IL121730A - PROCESS FOR THE PREPARATION OF 1-(2'-DEOXY-2-FLUORO-&beta:-L-ARABINO-FURANOSYL)-THYMINE - Google Patents

PROCESS FOR THE PREPARATION OF 1-(2'-DEOXY-2-FLUORO-&beta:-L-ARABINO-FURANOSYL)-THYMINE

Info

Publication number
IL121730A
IL121730A IL12173097A IL12173097A IL121730A IL 121730 A IL121730 A IL 121730A IL 12173097 A IL12173097 A IL 12173097A IL 12173097 A IL12173097 A IL 12173097A IL 121730 A IL121730 A IL 121730A
Authority
IL
Israel
Prior art keywords
furanosyl
arabino
thymine
deoxy
fluoro
Prior art date
Application number
IL12173097A
Other languages
English (en)
Other versions
IL121730A0 (en
Original Assignee
Univ Georgia Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgia Res Found filed Critical Univ Georgia Res Found
Publication of IL121730A0 publication Critical patent/IL121730A0/xx
Publication of IL121730A publication Critical patent/IL121730A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
IL12173097A 1997-07-23 1997-09-10 PROCESS FOR THE PREPARATION OF 1-(2'-DEOXY-2-FLUORO-&beta:-L-ARABINO-FURANOSYL)-THYMINE IL121730A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5348897P 1997-07-23 1997-07-23

Publications (2)

Publication Number Publication Date
IL121730A0 IL121730A0 (en) 1998-02-22
IL121730A true IL121730A (en) 2005-03-20

Family

ID=21984622

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12173097A IL121730A (en) 1997-07-23 1997-09-10 PROCESS FOR THE PREPARATION OF 1-(2'-DEOXY-2-FLUORO-&beta:-L-ARABINO-FURANOSYL)-THYMINE

Country Status (21)

Country Link
US (2) US6512107B2 (fr)
EP (2) EP1327637B1 (fr)
KR (1) KR100247505B1 (fr)
CN (1) CN1113892C (fr)
AR (1) AR009092A1 (fr)
AT (2) ATE304547T1 (fr)
AU (1) AU8758298A (fr)
BR (1) BR9810804B1 (fr)
DE (2) DE69831619T2 (fr)
DK (1) DK1327637T3 (fr)
ES (2) ES2249678T3 (fr)
ID (1) ID20624A (fr)
IL (1) IL121730A (fr)
IN (1) IN186807B (fr)
MY (1) MY117314A (fr)
PT (2) PT1327637E (fr)
SA (1) SA98180771B1 (fr)
SI (1) SI1327637T1 (fr)
TR (1) TR199701051A2 (fr)
TW (1) TW434252B (fr)
WO (2) WO1999005157A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW434252B (en) 1997-07-23 2001-05-16 Univ Georgia Res Found Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine
KR100449618B1 (ko) * 1998-03-27 2004-11-16 부광약품 주식회사 2'-플루오로-5-메틸-β-L-아라비노푸라노실유리딘의 제조방법
US6462191B1 (en) * 2000-07-13 2002-10-08 Air Products And Chemicals, Inc. Synthesis of 2-deoxy-2-fluoro-arabinose derivatives
CN101117346B (zh) * 2001-03-30 2012-12-12 富光药品株式会社 2'-卤代-β-L-阿拉伯呋喃糖基核苷的制备方法
KR100487992B1 (ko) * 2001-10-25 2005-05-09 부광약품 주식회사 2'-플루오로-5-메틸-β-엘-아라비노푸라노실유리딘의 황유도체
US7211570B2 (en) * 2001-12-20 2007-05-01 Pharmasset, Inc. Treatment of EBV and KHSV infection
KR100976778B1 (ko) 2003-04-17 2010-08-18 부광약품 주식회사 1-（2'-플루오로-베타-엘-아라비노푸라노실）티민의 황 유도체를 유효 활성 성분으로 하는 b형 간염 바이러스 치료제
SI3109244T1 (sl) 2004-09-14 2019-06-28 Gilead Pharmasset Llc Priprava 2'fluoro-2'-alkil-substituiranih ali drugih neobvezno substituiranih ribofuranozil pirimidinov in purinov in njihovih derivatov
BRPI0613796A2 (pt) * 2005-06-07 2011-02-15 Univ Yale composicões farmacêuticas e seus usos, e métodos de tratamento de cáncer e outras condições ou estados patológicos, por meio do uso de clevudina (lfmau) e telbivudina (ldt)
RU2443703C2 (ru) 2007-06-18 2012-02-27 Саншайн Лейк Фарма Ко., Лтд Бром-фенил замещенные тиазолилдигидропиримидины
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
AU2019216531A1 (en) 2018-02-02 2020-09-24 Maverix Oncology, Inc. Small molecule drug conjugates of gemcitabine monophosphate
CN109320564B (zh) * 2018-10-26 2022-05-31 浙江晟格生物科技有限公司 一种l-来苏糖的制备工艺
CN109467541A (zh) * 2018-11-17 2019-03-15 扬州工业职业技术学院 一种绿色合成克拉夫定药物中间体的方法
CN109467583A (zh) * 2018-11-17 2019-03-15 扬州工业职业技术学院 一种克拉夫定的绿色合成工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3714473A1 (de) * 1987-04-30 1988-11-10 Basf Ag Kontinuierliches verfahren zur epimerisierung von zuckern, insbesondere von d-arabinose zu d-ribose
JP2784230B2 (ja) 1988-02-09 1998-08-06 ユーオーピー・インコーポレーテッド エピマーアルドースおよびアルドース同族体の連続相互変換に用いる固体触媒
DE4002727A1 (de) * 1990-01-31 1991-08-01 Bayer Ag Mischungen aus waessrigen polymerdispersionen
US5587362A (en) 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
US5808040A (en) 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
TW434252B (en) 1997-07-23 2001-05-16 Univ Georgia Res Found Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine

Also Published As

Publication number Publication date
DE69831619D1 (de) 2005-10-20
WO1999005157A1 (fr) 1999-02-04
DE69812959D1 (de) 2003-05-08
IN186807B (fr) 2001-11-10
PT1327637E (pt) 2005-11-30
US20020062018A1 (en) 2002-05-23
EP0998482A1 (fr) 2000-05-10
EP1327637A1 (fr) 2003-07-16
MY117314A (en) 2004-06-30
ATE236187T1 (de) 2003-04-15
DE69831619T2 (de) 2006-06-14
WO1999005158A1 (fr) 1999-02-04
TR199701051A3 (tr) 1999-03-22
PT998482E (pt) 2003-08-29
KR19990013297A (ko) 1999-02-25
SA98180771B1 (ar) 2006-10-29
TR199701051A2 (xx) 1999-03-22
BR9810804A (pt) 2000-09-12
AR009092A1 (es) 2000-03-08
TW434252B (en) 2001-05-16
ES2249678T3 (es) 2006-04-01
DK1327637T3 (da) 2006-01-16
ATE304547T1 (de) 2005-09-15
SI1327637T1 (sl) 2005-12-31
CN1206012A (zh) 1999-01-27
EP0998482B1 (fr) 2003-04-02
IL121730A0 (en) 1998-02-22
DE69812959T2 (de) 2004-03-04
US20030139593A1 (en) 2003-07-24
ID20624A (id) 1999-01-28
ES2195370T3 (es) 2003-12-01
CN1113892C (zh) 2003-07-09
AU8758298A (en) 1999-02-16
EP1327637B1 (fr) 2005-09-14
KR100247505B1 (ko) 2000-03-15
BR9810804B1 (pt) 2012-01-10
US6894159B2 (en) 2005-05-17
US6512107B2 (en) 2003-01-28

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