IL112114A - 1,1-Dioxo-1,22-H-benzothiazinoylguanidines, process for their preparation and pharmaceutical preparations containing them - Google Patents

1,1-Dioxo-1,22-H-benzothiazinoylguanidines, process for their preparation and pharmaceutical preparations containing them

Info

Publication number
IL112114A
IL112114A IL11211494A IL11211494A IL112114A IL 112114 A IL112114 A IL 112114A IL 11211494 A IL11211494 A IL 11211494A IL 11211494 A IL11211494 A IL 11211494A IL 112114 A IL112114 A IL 112114A
Authority
IL
Israel
Prior art keywords
compound
treatment
production
medicament
formula
Prior art date
Application number
IL11211494A
Other languages
English (en)
Hebrew (he)
Other versions
IL112114A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL112114A0 publication Critical patent/IL112114A0/xx
Publication of IL112114A publication Critical patent/IL112114A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Compression, Expansion, Code Conversion, And Decoders (AREA)
  • Photoreceptors In Electrophotography (AREA)
IL11211494A 1993-12-24 1994-12-22 1,1-Dioxo-1,22-H-benzothiazinoylguanidines, process for their preparation and pharmaceutical preparations containing them IL112114A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4344550A DE4344550A1 (de) 1993-12-24 1993-12-24 Substituierte 1-Oxo-1,2-dihydro-isochinolinoyl- und 1,1-Dioxo-2H-1,2-benzothiazinoylguanidine, Verfahrenzu ihrer Herstellung, ihre Verwendung als Medikamentt oder Diagnostikum sowie sie enthaltendes Medikamen

Publications (2)

Publication Number Publication Date
IL112114A0 IL112114A0 (en) 1995-03-15
IL112114A true IL112114A (en) 2001-06-14

Family

ID=6506276

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11211494A IL112114A (en) 1993-12-24 1994-12-22 1,1-Dioxo-1,22-H-benzothiazinoylguanidines, process for their preparation and pharmaceutical preparations containing them

Country Status (20)

Country Link
US (1) US5547953A (fr)
EP (1) EP0659748B1 (fr)
JP (1) JP3790559B2 (fr)
KR (2) KR100360127B1 (fr)
CN (1) CN1053899C (fr)
AT (1) ATE194605T1 (fr)
AU (1) AU683320B2 (fr)
CA (1) CA2138466A1 (fr)
DE (2) DE4344550A1 (fr)
DK (1) DK0659748T3 (fr)
ES (1) ES2149233T3 (fr)
FI (1) FI946039A (fr)
GR (1) GR3034335T3 (fr)
HU (1) HU222524B1 (fr)
IL (1) IL112114A (fr)
NO (1) NO304787B1 (fr)
NZ (2) NZ272846A (fr)
PT (1) PT659748E (fr)
TW (1) TW504505B (fr)
ZA (1) ZA9410242B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4412334A1 (de) * 1994-04-11 1995-10-19 Hoechst Ag Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
EP0765867A1 (fr) * 1995-09-27 1997-04-02 Hoechst Aktiengesellschaft Benzoylguanidines substituées, procédé de leur préparation, leur utilisation comme agent antiarythmique ou diagnostique ainsi que le médicament les contenant
DE19540995A1 (de) * 1995-11-03 1997-05-07 Hoechst Ag Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19542306A1 (de) * 1995-11-14 1997-05-15 Hoechst Ag Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL316439A1 (en) * 1995-11-20 1997-05-26 Hoechst Ag Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (de) * 1995-12-14 1997-06-19 Hoechst Ag Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
DE19548708A1 (de) * 1995-12-23 1997-06-26 Merck Patent Gmbh Cyclische Sulfone
CA2195697A1 (fr) 1996-02-02 1997-08-03 Masahumi Kitano Derives substitues de la guanidine, procede pour leur obtention et leurs utilisations pharmaceutiques
JPH10152481A (ja) * 1996-09-25 1998-06-09 Kanebo Ltd ベンゾ［１，４］チアジン誘導体およびそれからなる医薬
ES2224365T3 (es) * 1997-02-12 2005-03-01 Smithkline Beecham Corporation Antagonistas de receptores de il-8.
US6436927B1 (en) 1997-02-12 2002-08-20 Smithkline Beecham Corporation IL-8 receptor antagonists
CA2283404A1 (fr) 1997-03-06 1998-09-11 Jun Sasamori Derives de cycloalca¬b|pyridine-3-carbonylguanidine, leur procede de production et medicaments les contenant
JP2002502414A (ja) * 1997-06-02 2002-01-22 藤沢薬品工業株式会社 細胞中のＮａ▲上＋▼／Ｈ▲上＋▼交換の阻害剤としてのグアニジン誘導体
US6703405B2 (en) 2001-12-22 2004-03-09 Aventis Pharma Deutschland Gmbh Substituted 4-phenyltetrahydroisoquinolinium salts, process for their preparation, their use as a medicament, and medicament containing them
DE10163914A1 (de) * 2001-12-22 2003-07-03 Aventis Pharma Gmbh Substituierte 4-Phenyltetrahydroisochinolinium-Salze, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament
WO2006044645A2 (fr) * 2004-10-13 2006-04-27 Adolor Corporation Sulfamoyle benzamides et procedes d'utilisation
CN103476252B (zh) 2010-12-08 2017-02-22 莱斯拉公司 吡唑基胍f1f0‑atp酶抑制剂及其治疗用途
JP6050242B2 (ja) 2010-12-08 2016-12-21 リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ ピリドニルグアニジンｆ１ｆ０−ａｔｐアーゼ阻害剤およびその治療的使用
US9169199B2 (en) 2010-12-08 2015-10-27 Lycera Corporation Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof
EP2866796A4 (fr) 2012-06-08 2015-11-25 Lycera Corp Inhibiteurs d' atpase de type f1f0, à base de guanidine d'indazole
WO2013185046A1 (fr) 2012-06-08 2013-12-12 Lycera Corporation Guanidine d'acyle saturée pour inhibition de l'atpase de type f1f0
EP2866893A4 (fr) 2012-06-08 2015-12-23 Lycera Corp Inhibiteurs d' atpase de type f1f0, à base de guanidine hétérocyclique et leurs utilisations thérapeutiques
WO2015089152A1 (fr) 2013-12-10 2015-06-18 Lycera Corporation Inhibiteurs de la f1fo-atpase à base de pyrazolyl guanidine à subsitution n et applications thérapeutiques associées
JP2016539983A (ja) 2013-12-10 2016-12-22 リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ アルキルピラゾリルグアニジンｆ１ｆ０−ａｔｐアーゼ阻害剤及びその治療用途
AU2014363904B2 (en) 2013-12-10 2018-10-04 Lycera Corporation Trifluoromethyl pyrazolyl guanidine F1Fo-ATPase inhibitors and therapeutic uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3780027A (en) * 1970-04-29 1973-12-18 Merck & Co Inc Anthranilic acid derivatives
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
EP0556674B1 (fr) * 1992-02-15 1996-06-19 Hoechst Aktiengesellschaft Benzoylguanidines 3,5-substitués avec une activité antiarrhythmique et une activité inhibitrice de la prolifération des cellules
ES2097409T3 (es) * 1992-09-22 1997-04-01 Hoechst Ag Benzoilguanidinas, procedimiento para su preparacion, asi como su empleo como antiarritmicos.
EP0590455B1 (fr) * 1992-09-28 2000-12-27 Hoechst Aktiengesellschaft 1-(2H)-Isoquinoleines substituées à activité antiarrythmique et cardioprotective, procédé de préparation, médicaments les contenant et leur utilisation pour la préparation de médicaments pour traiter l'insuffisance cardiaque
TW250479B (fr) * 1992-12-15 1995-07-01 Hoechst Ag

Also Published As

Publication number Publication date
HUT72749A (en) 1996-05-28
FI946039A (fi) 1995-06-25
ZA9410242B (en) 1995-08-02
DE4344550A1 (de) 1995-06-29
KR950017981A (ko) 1995-07-22
NO945015D0 (no) 1994-12-23
IL112114A0 (en) 1995-03-15
JPH07206823A (ja) 1995-08-08
JP3790559B2 (ja) 2006-06-28
DE59409439D1 (de) 2000-08-17
EP0659748A1 (fr) 1995-06-28
DK0659748T3 (da) 2000-10-02
FI946039A0 (fi) 1994-12-22
PT659748E (pt) 2000-11-30
NZ270264A (en) 1996-02-27
US5547953A (en) 1996-08-20
EP0659748B1 (fr) 2000-07-12
CA2138466A1 (fr) 1995-06-25
HU222524B1 (hu) 2003-08-28
AU8170094A (en) 1995-06-29
NO304787B1 (no) 1999-02-15
CN1053899C (zh) 2000-06-28
NO945015L (no) 1995-06-26
AU683320B2 (en) 1997-11-06
KR100360127B1 (ko) 2003-04-23
HU9403759D0 (en) 1995-02-28
ES2149233T3 (es) 2000-11-01
KR100353339B1 (ko) 2002-09-19
NZ272846A (en) 1996-02-27
CN1107840A (zh) 1995-09-06
ATE194605T1 (de) 2000-07-15
TW504505B (en) 2002-10-01
GR3034335T3 (en) 2000-12-29

Similar Documents

Publication Publication Date Title
US5547953A (en) Substituted 1-oxo-1,2-dihydroisoquinolinoylguanidines and 1,1-dioxo-2H-1,2-benzothiazinoylguanidines, a process for their preparation, their use as medicaments or diagnostic agents, and medicaments containing them
CA2130944C (fr) Derives de substitution en ortho de benzoylguanidines; methode de preparation; utilisation en pharmacie ou en diagnostic; produit pharmaceutique a base de ces derives
CA2089439C (fr) Benzoylguanidines a substituant en 3,5, procede d'obtention et emploi comme medicament ou diagnostique, et medicament qui les contient
JP3802582B2 (ja) ペルフルオロアルキル−置換ベンゾイルグアニジン類、その製造方法、医薬または診断剤としてのその使用およびそれを含有する医薬
US6025349A (en) Phenyl.-substituted alkenylcarboguanidides carrying perfluoroalkyl groups, a process for their preparation, their use as a medicament or diagnostic agent, and also a medicament containing them
US5516805A (en) 3,5-substituted aminobenzoylguanidines, their use as a medicament or diagnostic and medicament containing them
US5747541A (en) Substituted benzoylguanidines, a process for their preparation, their use as medicament of diagnostic agent, and medicament comprising them
US6632840B1 (en) Monoacyl-substituted guanidines, a process for their preparation, their use as a medicament or diagnostic aid, and pharmaceutical compositions containing them
JPH08259515A (ja) 塩基で置換されたベンゾイルグアニジン、その製造方法、医薬または診断剤としてのその使用およびそれを含有する医薬
CZ218496A3 (en) Substituted guanidines of cinnamic acid, process of their preparation, their use as a medicament or a diagnostic agent, as well as the medicament in which they are comprised
IL110625A (en) Benzoylguanidines are converted in urea, the process for their preparation and the seafood preparations containing them
RU2160727C2 (ru) Бензоилгуанидины, способ их получения, промежуточное соединение для их получения, способ ингибирования и лекарственное средство
CA2152878A1 (fr) Derives de substitution de benzoylguanidines, amines en ortho; methode de preparation; utilisation comme medicaments ou agents de diagnostic; medicaments renfermant ces derives
CA2206758C (fr) Benzoylguanidines ortho-substituees, procede de preparation, leur utilisation comme medicament ou produit diagnostique et medicament contenant ces composes
US6156800A (en) 4-fluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
US5856344A (en) Sulfonylamino-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic aid, and medicament containing them
CA2206362C (fr) 1-naphthoylguanidines de substitution, processus de preparation de celles-ci, leur utilisation comme medicament ou a des fins diagnostiques et medicament les renfermant
US5869531A (en) Fluoroalkyl substituted benzoylguanidines
JPH08225514A (ja) 置換ベンゾイルグアニジン、その製造方法、医薬または診断剤としてのその使用およびそれを含有する医薬
CZ65497A3 (cs) Ortho-substituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiva a léčiva, která je obsahují
MXPA97001323A (en) Benzoilguanidinas replaced in orthodous position, a procedure for its preparation, its use as a diagnostic medicine or agent, so i composed that conti

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees