IL120310A - מעכבי סרין פרוטאז ותכשירי רוקחות המכילים אותם - Google Patents
מעכבי סרין פרוטאז ותכשירי רוקחות המכילים אותםInfo
- Publication number
- IL120310A IL120310A IL12031097A IL12031097A IL120310A IL 120310 A IL120310 A IL 120310A IL 12031097 A IL12031097 A IL 12031097A IL 12031097 A IL12031097 A IL 12031097A IL 120310 A IL120310 A IL 120310A
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- pro
- chr2
- boc
- cha
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96200543 | 1996-03-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL120310A0 IL120310A0 (en) | 1997-06-10 |
| IL120310A true IL120310A (he) | 2002-02-10 |
Family
ID=8223736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12031097A IL120310A (he) | 1996-03-01 | 1997-02-25 | מעכבי סרין פרוטאז ותכשירי רוקחות המכילים אותם |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6410684B1 (he) |
| EP (1) | EP0886647B1 (he) |
| JP (1) | JP2000506837A (he) |
| KR (1) | KR19990087415A (he) |
| CN (1) | CN1212704A (he) |
| AR (1) | AR006310A1 (he) |
| AT (1) | ATE221080T1 (he) |
| AU (1) | AU709330B2 (he) |
| BR (1) | BR9707808A (he) |
| CA (1) | CA2246246A1 (he) |
| CZ (1) | CZ277898A3 (he) |
| DE (1) | DE69714222T2 (he) |
| DK (1) | DK0886647T3 (he) |
| ES (1) | ES2180933T3 (he) |
| HK (1) | HK1021541A1 (he) |
| HU (1) | HUP9900390A3 (he) |
| IL (1) | IL120310A (he) |
| NO (1) | NO983991L (he) |
| NZ (1) | NZ331484A (he) |
| PL (1) | PL328875A1 (he) |
| PT (1) | PT886647E (he) |
| RU (1) | RU2178419C2 (he) |
| TR (1) | TR199801704T2 (he) |
| TW (1) | TW442452B (he) |
| WO (1) | WO1997031937A1 (he) |
| ZA (1) | ZA971667B (he) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1007544A1 (en) * | 1996-02-13 | 2000-06-14 | Akzo Nobel N.V. | Serine protease inhibitors |
| CA2289625A1 (en) | 1997-05-15 | 1998-11-19 | Charles Van Jackson | Antithrombotic compound |
| CN1198838C (zh) | 1998-04-30 | 2005-04-27 | 阿格罗尼制药公司 | 抗小rna病毒化合物及其制备方法和用途 |
| AU9031598A (en) * | 1998-08-17 | 2000-03-06 | Cortech, Inc. | Serine protease inhibitors comprising alpha-keto heterocycles |
| WO2000051624A2 (en) | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Methods and compositions useful in inhibiting apoptosis |
| US6849605B1 (en) | 1999-03-05 | 2005-02-01 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of viral infections |
| AU3511500A (en) | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions |
| ES2230135T3 (es) * | 1999-08-04 | 2005-05-01 | Agouron Pharmaceuticals, Inc. | Compuestos y composiciones anti-picornavirales; utilizaciones farmaceuticas y materiales utilizados para su sintesis. |
| PL365470A1 (en) | 2000-06-14 | 2005-01-10 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis |
| HUP0303358A3 (en) * | 2000-07-21 | 2005-10-28 | Schering Corp | Novel peptides as ns3-serine protease inhibitors of hepatitis c virus and pharmaceutical compositions containing them |
| US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
| DK1385870T3 (da) | 2000-07-21 | 2010-07-05 | Schering Corp | Peptider som inhibitorer af NS3-serinprotease fra hepatitis C-virus |
| JP2004518688A (ja) | 2001-01-30 | 2004-06-24 | ブリストル−マイヤーズ スクイブ カンパニー | ファクターＸａ阻害剤のスルホンアミドラクタムおよびその方法 |
| US7405210B2 (en) * | 2003-05-21 | 2008-07-29 | Osi Pharmaceuticals, Inc. | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase |
| EP1725555B1 (en) | 2004-03-08 | 2010-10-06 | Prosidion Ltd. | Pyrrolopyridine-2-carboxylic acid hydrazides as inhibitors of glycogen phosphorylase |
| WO2006059164A2 (en) | 2004-12-02 | 2006-06-08 | Prosidion Limited | Pyrrolopyridine-2-carboxylic acid amides |
| MX2011003803A (es) * | 2008-10-15 | 2011-07-04 | Danisco Inc | Inhibidores de proteasa de bowman birk, variantes, modificados. |
| JP7164521B2 (ja) | 2016-06-21 | 2022-11-01 | オリオン・オフサルモロジー・エルエルシー | 炭素環式プロリンアミド誘導体 |
| CN114685453A (zh) | 2016-06-21 | 2022-07-01 | 奥瑞恩眼科有限责任公司 | 杂环脯氨酰胺衍生物 |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4556655A (en) * | 1984-09-24 | 1985-12-03 | Schering Corporation | Antihypertensive compounds having both diuretic and angiotensin converting enzyme inhibitory activity |
| ZW11290A1 (en) * | 1989-07-14 | 1990-10-31 | Smithkline Beecham Corp | Hemoregulatory peptides |
| JP3486412B2 (ja) * | 1993-04-30 | 2004-01-13 | メルク エンド カンパニー インコーポレーテッド | トロンビン阻害剤 |
| SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| ZA951617B (en) * | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
| ZA951618B (en) | 1994-03-04 | 1996-08-27 | Lilly Co Eli | Antithrombotic agents |
| US5561146A (en) | 1994-06-10 | 1996-10-01 | Bristol-Myers Squibb Company | Modified guanidino and amidino thrombin inhibitors |
| JPH10503176A (ja) | 1994-06-17 | 1998-03-24 | コーバス インターナショナル， インコーポレイテッド | 酵素インヒビターとしての３−アミノ−２−オキソ−１−ピペリジン酢酸誘導体 |
| JPH0820597A (ja) * | 1994-07-07 | 1996-01-23 | Meiji Seika Kaisha Ltd | トロンビン阻害作用を有する複素環カルボニル化合物 |
| SK83897A3 (en) | 1994-12-22 | 1998-05-06 | Iaf Biochem Int | Low molecular weight bicyclic thrombin inhibitors |
-
1997
- 1997-02-25 IL IL12031097A patent/IL120310A/he not_active IP Right Cessation
- 1997-02-25 TW TW086102261A patent/TW442452B/zh not_active IP Right Cessation
- 1997-02-26 BR BR9707808A patent/BR9707808A/pt not_active Application Discontinuation
- 1997-02-26 TR TR1998/01704T patent/TR199801704T2/xx unknown
- 1997-02-26 HU HU9900390A patent/HUP9900390A3/hu unknown
- 1997-02-26 WO PCT/EP1997/000938 patent/WO1997031937A1/en not_active Application Discontinuation
- 1997-02-26 RU RU98117949/04A patent/RU2178419C2/ru active
- 1997-02-26 JP JP9530600A patent/JP2000506837A/ja not_active Ceased
- 1997-02-26 EP EP97905099A patent/EP0886647B1/en not_active Expired - Lifetime
- 1997-02-26 CA CA002246246A patent/CA2246246A1/en not_active Abandoned
- 1997-02-26 ZA ZA9701667A patent/ZA971667B/xx unknown
- 1997-02-26 AU AU18775/97A patent/AU709330B2/en not_active Ceased
- 1997-02-26 DE DE69714222T patent/DE69714222T2/de not_active Expired - Fee Related
- 1997-02-26 NZ NZ331484A patent/NZ331484A/xx unknown
- 1997-02-26 PT PT97905099T patent/PT886647E/pt unknown
- 1997-02-26 PL PL97328875A patent/PL328875A1/xx unknown
- 1997-02-26 CZ CZ982778A patent/CZ277898A3/cs unknown
- 1997-02-26 DK DK97905099T patent/DK0886647T3/da active
- 1997-02-26 CN CN97192682A patent/CN1212704A/zh active Pending
- 1997-02-26 ES ES97905099T patent/ES2180933T3/es not_active Expired - Lifetime
- 1997-02-26 US US09/142,110 patent/US6410684B1/en not_active Expired - Fee Related
- 1997-02-26 KR KR1019980706833A patent/KR19990087415A/ko not_active Application Discontinuation
- 1997-02-26 AT AT97905099T patent/ATE221080T1/de not_active IP Right Cessation
- 1997-03-03 AR ARP970100833A patent/AR006310A1/es unknown
-
1998
- 1998-08-31 NO NO983991A patent/NO983991L/no not_active Application Discontinuation
-
1999
- 1999-06-22 HK HK99102658A patent/HK1021541A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69714222T2 (de) | 2003-02-20 |
| CZ277898A3 (cs) | 1999-06-16 |
| DE69714222D1 (de) | 2002-08-29 |
| NO983991D0 (no) | 1998-08-31 |
| PT886647E (pt) | 2002-12-31 |
| BR9707808A (pt) | 1999-07-27 |
| EP0886647A1 (en) | 1998-12-30 |
| ATE221080T1 (de) | 2002-08-15 |
| CA2246246A1 (en) | 1997-09-04 |
| US6410684B1 (en) | 2002-06-25 |
| EP0886647B1 (en) | 2002-07-24 |
| HK1021541A1 (en) | 2000-06-16 |
| JP2000506837A (ja) | 2000-06-06 |
| AU1877597A (en) | 1997-09-16 |
| DK0886647T3 (da) | 2002-11-04 |
| CN1212704A (zh) | 1999-03-31 |
| AR006310A1 (es) | 1999-08-25 |
| TW442452B (en) | 2001-06-23 |
| TR199801704T2 (xx) | 1998-12-21 |
| PL328875A1 (en) | 1999-03-01 |
| ES2180933T3 (es) | 2003-02-16 |
| NO983991L (no) | 1998-10-30 |
| IL120310A0 (en) | 1997-06-10 |
| HUP9900390A2 (hu) | 1999-06-28 |
| ZA971667B (en) | 1997-09-10 |
| WO1997031937A1 (en) | 1997-09-04 |
| RU2178419C2 (ru) | 2002-01-20 |
| HUP9900390A3 (en) | 2000-11-28 |
| KR19990087415A (ko) | 1999-12-27 |
| AU709330B2 (en) | 1999-08-26 |
| NZ331484A (en) | 2000-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| RH1 | Patent not in force |