IL111570A - Process for the synthesis of '2, -'- 3 didhydro-3-deoxytimidine (d4T) in large quantities, using solvate isolation of N d4T-methylpyrrolidone and the intermediate product the d4T NMPO sulfate - Google Patents

Process for the synthesis of '2, -'- 3 didhydro-3-deoxytimidine (d4T) in large quantities, using solvate isolation of N d4T-methylpyrrolidone and the intermediate product the d4T NMPO sulfate

Info

Publication number
IL111570A
IL111570A IL11157094A IL11157094A IL111570A IL 111570 A IL111570 A IL 111570A IL 11157094 A IL11157094 A IL 11157094A IL 11157094 A IL11157094 A IL 11157094A IL 111570 A IL111570 A IL 111570A
Authority
IL
Israel
Prior art keywords
solvate
nmpo
iii
isolated
heating
Prior art date
Application number
IL11157094A
Other languages
English (en)
Hebrew (he)
Other versions
IL111570A0 (en
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL111570A0 publication Critical patent/IL111570A0/xx
Publication of IL111570A publication Critical patent/IL111570A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL11157094A 1993-11-15 1994-11-09 Process for the synthesis of '2, -'- 3 didhydro-3-deoxytimidine (d4T) in large quantities, using solvate isolation of N d4T-methylpyrrolidone and the intermediate product the d4T NMPO sulfate IL111570A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15215593A 1993-11-15 1993-11-15
US15277893A 1993-11-15 1993-11-15
US08/309,636 US5539099A (en) 1993-11-15 1994-09-23 Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides

Publications (2)

Publication Number Publication Date
IL111570A0 IL111570A0 (en) 1995-01-24
IL111570A true IL111570A (en) 2001-07-24

Family

ID=27387202

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11157094A IL111570A (en) 1993-11-15 1994-11-09 Process for the synthesis of '2, -'- 3 didhydro-3-deoxytimidine (d4T) in large quantities, using solvate isolation of N d4T-methylpyrrolidone and the intermediate product the d4T NMPO sulfate

Country Status (19)

Country Link
US (1) US5539099A (ja)
EP (1) EP0653435B1 (ja)
JP (1) JP3884779B2 (ja)
KR (1) KR100329524B1 (ja)
CN (2) CN1043646C (ja)
AT (1) ATE148707T1 (ja)
AU (1) AU686249B2 (ja)
CA (1) CA2135853C (ja)
CY (1) CY2046B1 (ja)
DE (1) DE69401698T2 (ja)
DK (1) DK0653435T3 (ja)
ES (1) ES2098884T3 (ja)
FI (1) FI105402B (ja)
GR (1) GR3023305T3 (ja)
HK (1) HK116997A (ja)
HU (1) HU221012B1 (ja)
IL (1) IL111570A (ja)
SG (1) SG64336A1 (ja)
TW (1) TW399060B (ja)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5608049A (en) * 1995-03-10 1997-03-04 Bristol-Myers Squibb Company Preparation of d4T from 5-methyluridine
US5608048A (en) * 1995-06-05 1997-03-04 Bristol-Myers Squibb Company d4 T polymorphic Form 1 process
US6625641B1 (en) * 1996-06-03 2003-09-23 Sun Microsystems, Inc. Method and apparatus for providing client support without installation of server software
CN1054132C (zh) * 1998-01-05 2000-07-05 华东理工大学 一种从混合物中分离胸苷的方法
US6635753B1 (en) 1998-09-30 2003-10-21 Brantford Chemicals Inc. Process for the preparation of substantially pure stavudine and related intermediates useful in the preparation thereof
AU2001285197A1 (en) * 2000-09-06 2002-03-22 Bristol-Myers Squibb Company Stavudine polymorphic form 1 process
IL157478A0 (en) * 2001-03-01 2004-03-28 Pharmasset Ltd Method for the synthesis of 2', 3'-didehydronucleosides
US6884880B2 (en) * 2002-08-21 2005-04-26 Ash Stevens, Inc. Process for the preparation of 9-β-anomeric nucleoside analogs
WO2007099389A1 (en) * 2005-07-11 2007-09-07 Aurobindo Pharma Limited A new improved process for the preparation of stavudine form i
EP1957511B1 (en) * 2005-11-28 2013-05-15 Matrix Laboratories Ltd Process for the large scale production of stavudine
CN101029068B (zh) * 2007-04-09 2010-06-23 陆咏 一种2',3'-二脱氢-3'-脱氧胸苷的合成方法
CN102766182B (zh) * 2011-05-06 2015-03-04 江苏苏利精细化工股份有限公司 一种通过糖基转移反应合成二脱氧核苷的方法及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904770A (en) * 1988-03-24 1990-02-27 Bristol-Myers Company Production of 2',3'-dideoxy-2',3'-didehydronucleosides

Also Published As

Publication number Publication date
TW399060B (en) 2000-07-21
GR3023305T3 (en) 1997-08-29
CN1107856A (zh) 1995-09-06
IL111570A0 (en) 1995-01-24
AU686249B2 (en) 1998-02-05
AU7880394A (en) 1995-06-01
CA2135853A1 (en) 1995-05-16
CN1069648C (zh) 2001-08-15
HU221012B1 (hu) 2002-07-29
DK0653435T3 (da) 1997-07-14
KR950014131A (ko) 1995-06-15
EP0653435B1 (en) 1997-02-05
US5539099A (en) 1996-07-23
HK116997A (en) 1997-09-05
DE69401698D1 (de) 1997-03-20
HU9403256D0 (en) 1995-01-30
CN1043646C (zh) 1999-06-16
DE69401698T2 (de) 1997-09-11
EP0653435A1 (en) 1995-05-17
SG64336A1 (en) 1999-04-27
HUT69171A (en) 1995-08-28
FI945322A0 (fi) 1994-11-11
JPH07196682A (ja) 1995-08-01
ATE148707T1 (de) 1997-02-15
FI945322A (fi) 1995-05-16
CA2135853C (en) 2006-01-03
KR100329524B1 (ko) 2002-11-23
FI105402B (fi) 2000-08-15
CY2046B1 (en) 1998-04-30
CN1215057A (zh) 1999-04-28
JP3884779B2 (ja) 2007-02-21
ES2098884T3 (es) 1997-05-01

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