IL112588A - 2-Substituted imidazo Ú1,2-a¾ quinoxalin-4(5h)-one derivatives their preparation and pharmaceutical compositions containing them - Google Patents

2-Substituted imidazo Ú1,2-a¾ quinoxalin-4(5h)-one derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number
IL112588A
IL112588A IL11258895A IL11258895A IL112588A IL 112588 A IL112588 A IL 112588A IL 11258895 A IL11258895 A IL 11258895A IL 11258895 A IL11258895 A IL 11258895A IL 112588 A IL112588 A IL 112588A
Authority
IL
Israel
Prior art keywords
independently
image
alkoxy
optionally substituted
alkyl
Prior art date
Application number
IL11258895A
Other languages
English (en)
Other versions
IL112588A0 (en
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of IL112588A0 publication Critical patent/IL112588A0/xx
Publication of IL112588A publication Critical patent/IL112588A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL11258895A 1994-02-11 1995-02-09 2-Substituted imidazo Ú1,2-a¾ quinoxalin-4(5h)-one derivatives their preparation and pharmaceutical compositions containing them IL112588A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK18394 1994-02-11
DK135194 1994-11-25

Publications (2)

Publication Number Publication Date
IL112588A0 IL112588A0 (en) 1995-05-26
IL112588A true IL112588A (en) 1999-07-14

Family

ID=26063483

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11258895A IL112588A (en) 1994-02-11 1995-02-09 2-Substituted imidazo Ú1,2-a¾ quinoxalin-4(5h)-one derivatives their preparation and pharmaceutical compositions containing them

Country Status (15)

Country Link
US (1) US5741785A (xx)
EP (1) EP0743945B1 (xx)
JP (1) JPH09508632A (xx)
KR (1) KR970701192A (xx)
CN (1) CN1045964C (xx)
AT (1) ATE214069T1 (xx)
AU (1) AU692524B2 (xx)
CA (1) CA2182957A1 (xx)
DE (1) DE69525738D1 (xx)
FI (1) FI963130A (xx)
HU (1) HUT76323A (xx)
IL (1) IL112588A (xx)
NO (1) NO306781B1 (xx)
NZ (1) NZ281183A (xx)
WO (1) WO1995021842A1 (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10513435A (ja) * 1994-09-30 1998-12-22 ビーエーエスエフ アクチェンゲゼルシャフト 複素環で置換された新規イミダゾロキノキサリノン、その製造および使用
FR2743363A1 (fr) * 1996-01-10 1997-07-11 Rhone Poulenc Rorer Sa 5h,10h-imidazo(1,2-a)indeno(1,2-e)pyrazine-a-ones substituees en position 2, leur preparation et les medicaments les contenant
DE19611476A1 (de) * 1996-03-22 1997-09-25 Basf Ag Neue heterocyclische substituierte Imidazolo-chinoxalinone, ihre Herstellung und Verwendung
IL125950A0 (en) * 1997-09-05 1999-04-11 Pfizer Prod Inc Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy
KR101563103B1 (ko) 2006-12-13 2015-10-23 아스카 세이야쿠 가부시키가이샤 퀴녹살린 유도체
JP5496680B2 (ja) * 2006-12-28 2014-05-21 アッヴィ・インコーポレイテッド ポリ（ａｄｐ−リボース）ポリメラーゼの阻害剤
WO2023042888A1 (ja) 2021-09-15 2023-03-23 国立大学法人 琉球大学 認知機能低下、または過体重もしくは肥満症を処置することに用いるための医薬組成物
EP4403184A1 (en) 2021-09-15 2024-07-24 University of The Ryukyus Pharmaceutical composition for use in treating cognitive decline, excess weight, or obesity

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2448541A1 (fr) * 1979-02-09 1980-09-05 Roussel Uclaf Nouveaux derives de l'oxoimidazoquinoxaline et leurs sels, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
GB2043637B (en) * 1979-02-09 1983-03-16 Roussel Lab Ltd Heterotricyclic derivatives
GB2043064B (en) * 1979-02-09 1983-04-13 Roussel Lab Ltd Oximidazoquinoxaline derivatives
US5055465A (en) * 1989-05-31 1991-10-08 Berlex Laboratories, Inc. Imidazoquinoxalinones, their aza analogs and process for their preparation
US5153196A (en) * 1991-06-05 1992-10-06 Eli Lilly And Company Excitatory amino acid receptor antagonists and methods for the use thereof
US5182386A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands
WO1993020077A1 (en) * 1992-04-03 1993-10-14 Yamanouchi Pharmaceutical Co., Ltd. Fused quinoxalinone derivative and pharmaceutical composition containing the same
DE4329970A1 (de) * 1993-03-31 1994-10-06 Basf Ag Neue Imidazolo-chinoxalinone, ihre Hestellung und Verwendung
CN1041928C (zh) * 1993-03-31 1999-02-03 Basf公司 新的咪唑并喹喔啉酮及其制备方法和用途
DE4310523A1 (de) * 1993-03-31 1994-10-06 Basf Ag Imidazolo-chinoxalinone zur Behandlung zentralnervöser Erkrankungen

Also Published As

Publication number Publication date
FI963130A (fi) 1996-10-09
NO963337D0 (no) 1996-08-09
US5741785A (en) 1998-04-21
CN1045964C (zh) 1999-10-27
EP0743945B1 (en) 2002-03-06
NO306781B1 (no) 1999-12-20
ATE214069T1 (de) 2002-03-15
NO963337L (no) 1996-10-11
HUT76323A (en) 1997-08-28
NZ281183A (en) 1998-05-27
AU692524B2 (en) 1998-06-11
DE69525738D1 (de) 2002-04-11
FI963130A0 (fi) 1996-08-09
CN1145071A (zh) 1997-03-12
JPH09508632A (ja) 1997-09-02
EP0743945A1 (en) 1996-11-27
KR970701192A (ko) 1997-03-17
HU9602203D0 (en) 1996-10-28
CA2182957A1 (en) 1995-08-17
AU1805595A (en) 1995-08-29
WO1995021842A1 (en) 1995-08-17
IL112588A0 (en) 1995-05-26

Similar Documents

Publication Publication Date Title
ES2136704T3 (es) Derivados triciclicos y su uso como agentes anticancerigenos.
YU85001A (sh) Derivati 5-fenil-pirimidina
TW377354B (en) [1,2,4]triazolo[4,3-a]quinoxaline compounds, their preparation and use
IL112588A (en) 2-Substituted imidazo Ú1,2-a¾ quinoxalin-4(5h)-one derivatives their preparation and pharmaceutical compositions containing them
DE69509888D1 (de) IMIDAZO[1,2-a]INDENO [1,2-e] PYRAZINONE ANTAGONISTEN DER AMPA UND NMDA REZEPTOREN
DK0752992T3 (da) Imidazo[1,2-a]indeno[1,2-e]pyrazin-4-on-derivater og farmaceutiske præparater indeholdende disse derivater
ES8504189A1 (es) Un compuesto de pirazol (3,4-b) piridina.
NO305439B1 (no) Pyrido(1,2,3-de)kinoksalinderivater og legemidler inneholdende disse

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees