IL109605A - Oligonucleotides having 2'-ether groups their use as diagnostics and pharmaceutical compositions containing them - Google Patents

Oligonucleotides having 2'-ether groups their use as diagnostics and pharmaceutical compositions containing them

Info

Publication number
IL109605A
IL109605A IL10960594A IL10960594A IL109605A IL 109605 A IL109605 A IL 109605A IL 10960594 A IL10960594 A IL 10960594A IL 10960594 A IL10960594 A IL 10960594A IL 109605 A IL109605 A IL 109605A
Authority
IL
Israel
Prior art keywords
alkyl
hydrogen
diagnostics
oligonucleotides
pharmaceutical compositions
Prior art date
Application number
IL10960594A
Other languages
English (en)
Other versions
IL109605A0 (en
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Priority to IL12333094A priority Critical patent/IL123330A/xx
Publication of IL109605A0 publication Critical patent/IL109605A0/xx
Priority to IL12333098A priority patent/IL123330A0/xx
Publication of IL109605A publication Critical patent/IL109605A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL10960594A 1993-05-12 1994-05-10 Oligonucleotides having 2'-ether groups their use as diagnostics and pharmaceutical compositions containing them IL109605A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL12333094A IL123330A (en) 1993-05-12 1994-05-10 Nucleosides having 2'-ether group their preparation their use in the production of oligonucleotides and pharmaceutical compositions containing them
IL12333098A IL123330A0 (en) 1993-05-12 1998-02-17 Nucleosides having 2'-ether group their preparation and their use in the production of oligonucleotides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH146793 1993-05-12

Publications (2)

Publication Number Publication Date
IL109605A0 IL109605A0 (en) 1994-08-26
IL109605A true IL109605A (en) 1999-12-31

Family

ID=4211171

Family Applications (3)

Application Number Title Priority Date Filing Date
IL12333094A IL123330A (en) 1993-05-12 1994-05-10 Nucleosides having 2'-ether group their preparation their use in the production of oligonucleotides and pharmaceutical compositions containing them
IL10960594A IL109605A (en) 1993-05-12 1994-05-10 Oligonucleotides having 2'-ether groups their use as diagnostics and pharmaceutical compositions containing them
IL12333098A IL123330A0 (en) 1993-05-12 1998-02-17 Nucleosides having 2'-ether group their preparation and their use in the production of oligonucleotides

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL12333094A IL123330A (en) 1993-05-12 1994-05-10 Nucleosides having 2'-ether group their preparation their use in the production of oligonucleotides and pharmaceutical compositions containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL12333098A IL123330A0 (en) 1993-05-12 1998-02-17 Nucleosides having 2'-ether group their preparation and their use in the production of oligonucleotides

Country Status (11)

Country Link
US (1) US5969116A (fr)
EP (1) EP0626387B1 (fr)
JP (1) JP4012579B2 (fr)
CN (1) CN1100728A (fr)
AT (1) ATE177430T1 (fr)
AU (1) AU687796B2 (fr)
CA (1) CA2123241C (fr)
DE (1) DE59407895D1 (fr)
DK (1) DK0626387T3 (fr)
ES (1) ES2128535T3 (fr)
IL (3) IL123330A (fr)

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US6166197A (en) * 1995-03-06 2000-12-26 Isis Pharmaceuticals, Inc. Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions
US20110028350A1 (en) * 1995-12-15 2011-02-03 Affymetrix, Inc. Photocleavable protecting groups
US6147205A (en) * 1995-12-15 2000-11-14 Affymetrix, Inc. Photocleavable protecting groups and methods for their use
AU725262B2 (en) 1996-02-14 2000-10-12 Isis Pharmaceuticals, Inc. Sugar-modified gapped oligonucleotides
CA2256765A1 (fr) 1996-06-06 1997-12-11 Novartis Ag Nucleosides substitues en position 2' et derives oligonucleotidiques
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US9096636B2 (en) 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
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US20040186071A1 (en) 1998-04-13 2004-09-23 Bennett C. Frank Antisense modulation of CD40 expression
US20040063618A1 (en) * 2002-09-30 2004-04-01 Muthiah Manoharan Peptide nucleic acids having improved uptake and tissue distribution
US6093807A (en) * 1999-03-19 2000-07-25 Isis Pharmaceuticals, Inc. Sugar-modified 7-deaza-7-substituted oligonucleotides
CA2421732A1 (fr) * 2000-09-11 2002-03-14 Affymetrix, Inc. Groupes de protection photoclivables
US20030027169A1 (en) * 2000-10-27 2003-02-06 Sheng Zhang One-well assay for high throughput detection of single nucleotide polymorphisms
DE10238722A1 (de) 2002-08-23 2004-03-11 Bayer Ag Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
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UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
WO2010008582A2 (fr) 2008-07-18 2010-01-21 Rxi Pharmaceuticals Corporation Système permettant d'administrer un médicament aux cellules phagocytaires
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EP3336188B1 (fr) 2008-09-22 2020-05-06 Phio Pharmaceuticals Corp. Composés d'arni de taille réduite à auto-délivrance
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US8987435B2 (en) 2008-10-24 2015-03-24 Isis Pharmaceuticals, Inc. Oligomeric compounds and methods
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US9493774B2 (en) 2009-01-05 2016-11-15 Rxi Pharmaceuticals Corporation Inhibition of PCSK9 through RNAi
US9745574B2 (en) 2009-02-04 2017-08-29 Rxi Pharmaceuticals Corporation RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
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IL265674B2 (en) 2010-03-24 2024-05-01 Phio Pharm Corp Rana disorder in cutaneous and fibrotic symptoms
RU2615143C2 (ru) 2010-03-24 2017-04-04 Адвирна Самодоставляющие PHKi соединения уменьшенного размера
CN106074591B (zh) 2010-03-24 2020-01-14 菲奥医药公司 眼部症候中的rna干扰
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CN103154014B (zh) 2010-04-28 2015-03-25 Isis制药公司 修饰核苷、其类似物以及由它们制备的寡聚化合物
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US20130156845A1 (en) 2010-04-29 2013-06-20 Alnylam Pharmaceuticals, Inc. Lipid formulated single stranded rna
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EP2453017A1 (fr) 2010-11-12 2012-05-16 Antisense Pharma GmbH Oligonucléotides pour une utilisation dans la prévention et/ou le traitement de maladies surexprimant l'ARNm TGF-bêta1 et TGF-bêta2, TGF-bêta2 et TGF-bêta3, TGF-bêta1 et TGF-bêta3, ou TGF-bêta1, TGF-bêta2, et TGF-bêta3
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CN111819285B (zh) 2018-01-09 2024-08-09 希博斯美国有限公司 防碎基因和突变
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JPWO2023027065A1 (fr) 2021-08-24 2023-03-02
CN118076620A (zh) 2021-09-30 2024-05-24 日产化学株式会社 2’修饰嘧啶核苷的制造方法

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Publication number Priority date Publication date Assignee Title
US4806463A (en) * 1986-05-23 1989-02-21 Worcester Foundation For Experimental Biology Inhibition of HTLV-III by exogenous oligonucleotides
EP0266099A3 (fr) * 1986-10-28 1990-09-19 The Johns Hopkins University Alkyl- ou arylphosphonate oligonucléoside capable de réticulation avec des acides nucléiques ou de clevage d'acides nucléiques
AU636573B2 (en) * 1988-02-26 1993-05-06 Worcester Foundation For Biomedical Research, Inc. Inhibition of htlv-iii by exogenous oligonucleotides
ATE269870T1 (de) * 1989-10-24 2004-07-15 Isis Pharmaceuticals Inc 2'-modifizierte oligonukleotide
CA2073500C (fr) * 1990-01-11 2008-03-25 Phillip Dan Cook Compositions et methodes pour deceler et moduler l'activite de l'arn et l'expression genique
WO1993013121A1 (fr) * 1991-12-24 1993-07-08 Isis Pharmaceuticals, Inc. Oligonucleotides modifies en 2', a ouverture
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DK0549615T3 (da) * 1990-08-13 2006-07-03 Isis Pharmaceuticals Inc Sukkermodificerede oligonukleotider der påviser og modulerer genekspression
AU4684993A (en) * 1992-07-23 1994-02-14 Isis Pharmaceuticals, Inc. Novel 2'-o-alkyl nucleosides and phosphoramidites processes for the preparation and uses thereof

Also Published As

Publication number Publication date
ATE177430T1 (de) 1999-03-15
CA2123241C (fr) 2007-02-13
CA2123241A1 (fr) 1994-11-13
AU687796B2 (en) 1998-03-05
AU6304494A (en) 1994-11-17
JP4012579B2 (ja) 2007-11-21
EP0626387A1 (fr) 1994-11-30
EP0626387B1 (fr) 1999-03-10
IL123330A (en) 1999-12-31
US5969116A (en) 1999-10-19
JPH072889A (ja) 1995-01-06
ES2128535T3 (es) 1999-05-16
DK0626387T3 (da) 1999-09-27
IL109605A0 (en) 1994-08-26
CN1100728A (zh) 1995-03-29
DE59407895D1 (de) 1999-04-15
IL123330A0 (en) 1998-09-24

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