IL117497A - 17-difluoromethylene estratriene derivatives and pharmaceutical compositions containing the same - Google Patents

17-difluoromethylene estratriene derivatives and pharmaceutical compositions containing the same

Info

Publication number
IL117497A
IL117497A IL11749796A IL11749796A IL117497A IL 117497 A IL117497 A IL 117497A IL 11749796 A IL11749796 A IL 11749796A IL 11749796 A IL11749796 A IL 11749796A IL 117497 A IL117497 A IL 117497A
Authority
IL
Israel
Prior art keywords
difluoromethylene
hydrogen atom
same
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL11749796A
Other languages
English (en)
Other versions
IL117497A0 (en
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of IL117497A0 publication Critical patent/IL117497A0/xx
Publication of IL117497A publication Critical patent/IL117497A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Exhaust-Gas Circulating Devices (AREA)
  • Electrical Control Of Air Or Fuel Supplied To Internal-Combustion Engine (AREA)
  • Saccharide Compounds (AREA)
  • Vehicle Body Suspensions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Ceramic Products (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL11749796A 1995-03-13 1996-03-14 17-difluoromethylene estratriene derivatives and pharmaceutical compositions containing the same IL117497A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19509729A DE19509729A1 (de) 1995-03-13 1995-03-13 17-Difluormethylen-Estratriene

Publications (2)

Publication Number Publication Date
IL117497A0 IL117497A0 (en) 1996-07-23
IL117497A true IL117497A (en) 1999-12-22

Family

ID=7756963

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11749796A IL117497A (en) 1995-03-13 1996-03-14 17-difluoromethylene estratriene derivatives and pharmaceutical compositions containing the same

Country Status (21)

Country Link
US (2) US6018062A (is)
EP (1) EP0815120B1 (is)
JP (1) JPH11501644A (is)
KR (1) KR19980703002A (is)
AT (1) ATE199159T1 (is)
AU (1) AU693335B2 (is)
BR (1) BR9612787A (is)
CA (1) CA2215201A1 (is)
CZ (1) CZ281097A3 (is)
DE (2) DE19509729A1 (is)
HU (1) HUP9801846A3 (is)
IL (1) IL117497A (is)
IS (1) IS4556A (is)
NO (1) NO308306B1 (is)
PL (1) PL322199A1 (is)
RU (1) RU2155770C2 (is)
SI (1) SI9620030A (is)
SK (1) SK121697A3 (is)
TR (1) TR199700950T1 (is)
WO (1) WO1996028462A1 (is)
ZA (1) ZA962037B (is)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU703814B2 (en) * 1995-12-04 1999-04-01 Wyeth Antioxidant
US5773432A (en) * 1996-10-30 1998-06-30 Schering Aktiengesellschaft Method for lowering plasma levels of lipoprotein(a)
CA2534497A1 (en) * 2003-08-11 2005-02-17 Industria Chimica Reggiana I.C.R. S.P.A. Chemical composition and method of polymerisation thereof for use on vehicle bodywork repair
JP2008504329A (ja) * 2004-06-29 2008-02-14 ヤド テクノロジーズ ゲゼルシャフト ミット ベシュレンクテル ハフツング 脂質ラフト内の病理プロセスに関係する障害を治療するためのステロイド由来の医薬組成物の使用
US8030298B2 (en) 2005-05-26 2011-10-04 Abbott Products Gmbh 17β-HSD1 and STS inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3741800A1 (de) * 1987-12-07 1989-06-15 Schering Ag 17-halogenmethylen-estratriene
US5783571A (en) * 1991-01-07 1998-07-21 Pherin Corporation Method of altering hypothalamic function by nasal administration of estrene steroids
US5883087A (en) * 1991-01-07 1999-03-16 Pherin Corporation Androstane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
US5969168A (en) * 1991-01-07 1999-10-19 Pherin Corporation Androstanes for inducing hypothalamic effects
US5773432A (en) * 1996-10-30 1998-06-30 Schering Aktiengesellschaft Method for lowering plasma levels of lipoprotein(a)

Also Published As

Publication number Publication date
CA2215201A1 (en) 1996-09-19
DE59606435D1 (de) 2001-03-22
SI9620030A (sl) 1998-02-28
HUP9801846A3 (en) 1999-03-01
RU2155770C2 (ru) 2000-09-10
US6136800A (en) 2000-10-24
NO974206L (no) 1997-11-13
NO974206D0 (no) 1997-09-12
CZ281097A3 (cs) 1998-02-18
AU693335B2 (en) 1998-06-25
WO1996028462A1 (de) 1996-09-19
SK121697A3 (en) 1998-02-04
ATE199159T1 (de) 2001-02-15
TR199700950T1 (xx) 1998-02-21
US6018062A (en) 2000-01-25
BR9612787A (pt) 1999-11-23
DE19509729A1 (de) 1996-09-19
ZA962037B (en) 1996-09-25
MX9707006A (es) 1997-11-29
PL322199A1 (en) 1998-01-19
IS4556A (is) 1997-09-08
AU5107896A (en) 1996-10-02
EP0815120A1 (de) 1998-01-07
IL117497A0 (en) 1996-07-23
JPH11501644A (ja) 1999-02-09
EP0815120B1 (de) 2001-02-14
NO308306B1 (no) 2000-08-28
HUP9801846A2 (hu) 1998-12-28
KR19980703002A (ko) 1998-09-05

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Legal Events

Date Code Title Description
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees