IL115092A0 - Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents - Google Patents

Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents

Info

Publication number
IL115092A0
IL115092A0 IL11509295A IL11509295A IL115092A0 IL 115092 A0 IL115092 A0 IL 115092A0 IL 11509295 A IL11509295 A IL 11509295A IL 11509295 A IL11509295 A IL 11509295A IL 115092 A0 IL115092 A0 IL 115092A0
Authority
IL
Israel
Prior art keywords
chem
formula
reaction product
alkyl
reacting
Prior art date
Application number
IL11509295A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority to IL12888195A priority Critical patent/IL128881A/xx
Publication of IL115092A0 publication Critical patent/IL115092A0/xx
Priority to IL12888199A priority patent/IL128881A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
IL11509295A 1994-08-31 1995-08-28 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents IL115092A0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL12888195A IL128881A (en) 1994-08-31 1995-08-28 Process for preparing benzothiophene derivatives
IL12888199A IL128881A0 (en) 1994-08-31 1999-03-08 Process for preparing benzoic acid derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/298,636 US5631369A (en) 1994-08-31 1994-08-31 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents

Publications (1)

Publication Number Publication Date
IL115092A0 true IL115092A0 (en) 1995-12-08

Family

ID=23151367

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11509295A IL115092A0 (en) 1994-08-31 1995-08-28 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents

Country Status (17)

Country Link
US (2) US5631369A (hu)
EP (1) EP0699672B1 (hu)
JP (1) JPH08119964A (hu)
KR (1) KR100359959B1 (hu)
AT (1) ATE165355T1 (hu)
BR (1) BR9503846A (hu)
CA (1) CA2157236A1 (hu)
CY (1) CY2092B1 (hu)
DE (1) DE69502152T2 (hu)
DK (1) DK0699672T3 (hu)
ES (1) ES2114721T3 (hu)
FI (1) FI114706B (hu)
GR (1) GR3026742T3 (hu)
HK (1) HK1006912A1 (hu)
HU (2) HU0003473D0 (hu)
IL (1) IL115092A0 (hu)
TW (1) TW427975B (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR199900403T2 (xx) * 1996-08-28 2002-01-21 Eli Lilly And Company Amorf benzotiofenler, haz�rlama y�ntemleri ve kullanma y�ntemleri.
CA2231013A1 (en) * 1997-04-30 1998-10-30 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals
US7124425B1 (en) * 1999-03-08 2006-10-17 Immersion Entertainment, L.L.C. Audio/video system and method utilizing a head mounted apparatus with noise attenuation
WO2001023369A2 (en) * 1999-09-27 2001-04-05 Eli Lilly And Company Process for preparing benzoic acids
FR2817865B1 (fr) * 2000-12-11 2005-02-18 Sanofi Synthelabo Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
AU2003266940B2 (en) 2002-09-30 2007-02-08 A/S Gea Farmaceutisk Fabrik Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these
US7012153B2 (en) * 2003-12-22 2006-03-14 Eli Lilly And Company Process for preparing benzoic acids
CA2960377A1 (en) 2006-06-30 2008-01-03 Iceutica Pty Ltd Methods for the preparation of biologically active compounds in nanoparticulate form
CA2759125C (en) 2009-04-24 2017-08-15 Iceutica Pty Ltd A novel formulation of indomethacin
US9526734B2 (en) 2014-06-09 2016-12-27 Iceutica Pty Ltd. Formulation of meloxicam
KR102117214B1 (ko) 2020-03-26 2020-06-01 유지씨 주식회사 에어 리스 스프레이 건 용 도료 비산 방지 커버 하우징
KR102145873B1 (ko) 2020-06-10 2020-08-20 유지씨 주식회사 에어 리스 스프레이건 용 도료 비산 방지 커버 하우징 및 그 비산 방지 커버 하우징이 결합 된 고소작업대용 도색장치 및 그 비산 방지 커버 하우징이 결합 된 달비계용 도색 장치 및 그 비산 방지 커버 하우징이 결합 된 평면용 도색장치
KR102227020B1 (ko) 2020-12-18 2021-03-12 유지씨 주식회사 스프레이 건 용 도료 비산 방지 커버 하우징 결합체
KR102444617B1 (ko) 2021-05-28 2022-09-16 이다지 도장용 스프레이건의 비산방지장치
KR102607000B1 (ko) 2023-03-24 2023-11-29 이다지 도장용 스프레이 건의 비산방지장치

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
IL65379A0 (en) * 1981-04-03 1982-05-31 Lilly Co Eli Process for preparing acylated benzothiophenes
EP0062503A1 (en) * 1981-04-03 1982-10-13 Eli Lilly And Company Benzothiophene compounds and process for preparing them
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4358593A (en) * 1981-04-03 1982-11-09 Eli Lilly And Company Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4656187A (en) * 1981-08-03 1987-04-07 Eli Lilly And Company Treatment of mammary cancer
CA2020887A1 (en) * 1989-07-28 1991-01-29 Michael Klaus Aromatic carboxylic amides

Also Published As

Publication number Publication date
FI114706B (fi) 2004-12-15
DE69502152D1 (de) 1998-05-28
HU222121B1 (hu) 2003-04-28
GR3026742T3 (en) 1998-07-31
KR100359959B1 (ko) 2003-01-14
HU0003473D0 (hu) 1995-08-30
US5750688A (en) 1998-05-12
EP0699672B1 (en) 1998-04-22
BR9503846A (pt) 1996-09-17
HU9502537D0 (en) 1995-10-30
KR960007543A (ko) 1996-03-22
TW427975B (en) 2001-04-01
JPH08119964A (ja) 1996-05-14
ES2114721T3 (es) 1998-06-01
CY2092B1 (en) 2002-04-05
ATE165355T1 (de) 1998-05-15
CA2157236A1 (en) 1996-03-01
US5631369A (en) 1997-05-20
DE69502152T2 (de) 1998-09-17
EP0699672A1 (en) 1996-03-06
HUT73141A (en) 1996-06-28
FI954067A (fi) 1996-03-01
DK0699672T3 (da) 1998-10-07
FI954067A0 (fi) 1995-08-30
HK1006912A1 (en) 1999-03-19

Similar Documents

Publication Publication Date Title
GR3026742T3 (en) Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
IL115335A0 (en) Naphthyl compounds intermediates processes compositions and methods
ATE167662T1 (de) Verfahren zur herstellung eines lignan-derivats
TW368497B (en) Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
EP0094065B1 (en) 2-aminobenzoic acid derivatives, a process for their preparation and pharmaceutical compositions
KR20010005943A (ko) 0-(3-아미노-2-히드록시-프로필)-히드록심산할라이드의 제조방법
US4760146A (en) Cyclohexene carboxylic esters and amides as antidysrhythmic agents
US4960900A (en) Oxyimino derivatives of thiazole, method of preparation and use in therapy
KR870007111A (ko) β-비스(알콕시이미노) 사이클로알킬렌 유도체의 제조방법
KR840001732B1 (ko) 폴리프레닐 카르복실산 아미드의 제조방법
GR3034636T3 (en) Antifoaming agents.
HU209295B (en) Process for producing amine-substituted terciary carbinol derivatives
MXPA99009046A (en) Process for preparing o-(3-amino-2-hydroxy-propyl)-hydroxymic acid halides

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees