IL116281A - Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts - Google Patents

Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts

Info

Publication number
IL116281A
IL116281A IL11628195A IL11628195A IL116281A IL 116281 A IL116281 A IL 116281A IL 11628195 A IL11628195 A IL 11628195A IL 11628195 A IL11628195 A IL 11628195A IL 116281 A IL116281 A IL 116281A
Authority
IL
Israel
Prior art keywords
methoxyphenyl
isomer
dimethylaminomethyl
cyclohexanol
purification
Prior art date
Application number
IL11628195A
Other languages
English (en)
Other versions
IL116281A0 (en
Inventor
Ori Lerman
Michael Tennenbaum
Erez Gal
Joseph Kaspi
Original Assignee
Chemagis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemagis Ltd filed Critical Chemagis Ltd
Priority to IL11628195A priority Critical patent/IL116281A/xx
Publication of IL116281A0 publication Critical patent/IL116281A0/xx
Priority to US08/746,575 priority patent/US5672755A/en
Priority to DK96308347T priority patent/DK0778262T3/da
Priority to AT96308347T priority patent/ATE198879T1/de
Priority to PT96308347T priority patent/PT778262E/pt
Priority to EP96308347A priority patent/EP0778262B1/en
Priority to AU71818/96A priority patent/AU713304B2/en
Priority to ES96308347T priority patent/ES2154792T3/es
Priority to DE69611663T priority patent/DE69611663T2/de
Priority to SK1503-96A priority patent/SK282179B6/sk
Priority to CA002192155A priority patent/CA2192155C/en
Publication of IL116281A publication Critical patent/IL116281A/xx
Priority to GR20010400448T priority patent/GR3035602T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL11628195A 1995-12-07 1995-12-07 Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts IL116281A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IL11628195A IL116281A (en) 1995-12-07 1995-12-07 Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts
US08/746,575 US5672755A (en) 1995-12-07 1996-11-14 Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1-(3-methoxyphenyl)cyclohexanol and its salts
DE69611663T DE69611663T2 (de) 1995-12-07 1996-11-19 Verfahren zur Reinigung von (RR-SS)-2-Dimethyl-Aminomethyl-1-(3-Methoxyphenyl)Cyclohexanol und dessen Salzen
PT96308347T PT778262E (pt) 1995-12-07 1996-11-19 Processo para a purificacao de (rr-ss)-2-dimetilaminometil-1-(3-metoxifenil)ciclo-hexanol e seus sais
AT96308347T ATE198879T1 (de) 1995-12-07 1996-11-19 Verfahren zur reinigung von (rr-ss)-2-dimethyl- aminomethyl-1-(3-methoxyphenyl)cyclohexanol und dessen salzen
DK96308347T DK0778262T3 (da) 1995-12-07 1996-11-19 Fremgangsmåde til oprensning af (RR,SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol og dets salte
EP96308347A EP0778262B1 (en) 1995-12-07 1996-11-19 Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1-(3-methoxyphenyl)cyclohexanol and its salts
AU71818/96A AU713304B2 (en) 1995-12-07 1996-11-19 Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts
ES96308347T ES2154792T3 (es) 1995-12-07 1996-11-19 Procedimiento para la purificacion de (rr-ss)-2-dimetilaminometil-1-(3-metoxifenil)ciclohexanol y sus sales.
SK1503-96A SK282179B6 (sk) 1995-12-07 1996-11-22 Spôsob čistenia a izolácie (rr,ss)-2-dimetylaminometyl-1-(3-metoxyfenyl)cyklohexanolu
CA002192155A CA2192155C (en) 1995-12-07 1996-12-05 Process for the purification of (rr-ss)-2-dimethyl-aminomethyl-1-(3-methoxyphenyl)cyclohexanol and its salts
GR20010400448T GR3035602T3 (en) 1995-12-07 2001-03-20 Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1-(3-methoxyphenyl)cyclohexanol and its salts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL11628195A IL116281A (en) 1995-12-07 1995-12-07 Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts

Publications (2)

Publication Number Publication Date
IL116281A0 IL116281A0 (en) 1996-03-31
IL116281A true IL116281A (en) 1999-06-20

Family

ID=11068279

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11628195A IL116281A (en) 1995-12-07 1995-12-07 Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts

Country Status (12)

Country Link
US (1) US5672755A (pt)
EP (1) EP0778262B1 (pt)
AT (1) ATE198879T1 (pt)
AU (1) AU713304B2 (pt)
CA (1) CA2192155C (pt)
DE (1) DE69611663T2 (pt)
DK (1) DK0778262T3 (pt)
ES (1) ES2154792T3 (pt)
GR (1) GR3035602T3 (pt)
IL (1) IL116281A (pt)
PT (1) PT778262E (pt)
SK (1) SK282179B6 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL119121A (en) * 1996-08-22 2000-11-21 Chemagis Ltd Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride
JP2001510180A (ja) 1997-07-15 2001-07-31 ラシンスキィ・リミテッド トラマドール、その塩酸塩、及びそれらの製造方法
US5877351A (en) * 1997-12-24 1999-03-02 Wyckoff Chemical Company, Inc. Preparation and purification process for 2- (dimethylamino) methyl!-1-(3-methoxphenyl)-cyclohexanol and its salts
IT1298597B1 (it) * 1998-03-06 2000-01-12 Secifarma Spa Processo per la purificazione dell'(rr,ss)-2-(dimetilammino)metil- 1-(3-metossifenil)-cicloesanolo dall'(rs,sr)-2-(dimetilammino)
DE69913955T2 (de) * 1998-05-22 2004-12-16 Mallinckrodt, Inc. Ein verbessertes synthese- und reinigungsverfahren für (r*,r*)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol hydrochlorid
AU4211799A (en) * 1998-05-29 1999-12-13 Pharmacia & Upjohn Company 3-[(1--n-methylamino)ethyl-n-benzyl] pyrrolidine monomethanesulfonate
AU4775699A (en) * 1999-06-22 2001-01-09 Grunenthal Gmbh Method for separating the diastereomer bases of 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-cyclohexanol
GB0010437D0 (en) * 2000-04-28 2000-06-14 Darwin Discovery Ltd Process
DE10108308A1 (de) * 2001-02-21 2002-08-29 Gruenenthal Gmbh Verfahren zur Isolierung und Reinigung von (1RS,2RS)-2[(Dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol
US6649783B2 (en) * 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
WO2003048113A1 (en) 2001-11-30 2003-06-12 Sepracor Inc. Tramadol analogs and uses thereof
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
TWI319713B (en) * 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
DE102005031041A1 (de) * 2005-07-02 2007-01-04 Palitzsch, Peter Verfahren zur Isomerisierung von Tramadol
DK1940467T3 (da) 2005-09-09 2017-02-13 Paladin Labs Inc Lægemiddelsammensætning med langvarig frigivelse
EP1785412A1 (en) * 2005-11-14 2007-05-16 IPCA Laboratories Limited Tramadol recovery process

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1219503B (de) 1960-08-20 1966-06-23 Firth Cleveland Ltd Heiz- und/oder Kuehlgeraet
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US3653589A (en) 1970-07-27 1972-04-04 Carrier Corp Air conditioning system
IL103096A (en) 1992-09-08 1996-12-05 Chemagis Ltd Process for purification 2 -]) Dimethylamino (methyl-1-) 3-methoxycinyl (cyclohexanol and its salts.

Also Published As

Publication number Publication date
US5672755A (en) 1997-09-30
AU7181896A (en) 1997-06-12
GR3035602T3 (en) 2001-06-29
DE69611663D1 (de) 2001-03-01
EP0778262A3 (en) 1998-04-29
ES2154792T3 (es) 2001-04-16
CA2192155A1 (en) 1997-06-08
SK150396A3 (en) 1997-07-09
EP0778262B1 (en) 2001-01-24
EP0778262A2 (en) 1997-06-11
IL116281A0 (en) 1996-03-31
ATE198879T1 (de) 2001-02-15
AU713304B2 (en) 1999-11-25
PT778262E (pt) 2001-05-31
CA2192155C (en) 2005-06-14
SK282179B6 (sk) 2001-11-06
DE69611663T2 (de) 2001-06-13
DK0778262T3 (da) 2001-03-05

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Legal Events

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FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees