ATE199159T1 - 17-difluormethylen-estratriene - Google Patents
17-difluormethylen-estratrieneInfo
- Publication number
- ATE199159T1 ATE199159T1 AT96907453T AT96907453T ATE199159T1 AT E199159 T1 ATE199159 T1 AT E199159T1 AT 96907453 T AT96907453 T AT 96907453T AT 96907453 T AT96907453 T AT 96907453T AT E199159 T1 ATE199159 T1 AT E199159T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrogen atom
- estratrienes
- difluoromethylene
- beta
- alpha
- Prior art date
Links
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- BSGPCYMUVXVZHZ-DCTDBFQOSA-N (9r,10s,13s)-17-(difluoromethylidene)-13-methyl-2,3,4,5,9,10,11,12-octahydro-1h-cyclopenta[a]phenanthrene Chemical class C([C@@H]1[C@H]2CC3)CCCC1C=CC2=C1[C@@]3(C)C(=C(F)F)C=C1 BSGPCYMUVXVZHZ-DCTDBFQOSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Ceramic Products (AREA)
- Photoreceptors In Electrophotography (AREA)
- Exhaust-Gas Circulating Devices (AREA)
- Electrical Control Of Air Or Fuel Supplied To Internal-Combustion Engine (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Saccharide Compounds (AREA)
- Vehicle Body Suspensions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19509729A DE19509729A1 (de) | 1995-03-13 | 1995-03-13 | 17-Difluormethylen-Estratriene |
| PCT/EP1996/001069 WO1996028462A1 (de) | 1995-03-13 | 1996-03-13 | 17-difluormethylen-estratriene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE199159T1 true ATE199159T1 (de) | 2001-02-15 |
Family
ID=7756963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96907453T ATE199159T1 (de) | 1995-03-13 | 1996-03-13 | 17-difluormethylen-estratriene |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6018062A (de) |
| EP (1) | EP0815120B1 (de) |
| JP (1) | JPH11501644A (de) |
| KR (1) | KR19980703002A (de) |
| AT (1) | ATE199159T1 (de) |
| AU (1) | AU693335B2 (de) |
| BR (1) | BR9612787A (de) |
| CA (1) | CA2215201A1 (de) |
| CZ (1) | CZ281097A3 (de) |
| DE (2) | DE19509729A1 (de) |
| HU (1) | HUP9801846A3 (de) |
| IL (1) | IL117497A (de) |
| IS (1) | IS4556A (de) |
| NO (1) | NO308306B1 (de) |
| PL (1) | PL322199A1 (de) |
| RU (1) | RU2155770C2 (de) |
| SI (1) | SI9620030A (de) |
| SK (1) | SK121697A3 (de) |
| TR (1) | TR199700950T1 (de) |
| WO (1) | WO1996028462A1 (de) |
| ZA (1) | ZA962037B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU703814B2 (en) * | 1995-12-04 | 1999-04-01 | Wyeth | Antioxidant |
| US5773432A (en) * | 1996-10-30 | 1998-06-30 | Schering Aktiengesellschaft | Method for lowering plasma levels of lipoprotein(a) |
| WO2005014721A1 (en) * | 2003-08-11 | 2005-02-17 | Industria Chimica Reggiana I.C.R. S.P.A. | Chemical composition and method of polymerisation thereof for use on vehicle bodywork repair |
| JP2008504329A (ja) * | 2004-06-29 | 2008-02-14 | ヤド テクノロジーズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 脂質ラフト内の病理プロセスに関係する障害を治療するためのステロイド由来の医薬組成物の使用 |
| US8030298B2 (en) | 2005-05-26 | 2011-10-04 | Abbott Products Gmbh | 17β-HSD1 and STS inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3741800A1 (de) * | 1987-12-07 | 1989-06-15 | Schering Ag | 17-halogenmethylen-estratriene |
| US5883087A (en) * | 1991-01-07 | 1999-03-16 | Pherin Corporation | Androstane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods |
| US5783571A (en) * | 1991-01-07 | 1998-07-21 | Pherin Corporation | Method of altering hypothalamic function by nasal administration of estrene steroids |
| US5969168A (en) * | 1991-01-07 | 1999-10-19 | Pherin Corporation | Androstanes for inducing hypothalamic effects |
| US5773432A (en) * | 1996-10-30 | 1998-06-30 | Schering Aktiengesellschaft | Method for lowering plasma levels of lipoprotein(a) |
-
1995
- 1995-03-13 DE DE19509729A patent/DE19509729A1/de not_active Withdrawn
-
1996
- 1996-03-13 SI SI9620030A patent/SI9620030A/sl unknown
- 1996-03-13 SK SK1216-97A patent/SK121697A3/sk unknown
- 1996-03-13 EP EP96907453A patent/EP0815120B1/de not_active Expired - Lifetime
- 1996-03-13 ZA ZA962037A patent/ZA962037B/xx unknown
- 1996-03-13 AT AT96907453T patent/ATE199159T1/de not_active IP Right Cessation
- 1996-03-13 HU HU9801846A patent/HUP9801846A3/hu unknown
- 1996-03-13 PL PL96322199A patent/PL322199A1/xx unknown
- 1996-03-13 TR TR97/00950T patent/TR199700950T1/xx unknown
- 1996-03-13 RU RU97116513/04A patent/RU2155770C2/ru active
- 1996-03-13 JP JP8527276A patent/JPH11501644A/ja active Pending
- 1996-03-13 CZ CZ972810A patent/CZ281097A3/cs unknown
- 1996-03-13 CA CA002215201A patent/CA2215201A1/en not_active Abandoned
- 1996-03-13 US US08/913,325 patent/US6018062A/en not_active Expired - Fee Related
- 1996-03-13 AU AU51078/96A patent/AU693335B2/en not_active Ceased
- 1996-03-13 BR BR9612787-2A patent/BR9612787A/pt not_active Application Discontinuation
- 1996-03-13 WO PCT/EP1996/001069 patent/WO1996028462A1/de not_active Ceased
- 1996-03-13 KR KR1019970706410A patent/KR19980703002A/ko not_active Withdrawn
- 1996-03-13 DE DE59606435T patent/DE59606435D1/de not_active Expired - Fee Related
- 1996-03-14 IL IL11749796A patent/IL117497A/xx not_active IP Right Cessation
-
1997
- 1997-09-08 IS IS4556A patent/IS4556A/is unknown
- 1997-09-12 NO NO974206A patent/NO308306B1/no unknown
-
1999
- 1999-03-08 US US09/263,062 patent/US6136800A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL117497A (en) | 1999-12-22 |
| DE59606435D1 (de) | 2001-03-22 |
| PL322199A1 (en) | 1998-01-19 |
| NO974206D0 (no) | 1997-09-12 |
| US6018062A (en) | 2000-01-25 |
| DE19509729A1 (de) | 1996-09-19 |
| CA2215201A1 (en) | 1996-09-19 |
| ZA962037B (en) | 1996-09-25 |
| NO974206L (no) | 1997-11-13 |
| AU693335B2 (en) | 1998-06-25 |
| BR9612787A (pt) | 1999-11-23 |
| AU5107896A (en) | 1996-10-02 |
| US6136800A (en) | 2000-10-24 |
| EP0815120A1 (de) | 1998-01-07 |
| KR19980703002A (ko) | 1998-09-05 |
| NO308306B1 (no) | 2000-08-28 |
| RU2155770C2 (ru) | 2000-09-10 |
| SK121697A3 (en) | 1998-02-04 |
| CZ281097A3 (cs) | 1998-02-18 |
| HUP9801846A3 (en) | 1999-03-01 |
| MX9707006A (es) | 1997-11-29 |
| IL117497A0 (en) | 1996-07-23 |
| IS4556A (is) | 1997-09-08 |
| TR199700950T1 (xx) | 1998-02-21 |
| SI9620030A (sl) | 1998-02-28 |
| HUP9801846A2 (hu) | 1998-12-28 |
| JPH11501644A (ja) | 1999-02-09 |
| WO1996028462A1 (de) | 1996-09-19 |
| EP0815120B1 (de) | 2001-02-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |