IL123431A - תרכובות מרקפטואלקיל פפטידיל בעלי מתמיר אימידזול ושימוש בהן כמערכבי מטריקס פרוטאנאזים מתכתיים (mmp) ו/ או גורם למקקת גידול (tnf) - Google Patents

תרכובות מרקפטואלקיל פפטידיל בעלי מתמיר אימידזול ושימוש בהן כמערכבי מטריקס פרוטאנאזים מתכתיים (mmp) ו/ או גורם למקקת גידול (tnf)

Info

Publication number
IL123431A
IL123431A IL12343196A IL12343196A IL123431A IL 123431 A IL123431 A IL 123431A IL 12343196 A IL12343196 A IL 12343196A IL 12343196 A IL12343196 A IL 12343196A IL 123431 A IL123431 A IL 123431A
Authority
IL
Israel
Prior art keywords
alkyl
methyl
amino
pentanoyl
aryl
Prior art date
Application number
IL12343196A
Other languages
English (en)
Other versions
IL123431A0 (en
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9523828.3A external-priority patent/GB9523828D0/en
Priority claimed from GBGB9607121.2A external-priority patent/GB9607121D0/en
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Publication of IL123431A0 publication Critical patent/IL123431A0/xx
Publication of IL123431A publication Critical patent/IL123431A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IL12343196A 1995-11-22 1996-11-22 תרכובות מרקפטואלקיל פפטידיל בעלי מתמיר אימידזול ושימוש בהן כמערכבי מטריקס פרוטאנאזים מתכתיים (mmp) ו/ או גורם למקקת גידול (tnf) IL123431A (he)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9523828.3A GB9523828D0 (en) 1995-11-22 1995-11-22 Compounds
GBGB9607121.2A GB9607121D0 (en) 1996-04-04 1996-04-04 Compounds
PCT/GB1996/002892 WO1997019075A1 (en) 1995-11-22 1996-11-22 Mercaptoalkylpeptidyl compounds having an imidazole substituent and their use as inhibitors of matrix metalloproteinases (mmp) and/or tumour necrosis factor (tnf)

Publications (2)

Publication Number Publication Date
IL123431A0 IL123431A0 (en) 1998-09-24
IL123431A true IL123431A (he) 2001-05-20

Family

ID=26308152

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12343196A IL123431A (he) 1995-11-22 1996-11-22 תרכובות מרקפטואלקיל פפטידיל בעלי מתמיר אימידזול ושימוש בהן כמערכבי מטריקס פרוטאנאזים מתכתיים (mmp) ו/ או גורם למקקת גידול (tnf)

Country Status (19)

Country Link
US (1) US6048841A (he)
EP (1) EP0874842B1 (he)
JP (1) JP2000500482A (he)
KR (1) KR19990067687A (he)
CN (1) CN1072667C (he)
AT (1) ATE215946T1 (he)
AU (1) AU711907B2 (he)
BR (1) BR9611636A (he)
CA (1) CA2229438C (he)
CZ (1) CZ291337B6 (he)
DE (1) DE69620639T2 (he)
ES (1) ES2172690T3 (he)
HU (1) HUP9904131A3 (he)
IL (1) IL123431A (he)
MX (1) MX9804052A (he)
NO (1) NO982290L (he)
NZ (1) NZ322565A (he)
PL (1) PL326710A1 (he)
WO (1) WO1997019075A1 (he)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6673927B2 (en) 1996-02-16 2004-01-06 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Farnesyl transferase inhibitors
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
RU2201931C2 (ru) 1996-11-20 2003-04-10 Биомежер Инкорпорэйтед Ингибиторы фарнезилтрансферазы и способы ингибирования фарнезилтрансферазы
WO2001087849A2 (en) 2000-05-12 2001-11-22 Genzyme Corporation Modulators of tnf- alpha signaling
AU778368B2 (en) 2000-05-15 2004-12-02 Darwin Discovery Limited Hydroxamic acid derivatives
SE0100903D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0100902D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0103710D0 (sv) * 2001-11-07 2001-11-07 Astrazeneca Ab Compounds
EP1474425B9 (en) * 2002-01-07 2008-07-02 Eisai Co., Ltd. Deazapurines and uses thereof
SE0202539D0 (sv) 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
GB0221246D0 (en) * 2002-09-13 2002-10-23 Astrazeneca Ab Compounds
US7687530B2 (en) * 2002-11-21 2010-03-30 Genzyme Corporation Inhibition of chronic tissue transplant rejection
PT1562571E (pt) * 2002-11-21 2011-11-25 Genzyme Corp Combinação de derivados de diamina e agentes imunossupressores para a indução da tolerância imunológica
US20040259744A1 (en) * 2003-12-19 2004-12-23 Meidong Yang Skin and hair cleansers containing sulfur
SE0401762D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
US7648992B2 (en) 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
SE0403086D0 (sv) * 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
SE0403085D0 (sv) * 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
TW200831488A (en) * 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds
PL227790B1 (pl) 2015-08-13 2018-01-31 Slaski Univ Medyczny W Katowicach Fosfoniany acetylenowych pochodnych betuliny o działaniu przeciwnowotworowym, sposób ich wytwarzania i zastosowanie.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0634998B1 (en) * 1992-04-07 1997-03-19 British Biotech Pharmaceuticals Limited Hydroxamic acid based collagenase and cytokine inhibitors
GB9215665D0 (en) * 1992-07-23 1992-09-09 British Bio Technology Compounds
GB9323165D0 (en) * 1993-11-10 1994-01-05 Chiros Ltd Compounds
GB9404046D0 (en) * 1994-03-03 1994-04-20 Smithkline Beecham Corp Novel compounds
DE69509401T2 (de) * 1994-10-05 1999-08-19 Darwin Discovery Ltd. Peptidische verbindungen und deren therapeutische verwendung als metalloproteinase-inhibitoren

Also Published As

Publication number Publication date
AU7634396A (en) 1997-06-11
IL123431A0 (en) 1998-09-24
ES2172690T3 (es) 2002-10-01
US6048841A (en) 2000-04-11
KR19990067687A (ko) 1999-08-25
DE69620639D1 (de) 2002-05-16
WO1997019075A1 (en) 1997-05-29
NO982290D0 (no) 1998-05-20
NO982290L (no) 1998-05-20
EP0874842A1 (en) 1998-11-04
AU711907B2 (en) 1999-10-21
HUP9904131A2 (hu) 2000-06-28
MX9804052A (es) 1998-09-30
CA2229438C (en) 2006-01-17
PL326710A1 (en) 1998-10-26
CA2229438A1 (en) 1997-05-29
HUP9904131A3 (en) 2002-04-29
DE69620639T2 (de) 2002-10-17
CZ291337B6 (cs) 2003-02-12
NZ322565A (en) 1999-11-29
ATE215946T1 (de) 2002-04-15
JP2000500482A (ja) 2000-01-18
EP0874842B1 (en) 2002-04-10
BR9611636A (pt) 1999-12-28
CZ145598A3 (cs) 1998-08-12
CN1202895A (zh) 1998-12-23
CN1072667C (zh) 2001-10-10

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Legal Events

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KB Patent renewed
RH1 Patent not in force