IL122242A - Combination of an angiotensin II receptor antigen and an epoxy-steroidal aldosterone receptor antigen - Google Patents
Combination of an angiotensin II receptor antigen and an epoxy-steroidal aldosterone receptor antigenInfo
- Publication number
- IL122242A IL122242A IL12224296A IL12224296A IL122242A IL 122242 A IL122242 A IL 122242A IL 12224296 A IL12224296 A IL 12224296A IL 12224296 A IL12224296 A IL 12224296A IL 122242 A IL122242 A IL 122242A
- Authority
- IL
- Israel
- Prior art keywords
- angiotensin
- epoxy
- receptor antagonist
- compound
- oxo
- Prior art date
Links
- 239000002333 angiotensin II receptor antagonist Substances 0.000 title claims abstract description 141
- 102000003979 Mineralocorticoid Receptors Human genes 0.000 title claims abstract description 35
- 108090000375 Mineralocorticoid Receptors Proteins 0.000 title claims abstract description 35
- 229940044551 receptor antagonist Drugs 0.000 title claims abstract description 32
- 239000002464 receptor antagonist Substances 0.000 title claims abstract description 32
- 229940126317 angiotensin II receptor antagonist Drugs 0.000 title claims abstract description 19
- 150000001875 compounds Chemical class 0.000 claims description 183
- -1 3,5-dibutyl-1 H-1 ,2,4-triazol-l -yl Chemical group 0.000 claims description 53
- 150000003839 salts Chemical class 0.000 claims description 14
- 239000004593 Epoxy Substances 0.000 claims description 12
- 230000003637 steroidlike Effects 0.000 claims description 10
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical class [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 5
- 108010083387 Saralasin Proteins 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- 150000004702 methyl esters Chemical class 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- PFGWGEPQIUAZME-NXSMLHPHSA-N saralasin Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(O)=O)C1=CC=C(O)C=C1 PFGWGEPQIUAZME-NXSMLHPHSA-N 0.000 claims description 2
- 229960004785 saralasin Drugs 0.000 claims description 2
- AGWFKXDTYITCSP-NHGLSFBUSA-N (8s,9s,10r,13r,14s,17r)-17-(2-carboxyethyl)-10,13-dimethyl-2,3,6,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthrene-7-carboxylic acid Chemical compound C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)CCC(O)=O)[C@@H]4[C@@H]3C(C(O)=O)CC2=C1 AGWFKXDTYITCSP-NHGLSFBUSA-N 0.000 claims 6
- KLVDUSUYBDMJKR-SANMLTNESA-N (6s)-1-[(4-amino-3-methylphenyl)methyl]-5-(2,2-diphenylacetyl)-6,7-dihydro-4h-imidazo[4,5-c]pyridine-6-carboxylic acid Chemical compound C1=C(N)C(C)=CC(CN2C=3C[C@H](N(CC=3N=C2)C(=O)C(C=2C=CC=CC=2)C=2C=CC=CC=2)C(O)=O)=C1 KLVDUSUYBDMJKR-SANMLTNESA-N 0.000 claims 1
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- 239000002083 C09CA01 - Losartan Substances 0.000 claims 1
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- 239000002947 C09CA04 - Irbesartan Substances 0.000 claims 1
- 239000002081 C09CA05 - Tasosartan Substances 0.000 claims 1
- 239000002053 C09CA06 - Candesartan Substances 0.000 claims 1
- YBZYNINTWCLDQA-UHKVWXOHSA-N acetic acid;(2s)-2-[[(2s)-1-[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1h-imidazol-5-yl)prop Chemical compound O.CC(O)=O.C([C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(O)=O)C1=CC=C(O)C=C1 YBZYNINTWCLDQA-UHKVWXOHSA-N 0.000 claims 1
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- OROAFUQRIXKEMV-LDADJPATSA-N eprosartan Chemical compound C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 OROAFUQRIXKEMV-LDADJPATSA-N 0.000 claims 1
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- ZEUXAIYYDDCIRX-UHFFFAOYSA-N losartan carboxylic acid Chemical compound CCCCC1=NC(Cl)=C(C(O)=O)N1CC1=CC=C(C=2C(=CC=CC=2)C2=NNN=N2)C=C1 ZEUXAIYYDDCIRX-UHFFFAOYSA-N 0.000 claims 1
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- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 1
- PZQSQRCNMZGWFT-QXMHVHEDSA-N propan-2-yl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC(C)C PZQSQRCNMZGWFT-QXMHVHEDSA-N 0.000 claims 1
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- 229960000651 tasosartan Drugs 0.000 claims 1
- ADXGNEYLLLSOAR-UHFFFAOYSA-N tasosartan Chemical compound C12=NC(C)=NC(C)=C2CCC(=O)N1CC(C=C1)=CC=C1C1=CC=CC=C1C=1N=NNN=1 ADXGNEYLLLSOAR-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Quinoline Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48645695A | 1995-06-07 | 1995-06-07 | |
| PCT/US1996/009335 WO1996040257A1 (en) | 1995-06-07 | 1996-06-05 | Epoxy-steroidal aldosterone antagonist and angiotensin ii antagonist combination therapy for treatment of congestive heart failure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL122242A0 IL122242A0 (en) | 1998-04-05 |
| IL122242A true IL122242A (en) | 2001-07-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12224296A IL122242A (en) | 1995-06-07 | 1996-06-05 | Combination of an angiotensin II receptor antigen and an epoxy-steroidal aldosterone receptor antigen |
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|---|---|
| US (1) | US6653306B1 (enExample) |
| EP (1) | EP0831910B1 (enExample) |
| JP (1) | JPH11507627A (enExample) |
| KR (1) | KR100618466B1 (enExample) |
| CN (2) | CN1522701A (enExample) |
| AT (1) | ATE209047T1 (enExample) |
| AU (1) | AU725689B2 (enExample) |
| BR (1) | BR9609066A (enExample) |
| CA (1) | CA2224079A1 (enExample) |
| CZ (1) | CZ297975B6 (enExample) |
| DE (1) | DE69617235T2 (enExample) |
| DK (1) | DK0831910T3 (enExample) |
| ES (1) | ES2167571T3 (enExample) |
| IL (1) | IL122242A (enExample) |
| NO (1) | NO318184B1 (enExample) |
| NZ (1) | NZ310730A (enExample) |
| PL (1) | PL185150B1 (enExample) |
| PT (1) | PT831910E (enExample) |
| RO (1) | RO118046B1 (enExample) |
| RU (1) | RU2166330C2 (enExample) |
| WO (1) | WO1996040257A1 (enExample) |
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| US6201002B1 (en) | 1997-01-10 | 2001-03-13 | Merck & Co., Inc. | Method for reducing mortality with an angiotensin II antagonist |
| ES2200310T3 (es) * | 1997-01-10 | 2004-03-01 | MERCK & CO., INC. | Uso de antagonistas de la angiotensina ii losartan y exp-3174 en el tratamiento de la insuficiencia cardiaca sintomatica. |
| US6306826B1 (en) | 1997-06-04 | 2001-10-23 | The Regents Of The University Of California | Treatment of heart failure with growth hormone |
| TR200102581T2 (tr) * | 1999-03-05 | 2002-04-22 | G.D. Searle Llc | Kardiovasküler hastalığın tedavisi için anjiyotensin konversiyon enzimi inhibitörünün ve epoksi-sterodial aldosteron antagonistinin kombinasyon terapisi. |
| US6211217B1 (en) | 1999-03-16 | 2001-04-03 | Novartis Ag | Method for reducing pericardial fibrosis and adhesion formation |
| US20030083342A1 (en) * | 2002-08-27 | 2003-05-01 | Steele Ronald Edward | Combination of organic compounds |
| EP1280533A2 (en) * | 2000-05-11 | 2003-02-05 | Pharmacia Corporation | Aldosterone antagonist composition for release during aldosterone acrophase |
| AU8576801A (en) * | 2000-06-22 | 2002-01-02 | Novartis Ag | Pharmaceutical compositions |
| ATE357257T1 (de) * | 2000-07-27 | 2007-04-15 | Pharmacia Corp | Kombinationstherapie mit epoxy-steroidalen aldosteronantagonisten und kalziumkanalblocker zur behandlung von kongestivem herzversagen |
| ES2269442T3 (es) * | 2000-07-27 | 2007-04-01 | Pharmacia Corporation | Terapia de combinacion de antagonista de aldosterona e inhibidor de ciclooxigenasa-2 para prevenir o tratar trastornos cardiovasculares relacionados con la inflamacion. |
| JP5082033B2 (ja) | 2001-12-21 | 2012-11-28 | エグゼリクシス パテント カンパニー エルエルシー | Ｌｘｒのモジュレーター |
| US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| EP1487424B1 (en) * | 2002-03-15 | 2006-09-13 | Novartis AG | 4-(4-methylpiperazin-1-ylmethyl)-n-(4-methyl-3(4-pyridin-3-yl)pyrimidin-2-yl-amino)phenyl)-benzamide for treating ang ii-mediated diseases |
| GB0212412D0 (en) * | 2002-05-29 | 2002-07-10 | Novartis Ag | Combination of organic compounds |
| CL2004000545A1 (es) * | 2003-03-18 | 2005-01-28 | Pharmacia Corp Sa Organizada B | Uso de un antagonista de los receptores de aldosterona y un antagonista de receptores de endotelina para el tratamiento o profilaxis de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopatia y enfermedades cardiovascul |
| US20050153885A1 (en) * | 2003-10-08 | 2005-07-14 | Yun Anthony J. | Treatment of conditions through modulation of the autonomic nervous system |
| WO2005039637A2 (en) * | 2003-10-17 | 2005-05-06 | Novartis Ag | Combinations of an aldosterone receptor antagonist, a diuretic and an angiotensin blocker |
| CA2568640C (en) | 2004-06-04 | 2011-08-09 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical composition containing irbesartan |
| US8569277B2 (en) | 2004-08-11 | 2013-10-29 | Palo Alto Investors | Methods of treating a subject for a condition |
| WO2006068760A2 (en) | 2004-11-19 | 2006-06-29 | The Regents Of The University Of California | Anti-inflammatory pyrazolopyrimidines |
| CN101024643A (zh) * | 2006-02-20 | 2007-08-29 | 上海艾力斯医药科技有限公司 | 咪唑－5－羧酸类衍生物、制备方法及其应用 |
| CA2909277A1 (en) | 2006-04-04 | 2007-10-11 | Kevan M. Shokat | Kinase antagonists |
| WO2009046448A1 (en) | 2007-10-04 | 2009-04-09 | Intellikine, Inc. | Chemical entities and therapeutic uses thereof |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| DK2240451T3 (da) | 2008-01-04 | 2017-11-20 | Intellikine Llc | Isoquinolinonderivater substitueret med en purin, der er anvendelig som pi3k-inhibitorer |
| EP2252293B1 (en) | 2008-03-14 | 2018-06-27 | Intellikine, LLC | Kinase inhibitors and methods of use |
| WO2009114874A2 (en) | 2008-03-14 | 2009-09-17 | Intellikine, Inc. | Benzothiazole kinase inhibitors and methods of use |
| US9096611B2 (en) | 2008-07-08 | 2015-08-04 | Intellikine Llc | Kinase inhibitors and methods of use |
| US20110224223A1 (en) | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
| WO2010036380A1 (en) | 2008-09-26 | 2010-04-01 | Intellikine, Inc. | Heterocyclic kinase inhibitors |
| US8697709B2 (en) | 2008-10-16 | 2014-04-15 | The Regents Of The University Of California | Fused ring heteroaryl kinase inhibitors |
| US8476431B2 (en) | 2008-11-03 | 2013-07-02 | Itellikine LLC | Benzoxazole kinase inhibitors and methods of use |
| AR075344A1 (es) | 2009-01-30 | 2011-03-23 | Takeda Pharmaceutical | Derivados heterociclicos nitrogenados fusionados, medicamentos que los contienen y uso de los mismos en el tratamiento de enfermedades cardiacas, renales y metabolicas, entre otras |
| EP2427195B1 (en) | 2009-05-07 | 2019-05-01 | Intellikine, LLC | Heterocyclic compounds and uses thereof |
| WO2011047384A2 (en) | 2009-10-16 | 2011-04-21 | The Regents Of The University Of California | Methods of inhibiting ire1 |
| EP2571357B1 (en) | 2010-05-21 | 2016-07-06 | Infinity Pharmaceuticals, Inc. | Chemical compounds, compositions and methods for kinase modulation |
| WO2012064973A2 (en) | 2010-11-10 | 2012-05-18 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| DK2663309T3 (en) | 2011-01-10 | 2017-06-19 | Infinity Pharmaceuticals Inc | METHODS FOR PRODUCING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| FI77669C (fi) * | 1983-04-13 | 1989-04-10 | Ciba Geigy Ag | 20-spiroxaner och analoger, som innehaoller en oeppen ring e, foerfarande foer deras framstaellning samt dessa innehaollande farmaceutiska preparat. |
| US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
| CA2053148A1 (en) * | 1990-10-16 | 1992-04-17 | Karnail Atwal | Dihydropyrimidine derivatives |
| US5049565A (en) * | 1990-12-07 | 1991-09-17 | Merck & Co., Inc. | Microbial transformation process for preparing anti-hypertensive products |
| EP0586513A1 (en) * | 1991-05-10 | 1994-03-16 | Merck & Co. Inc. | Acidic aralkyl triazole derivatives active as angiotensin ii antagonists |
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| US5529992A (en) * | 1992-04-21 | 1996-06-25 | Curators Of The University Of Missouri | Method for inhibiting myocardial fibrosis by administering an aldosterone antagonist which suppresses aldoster one receptors |
| WO1994009778A1 (en) * | 1992-10-26 | 1994-05-11 | Merck & Co., Inc. | Combinations of angiotensin-ii receptor antagonists and diuretics |
| CA2125251C (en) * | 1993-06-07 | 2005-04-26 | Yoshiyuki Inada | A pharmaceutical composition for angiotensin ii-mediated diseases |
-
1996
- 1996-06-05 AT AT96919170T patent/ATE209047T1/de not_active IP Right Cessation
- 1996-06-05 ES ES96919170T patent/ES2167571T3/es not_active Expired - Lifetime
- 1996-06-05 CN CNA2004100027960A patent/CN1522701A/zh active Pending
- 1996-06-05 NZ NZ310730A patent/NZ310730A/xx unknown
- 1996-06-05 AU AU61577/96A patent/AU725689B2/en not_active Ceased
- 1996-06-05 EP EP96919170A patent/EP0831910B1/en not_active Expired - Lifetime
- 1996-06-05 BR BR9609066A patent/BR9609066A/pt not_active Application Discontinuation
- 1996-06-05 JP JP9501678A patent/JPH11507627A/ja not_active Ceased
- 1996-06-05 IL IL12224296A patent/IL122242A/en not_active IP Right Cessation
- 1996-06-05 DK DK96919170T patent/DK0831910T3/da active
- 1996-06-05 RU RU98100250/14A patent/RU2166330C2/ru not_active IP Right Cessation
- 1996-06-05 PL PL96324001A patent/PL185150B1/pl not_active IP Right Cessation
- 1996-06-05 CZ CZ0385097A patent/CZ297975B6/cs not_active IP Right Cessation
- 1996-06-05 CN CNB961961554A patent/CN1142793C/zh not_active Expired - Fee Related
- 1996-06-05 PT PT96919170T patent/PT831910E/pt unknown
- 1996-06-05 KR KR1019970709029A patent/KR100618466B1/ko not_active Expired - Fee Related
- 1996-06-05 DE DE69617235T patent/DE69617235T2/de not_active Expired - Fee Related
- 1996-06-05 CA CA002224079A patent/CA2224079A1/en not_active Abandoned
- 1996-06-05 RO RO97-02272A patent/RO118046B1/ro unknown
- 1996-06-05 WO PCT/US1996/009335 patent/WO1996040257A1/en not_active Ceased
-
1997
- 1997-01-09 US US08/781,786 patent/US6653306B1/en not_active Expired - Fee Related
-
2004
- 2004-11-23 NO NO19975741A patent/NO318184B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ297975B6 (cs) | 2007-05-09 |
| WO1996040257A1 (en) | 1996-12-19 |
| US6653306B1 (en) | 2003-11-25 |
| NZ310730A (en) | 2001-01-26 |
| CA2224079A1 (en) | 1996-12-19 |
| IL122242A0 (en) | 1998-04-05 |
| ATE209047T1 (de) | 2001-12-15 |
| JPH11507627A (ja) | 1999-07-06 |
| NO318184B1 (no) | 2005-02-14 |
| AU6157796A (en) | 1996-12-30 |
| CN1522701A (zh) | 2004-08-25 |
| AU725689B2 (en) | 2000-10-19 |
| KR100618466B1 (ko) | 2006-12-13 |
| DK0831910T3 (da) | 2002-05-21 |
| DE69617235D1 (de) | 2002-01-03 |
| RU2166330C2 (ru) | 2001-05-10 |
| PL185150B1 (pl) | 2003-03-31 |
| ES2167571T3 (es) | 2002-05-16 |
| PT831910E (pt) | 2002-05-31 |
| RO118046B1 (ro) | 2003-01-30 |
| EP0831910A1 (en) | 1998-04-01 |
| KR19990022548A (ko) | 1999-03-25 |
| DE69617235T2 (de) | 2002-07-25 |
| EP0831910B1 (en) | 2001-11-21 |
| CZ385097A3 (cs) | 1998-06-17 |
| CN1142793C (zh) | 2004-03-24 |
| CN1192697A (zh) | 1998-09-09 |
| PL324001A1 (en) | 1998-04-27 |
| NO975741D0 (no) | 1997-12-05 |
| BR9609066A (pt) | 1999-01-26 |
| NO975741L (no) | 1998-01-29 |
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