IL113706A - N-hydroxyurea alkyl phenyl oxazoles and thiazoles uses thereof as anti-inflammatory agents and pharmaceutical compositions containing them - Google Patents

N-hydroxyurea alkyl phenyl oxazoles and thiazoles uses thereof as anti-inflammatory agents and pharmaceutical compositions containing them

Info

Publication number
IL113706A
IL113706A IL11370695A IL11370695A IL113706A IL 113706 A IL113706 A IL 113706A IL 11370695 A IL11370695 A IL 11370695A IL 11370695 A IL11370695 A IL 11370695A IL 113706 A IL113706 A IL 113706A
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
hydroxyurea
pct
thiazoles
compositions containing
Prior art date
Application number
IL11370695A
Other languages
English (en)
Other versions
IL113706A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL113706A0 publication Critical patent/IL113706A0/xx
Publication of IL113706A publication Critical patent/IL113706A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL11370695A 1994-05-19 1995-05-11 N-hydroxyurea alkyl phenyl oxazoles and thiazoles uses thereof as anti-inflammatory agents and pharmaceutical compositions containing them IL113706A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP12810594A JP3179286B2 (ja) 1994-05-19 1994-05-19 Ｎ−ヒドロキシ尿素系抗炎症剤
PCT/JP1995/001127 WO1996040659A1 (en) 1994-05-19 1995-06-07 N-hydroxyureas as antiinflammatory agents
CA002223023A CA2223023C (en) 1994-05-19 1995-06-07 N-hydroxyureas as antiinflammatory agents

Publications (2)

Publication Number Publication Date
IL113706A0 IL113706A0 (en) 1995-08-31
IL113706A true IL113706A (en) 1999-08-17

Family

ID=27170556

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11370695A IL113706A (en) 1994-05-19 1995-05-11 N-hydroxyurea alkyl phenyl oxazoles and thiazoles uses thereof as anti-inflammatory agents and pharmaceutical compositions containing them

Country Status (19)

Country Link
US (1) US5814648A (cs)
EP (1) EP0832078B1 (cs)
JP (2) JP3179286B2 (cs)
AT (1) ATE185803T1 (cs)
AU (1) AU705505B2 (cs)
BR (1) BR9502072A (cs)
CA (1) CA2223023C (cs)
CZ (1) CZ286331B6 (cs)
DE (1) DE69512940T2 (cs)
DK (1) DK0832078T3 (cs)
ES (1) ES2138211T3 (cs)
FI (1) FI974444L (cs)
GR (1) GR3032301T3 (cs)
HU (1) HUT77950A (cs)
IL (1) IL113706A (cs)
NO (1) NO310288B1 (cs)
NZ (1) NZ287551A (cs)
PL (1) PL179853B1 (cs)
WO (1) WO1996040659A1 (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19548419A1 (de) * 1995-12-22 1997-06-26 Bayer Ag Substituierte Thiazoline
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2006103045A1 (en) * 2005-03-31 2006-10-05 Ucb Pharma S.A. Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses
JP2008539047A (ja) 2005-04-28 2008-11-13 プロテウス バイオメディカル インコーポレイテッド ファーマインフォーマティックスシステム
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
NZ720946A (en) 2009-04-29 2017-09-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
WO2021214048A1 (en) * 2020-04-20 2021-10-28 Johann Wolfgang Goethe-Universität Frankfurt am Main Dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2095325T3 (es) * 1990-07-25 1997-02-16 Abbott Lab Derivados de acetileno con una actividad de inhibicion de la lipoxigenasa.
JP2528741B2 (ja) * 1991-01-09 1996-08-28 ファイザー製薬株式会社 オキサゾ―ル、チアゾ―ルおよびイミダゾ―ル化合物
JPH07100687B2 (ja) * 1991-06-13 1995-11-01 ファイザー製薬株式会社 新規なｎ−ヒドロキシ尿素化合物および組成物
US5288751A (en) * 1992-11-06 1994-02-22 Abbott Laboratories [(Substituted) phenyalkyl]furylalkynyl-and [substituted) phenyalkyl] thienylalkynyl-N-hydroxyurea inhibitors or leukotriene biosynthesis
US5681858A (en) * 1993-04-07 1997-10-28 Pfizer Inc. Cycloalkyl hydroxyureas

Also Published As

Publication number Publication date
NO310288B1 (no) 2001-06-18
JP3179286B2 (ja) 2001-06-25
AU2629495A (en) 1996-12-30
HUT77950A (hu) 1998-12-28
BR9502072A (pt) 1996-04-09
CA2223023A1 (en) 1996-12-19
DE69512940T2 (de) 2000-02-17
FI974444A7 (fi) 1998-02-04
PL179853B1 (pl) 2000-11-30
DK0832078T3 (da) 2000-04-25
JPH07309849A (ja) 1995-11-28
EP0832078A1 (en) 1998-04-01
GR3032301T3 (en) 2000-04-27
US5814648A (en) 1998-09-29
PL324012A1 (en) 1998-04-27
NO975726D0 (no) 1997-12-05
ATE185803T1 (de) 1999-11-15
CA2223023C (en) 2001-07-17
NZ287551A (en) 1999-02-25
EP0832078B1 (en) 1999-10-20
AU705505B2 (en) 1999-05-27
CZ382497A3 (cs) 1999-03-17
DE69512940D1 (de) 1999-11-25
WO1996040659A1 (en) 1996-12-19
NO975726L (no) 1998-02-03
MX9709986A (es) 1998-03-29
IL113706A0 (en) 1995-08-31
JPH10506649A (ja) 1998-06-30
FI974444A0 (fi) 1997-12-05
FI974444L (fi) 1998-02-04
CZ286331B6 (cs) 2000-03-15
ES2138211T3 (es) 2000-01-01

Similar Documents

Publication Publication Date Title
ZA919317B (en) Novel hydroxamic acid and N-hydroxyurea derivatives and their use.
ATE206123T1 (de) Phenylxanthin-derivate
TR200001816T2 (tr) Hipolipidemik benzotiyazepin bileşikleri
ES2147399T3 (es) Nuevos derivados de 2,3,5-trimetil-4-hidroxianilidas, su preparacion y su aplicacion terapeutica.
IL113706A (en) N-hydroxyurea alkyl phenyl oxazoles and thiazoles uses thereof as anti-inflammatory agents and pharmaceutical compositions containing them
GB9418912D0 (en) Pharmaceutically active compounds
CA2139731A1 (en) 2-heterocyclic-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents
PL313037A1 (en) Phenoxphenylocyclopententenylohydroxyureas
FI932654A0 (fi) Hydroxamsyraderivat, som hindrar lipoxigenas
GR3035010T3 (en) New derivatives of glycylanilides, preparation and therapeutical application

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees