IL113941A - Perfluoroalkyl ketone inhibitors of elastase processes for making the same and pharmaceutical compositions containing them - Google Patents

Perfluoroalkyl ketone inhibitors of elastase processes for making the same and pharmaceutical compositions containing them

Info

Publication number
IL113941A
IL113941A IL11394195A IL11394195A IL113941A IL 113941 A IL113941 A IL 113941A IL 11394195 A IL11394195 A IL 11394195A IL 11394195 A IL11394195 A IL 11394195A IL 113941 A IL113941 A IL 113941A
Authority
IL
Israel
Prior art keywords
elastase
making
same
processes
pct
Prior art date
Application number
IL11394195A
Other languages
English (en)
Other versions
IL113941A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Priority to IL12542995A priority Critical patent/IL125429A/en
Publication of IL113941A0 publication Critical patent/IL113941A0/xx
Publication of IL113941A publication Critical patent/IL113941A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06191Dipeptides containing heteroatoms different from O, S, or N
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL11394195A 1994-06-02 1995-05-31 Perfluoroalkyl ketone inhibitors of elastase processes for making the same and pharmaceutical compositions containing them IL113941A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL12542995A IL125429A (en) 1994-06-02 1995-05-31 Perfluoroalkyl ketone inhibitors of elastase, processes for making the same and pharmaceutical compositions containing them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25285794A 1994-06-02 1994-06-02
US32752094A 1994-10-20 1994-10-20

Publications (2)

Publication Number Publication Date
IL113941A0 IL113941A0 (en) 1995-08-31
IL113941A true IL113941A (en) 2000-02-17

Family

ID=26942742

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11394195A IL113941A (en) 1994-06-02 1995-05-31 Perfluoroalkyl ketone inhibitors of elastase processes for making the same and pharmaceutical compositions containing them

Country Status (19)

Country Link
US (1) US6008196A (sv)
EP (1) EP0763055B1 (sv)
JP (1) JP3721538B2 (sv)
KR (1) KR100366328B1 (sv)
CN (1) CN1152048C (sv)
AT (1) ATE186305T1 (sv)
AU (1) AU690986B2 (sv)
CA (1) CA2189526C (sv)
DE (1) DE69513167T2 (sv)
DK (1) DK0763055T3 (sv)
ES (1) ES2137509T3 (sv)
FI (1) FI964789A0 (sv)
GR (1) GR3032294T3 (sv)
HU (1) HU221311B1 (sv)
IL (1) IL113941A (sv)
NO (1) NO316706B1 (sv)
NZ (1) NZ284766A (sv)
TW (1) TW376388B (sv)
WO (1) WO1995033762A1 (sv)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
NZ284766A (en) * 1994-06-02 1998-06-26 Merrell Pharma Inc Perfluoro amino ketones; medicaments as elastase inhibitors
ES2161293T3 (es) * 1994-06-02 2001-12-01 Merrell Pharma Inc Derivados de enol acilados como profarmacos de inhibidores de la elastasa.
US6100238A (en) * 1994-11-21 2000-08-08 Cortech Inc. Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
US5998379A (en) * 1994-11-21 1999-12-07 Cortech Inc. Serine protease inhibitors-proline analogs
US6001811A (en) * 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors--N-substituted derivatives
US6159938A (en) * 1994-11-21 2000-12-12 Cortech, Inc. Serine protease inhibitors comprising α-keto heterocycles
US20020119985A1 (en) 1994-11-21 2002-08-29 Albert Gyorkos Serine protease inhibitors
US6150334A (en) * 1994-11-21 2000-11-21 Cortech, Inc. Serine protease inhibitors-tripeptoid analogs
US6001813A (en) * 1994-11-21 1999-12-14 Cortech Inc. Val-pro containing α-keto oxadiazoles as serine protease inhibitors
US6001814A (en) * 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors
US6015791A (en) * 1994-11-21 2000-01-18 Cortech Inc. Serine protease inhibitors-cycloheptane derivatives
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
HUP0100669A3 (en) * 1996-12-06 2001-12-28 Cortech Inc Denver Peptide derivatives as serine protease inhibitors, their use and pharmaceutical compositions comprising thereof
US6656910B2 (en) 1997-12-04 2003-12-02 Cortech, Inc. Serine protease inhibitors
JP2003520185A (ja) 1998-06-03 2003-07-02 コーテック インコーポレーテッド セリンプロテアーゼ阻害剤としてのα−ケトオキサジアゾール類
AU3731400A (en) * 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Methods and compositions useful in inhibiting apoptosis
KR101036058B1 (ko) * 2002-04-25 2011-05-19 더 스크립스 리서치 인스티튜트 폐질환 증상의 치료 및 예방
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
ATE528014T1 (de) 2002-06-07 2011-10-15 Dyax Corp Polypeptid mit modifizierten kunitz domains
AU2004268144A1 (en) * 2003-08-29 2005-03-10 Dyax Corp. Modified protease inhibitors
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
LT1981519T (lt) * 2005-12-29 2018-04-25 Dyax Corp. Proteazės slopinimas
AU2008289005A1 (en) * 2007-08-21 2009-02-26 Genzyme Corporation Treatment with kallikrein inhibitors
WO2010080833A1 (en) * 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
HUE057244T2 (hu) 2010-01-06 2022-04-28 Takeda Pharmaceuticals Co Plazma kallikreint kötõ fehérjék
JP2014506257A (ja) 2011-01-06 2014-03-13 ダイアックス コーポレーション 血漿カリクレイン結合タンパク質
JP6719384B2 (ja) 2014-03-27 2020-07-15 ダイアックス コーポレーション 糖尿病黄斑浮腫の治療のための組成物および方法
US11286307B2 (en) 2015-12-11 2022-03-29 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
CN114650819A (zh) 2019-09-17 2022-06-21 美莱奥生物制药第四有限公司 用于治疗移植物排斥、闭塞性细支气管炎综合征和移植物抗宿主病的阿维来司他
EP4252850A3 (en) 2020-04-16 2023-11-15 Mereo Biopharma 4 Limited Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
WO2023067103A1 (en) 2021-10-20 2023-04-27 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308384A (en) * 1978-09-18 1981-12-29 Glaxo Group Limited Production of triazinones
US4277395A (en) * 1980-06-16 1981-07-07 Richardson-Merrell Inc. Novel enzyme inhibitors
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
DE3324534A1 (de) * 1983-07-07 1985-01-17 Ciba-Geigy Ag, Basel Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
CA1267499A (en) * 1983-07-12 1990-04-03 Cedric H. Hassall Peptide amides and aldehydes
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
US4643991A (en) * 1984-12-18 1987-02-17 The University Of Kentucky Research Foundation Peptide elastase inhibitors and methods
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
US5496927A (en) * 1985-02-04 1996-03-05 Merrell Pharmaceuticals Inc. Peptidase inhibitors
CA1341029C (en) * 1985-02-04 2000-06-20 Michael Kolb Peptidase inhibitors
DE3683541D1 (de) * 1985-06-07 1992-03-05 Ici America Inc Selektionierte difluorverbindungen.
GB8613703D0 (en) * 1986-06-05 1986-07-09 Ici America Inc Difluoro peptide compounds
US4935405A (en) * 1986-10-31 1990-06-19 Pfizer Inc. Nor-statine and nor-cyclostatine polypeptides
US4855303A (en) * 1987-07-01 1989-08-08 Pfizer Inc. Fluorine containing renin inhibitors
EP0318318A1 (en) * 1987-11-27 1989-05-31 Sensititre Limited Urine assay process and kit
US5162307A (en) * 1988-09-09 1992-11-10 Board Of Trustees Of The University Of Kentucky Polymer bound elastase inhibitors
EP0371179A1 (en) * 1988-10-28 1990-06-06 Merrell Dow Pharmaceuticals Inc. Novel analogs of peptidase substrates
EP0369391A3 (en) * 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituted amides
ZA905737B (en) * 1989-07-26 1991-05-29 Merrell Dow Pharma Novel peptidase inhibitors
US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
AU661270B2 (en) * 1990-03-05 1995-07-20 Cephalon, Inc. Chymotrypsin-like proteases and their inhibitors
KR920701200A (ko) * 1990-03-30 1992-08-11 미즈노 시게루 신규의 4h-3,1-벤조옥사진-4-온 유도체
CA2098702A1 (en) * 1990-12-28 1992-06-29 James C. Powers Peptide ketoamides, ketoacids, and ketoesters
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof
ATE431364T1 (de) * 1991-03-01 2009-05-15 Dyax Corp Inhibitoren der menschlichen elastase von neutrophilen
WO1992020357A1 (en) * 1991-05-23 1992-11-26 Merrell Dow Pharmaceuticals Inc. Inhibitors of cathepsin g and elastase for preventing connective tissue degradation
ZA926185B (en) * 1991-08-22 1993-03-01 Merrell Dow Pharma Novel orally-active elastase inhibitors.
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
WO1995009838A1 (en) * 1993-10-01 1995-04-13 Merrell Pharmaceuticals Inc. INHIBITORS OF β-AMYLOID PROTEIN PRODUCTION
ES2161293T3 (es) * 1994-06-02 2001-12-01 Merrell Pharma Inc Derivados de enol acilados como profarmacos de inhibidores de la elastasa.
DE69531459T2 (de) * 1994-06-02 2004-06-24 Aventis Pharmaceuticals Inc. Elatase-inhibitoren
NZ284766A (en) * 1994-06-02 1998-06-26 Merrell Pharma Inc Perfluoro amino ketones; medicaments as elastase inhibitors

Also Published As

Publication number Publication date
WO1995033762A1 (en) 1995-12-14
NO316706B1 (no) 2004-04-13
NZ284766A (en) 1998-06-26
GR3032294T3 (en) 2000-04-27
CN1152048C (zh) 2004-06-02
CA2189526C (en) 2001-02-27
NO965098D0 (no) 1996-11-29
DK0763055T3 (da) 2000-05-08
US6008196A (en) 1999-12-28
EP0763055B1 (en) 1999-11-03
CA2189526A1 (en) 1995-12-14
TW376388B (en) 1999-12-11
IL113941A0 (en) 1995-08-31
AU2400095A (en) 1996-01-04
KR100366328B1 (ko) 2003-03-06
FI964789A (sv) 1996-11-29
DE69513167T2 (de) 2000-06-15
AU690986B2 (en) 1998-05-07
NO965098L (no) 1997-01-31
JP3721538B2 (ja) 2005-11-30
ES2137509T3 (es) 1999-12-16
HU9603311D0 (en) 1997-01-28
JPH10501529A (ja) 1998-02-10
ATE186305T1 (de) 1999-11-15
EP0763055A1 (en) 1997-03-19
HUT75318A (en) 1997-05-28
HU221311B1 (en) 2002-09-28
CN1149876A (zh) 1997-05-14
FI964789A0 (sv) 1996-11-29
MX9606031A (es) 1998-05-31
DE69513167D1 (de) 1999-12-09

Similar Documents

Publication Publication Date Title
IL113941A (en) Perfluoroalkyl ketone inhibitors of elastase processes for making the same and pharmaceutical compositions containing them
NO952228L (no) Anvendelse av lamotrigin ved behandling av neurologiske lesjoner relatert til traumatiske skader
PT758241E (pt) Utilizacao de certos derivados de acido metanobisfosfonico para impedir o desprendimento de proteses e a migracao de proteses
DE69326776D1 (de) Verwendung von n-arylmethylen ethylendiamintriacetate, n-arylmethylen iminodiacetat oder n,n'-diarylmethylen ethylendiamindiacetat gegen oxidativen stress
FI960102A (sv) En ny farmaceutisk blandning
IL116385A (en) Sulphonamides their manufacture and pharmaceutical compositions containing them
BR9808812A (pt) Composição compreendendo partìculas cristalinas, finamente divididas de budesonida
BG101118A (en) Therapeutical compounds
ZA965235B (en) Pharmaceutical and diet formulations for the prophylaxis and treatment of gastrointestinal disorders
MX9704030A (es) 1,1-dioxidos de 2-heterocicliloxi y tiometil-1,2,5-tiadiazolidin-3-ona y composiciones y metodo de uso de los mismos.
IL132608A0 (en) Fused dihydropyran compounds medicaments containing the same and the use thereof
EP0793660A4 (en) 2-SUBSTITUTED 1,2,5-THIADIAZOLIDIN-3-ON-1,1-DIOXIDES, COMPOSITION AND THEIR USE
IL113940A (en) Synthetic peptides which are elastase inhibitors and pharmaceutical compositions for the treatment of neutrophil associated inflammatory disease containing said inhibitors
HUT77868A (hu) Imidazopiridin-azolidinonok, ezeket tartalmazó gyógyszerkészítmények, alkalmazásuk és eljárás előállításukra
NZ268914A (en) Use of efaroxan and derivatives to prepare medicaments for treating neurodegenerative diseases especially alzheimer's disease
ZA983211B (en) Use of mizolastine for preparing medication for the treatment of inflammation
PL322847A1 (en) Condensed b-carbolins

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees
HC Change of name of proprietor(s)

Owner name: AVENTIS INC.

Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC.