IL114216A - Alkynylcarboguanidides are converted to phenyl bearing perfluoroalkyl groups, a process for their preparation and pharmaceutical compositions containing them - Google Patents

Alkynylcarboguanidides are converted to phenyl bearing perfluoroalkyl groups, a process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL114216A
IL114216A IL11421695A IL11421695A IL114216A IL 114216 A IL114216 A IL 114216A IL 11421695 A IL11421695 A IL 11421695A IL 11421695 A IL11421695 A IL 11421695A IL 114216 A IL114216 A IL 114216A
Authority
IL
Israel
Prior art keywords
alkyl
compound
zero
group
preparation
Prior art date
Application number
IL11421695A
Other languages
English (en)
Hebrew (he)
Other versions
IL114216A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL114216A0 publication Critical patent/IL114216A0/xx
Publication of IL114216A publication Critical patent/IL114216A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL11421695A 1994-06-20 1995-06-19 Alkynylcarboguanidides are converted to phenyl bearing perfluoroalkyl groups, a process for their preparation and pharmaceutical compositions containing them IL114216A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4421536A DE4421536A1 (de) 1994-06-20 1994-06-20 Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (2)

Publication Number Publication Date
IL114216A0 IL114216A0 (en) 1995-10-31
IL114216A true IL114216A (en) 2001-01-11

Family

ID=6521042

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11421695A IL114216A (en) 1994-06-20 1995-06-19 Alkynylcarboguanidides are converted to phenyl bearing perfluoroalkyl groups, a process for their preparation and pharmaceutical compositions containing them

Country Status (22)

Country Link
US (1) US6025349A (zh)
EP (1) EP0688766B1 (zh)
JP (1) JP3718257B2 (zh)
KR (1) KR100368513B1 (zh)
CN (1) CN1062858C (zh)
AT (1) ATE178050T1 (zh)
AU (1) AU692539B2 (zh)
CA (1) CA2152137C (zh)
CZ (1) CZ287263B6 (zh)
DE (2) DE4421536A1 (zh)
DK (1) DK0688766T3 (zh)
ES (1) ES2130472T3 (zh)
FI (1) FI953003A (zh)
GR (1) GR3030231T3 (zh)
HU (1) HU217971B (zh)
IL (1) IL114216A (zh)
NO (1) NO304264B1 (zh)
NZ (1) NZ272373A (zh)
PL (1) PL179395B1 (zh)
SK (1) SK80395A3 (zh)
TW (1) TW332812B (zh)
ZA (1) ZA955027B (zh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19518796A1 (de) 1995-05-22 1996-11-28 Hoechst Ag Fluorphenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19532553A1 (de) * 1995-09-04 1997-03-06 Hoechst Ag Verfahren zur Herstellung substituierter N-Ethyl-Glycinderivate
EP0765867A1 (de) * 1995-09-27 1997-04-02 Hoechst Aktiengesellschaft Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Antiarrhytmika oder Diagnostikum sowie sie enthaltendes Medikament
DE19546736A1 (de) * 1995-12-14 1997-06-19 Hoechst Ag Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
NZ314105A (en) * 1996-02-02 1997-12-19 Sumitomo Pharma Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring
DE19605610A1 (de) * 1996-02-15 1997-08-21 Hoechst Ag Substituierte Thiophenylalkenylcarbonsäureguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
AU2193797A (en) * 1996-03-01 1997-09-16 Chiron Corporation Delivery of therapeutic agents to the prostate
EP0837055A1 (en) * 1996-07-30 1998-04-22 Hoechst Aktiengesellschaft Substituted Indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them
DE19633966A1 (de) * 1996-08-22 1998-02-26 Hoechst Ag Phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19737224A1 (de) 1997-08-27 1999-03-18 Hoechst Marion Roussel De Gmbh Pharmazeutisches Kombinationspräparat aus einem Inhibitor des Natrium-Wasserstoff-Austauschers und einem Arzneimittel zur Behandlung von Herz-Kreislauferkrankungen
US6958324B2 (en) 1998-12-02 2005-10-25 Inotek Pharmaceuticals Corporation Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease
WO2001052860A2 (en) * 2000-01-24 2001-07-26 Inotek Corporation Method and composition for modulating an immune response
DE10024319A1 (de) * 2000-05-17 2001-11-22 Merck Patent Gmbh Bisacylguanidine
DE10219545A1 (de) * 2002-04-26 2003-11-06 Lang Florian Regulation der Apoptose
NZ544671A (en) 2003-06-26 2009-02-28 Biotron Ltd Antiviral compounds and methods
AU2013205388B2 (en) * 2005-06-24 2016-05-05 Biotron Limited Antiviral compounds and methods
PL2826770T3 (pl) 2005-06-24 2019-02-28 Biotron Limited Przeciwwirusowe związki acyloguanidynowe
US7840502B2 (en) * 2007-06-13 2010-11-23 Microsoft Corporation Classification of images as advertisement images or non-advertisement images of web pages
DE102007039246A1 (de) * 2007-08-20 2009-02-26 Robert Bosch Gmbh Formmasse und Verfahren zur Herstellung einer Formmasse
AR085073A1 (es) * 2012-01-11 2013-09-11 Richmond Sa Com Ind Y Financiera Lab Compuestos con actividad antibacteriana, un procedimiento para su obtencion y composiciones farmaceuticas que los comprenden

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1298112A (en) * 1969-02-20 1972-11-29 Wander Ag Dr A Phenyl acetyl guanidine derivatives
US3780027A (en) * 1970-04-29 1973-12-18 Merck & Co Inc Anthranilic acid derivatives
US4101675A (en) * 1973-11-09 1978-07-18 Akzona Incorporated Novel 2,6-di-substituted phenyl-aminoquanidine containing compositions and methods of using same and pharmaceutical compositions containing the same and therapeutic method
GB1519762A (en) * 1974-08-09 1978-08-02 Wellcome Found Cinnamamides their preparation and pharmaceutical compositions containing them
DE2931735A1 (de) * 1979-08-04 1981-02-19 Beiersdorf Ag Neue substituierte phenylacetylguanidine und verfahren zu ihrer herstellung
US4544670A (en) * 1982-08-24 1985-10-01 William H. Rorer, Inc. Method of treating coccidiosis with acyl guanidines
ATE157351T1 (de) * 1993-02-20 1997-09-15 Hoechst Ag Substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament, als inhibitoren des zellulären na+/h+-austauschs oder als diagnostikum sowie sie enthaltendes medikament
JPH06256210A (ja) * 1993-03-10 1994-09-13 Hoechst Japan Ltd 骨関連転写制御因子様タンパク質およびその製造法
DE4318756A1 (de) * 1993-06-05 1994-12-08 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
US6025349A (en) 2000-02-15
IL114216A0 (en) 1995-10-31
SK80395A3 (en) 1996-06-05
ZA955027B (en) 1996-02-08
DE59505412D1 (de) 1999-04-29
NO952450L (no) 1995-12-21
DE4421536A1 (de) 1995-12-21
EP0688766B1 (de) 1999-03-24
NZ272373A (en) 1996-07-26
CZ287263B6 (en) 2000-10-11
JP3718257B2 (ja) 2005-11-24
PL309168A1 (en) 1995-12-27
EP0688766A1 (de) 1995-12-27
KR960000861A (ko) 1996-01-25
FI953003A (fi) 1995-12-21
NO304264B1 (no) 1998-11-23
AU2172095A (en) 1996-01-04
JPH0827093A (ja) 1996-01-30
TW332812B (en) 1998-06-01
CA2152137A1 (en) 1995-12-21
ATE178050T1 (de) 1999-04-15
FI953003A0 (fi) 1995-06-16
ES2130472T3 (es) 1999-07-01
HUT74002A (en) 1996-10-28
CN1122329A (zh) 1996-05-15
GR3030231T3 (en) 1999-08-31
CN1062858C (zh) 2001-03-07
HU217971B (hu) 2000-05-28
AU692539B2 (en) 1998-06-11
KR100368513B1 (ko) 2003-03-19
CZ160795A3 (en) 1996-05-15
NO952450D0 (no) 1995-06-19
HU9501796D0 (en) 1995-08-28
DK0688766T3 (da) 1999-10-11
PL179395B1 (pl) 2000-08-31
CA2152137C (en) 2007-11-13

Similar Documents

Publication Publication Date Title
US5965744A (en) Ortho-substituted benzoylguanidines, including composition and methods of using them
US5849775A (en) Substituted benzoylguanidines process for their preparation, their use as a medicament or diagnostic, and pharmaceutical containing them
US5693672A (en) 3,4,5-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicament containing them
US6025349A (en) Phenyl.-substituted alkenylcarboguanidides carrying perfluoroalkyl groups, a process for their preparation, their use as a medicament or diagnostic agent, and also a medicament containing them
US5547953A (en) Substituted 1-oxo-1,2-dihydroisoquinolinoylguanidines and 1,1-dioxo-2H-1,2-benzothiazinoylguanidines, a process for their preparation, their use as medicaments or diagnostic agents, and medicaments containing them
US5880156A (en) Substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicament containing them
US6504057B2 (en) Fluorophenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
US5516805A (en) 3,5-substituted aminobenzoylguanidines, their use as a medicament or diagnostic and medicament containing them
US5631293A (en) Preparation of amino acid-substituted benzoylguanidines as diagnostic agents
US5883133A (en) Substituted cinnamic acid guanidides, a process for their preparation, their use as medicaments or diagnostic agents and medicaments comprising them
US5747541A (en) Substituted benzoylguanidines, a process for their preparation, their use as medicament of diagnostic agent, and medicament comprising them
US6632840B1 (en) Monoacyl-substituted guanidines, a process for their preparation, their use as a medicament or diagnostic aid, and pharmaceutical compositions containing them
US5559153A (en) Urea-substituted benzoylguanidines, process for their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them
US5567734A (en) Phenyl-substituted alkylcarboguanidides carrying perfluoroalkyl groups, a process for their preparation, their use as a medicament or a diagnostic agent, and a medicament containing them
CA2152878A1 (en) Ortho-amino-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and also a medicament containing them
US5665739A (en) Substituted benzoylguanidines, process and their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them
US6156800A (en) 4-fluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
US5756535A (en) Substituted thiophenylalkenylcarboxylic acid guanidines, processes for their preparation, their use as a medicament or diagnositc, and a medicament containing them
US6262123B1 (en) Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them
US5856574A (en) Ortho-subsituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
US6153651A (en) Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees