SI0778023T1 - Product comprising rapamycin or particular derivatives and an NMDA or AMPA antagonist for use for the treatment of epilepsy or Huntington's Disease, and the use of rapamycin or particular derivatives for the manufacture of a medicament for the treatment of epilepsy or Huntington's Disease. - Google Patents
Product comprising rapamycin or particular derivatives and an NMDA or AMPA antagonist for use for the treatment of epilepsy or Huntington's Disease, and the use of rapamycin or particular derivatives for the manufacture of a medicament for the treatment of epilepsy or Huntington's Disease.Info
- Publication number
- SI0778023T1 SI0778023T1 SI9630586T SI9630586T SI0778023T1 SI 0778023 T1 SI0778023 T1 SI 0778023T1 SI 9630586 T SI9630586 T SI 9630586T SI 9630586 T SI9630586 T SI 9630586T SI 0778023 T1 SI0778023 T1 SI 0778023T1
- Authority
- SI
- Slovenia
- Prior art keywords
- rapamycin
- huntington
- epilepsy
- disease
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US833795P | 1995-12-07 | 1995-12-07 | |
EP96308786A EP0778023B1 (de) | 1995-12-07 | 1996-12-04 | Produkt enthaltend Rapamycin oder ausgewählte Derivate und einen NMDA- oder AMPA-Antagonisten zur Verwendung für die Behandlung von Epilepsie oder Morbus Huntington, und die Verwendung von Rapamycin oder von ausgewählten Derivaten für die Herstellung eines Medikaments für die Behandlung von Epilepsie oder Morbus Huntington. |
Publications (1)
Publication Number | Publication Date |
---|---|
SI0778023T1 true SI0778023T1 (en) | 2003-08-31 |
Family
ID=21731060
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9630586T SI0778023T1 (en) | 1995-12-07 | 1996-12-04 | Product comprising rapamycin or particular derivatives and an NMDA or AMPA antagonist for use for the treatment of epilepsy or Huntington's Disease, and the use of rapamycin or particular derivatives for the manufacture of a medicament for the treatment of epilepsy or Huntington's Disease. |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP0778023B1 (de) |
JP (1) | JPH09183727A (de) |
KR (1) | KR970032856A (de) |
CN (1) | CN1112925C (de) |
AR (1) | AR008747A1 (de) |
AT (1) | ATE234095T1 (de) |
AU (1) | AU700653B2 (de) |
BR (1) | BR9605895A (de) |
CA (1) | CA2192298A1 (de) |
CZ (2) | CZ354496A3 (de) |
DE (1) | DE69626610T2 (de) |
DK (1) | DK0778023T3 (de) |
ES (1) | ES2188730T3 (de) |
HU (1) | HUP9603370A3 (de) |
IL (1) | IL119778A (de) |
MX (1) | MX9606131A (de) |
NO (1) | NO309966B1 (de) |
NZ (1) | NZ299888A (de) |
PT (1) | PT778023E (de) |
SI (1) | SI0778023T1 (de) |
SK (1) | SK154796A3 (de) |
TW (1) | TW427904B (de) |
ZA (1) | ZA9610245B (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1002535A1 (de) * | 1998-10-28 | 2000-05-24 | Hrissanthi Ikonomidou | Neue Verwendung von Glutamat-Antagonisten zur Behandlung von Krebs |
US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
US6417189B1 (en) * | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
FR2806626B1 (fr) * | 2000-03-22 | 2003-11-28 | Centre Nat Rech Scient | Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues |
WO2001079177A1 (en) * | 2000-04-17 | 2001-10-25 | Gpi Nil Holdings, Inc. | Cyclic diaza compounds for treating neurodegenerative disorders |
GB0117645D0 (en) * | 2001-07-19 | 2001-09-12 | Isis Innovation | Therapeutic stratergies for prevention and treatment of alzheimers disease |
UA78529C2 (en) | 2001-10-10 | 2007-04-10 | Wyeth Corp | Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain |
US20030176455A1 (en) * | 2002-03-13 | 2003-09-18 | Wyeth | Method of inhibiting cell death |
CN1802161A (zh) * | 2003-04-09 | 2006-07-12 | 惠氏公司 | [2-(8,9-二氧代-2,6-二氮杂双环[5.2.0]壬-1(7)-烯-2-基)烷基]-膦酸及其衍生物的鼻内给药药用组合物及用法 |
US7253153B2 (en) | 2003-04-09 | 2007-08-07 | Wyeth | Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and methods of use thereof |
WO2004089369A2 (en) * | 2003-04-11 | 2004-10-21 | Cambridge University Technical Services Limited | Methods and means for treating protein conformational disorders |
US7485706B2 (en) * | 2003-07-30 | 2009-02-03 | The Board Of Trustees Of The Leland Stanford Junior University | Neurodegenerative protein aggregation inhibition methods and compounds |
TW200514775A (en) | 2003-10-22 | 2005-05-01 | Wyeth Corp | Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid and esters thereof |
ATE549342T1 (de) * | 2004-12-20 | 2012-03-15 | Wyeth Llc | Rapamycinanaloge und deren verwendungen bei der behandlung proliferativer, entzündlicher und neurologischer störungen |
EP1828203A2 (de) | 2004-12-20 | 2007-09-05 | Wyeth | Rapamycinderivate und ihre verwendung bei der behandlung von nervenerkrankungen |
JP4857071B2 (ja) * | 2006-10-12 | 2012-01-18 | 潤平 笹部 | 筋萎縮性側策硬化症(als)の検出方法 |
EP2065038A1 (de) | 2007-11-30 | 2009-06-03 | Pharnext | Neue therapeutische Ansätze zur Behandlung der Charcot-Marie-Tooth Krankheit |
EP2135607A1 (de) | 2008-06-18 | 2009-12-23 | Pharnext | Kombination aus Pilocarpin und Methimazol zur Behandlung der Charcot-Marie-Tooth Krankheit und verwandten Erkrankungen |
ES2685947T3 (es) * | 2009-04-10 | 2018-10-15 | Haiyan Qi | Agentes antienvejecimiento |
EP2263665A1 (de) * | 2009-06-02 | 2010-12-22 | Pharnext | Neue Zusammensetzungen zur Behandlung von CMT und verwandten Erkrankungen |
US9393241B2 (en) | 2009-06-02 | 2016-07-19 | Pharnext | Compositions for treating CMT and related disorders |
EP2456437A4 (de) * | 2009-07-24 | 2013-01-09 | Inst Nat Rech Scient | Kombinationen aus curcumoiden- und mtor-hemmern für die behandlung von tauopathien |
US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
US9121859B2 (en) * | 2012-12-04 | 2015-09-01 | Siemens Healthcare Diagnostics Inc. | Compounds and methods for determination of FKBP-binding immunosuppressant drugs |
JP6300906B2 (ja) | 2013-06-05 | 2018-03-28 | ファーネクストPharnext | 併用医薬有効成分(api)用安定性経口液剤 |
US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
US10383870B2 (en) | 2016-06-10 | 2019-08-20 | Pharnext | Early treatment of CMT disease |
US20200354445A1 (en) * | 2017-11-15 | 2020-11-12 | Vanderbilt University | Methods and compositions for the improvement of lysosomal function and treatment of neurodegenerative disease |
CN114366738A (zh) * | 2021-12-20 | 2022-04-19 | 中国人民解放军军事科学院军事医学研究院 | 雷帕霉素在促进神经干细胞扩增中的用途 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5206018A (en) * | 1978-11-03 | 1993-04-27 | Ayerst, Mckenna & Harrison, Inc. | Use of rapamycin in treatment of tumors |
JPH04230389A (ja) * | 1990-07-16 | 1992-08-19 | American Home Prod Corp | ラパマイシン誘導体 |
US5078999A (en) * | 1991-02-22 | 1992-01-07 | American Home Products Corporation | Method of treating systemic lupus erythematosus |
IL101353A0 (en) * | 1991-04-03 | 1992-11-15 | American Home Prod | Pharmaceutical compositions for treating diabetes |
DE4118740A1 (de) * | 1991-06-05 | 1992-12-10 | Schering Ag | Neue kombinationspraeparate zur behandlung des morbus parkinson |
IL102414A (en) * | 1991-07-25 | 1996-08-04 | Univ Louisville Res Found | Medicinal preparations for the treatment of ocular inflammation, containing rapamycin |
US5260299A (en) * | 1992-03-05 | 1993-11-09 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-Carboalkoxy)Sulfamates Useful as Immunosuppressive Agents |
IL111003A0 (en) * | 1993-09-30 | 1994-11-28 | American Home Prod | Multi-component oral rapamycin formulation |
-
1996
- 1996-11-28 TW TW085114700A patent/TW427904B/zh not_active IP Right Cessation
- 1996-12-04 DE DE69626610T patent/DE69626610T2/de not_active Expired - Fee Related
- 1996-12-04 SI SI9630586T patent/SI0778023T1/xx unknown
- 1996-12-04 AT AT96308786T patent/ATE234095T1/de not_active IP Right Cessation
- 1996-12-04 ES ES96308786T patent/ES2188730T3/es not_active Expired - Lifetime
- 1996-12-04 DK DK96308786T patent/DK0778023T3/da active
- 1996-12-04 EP EP96308786A patent/EP0778023B1/de not_active Expired - Lifetime
- 1996-12-04 CZ CZ963544A patent/CZ354496A3/cs unknown
- 1996-12-04 PT PT96308786T patent/PT778023E/pt unknown
- 1996-12-04 SK SK1547-96A patent/SK154796A3/sk unknown
- 1996-12-04 CZ CZ9864A patent/CZ6498A3/cs unknown
- 1996-12-05 ZA ZA9610245A patent/ZA9610245B/xx unknown
- 1996-12-05 KR KR1019960062011A patent/KR970032856A/ko not_active Application Discontinuation
- 1996-12-05 MX MX9606131A patent/MX9606131A/es unknown
- 1996-12-05 AU AU74178/96A patent/AU700653B2/en not_active Ceased
- 1996-12-05 NZ NZ299888A patent/NZ299888A/en unknown
- 1996-12-06 BR BR9605895A patent/BR9605895A/pt not_active Application Discontinuation
- 1996-12-06 JP JP8326582A patent/JPH09183727A/ja active Pending
- 1996-12-06 CA CA002192298A patent/CA2192298A1/en not_active Abandoned
- 1996-12-06 IL IL11977896A patent/IL119778A/xx not_active IP Right Cessation
- 1996-12-06 HU HU9603370A patent/HUP9603370A3/hu unknown
- 1996-12-06 CN CN96123098A patent/CN1112925C/zh not_active Expired - Fee Related
- 1996-12-06 AR ARP960105543A patent/AR008747A1/es not_active Application Discontinuation
- 1996-12-06 NO NO965238A patent/NO309966B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69626610D1 (de) | 2003-04-17 |
ES2188730T3 (es) | 2003-07-01 |
CA2192298A1 (en) | 1997-06-08 |
CN1159915A (zh) | 1997-09-24 |
AU7417896A (en) | 1997-06-12 |
CZ6498A3 (cs) | 1998-06-17 |
ATE234095T1 (de) | 2003-03-15 |
IL119778A (en) | 1999-07-14 |
KR970032856A (ko) | 1997-07-22 |
PT778023E (pt) | 2003-06-30 |
TW427904B (en) | 2001-04-01 |
DE69626610T2 (de) | 2003-10-02 |
HUP9603370A2 (en) | 1997-05-28 |
NO965238D0 (no) | 1996-12-06 |
AR008747A1 (es) | 2000-02-23 |
HUP9603370A3 (en) | 1998-12-28 |
BR9605895A (pt) | 1998-08-18 |
IL119778A0 (en) | 1997-03-18 |
CN1112925C (zh) | 2003-07-02 |
EP0778023A1 (de) | 1997-06-11 |
MX9606131A (es) | 1997-08-30 |
EP0778023B1 (de) | 2003-03-12 |
CZ354496A3 (cs) | 1998-03-18 |
NO965238L (no) | 1997-06-09 |
HU9603370D0 (en) | 1997-01-28 |
JPH09183727A (ja) | 1997-07-15 |
NO309966B1 (no) | 2001-04-30 |
AU700653B2 (en) | 1999-01-14 |
ZA9610245B (en) | 1998-06-05 |
DK0778023T3 (da) | 2003-06-30 |
SK154796A3 (en) | 1997-09-10 |
NZ299888A (en) | 2001-02-23 |
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