MX9707006A - Estratrienos de 17-difluorometileno. - Google Patents
Estratrienos de 17-difluorometileno.Info
- Publication number
- MX9707006A MX9707006A MX9707006A MX9707006A MX9707006A MX 9707006 A MX9707006 A MX 9707006A MX 9707006 A MX9707006 A MX 9707006A MX 9707006 A MX9707006 A MX 9707006A MX 9707006 A MX9707006 A MX 9707006A
- Authority
- MX
- Mexico
- Prior art keywords
- hydrogen atom
- oestratrienes
- difluoromethylene
- beta
- alpha
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Photoreceptors In Electrophotography (AREA)
- Exhaust-Gas Circulating Devices (AREA)
- Electrical Control Of Air Or Fuel Supplied To Internal-Combustion Engine (AREA)
- Saccharide Compounds (AREA)
- Vehicle Body Suspensions (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Ceramic Products (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invencion describe nuevos estratienos de 17-difluorometileno de la formula general I, en donde significa: R1 un átomo de hidrogeno o un grupo alquilo con de 1 a 10 átomos de carbono, R5 un grupo metilo o etilo; R2 un átomo de hidrogeno o un grupo alquilo alfa o beta estable con de 1 a 10 átomos de carbono; R3 un grupo alquiloxi alfa o beta estable de 1 a 10 átomos de carbono o hidrogeno; R4 un átomo de hidrogeno alfa o beta estable, así como; A, B, D, E y G, cada uno un átomo de hidrogeno, así como dado el caso adicionalmente cuando menos uno de los pares de sustituyentes G y R2, R2 y R4, R4 y A, A y R3, B y D, D y E un enlace doble. Los nuevos compuestos presentan propiedades antioxidantes y vasculoprotectoras hasta ahora no descritas para los esteroides y son adecuados para la preparacion de preparados farmacéuticas.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19509729A DE19509729A1 (de) | 1995-03-13 | 1995-03-13 | 17-Difluormethylen-Estratriene |
| DE19509729.7 | 1995-03-13 | ||
| PCT/EP1996/001069 WO1996028462A1 (de) | 1995-03-13 | 1996-03-13 | 17-difluormethylen-estratriene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9707006A true MX9707006A (es) | 1997-11-29 |
| MXPA97007006A MXPA97007006A (es) | 1998-07-03 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| CA2215201A1 (en) | 1996-09-19 |
| DE59606435D1 (de) | 2001-03-22 |
| SI9620030A (sl) | 1998-02-28 |
| HUP9801846A3 (en) | 1999-03-01 |
| RU2155770C2 (ru) | 2000-09-10 |
| US6136800A (en) | 2000-10-24 |
| NO974206L (no) | 1997-11-13 |
| NO974206D0 (no) | 1997-09-12 |
| CZ281097A3 (cs) | 1998-02-18 |
| AU693335B2 (en) | 1998-06-25 |
| WO1996028462A1 (de) | 1996-09-19 |
| SK121697A3 (en) | 1998-02-04 |
| ATE199159T1 (de) | 2001-02-15 |
| TR199700950T1 (xx) | 1998-02-21 |
| US6018062A (en) | 2000-01-25 |
| BR9612787A (pt) | 1999-11-23 |
| DE19509729A1 (de) | 1996-09-19 |
| ZA962037B (en) | 1996-09-25 |
| PL322199A1 (en) | 1998-01-19 |
| IS4556A (is) | 1997-09-08 |
| AU5107896A (en) | 1996-10-02 |
| EP0815120A1 (de) | 1998-01-07 |
| IL117497A0 (en) | 1996-07-23 |
| JPH11501644A (ja) | 1999-02-09 |
| IL117497A (en) | 1999-12-22 |
| EP0815120B1 (de) | 2001-02-14 |
| NO308306B1 (no) | 2000-08-28 |
| HUP9801846A2 (hu) | 1998-12-28 |
| KR19980703002A (ko) | 1998-09-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |