DK1047664T3 - Tricykliske forbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse - Google Patents

Tricykliske forbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse

Info

Publication number
DK1047664T3
DK1047664T3 DK98959957T DK98959957T DK1047664T3 DK 1047664 T3 DK1047664 T3 DK 1047664T3 DK 98959957 T DK98959957 T DK 98959957T DK 98959957 T DK98959957 T DK 98959957T DK 1047664 T3 DK1047664 T3 DK 1047664T3
Authority
DK
Denmark
Prior art keywords
processes
preparation
pharmaceutical compositions
compositions containing
tricyclic compounds
Prior art date
Application number
DK98959957T
Other languages
English (en)
Inventor
Michel Langlois
Monique Mathe-Allainmat
Carole Jellimann
Jean Andrieux
Caroline Bennejean
Pierre Renard
Philippe Delagrange
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of DK1047664T3 publication Critical patent/DK1047664T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/20—Acenaphthenes; Hydrogenated acenaphthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/28—Phenalenes; Hydrogenated phenalenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)
DK98959957T 1998-01-16 1998-12-11 Tricykliske forbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse DK1047664T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9800424A FR2773798B1 (fr) 1998-01-16 1998-01-16 Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
DK1047664T3 true DK1047664T3 (da) 2004-09-13

Family

ID=9521844

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98959957T DK1047664T3 (da) 1998-01-16 1998-12-11 Tricykliske forbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse

Country Status (20)

Country Link
US (1) US6423870B1 (da)
EP (1) EP1047664B1 (da)
JP (1) JP2002509130A (da)
CN (1) CN1247528C (da)
AT (1) ATE267163T1 (da)
AU (1) AU739488B2 (da)
BR (1) BR9815081A (da)
CA (1) CA2318381C (da)
DE (1) DE69824046T2 (da)
DK (1) DK1047664T3 (da)
ES (1) ES2221999T3 (da)
FR (1) FR2773798B1 (da)
HK (1) HK1033455A1 (da)
HU (1) HUP0100283A3 (da)
NO (1) NO20003604L (da)
NZ (1) NZ505323A (da)
PL (1) PL195664B1 (da)
PT (1) PT1047664E (da)
WO (1) WO1999036392A1 (da)
ZA (1) ZA9811380B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025355A (en) * 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
GB9726569D0 (en) * 1997-12-16 1998-02-11 Univ Southampton Neuroprotective agents
DE10133927A1 (de) * 2001-07-12 2003-01-23 Bayer Ag Benzodioxinothiophene, deren Herstellung und Verwendung
DE60208683T2 (de) * 2001-08-01 2006-11-02 Basell Polyolefine Gmbh Verfahren zur herstellung von heterocyclischen pentalen derivaten
JP5291470B2 (ja) * 2006-12-28 2013-09-18 武田薬品工業株式会社 三環性化合物およびその医薬用途
FR2934857B1 (fr) * 2008-08-05 2010-08-27 Servier Lab Nouveau procede de synthese de l'agomelatine
WO2022032147A1 (en) * 2020-08-06 2022-02-10 Tactogen Inc 2-aminoindane compounds for mental disorders or enhancement

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9407919D0 (en) * 1994-04-21 1994-06-15 Glaxo Group Ltd Chemical compounds
US6235789B1 (en) 1994-09-12 2001-05-22 Takeda Chemical Industries, Ltd. Benzocycloalkene compounds, their production and use
FR2725985B1 (fr) * 1994-10-21 1996-11-15 Adir Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2732964B1 (fr) * 1995-04-14 1997-05-16 Adir Nouveaux amides tricycliques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2734815B1 (fr) * 1995-05-31 1997-07-04 Adir Nouveaux composes arylalkyl (thio) carboxamides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
DE69713294T3 (de) * 1996-03-08 2009-01-15 Takeda Pharmaceutical Co. Ltd. Tricyclische Verbindungen mit Bindungsaffinität für Melatoninrezeptoren, deren Herstellung und Verwendung

Also Published As

Publication number Publication date
HUP0100283A2 (hu) 2002-04-29
CA2318381C (fr) 2007-04-17
US6423870B1 (en) 2002-07-23
CN1285817A (zh) 2001-02-28
PL195664B1 (pl) 2007-10-31
BR9815081A (pt) 2000-10-17
PT1047664E (pt) 2004-08-31
NO20003604D0 (no) 2000-07-13
ES2221999T3 (es) 2005-01-16
HUP0100283A3 (en) 2002-05-28
DE69824046D1 (de) 2004-06-24
PL341837A1 (en) 2001-05-07
CN1247528C (zh) 2006-03-29
NZ505323A (en) 2002-10-25
ZA9811380B (da) 1999-06-14
AU1567699A (en) 1999-08-02
FR2773798A1 (fr) 1999-07-23
FR2773798B1 (fr) 2001-02-02
HK1033455A1 (en) 2001-08-31
EP1047664A1 (fr) 2000-11-02
NO20003604L (no) 2000-09-12
CA2318381A1 (fr) 1999-07-22
EP1047664B1 (fr) 2004-05-19
WO1999036392A1 (fr) 1999-07-22
ATE267163T1 (de) 2004-06-15
DE69824046T2 (de) 2005-06-30
JP2002509130A (ja) 2002-03-26
AU739488B2 (en) 2001-10-11

Similar Documents

Publication Publication Date Title
NL350075I2 (da)
IL135536A0 (en) Ortho-anthranilamide derivatives and pharmaceutical compositions containing the same
PL344012A1 (en) Novel substituted cyclic compounds, preparation method and pharmaceutical compositions containing them
MXPA02012033A (es) Derivados de 2-aminocarbonil-9h-purina.
PL366198A1 (en) Novel compounds
BR0014225A (pt) Derivados de pirazol
MX9301032A (es) Compuestos farmaceuticos y procedimento para su preparacion
DK0766696T3 (da) Thiazolidinderivater, fremstilling af disse forbindelser og lægemidler indeholdende disse forbindelser
DK1026167T3 (da) Tricykliske triazolobenzazepinderivater, fremgangsmåde til fremstilling af disse samt antiallergiske midler
MXPA02012569A (es) Ftalidas substituidas novedosas, un procedimiento para su preparacion y las composiciones farmaceuticas que contienen a las mismas.
GB9507808D0 (en) Novel amine compounds
DK1047664T3 (da) Tricykliske forbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
YU76500A (sh) Hemijska sinzeza morfolinskih derivata
TR200401052T4 (tr) Yeni bileşikler
WO1998049998A3 (de) Verwendung von glykosidischen siliconverbindungen zur herstellung von kosmetischen und/oder pharmazeutischen zubereitungen
WO1999007718A3 (de) Substituierte tetrahydropyranderivate, verfahren zu deren herstellung, deren verwendung als arzneimittel oder diagnostikum sowie sie enthaltendes arzneimittel
MY118946A (en) Novel intermediates and their use to prepare n, n''- bridged bisindolylmaleimides
IL117497A (en) 17-difluoromethylene estratriene derivatives and pharmaceutical compositions containing the same
AP2003002831A0 (en) Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
ZA946221B (en) Azoxycyanobenzene derivatives
MY133098A (en) New nitromethyl ketones, process for preparing them and compositions containing them
ATE204847T1 (de) Tetracyclische aromatische retinoide verbindungen,ihre herstellung und verwendung
NO305116B1 (no) Fremgangsmate for fremstilling av C-substituerte dietylentriaminer
WO2002040005A3 (en) Blockade of sodium channels by phenol derivatives
GR3029453T3 (en) NOVEL PROCESSES AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF PLATELET CLYCOPROTEIN IIb/IIIa INHIBITORS