IL119778A - Neuropretective pharmaceutical compositions containing rapamycin derivatives - Google Patents
Neuropretective pharmaceutical compositions containing rapamycin derivativesInfo
- Publication number
- IL119778A IL119778A IL11977896A IL11977896A IL119778A IL 119778 A IL119778 A IL 119778A IL 11977896 A IL11977896 A IL 11977896A IL 11977896 A IL11977896 A IL 11977896A IL 119778 A IL119778 A IL 119778A
- Authority
- IL
- Israel
- Prior art keywords
- neuropretective
- pharmaceutical compositions
- compositions containing
- rapamycin derivatives
- containing rapamycin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US833795P | 1995-12-07 | 1995-12-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL119778A0 IL119778A0 (en) | 1997-03-18 |
| IL119778A true IL119778A (en) | 1999-07-14 |
Family
ID=21731060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11977896A IL119778A (en) | 1995-12-07 | 1996-12-06 | Neuropretective pharmaceutical compositions containing rapamycin derivatives |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0778023B1 (de) |
| JP (1) | JPH09183727A (de) |
| KR (1) | KR970032856A (de) |
| CN (1) | CN1112925C (de) |
| AR (1) | AR008747A1 (de) |
| AT (1) | ATE234095T1 (de) |
| AU (1) | AU700653B2 (de) |
| BR (1) | BR9605895A (de) |
| CA (1) | CA2192298A1 (de) |
| CZ (2) | CZ6498A3 (de) |
| DE (1) | DE69626610T2 (de) |
| DK (1) | DK0778023T3 (de) |
| ES (1) | ES2188730T3 (de) |
| HU (1) | HUP9603370A3 (de) |
| IL (1) | IL119778A (de) |
| MX (1) | MX9606131A (de) |
| NO (1) | NO309966B1 (de) |
| NZ (1) | NZ299888A (de) |
| PT (1) | PT778023E (de) |
| SI (1) | SI0778023T1 (de) |
| SK (1) | SK154796A3 (de) |
| TW (1) | TW427904B (de) |
| ZA (1) | ZA9610245B (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1002535A1 (de) * | 1998-10-28 | 2000-05-24 | Hrissanthi Ikonomidou | Neue Verwendung von Glutamat-Antagonisten zur Behandlung von Krebs |
| US6417189B1 (en) * | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
| US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
| FR2806626B1 (fr) * | 2000-03-22 | 2003-11-28 | Centre Nat Rech Scient | Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues |
| WO2001079177A1 (en) * | 2000-04-17 | 2001-10-25 | Gpi Nil Holdings, Inc. | Cyclic diaza compounds for treating neurodegenerative disorders |
| GB0117645D0 (en) | 2001-07-19 | 2001-09-12 | Isis Innovation | Therapeutic stratergies for prevention and treatment of alzheimers disease |
| UA78529C2 (en) * | 2001-10-10 | 2007-04-10 | Wyeth Corp | Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain |
| US20030176455A1 (en) * | 2002-03-13 | 2003-09-18 | Wyeth | Method of inhibiting cell death |
| ATE481103T1 (de) | 2003-04-09 | 2010-10-15 | Wyeth Llc | Derivate von 2-(8,9-dioxo-2,6- diazabicyclo(5.2.0)non-1(7)-en-2- yl)alkylphosphonsäure und deren verwendung als n- methyl-d-aspartat- (nmda-) rezeptorantagonisten |
| EP1622625A1 (de) * | 2003-04-09 | 2006-02-08 | Wyeth | Pharmazeutische zusammensetzungen für die intranasale verabreichung von [2-(8,9-dioxo-2,6-diazabicyclo [5.2.0] non-1 (7)-en-2-yl)alkyl] phosphonsäure und derivaten und anwendungsverfahren dafür |
| US20070155771A1 (en) * | 2003-04-11 | 2007-07-05 | David Rubinsztein | Methods and means for treating protein conformational disorders |
| US7485706B2 (en) * | 2003-07-30 | 2009-02-03 | The Board Of Trustees Of The Leland Stanford Junior University | Neurodegenerative protein aggregation inhibition methods and compounds |
| TW200514775A (en) | 2003-10-22 | 2005-05-01 | Wyeth Corp | Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid and esters thereof |
| MX2007007409A (es) | 2004-12-20 | 2007-07-12 | Wyeth Corp | Derivados de rapamicina y los usos de los mismos en el tratamiento de trastornos neurologicos. |
| ES2380779T3 (es) | 2004-12-20 | 2012-05-18 | Wyeth Llc | Análogos de rapamicina y usos de los mismos en el tratamiento de trastornos neurológicos, proliferativos e inflamatorios |
| JP4857071B2 (ja) * | 2006-10-12 | 2012-01-18 | 潤平 笹部 | 筋萎縮性側策硬化症（ａｌｓ）の検出方法 |
| EP2065038A1 (de) | 2007-11-30 | 2009-06-03 | Pharnext | Neue therapeutische Ansätze zur Behandlung der Charcot-Marie-Tooth Krankheit |
| EP2135607A1 (de) | 2008-06-18 | 2009-12-23 | Pharnext | Kombination aus Pilocarpin und Methimazol zur Behandlung der Charcot-Marie-Tooth Krankheit und verwandten Erkrankungen |
| CN102612564B (zh) * | 2009-04-10 | 2015-08-26 | 齐海燕 | 新的抗衰老试剂及其鉴别方法 |
| US9393241B2 (en) | 2009-06-02 | 2016-07-19 | Pharnext | Compositions for treating CMT and related disorders |
| EP2263665A1 (de) * | 2009-06-02 | 2010-12-22 | Pharnext | Neue Zusammensetzungen zur Behandlung von CMT und verwandten Erkrankungen |
| US20120122913A1 (en) * | 2009-07-24 | 2012-05-17 | Institut National De La Recherche Scientifque | Combination of curcuminoids and mtor inhibitors for the treatment of tauopathies |
| US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| US9121859B2 (en) * | 2012-12-04 | 2015-09-01 | Siemens Healthcare Diagnostics Inc. | Compounds and methods for determination of FKBP-binding immunosuppressant drugs |
| CN105473131A (zh) | 2013-06-05 | 2016-04-06 | 法奈克斯公司 | 用于组合的活性药物成分的稳定口服溶液 |
| US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
| US10383870B2 (en) | 2016-06-10 | 2019-08-20 | Pharnext | Early treatment of CMT disease |
| KR20200088856A (ko) * | 2017-11-15 | 2020-07-23 | 벤더르빌트 유니버시티 | 리소좀 기능의 개선 및 퇴행성 신경 질환의 치료를 위한 방법 및 조성물 |
| CN114366738A (zh) * | 2021-12-20 | 2022-04-19 | 中国人民解放军军事科学院军事医学研究院 | 雷帕霉素在促进神经干细胞扩增中的用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206018A (en) * | 1978-11-03 | 1993-04-27 | Ayerst, Mckenna & Harrison, Inc. | Use of rapamycin in treatment of tumors |
| JPH04230389A (ja) * | 1990-07-16 | 1992-08-19 | American Home Prod Corp | ラパマイシン誘導体 |
| US5078999A (en) * | 1991-02-22 | 1992-01-07 | American Home Products Corporation | Method of treating systemic lupus erythematosus |
| IL101353A0 (en) * | 1991-04-03 | 1992-11-15 | American Home Prod | Pharmaceutical compositions for treating diabetes |
| DE4118740A1 (de) * | 1991-06-05 | 1992-12-10 | Schering Ag | Neue kombinationspraeparate zur behandlung des morbus parkinson |
| IL102414A (en) * | 1991-07-25 | 1996-08-04 | Univ Louisville Res Found | Medicinal preparations for the treatment of ocular inflammation, containing rapamycin |
| US5260299A (en) * | 1992-03-05 | 1993-11-09 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-Carboalkoxy)Sulfamates Useful as Immunosuppressive Agents |
| IL111003A0 (en) * | 1993-09-30 | 1994-11-28 | American Home Prod | Multi-component oral rapamycin formulation |
-
1996
- 1996-11-28 TW TW085114700A patent/TW427904B/zh not_active IP Right Cessation
- 1996-12-04 PT PT96308786T patent/PT778023E/pt unknown
- 1996-12-04 CZ CZ9864A patent/CZ6498A3/cs unknown
- 1996-12-04 SK SK1547-96A patent/SK154796A3/sk unknown
- 1996-12-04 SI SI9630586T patent/SI0778023T1/xx unknown
- 1996-12-04 ES ES96308786T patent/ES2188730T3/es not_active Expired - Lifetime
- 1996-12-04 DE DE69626610T patent/DE69626610T2/de not_active Expired - Fee Related
- 1996-12-04 DK DK96308786T patent/DK0778023T3/da active
- 1996-12-04 EP EP96308786A patent/EP0778023B1/de not_active Expired - Lifetime
- 1996-12-04 CZ CZ963544A patent/CZ354496A3/cs unknown
- 1996-12-04 AT AT96308786T patent/ATE234095T1/de not_active IP Right Cessation
- 1996-12-05 NZ NZ299888A patent/NZ299888A/en unknown
- 1996-12-05 AU AU74178/96A patent/AU700653B2/en not_active Ceased
- 1996-12-05 KR KR1019960062011A patent/KR970032856A/ko not_active Application Discontinuation
- 1996-12-05 ZA ZA9610245A patent/ZA9610245B/xx unknown
- 1996-12-05 MX MX9606131A patent/MX9606131A/es unknown
- 1996-12-06 JP JP8326582A patent/JPH09183727A/ja active Pending
- 1996-12-06 HU HU9603370A patent/HUP9603370A3/hu unknown
- 1996-12-06 NO NO965238A patent/NO309966B1/no not_active IP Right Cessation
- 1996-12-06 BR BR9605895A patent/BR9605895A/pt not_active Application Discontinuation
- 1996-12-06 AR ARP960105543A patent/AR008747A1/es not_active Application Discontinuation
- 1996-12-06 CA CA002192298A patent/CA2192298A1/en not_active Abandoned
- 1996-12-06 CN CN96123098A patent/CN1112925C/zh not_active Expired - Fee Related
- 1996-12-06 IL IL11977896A patent/IL119778A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO965238D0 (no) | 1996-12-06 |
| KR970032856A (ko) | 1997-07-22 |
| HU9603370D0 (en) | 1997-01-28 |
| SK154796A3 (en) | 1997-09-10 |
| NO965238L (no) | 1997-06-09 |
| NO309966B1 (no) | 2001-04-30 |
| DE69626610D1 (de) | 2003-04-17 |
| AU700653B2 (en) | 1999-01-14 |
| BR9605895A (pt) | 1998-08-18 |
| HUP9603370A2 (en) | 1997-05-28 |
| CN1159915A (zh) | 1997-09-24 |
| CZ354496A3 (cs) | 1998-03-18 |
| IL119778A0 (en) | 1997-03-18 |
| CA2192298A1 (en) | 1997-06-08 |
| ZA9610245B (en) | 1998-06-05 |
| HUP9603370A3 (en) | 1998-12-28 |
| CN1112925C (zh) | 2003-07-02 |
| EP0778023A1 (de) | 1997-06-11 |
| PT778023E (pt) | 2003-06-30 |
| CZ6498A3 (cs) | 1998-06-17 |
| JPH09183727A (ja) | 1997-07-15 |
| EP0778023B1 (de) | 2003-03-12 |
| AU7417896A (en) | 1997-06-12 |
| SI0778023T1 (en) | 2003-08-31 |
| DK0778023T3 (da) | 2003-06-30 |
| ES2188730T3 (es) | 2003-07-01 |
| ATE234095T1 (de) | 2003-03-15 |
| DE69626610T2 (de) | 2003-10-02 |
| TW427904B (en) | 2001-04-01 |
| MX9606131A (es) | 1997-08-30 |
| NZ299888A (en) | 2001-02-23 |
| AR008747A1 (es) | 2000-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| FF | Patent granted | ||
| HCA | Change of name of proprietor(s) after amalgamation | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |