ATE199159T1 - 17-difluormethylen-estratriene - Google Patents

17-difluormethylen-estratriene

Info

Publication number
ATE199159T1
ATE199159T1 AT96907453T AT96907453T ATE199159T1 AT E199159 T1 ATE199159 T1 AT E199159T1 AT 96907453 T AT96907453 T AT 96907453T AT 96907453 T AT96907453 T AT 96907453T AT E199159 T1 ATE199159 T1 AT E199159T1
Authority
AT
Austria
Prior art keywords
hydrogen atom
estratrienes
difluoromethylene
beta
alpha
Prior art date
Application number
AT96907453T
Other languages
English (en)
Inventor
Rolf Dr Bohlmann
Gabor Prof Dr Rubanyl
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of ATE199159T1 publication Critical patent/ATE199159T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Exhaust-Gas Circulating Devices (AREA)
  • Electrical Control Of Air Or Fuel Supplied To Internal-Combustion Engine (AREA)
  • Saccharide Compounds (AREA)
  • Vehicle Body Suspensions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Ceramic Products (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT96907453T 1995-03-13 1996-03-13 17-difluormethylen-estratriene ATE199159T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19509729A DE19509729A1 (de) 1995-03-13 1995-03-13 17-Difluormethylen-Estratriene
PCT/EP1996/001069 WO1996028462A1 (de) 1995-03-13 1996-03-13 17-difluormethylen-estratriene

Publications (1)

Publication Number Publication Date
ATE199159T1 true ATE199159T1 (de) 2001-02-15

Family

ID=7756963

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96907453T ATE199159T1 (de) 1995-03-13 1996-03-13 17-difluormethylen-estratriene

Country Status (21)

Country Link
US (2) US6018062A (de)
EP (1) EP0815120B1 (de)
JP (1) JPH11501644A (de)
KR (1) KR19980703002A (de)
AT (1) ATE199159T1 (de)
AU (1) AU693335B2 (de)
BR (1) BR9612787A (de)
CA (1) CA2215201A1 (de)
CZ (1) CZ281097A3 (de)
DE (2) DE19509729A1 (de)
HU (1) HUP9801846A3 (de)
IL (1) IL117497A (de)
IS (1) IS4556A (de)
NO (1) NO308306B1 (de)
PL (1) PL322199A1 (de)
RU (1) RU2155770C2 (de)
SI (1) SI9620030A (de)
SK (1) SK121697A3 (de)
TR (1) TR199700950T1 (de)
WO (1) WO1996028462A1 (de)
ZA (1) ZA962037B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU703814B2 (en) * 1995-12-04 1999-04-01 Wyeth Antioxidant
US5773432A (en) * 1996-10-30 1998-06-30 Schering Aktiengesellschaft Method for lowering plasma levels of lipoprotein(a)
CA2534497A1 (en) * 2003-08-11 2005-02-17 Industria Chimica Reggiana I.C.R. S.P.A. Chemical composition and method of polymerisation thereof for use on vehicle bodywork repair
AU2005259499A1 (en) * 2004-06-29 2006-01-12 Jado Technologies Gmbh Use of steroid-derived pharmaceutical compositions for treating disorders relating to pathological processes in lipid rafts
US8030298B2 (en) 2005-05-26 2011-10-04 Abbott Products Gmbh 17β-HSD1 and STS inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3741800A1 (de) * 1987-12-07 1989-06-15 Schering Ag 17-halogenmethylen-estratriene
US5883087A (en) * 1991-01-07 1999-03-16 Pherin Corporation Androstane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
US5783571A (en) * 1991-01-07 1998-07-21 Pherin Corporation Method of altering hypothalamic function by nasal administration of estrene steroids
US5969168A (en) * 1991-01-07 1999-10-19 Pherin Corporation Androstanes for inducing hypothalamic effects
US5773432A (en) * 1996-10-30 1998-06-30 Schering Aktiengesellschaft Method for lowering plasma levels of lipoprotein(a)

Also Published As

Publication number Publication date
AU693335B2 (en) 1998-06-25
DE59606435D1 (de) 2001-03-22
RU2155770C2 (ru) 2000-09-10
IL117497A (en) 1999-12-22
KR19980703002A (ko) 1998-09-05
AU5107896A (en) 1996-10-02
PL322199A1 (en) 1998-01-19
DE19509729A1 (de) 1996-09-19
EP0815120B1 (de) 2001-02-14
NO974206L (no) 1997-11-13
NO974206D0 (no) 1997-09-12
SK121697A3 (en) 1998-02-04
NO308306B1 (no) 2000-08-28
SI9620030A (sl) 1998-02-28
ZA962037B (en) 1996-09-25
HUP9801846A3 (en) 1999-03-01
CA2215201A1 (en) 1996-09-19
TR199700950T1 (xx) 1998-02-21
JPH11501644A (ja) 1999-02-09
HUP9801846A2 (hu) 1998-12-28
IS4556A (is) 1997-09-08
MX9707006A (es) 1997-11-29
IL117497A0 (en) 1996-07-23
BR9612787A (pt) 1999-11-23
CZ281097A3 (cs) 1998-02-18
US6018062A (en) 2000-01-25
US6136800A (en) 2000-10-24
EP0815120A1 (de) 1998-01-07
WO1996028462A1 (de) 1996-09-19

Similar Documents

Publication Publication Date Title
TR199801399T2 (xx) Yeni 19-nor-pregnen t�revleri.
HUP0001192A2 (hu) Topiramát és származékainak alkalmazása elhízás kezelésére használható gyógyszerkészítmények előállítására
AR001440A1 (es) Nuevos taxoides, su preparación y composiciones farmacéuticas que los contienen.
YU11997A (sh) Laktamski derivati i njihove farmaceutske kompozicije
DE69716292D1 (de) Benzopyranderivate
TR200201102T2 (tr) Yeni oligosakkaritler, bunların hazırlanması ve bunları içeren ilaç bileşimleri
BG102625A (en) Lactone derivatives of 17-beta-carboxy, carbothio and amide androstane derivatives
FI104178B1 (fi) 17-spirofuran-3'-ylideenisteroidit
IT1271325B (it) Composti diastereomericamente puri derivati da 3-oxo e 3-tioxo-4-azaandrostani e loro uso come antiandrogeni
BG102015A (en) Azacycloalkane derivatives, their preparation and application in therapy
DK0934080T3 (da) 1,3-Bis-(N-lactamyl)propaner og deres farmaceutiske og kosmetiske anvendelse
ATE199159T1 (de) 17-difluormethylen-estratriene
DK0852580T3 (da) Fremgangsmåde til fremstilling af dihydroxypyrimidin-derivater
TW350041B (en) Bis-depside tertiary alkyl ester derivatives and chemical positive photoresist material
TR199700802T2 (xx) Triazin t�revleri.
TR199701298T1 (xx) Tetralinler.
ATE345335T1 (de) Acetale, ihre verwendung als riechstoffe und verfahren zu ihrer herstellung
AR009105A1 (es) Derivados de n-(benzotiazol-2-il) piperidina-1-etanamina, su preparacion y aplicacion en terapeutica
WO1998049998A3 (de) Verwendung von glykosidischen siliconverbindungen zur herstellung von kosmetischen und/oder pharmazeutischen zubereitungen
ATE213236T1 (de) Substituierte benzyloxyimino-verbindungen
HUP9903828A2 (hu) Peroxisavak
DK0788472T3 (da) Fremgangsmåde til fremstilling af 5,6-dihydroxy-2-amino-1,2,3,4-tetrahydronaphthalenderivater
RO116856B1 (ro) Compoziţie erbicidă, lichidă, pe bază de n-(fosfonometil)glicină
ES2061336T3 (es) 3-(2-cloro-4-(trifluorometil)fenoxi)-1-azetidincarboxamidas que tienen actividad anticonvulsiva.
ATE219497T1 (de) 15-methyl-cyclopropanosteroide und verfharen zu ihrer herstellung

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee