IL115854A - Process for purifying and isolating beta-anomer enriched 2'-deoxy-2',2'-difluoro-D-ribofuranosyl-4-aminopyrimidin-2-one - Google Patents

Process for purifying and isolating beta-anomer enriched 2'-deoxy-2',2'-difluoro-D-ribofuranosyl-4-aminopyrimidin-2-one

Info

Publication number
IL115854A
IL115854A IL11585495A IL11585495A IL115854A IL 115854 A IL115854 A IL 115854A IL 11585495 A IL11585495 A IL 11585495A IL 11585495 A IL11585495 A IL 11585495A IL 115854 A IL115854 A IL 115854A
Authority
IL
Israel
Prior art keywords
aminopyrimidin
ribofuranosyl
deoxy
difluoro
purifying
Prior art date
Application number
IL11585495A
Other languages
English (en)
Other versions
IL115854A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23335711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL115854(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL115854A0 publication Critical patent/IL115854A0/xx
Publication of IL115854A publication Critical patent/IL115854A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
IL11585495A 1994-11-17 1995-11-02 Process for purifying and isolating beta-anomer enriched 2'-deoxy-2',2'-difluoro-D-ribofuranosyl-4-aminopyrimidin-2-one IL115854A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/340,972 US5606048A (en) 1992-06-22 1994-11-17 Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides

Publications (2)

Publication Number Publication Date
IL115854A0 IL115854A0 (en) 1996-01-31
IL115854A true IL115854A (en) 2000-07-16

Family

ID=23335711

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11585495A IL115854A (en) 1994-11-17 1995-11-02 Process for purifying and isolating beta-anomer enriched 2'-deoxy-2',2'-difluoro-D-ribofuranosyl-4-aminopyrimidin-2-one

Country Status (34)

Country Link
US (1) US5606048A (cs)
EP (1) EP0712860B1 (cs)
JP (1) JPH10509170A (cs)
KR (1) KR100424990B1 (cs)
CN (1) CN1044119C (cs)
AR (1) AR001045A1 (cs)
AT (1) ATE210142T1 (cs)
AU (1) AU702588B2 (cs)
BG (1) BG62737B1 (cs)
BR (1) BR9509904A (cs)
CA (1) CA2205350C (cs)
CO (1) CO4600741A1 (cs)
CZ (1) CZ292013B6 (cs)
DE (1) DE69524365T2 (cs)
DK (1) DK0712860T3 (cs)
ES (1) ES2164745T3 (cs)
HU (1) HU219019B (cs)
IL (1) IL115854A (cs)
MX (1) MX9703548A (cs)
MY (1) MY115183A (cs)
NO (1) NO308305B1 (cs)
NZ (1) NZ296712A (cs)
PE (1) PE50196A1 (cs)
PL (1) PL182052B1 (cs)
PT (1) PT712860E (cs)
RO (1) RO118296B1 (cs)
RU (1) RU2161622C2 (cs)
SI (1) SI0712860T1 (cs)
SK (1) SK283160B6 (cs)
TW (1) TW377356B (cs)
UA (1) UA53614C2 (cs)
WO (1) WO1996016072A1 (cs)
YU (1) YU49446B (cs)
ZA (1) ZA959321B (cs)

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MXPA02011691A (es) 2000-05-26 2004-05-17 Idenix Cayman Ltd Metodos y composiciones para el tratamiento de flavivirus y pestivirus.
US7435755B2 (en) * 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
AU2003235676A1 (en) * 2002-01-15 2003-07-30 Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
CN101172993A (zh) * 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
JP2005533824A (ja) * 2002-06-28 2005-11-10 イデニクス（ケイマン）リミテツド フラビウイルス科感染の治療のための２’−ｃ−メチル−３’−ｏ−ｌ−バリンエステルリボフラノシルシチジン
EP1567169A4 (en) * 2002-11-04 2009-10-21 Xenoport Inc GEMCITABINE PROMOTERS, THEIR PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
PL377342A1 (pl) * 2002-11-15 2006-01-23 Idenix (Cayman) Limited Nukleozydy rozgałęzione w pozycji 2' oraz mutacja Flaviviridae
AU2003300901A1 (en) * 2002-12-12 2004-06-30 Idenix (Cayman) Limited Process for the production of 2'-branched nucleosides
AU2005256963A1 (en) * 2004-06-23 2006-01-05 Centre National De La Recherche Scientifique 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
JP2007522151A (ja) * 2004-12-08 2007-08-09 シコール インコーポレイティド ジフルオロヌクレオシド及びその調製方法
WO2006070985A1 (en) 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
AU2005320374B2 (en) * 2004-12-30 2009-01-08 Hanmi Science Co., Ltd. Method for the preparation of 2'-deoxy-2',2'-difluorocytidine
CA2598895A1 (en) * 2005-03-04 2006-09-08 Dabur Pharma Limited Intermediate and process for preparing of beta- anomer enriched 21deoxy, 21 ,21-difluoro-d-ribofuranosyl nucleosides
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
AU2011202539B2 (en) * 2005-06-03 2012-07-05 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
CN101203525B (zh) * 2005-06-03 2012-06-13 台湾神隆股份有限公司 制备α-端基异构体富集的2-脱氧-2,2-二氟-D-呋喃核糖基磺酸酯的方法及其制备β核苷的应用
US8193354B2 (en) 2005-10-28 2012-06-05 Arch Pharmalabs Limited Process for preparation of Gemcitabine hydrochloride
EP1976382B1 (en) * 2005-12-23 2013-04-24 IDENIX Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
US20090069557A1 (en) * 2006-02-06 2009-03-12 Dr. Reddy's Laboratories Ltd. Preparation of gemcitabine
WO2008064132A2 (en) * 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
CA2670099A1 (en) * 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
EP2139884B1 (en) * 2007-03-23 2013-12-04 Dongwoo Syntech Co., Ltd. Process for preparing of 2'-deoxy-2'2'-difluorocytidine
CN100475832C (zh) * 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
WO2009023845A2 (en) * 2007-08-15 2009-02-19 The Board Of Regents Of The University Of Texas System Combination therapy with synthetic triterpenoids and gemcitabine
EP2050757A1 (en) 2007-10-10 2009-04-22 Cilag AG Method of producing 2' -deoxy-5-azacytidine (Decitabine)
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain Compounds, Compositions and Methods
LT2252283T (lt) 2008-01-11 2019-03-25 Reata Pharmaceuticals, Inc. Sintetiniai triterpenoidai ir jų panaudojimo būdai gydant ligą
EA022588B1 (ru) 2008-04-18 2016-01-29 Ритэ Фамэсутикл, Инк. Антиоксидантные модуляторы воспаления: производные олеанолевой кислоты с насыщением в с-кольце
JP5529851B2 (ja) 2008-04-18 2014-06-25 リアタ ファーマシューティカルズ インコーポレイテッド 抗酸化炎症モジュレーター：ｃ−１７においてアミノ改変およびその他の改変を加えたオレアノール酸誘導体
LT2271658T (lt) 2008-04-18 2017-02-27 Reata Pharmaceuticals, Inc. Antioksidantai uždegimo moduliatoriai:oleanolio rūgšties c-17 patvirtinti dariniai
CN103588678A (zh) 2008-04-18 2014-02-19 里亚塔医药公司 包含抗炎症药效团的化合物以及使用方法
WO2009146216A2 (en) 2008-04-18 2009-12-03 Reata Pharmaceuticals. Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
US8314137B2 (en) * 2008-07-22 2012-11-20 Trustess Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
ES2628609T3 (es) * 2009-04-06 2017-08-03 Otsuka Pharmaceutical Co., Ltd. Combinación de fármacos antineoplásicos a base de citidina con inhibidor de citidina deaminasa y uso del mismo en el tratamiento de cáncer
WO2010118006A1 (en) * 2009-04-06 2010-10-14 Eisai Inc. (2 ' -deoxy-ribofuranosyl) -1,3,4, 7-tetrahydro- (1,3) iazepin-2-0ne derivatives for treating cancer
WO2010118010A1 (en) * 2009-04-06 2010-10-14 Eisai Inc. Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer
US9913822B2 (en) 2012-04-04 2018-03-13 Halozyme, Inc. Combination therapy with an anti-hyaluronan agent and therapeutic agent
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

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US3282921A (en) * 1964-06-04 1966-11-01 Syntex Corp Halo-deoxynucleosides and processes for the preparation thereof
US3721664A (en) * 1970-01-27 1973-03-20 Hoffmann La Roche Preparation of 5-cytosine nucleosides
DE2628202A1 (de) * 1976-06-23 1977-12-29 Max Planck Gesellschaft Verfahren zur herstellung von 2'-substituierten-d-ribofuranosylpurinderivaten
DE2721466A1 (de) * 1977-05-12 1978-11-16 Robugen Gmbh Verfahren zur herstellung von 2'-desoxyribofuranosylnucleosiden
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US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
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Also Published As

Publication number Publication date
HU219019B (hu) 2001-01-29
MX9703548A (es) 1997-08-30
RU2161622C2 (ru) 2001-01-10
MY115183A (en) 2003-04-30
PT712860E (pt) 2002-05-31
DE69524365T2 (de) 2002-08-14
CO4600741A1 (es) 1998-05-08
AU702588B2 (en) 1999-02-25
PE50196A1 (es) 1996-11-30
CN1165519A (zh) 1997-11-19
EP0712860A2 (en) 1996-05-22
NO972214D0 (no) 1997-05-14
SK48597A3 (en) 1997-11-05
PL320634A1 (en) 1997-10-13
RO118296B1 (ro) 2003-04-30
KR100424990B1 (ko) 2004-05-20
US5606048A (en) 1997-02-25
SK283160B6 (sk) 2003-03-04
HUT77926A (hu) 1998-11-30
AR001045A1 (es) 1997-09-24
WO1996016072A1 (en) 1996-05-30
NZ296712A (en) 1999-01-28
BR9509904A (pt) 1997-10-14
JPH10509170A (ja) 1998-09-08
PL182052B1 (pl) 2001-10-31
NO308305B1 (no) 2000-08-28
DE69524365D1 (de) 2002-01-17
AU4139396A (en) 1996-06-17
EP0712860A3 (en) 1996-09-25
UA53614C2 (uk) 2003-02-17
DK0712860T3 (da) 2002-03-04
CZ292013B6 (cs) 2003-07-16
IL115854A0 (en) 1996-01-31
NO972214L (no) 1997-05-14
ES2164745T3 (es) 2002-03-01
YU70995A (sh) 1998-09-18
BG62737B1 (bg) 2000-06-30
ZA959321B (en) 1997-05-05
TW377356B (en) 1999-12-21
CN1044119C (zh) 1999-07-14
CA2205350A1 (en) 1996-05-30
CZ148197A3 (en) 1997-08-13
CA2205350C (en) 2007-09-04
BG101485A (en) 1998-03-31
KR970707143A (ko) 1997-12-01
YU49446B (sh) 2006-03-03
SI0712860T1 (en) 2002-04-30
ATE210142T1 (de) 2001-12-15
EP0712860B1 (en) 2001-12-05

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