IL111725A - History of 3-Aziridino-anthracycline, their preparation and pharmaceutical preparations containing them - Google Patents

History of 3-Aziridino-anthracycline, their preparation and pharmaceutical preparations containing them

Info

Publication number
IL111725A
IL111725A IL11172594A IL11172594A IL111725A IL 111725 A IL111725 A IL 111725A IL 11172594 A IL11172594 A IL 11172594A IL 11172594 A IL11172594 A IL 11172594A IL 111725 A IL111725 A IL 111725A
Authority
IL
Israel
Prior art keywords
formula
group
deamino
anthracycline glycoside
pharmaceutically acceptable
Prior art date
Application number
IL11172594A
Other languages
English (en)
Hebrew (he)
Other versions
IL111725A0 (en
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of IL111725A0 publication Critical patent/IL111725A0/xx
Publication of IL111725A publication Critical patent/IL111725A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
IL11172594A 1993-12-13 1994-11-22 History of 3-Aziridino-anthracycline, their preparation and pharmaceutical preparations containing them IL111725A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939325417A GB9325417D0 (en) 1993-12-13 1993-12-13 3'- aziridino-anthracycline derivatives

Publications (2)

Publication Number Publication Date
IL111725A0 IL111725A0 (en) 1995-01-24
IL111725A true IL111725A (en) 1998-07-15

Family

ID=10746494

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11172594A IL111725A (en) 1993-12-13 1994-11-22 History of 3-Aziridino-anthracycline, their preparation and pharmaceutical preparations containing them

Country Status (26)

Country Link
US (1) US5532218A (pl)
EP (1) EP0683788B1 (pl)
JP (1) JPH08506835A (pl)
KR (1) KR100352734B1 (pl)
CN (1) CN1039123C (pl)
AT (1) ATE157369T1 (pl)
AU (1) AU676625B2 (pl)
CA (1) CA2154890A1 (pl)
DE (1) DE69405214T2 (pl)
DK (1) DK0683788T3 (pl)
ES (1) ES2107294T3 (pl)
FI (1) FI108036B (pl)
GB (1) GB9325417D0 (pl)
GR (1) GR3025266T3 (pl)
HK (1) HK1011692A1 (pl)
HU (1) HU217630B (pl)
IL (1) IL111725A (pl)
MY (1) MY117086A (pl)
NO (1) NO304951B1 (pl)
NZ (1) NZ276401A (pl)
PL (1) PL178806B1 (pl)
RU (1) RU2149163C1 (pl)
TW (1) TW336235B (pl)
UA (1) UA43839C2 (pl)
WO (1) WO1995016695A2 (pl)
ZA (1) ZA949701B (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948896A (en) * 1997-08-13 1999-09-07 Gem Pharmaceuticals Processes for preparing 13-deoxy anthracycline derivatives
US5942605A (en) * 1998-03-03 1999-08-24 Gem Pharmaceuticals, Inc. 5-imino-13-deoxy anthracycline derivatives, their uses, and processes for preparing them
GB9806324D0 (en) * 1998-03-24 1998-05-20 Pharmacia & Upjohn Spa Antitumour synergetic composition
GB9808027D0 (en) * 1998-04-15 1998-06-17 Pharmacia & Upjohn Spa 13-dihydro-3' aziridino anthracyclines
GB9904386D0 (en) 1999-02-25 1999-04-21 Pharmacia & Upjohn Spa Antitumour synergistic composition
GB9904387D0 (en) * 1999-02-25 1999-04-21 Pharmacia & Upjohn Spa Antitumour synergistic composition
GB0006601D0 (en) * 2000-03-17 2000-05-10 Pharmacia & Upjohn Spa Crystalline alkycycline derivative
GB0117403D0 (en) * 2001-07-17 2001-09-05 Pharmacia & Upjohn Spa Solvent-free crystalline anthracycline derivatives
WO2006124720A1 (en) * 2005-05-12 2006-11-23 The Ohio State University Research Foundation Multidrug resistant anticancer anthracyclines
EP2277884B1 (en) * 2008-04-11 2017-08-23 Tianjin Hemay Oncology Pharmaceutical Co., Ltd Anthracycline antibiotic derivatives with high activity, preparation methods and uses thereof
CN101912600B (zh) * 2010-01-11 2014-01-29 杨国汉 改善胰岛素在溶液中稳定性的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54141759A (en) * 1978-04-24 1979-11-05 Microbial Chem Res Found Novel anthracycline derivative
GB8614323D0 (en) * 1986-06-12 1986-07-16 Erba Farmitalia Anthracyclines
US5413992A (en) * 1992-07-31 1995-05-09 The Scripps Research Institute Daunomycin derivative with reduced cytotoxicity toward normal cells

Also Published As

Publication number Publication date
HK1011692A1 (en) 1999-07-16
DE69405214T2 (de) 1998-01-29
FI953784A (fi) 1995-08-09
CA2154890A1 (en) 1995-06-22
NO953163D0 (no) 1995-08-11
NO953163L (no) 1995-10-02
FI108036B (fi) 2001-11-15
RU2149163C1 (ru) 2000-05-20
DK0683788T3 (da) 1997-10-27
AU1066095A (en) 1995-07-03
IL111725A0 (en) 1995-01-24
US5532218A (en) 1996-07-02
WO1995016695A2 (en) 1995-06-22
PL178806B1 (pl) 2000-06-30
ZA949701B (en) 1995-12-12
CN1039123C (zh) 1998-07-15
ATE157369T1 (de) 1997-09-15
UA43839C2 (uk) 2002-01-15
CN1117734A (zh) 1996-02-28
NZ276401A (en) 1997-10-24
JPH08506835A (ja) 1996-07-23
WO1995016695A3 (en) 1995-07-13
KR100352734B1 (ko) 2003-02-17
MY117086A (en) 2004-05-31
FI953784A0 (fi) 1995-08-09
ES2107294T3 (es) 1997-11-16
HUT73172A (en) 1996-06-28
EP0683788A1 (en) 1995-11-29
TW336235B (en) 1998-07-11
GR3025266T3 (en) 1998-02-27
NO304951B1 (no) 1999-03-08
KR960701074A (ko) 1996-02-24
HU217630B (hu) 2000-03-28
DE69405214D1 (de) 1997-10-02
GB9325417D0 (en) 1994-02-16
PL310177A1 (en) 1995-11-27
AU676625B2 (en) 1997-03-13
HU9502662D0 (en) 1995-11-28
EP0683788B1 (en) 1997-08-27

Similar Documents

Publication Publication Date Title
EP0889898B1 (en) Morpholinyl anthracycline derivatives
US5532218A (en) 3'-aziridino-anthracycline derivatives
EP0434960A1 (en) Chiral 1,5-diiodo-2-methoxy or benzyloxy intermediates
US5496808A (en) Mono and bis alkylamino-anthracyclines
AU632102B2 (en) New 3'-(4-morpholinyl)- and 3'-(2-methoxy-4-morpholinyl)- anthracycline derivatives
US5510469A (en) 2-acyloxy-4-morpholinyl anthracyclines
CH676985A5 (pl)
GB2144744A (en) 4'-halo-anthracycline glycosides
EP0683787B1 (en) 4'-o-sulfonyl-anthracycline derivatives
KR0157612B1 (ko) 신규 안트라사이클린 글리코사이드 유도체
GB2287463A (en) Bis-anthracycline derivatives
JPH01311095A (ja) ４―デメトキシ―４′―デオキシ―４′―ヨードアントラサイクリングリコシド

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees