946846A1 (en) 2014-05-15 2015-11-19 Calysta, Inc. Methods for biological production of very long carbon chain compounds
CA2956545A1 (en) 2014-08-04 2016-02-11 Fred Hutchinson Cancer Research Center T cell immunotherapy specific for wt-1
MX389823B (es) 2014-10-27 2025-03-20 Fred Hutchinson Cancer Center Composiciones y metodos para reforzar la eficacia de inmunoterapia celular adoptiva.
KR20180002700A (ko) 2015-05-06 2018-01-08 트렐 와이에스, 인코포레이티드 메티오닌의 생물학적 생산을 위한 조성물 및 방법
WO2016187486A1 (en) 2015-05-19 2016-11-24 Fred Hutchinson Cancer Research Center Biomarkers and uses thereof for selecting pancreas cancer intervention
KR102784293B1 (ko) 2015-09-21 2025-03-20 압테보 리서치 앤드 디벨롭먼트 엘엘씨 Cd3 결합 폴리펩타이드
EP3394092A1 (de) 2015-12-23 2018-10-31 Fred Hutchinson Cancer Research Center T-zellrezeptoren mit hoher affinität und deren verwendungen
US20170191136A1 (en) 2015-12-31 2017-07-06 Effector Therapeutics, Inc. Mnk biomarkers and uses thereof
CA3010977A1 (en) 2016-01-11 2017-07-20 Zoetis Services Llc Novel cross protective vaccine compositions for porcine epidemic diarrhea virus
US11723962B2 (en) 2016-05-04 2023-08-15 Fred Hutchinson Cancer Center Cell-based neoantigen vaccines and uses thereof
EP3452514A1 (de) 2016-05-06 2019-03-13 Fred Hutchinson Cancer Research Center Mart-1-spezifische t-zell-immuntherapie
MX2019003176A (es) 2016-09-23 2019-07-04 Hutchinson Fred Cancer Res Receptores de linfocitos t (tcr) especificos del antigeno menor de histocompatibilidad (h) ah-1 y sus usos.
RU2019112860A (ru) 2016-09-27 2020-10-30 Серо Терапьютикс, Инк. Молекулы химерных интернализационных рецепторов
US11534461B2 (en) 2016-11-14 2022-12-27 Fred Hutchinson Cancer Center High affinity merkel cell polyomavirus T antigen-specific TCRS and uses thereof
CA3047294A1 (en) 2016-12-14 2018-06-21 Zoetis Services Llc Effective vaccination against european strains of porcine reproductive and respiratory syndrome (prrs) virus prior to weaning
EP3580568A1 (de) 2017-02-09 2019-12-18 Fred Hutchinson Cancer Research Center Biomarker und verwendungen davon zur auswahl von immuntherapieinterventionen
EP3595708A4 (de) 2017-03-15 2020-12-16 Fred Hutchinson Cancer Research Center Hochwirksame mage-a1-spezifische tcrs und deren verwendungen
CA3064000A1 (en) 2017-05-24 2018-11-29 Effector Therapeutics, Inc. Methods and compositions for cellular immunotherapy
IL272103B2 (en) 2017-07-20 2024-10-01 Aptevo Res & Development Llc Antigen binding proteins binding to 5T4 and 4-1BB and related compositions and methods of treating cancer
US12398191B2 (en) 2017-08-11 2025-08-26 Fred Hutchinson Cancer Center BRAF-specific TCRs and uses thereof
WO2019055862A1 (en) 2017-09-14 2019-03-21 Fred Hutchinson Cancer Research Center HIGH AFFINITY T CELL RECEPTORS AND USES THEREOF
AU2018341244A1 (en) 2017-09-26 2020-03-05 Cero Therapeutics, Inc. Chimeric engulfment receptor molecules and methods of use
WO2019109047A1 (en) 2017-12-01 2019-06-06 Fred Hutchinson Cancer Research Center Binding proteins specific for 5t4 and uses thereof
AU2018391831B2 (en) 2017-12-20 2022-08-04 Harbour Biomed (Shanghai) Co., Ltd Antibodies binding CTLA-4 and uses thereof
WO2019140278A1 (en) 2018-01-11 2019-07-18 Fred Hutchinson Cancer Research Center Immunotherapy targeting core binding factor antigens
CA3090700A1 (en) 2018-02-12 2019-08-15 Fred Hutchinson Cancer Research Center Cyclin a1 specific t cell receptors and uses thereof
EP3759130A1 (de) 2018-02-26 2021-01-06 Fred Hutchinson Cancer Research Center Zusammensetzungen und verfahren zur zellulären immuntherapie
MX2020010235A (es) 2018-03-28 2020-10-28 Cero Therapeutics Inc Vectores de expresion para receptores de engullimiento quimerico, celulas hospederas geneticamente modificadas y usos de los mismos.
WO2019191334A1 (en) 2018-03-28 2019-10-03 Cero Therapeutics, Inc. Chimeric tim4 receptors and uses thereof
US20210015865A1 (en) 2018-03-28 2021-01-21 Cero Therapeutics, Inc. Chimeric engulfment receptors and uses thereof for neurodegenerative diseases
EP3774865A1 (de) 2018-03-28 2021-02-17 Cero Therapeutics, Inc. Zelluläre immunotherapiezusammensetzungen und ihre verwendungen
US20210223248A1 (en) 2018-06-01 2021-07-22 Fred Hutchinson Cancer Research Center Biomarkers, uses thereof for selecting immunotherapy intervention, and immunotherapy methods
WO2020139974A1 (en) 2018-12-27 2020-07-02 Calysta, Inc. Glycogen-null methanotrophs and uses thereof
GB2596461B (en) 2019-02-20 2023-09-27 Fred Hutchinson Cancer Center Binding proteins specific for RAS neoantigens and uses thereof
WO2020185796A1 (en) 2019-03-11 2020-09-17 Fred Hutchinson Cancer Research Center High avidity wt1 t cell receptors and uses thereof
AU2020334064A1 (en) 2019-08-20 2022-03-03 Fred Hutchinson Cancer Center T-cell immunotherapy specific for WT-1
WO2021067875A1 (en) 2019-10-03 2021-04-08 Cero Therapeutics, Inc. Chimeric tim4 receptors and uses thereof
WO2021146328A1 (en) 2020-01-13 2021-07-22 Aptevo Research And Development Llc Formulations for protein therapeutics
KR20220140500A (ko) 2020-01-13 2022-10-18 압테보 리서치 앤드 디벨롭먼트 엘엘씨 약물 전달 시스템 성분에 대한 치료제 단백질의 흡착을 방지하기 위한 방법 및 조성물
WO2021178637A1 (en) 2020-03-05 2021-09-10 Iowa State University Research Foundation, Inc. IMMUNOGENIC AND VACCINE COMPOSITIONS AGAINST SARS-CoV-2
EP4121110A4 (de) 2020-03-18 2024-06-12 Memorial Sloan Kettering Cancer Center Anti-ceramid-antikörper
WO2022036265A1 (en) 2020-08-14 2022-02-17 Cero Therapeutics, Inc. Chimeric tim receptors and uses thereof
WO2022036285A1 (en) 2020-08-14 2022-02-17 Cero Therapeutics, Inc. Compositions and methods for treating cancer with chimeric tim receptors in combination with inhibitors of poly (adp-ribose) polymerase
WO2022036287A1 (en) 2020-08-14 2022-02-17 Cero Therapeutics, Inc. Anti-cd72 chimeric receptors and uses thereof
WO2022066973A1 (en) 2020-09-24 2022-03-31 Fred Hutchinson Cancer Research Center Immunotherapy targeting pbk or oip5 antigens
CN116724053A (zh) 2020-09-24 2023-09-08 弗雷德哈钦森癌症中心 靶向sox2抗原的免疫治疗
WO2022072431A1 (en) 2020-09-30 2022-04-07 Zoetis Services Llc Novel pasteurella multocida strains and vaccines having hyac and nanp deletions
TW202222841A (zh) 2020-10-06 2022-06-16 福瑞德哈金森腫瘤研究中心 用於治療表現mage-a1之疾病的組成物及方法
AU2022227021A1 (en) 2021-02-26 2023-09-21 Kelonia Therapeutics, Inc. Lymphocyte targeted lentiviral vectors
CN115216451A (zh) 2021-04-16 2022-10-21 硕腾服务有限责任公司 伪狂犬病病毒疫苗
JP2024519964A (ja) 2021-05-21 2024-05-21 アプティーボ リサーチ アンド デベロップメント エルエルシー タンパク質治療薬のための投薬レジメン
US20250127896A1 (en) 2021-07-28 2025-04-24 Cero Therapeutics Holdings, Inc. Chimeric tim4 receptors and uses thereof
JP2024546914A (ja) 2021-12-15 2024-12-26 インテリウス・バイオセラピューティクス・インコーポレイテッド 偽型ウイルス粒子、それを含む組成物、及びそれらの使用
JP2025510266A (ja) 2022-03-25 2025-04-14 嘉和生物▲薬▼▲業▼有限公司 Ｃｄ３を標的とする抗体及びその使用
CA3262768A1 (en) 2022-07-25 2024-02-01 Interius Biotherapeutics, Inc. Mutated polypeptides, compositions containing them, and their uses
CN118267462A (zh) 2022-12-29 2024-07-02 硕腾服务有限责任公司 接种猪以抗伪狂犬病病毒的方法
CN120584137A (zh) 2023-01-06 2025-09-02 阿帕特夫研究和发展有限公司 双特异性pd-l1和cd40结合分子以及其用途
WO2025081123A1 (en) 2023-10-12 2025-04-17 Fred Hutchinson Cancer Center Methods and compositions for improving t cell immunotherapy
WO2025245169A1 (en) 2024-05-21 2025-11-27 Fred Hutchinson Cancer Center Immunotherapy cells equipped with a collagen-targeting payload

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL322876A1 (en) * 1995-11-16 1998-03-02 Icos Corp Pik type kinase of cellular cycle control point: materials and methods

Also Published As

Publication number Publication date
PL325427A1 (en) 1998-07-20
GB9518220D0 (en) 1995-11-08
NO980957L (no) 1998-05-05
NO980957D0 (no) 1998-03-05
EP0856058B1 (de) 2006-07-26
AU6884696A (en) 1997-03-27
WO1997009433A1 (en) 1997-03-13
CZ65698A3 (cs) 2000-01-12
CZ292808B6 (cs) 2003-12-17
CN1201492A (zh) 1998-12-09
AU730220B2 (en) 2001-03-01
BR9610168A (pt) 1998-08-11
SK30298A3 (en) 2000-04-10
CA2231190A1 (en) 1997-03-13
EP0856058A1 (de) 1998-08-05
JPH11511984A (ja) 1999-10-19

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