IL108856A - Hydroxymethyl furazancarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

Hydroxymethyl furazancarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL108856A
IL108856A IL108856A IL10885694A IL108856A IL 108856 A IL108856 A IL 108856A IL 108856 A IL108856 A IL 108856A IL 10885694 A IL10885694 A IL 10885694A IL 108856 A IL108856 A IL 108856A
Authority
IL
Israel
Prior art keywords
alkyl
amino
once
cycloalkyl
phenyl
Prior art date
Application number
IL108856A
Other languages
English (en)
Other versions
IL108856A0 (en
Original Assignee
Cassella Farbwerke Mainkur Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cassella Farbwerke Mainkur Ag filed Critical Cassella Farbwerke Mainkur Ag
Publication of IL108856A0 publication Critical patent/IL108856A0/xx
Publication of IL108856A publication Critical patent/IL108856A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL108856A 1993-03-06 1994-03-04 Hydroxymethyl furazancarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them IL108856A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4307105A DE4307105A1 (de) 1993-03-06 1993-03-06 Hydroxymethylfurazancarbonsäurederivate

Publications (2)

Publication Number Publication Date
IL108856A0 IL108856A0 (en) 1994-06-24
IL108856A true IL108856A (en) 1997-07-13

Family

ID=6482135

Family Applications (1)

Application Number Title Priority Date Filing Date
IL108856A IL108856A (en) 1993-03-06 1994-03-04 Hydroxymethyl furazancarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them

Country Status (21)

Country Link
US (1) US5486531A (cs)
EP (1) EP0687256B1 (cs)
JP (1) JP3578456B2 (cs)
KR (1) KR960701029A (cs)
CN (1) CN1043140C (cs)
AT (1) ATE157660T1 (cs)
AU (1) AU676718B2 (cs)
CA (1) CA2155840C (cs)
CZ (1) CZ284264B6 (cs)
DE (2) DE4307105A1 (cs)
DK (1) DK0687256T3 (cs)
ES (1) ES2108977T3 (cs)
FI (1) FI954138A7 (cs)
GR (1) GR3024928T3 (cs)
HU (1) HUT72641A (cs)
IL (1) IL108856A (cs)
PL (1) PL177603B1 (cs)
RU (1) RU2134687C1 (cs)
SK (1) SK280354B6 (cs)
WO (1) WO1994020478A1 (cs)
ZA (1) ZA941533B (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4401150A1 (de) * 1994-01-17 1995-07-20 Cassella Ag Furazancarbonsäurederivate
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US7094782B1 (en) * 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
RU2240321C2 (ru) * 2002-02-07 2004-11-20 ЗАО "АСГЛ-Исследовательские лаборатории" Производные 3,4-бис(фуразан-3-ил)фуроксана, генерирующие оксид азота, активирующие растворимую форму гуанилатциклазы, ингибирующие агрегацию тромбоцитов и обладающие спазмолитическим, сосудорасширяющим, гипотензивным действием, и фармацевтическая композиция на их основе
ATE384718T1 (de) * 2003-05-23 2008-02-15 Basilea Pharmaceutica Ag Furazanobenzimidazole
US8822509B2 (en) 2006-12-29 2014-09-02 The University Of Queensland Pain-relieving compositions and uses therefor
CN112125865B (zh) * 2020-09-30 2022-08-12 北京理工大学 氧化呋咱化合物的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3012862A1 (de) * 1980-04-02 1981-10-08 Cassella Ag, 6000 Frankfurt Substituierte 1,2,5-oxdiazol-2-oxide als pharmazeutische wirkstoffe, ihre verwendung und sie enthaltende arzneimittel
DE3047730A1 (de) * 1980-12-18 1982-07-15 Cassella Ag, 6000 Frankfurt 3,4-bis-substituierte 1,2,5-oxdiazol-2-oxide, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische zubereitungen

Also Published As

Publication number Publication date
FI954138A0 (fi) 1995-09-04
DE4307105A1 (de) 1994-09-08
EP0687256A1 (de) 1995-12-20
AU6141494A (en) 1994-09-26
PL310655A1 (en) 1995-12-27
CN1043140C (zh) 1999-04-28
IL108856A0 (en) 1994-06-24
CN1119013A (zh) 1996-03-20
CZ228195A3 (en) 1995-12-13
CA2155840A1 (en) 1994-09-15
CZ284264B6 (cs) 1998-10-14
CA2155840C (en) 2005-05-24
JP3578456B2 (ja) 2004-10-20
RU2134687C1 (ru) 1999-08-20
SK110095A3 (en) 1996-01-10
ES2108977T3 (es) 1998-01-01
DK0687256T3 (da) 1998-03-30
KR960701029A (ko) 1996-02-24
GR3024928T3 (en) 1998-01-30
ZA941533B (en) 1994-10-06
WO1994020478A1 (de) 1994-09-15
US5486531A (en) 1996-01-23
FI954138L (fi) 1995-09-04
SK280354B6 (sk) 1999-12-10
AU676718B2 (en) 1997-03-20
PL177603B1 (pl) 1999-12-31
DE59403966D1 (de) 1997-10-09
FI954138A7 (fi) 1995-09-04
EP0687256B1 (de) 1997-09-03
HU9502603D0 (en) 1995-11-28
HUT72641A (en) 1996-05-28
ATE157660T1 (de) 1997-09-15
JPH08507299A (ja) 1996-08-06

Similar Documents

Publication Publication Date Title
GB9218322D0 (en) Therapeutic agents
IL108856A (en) Hydroxymethyl furazancarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them
DE69720965D1 (de) Chinazolinderivate und deren verwendung als vegf hemmer
DE69225500D1 (de) Chinazolinone als mittel gegen angina
TW369526B (en) Diazabicyclic neurokinin antagonists
TW358096B (en) Pyrazolopyridimidinone antianginal agents
IL102383A0 (en) Methylene-oxindole derivatives,their preparation and pharmaceutical compositions containing them
MY117803A (en) Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
HUT60733A (en) Process for producing new n-(4-piperidinyl)-(dihydrobenzofuran or dihydro-2h-benzopyran)-carboxamide derivatives and pharmaceutical compositions comprising such compounds
MY119623A (en) Quinoline and quinazoline compounds useful in therapy, particularly in the treatment of benign prostatic hyperplasia
NZ502281A (en) 2-aminopyridines containing fused ring substituents as nitric oxide synthase (NOS) inhibitors
AU2190895A (en) Amidino derivatives useful as nitric oxide synthase inhibitors
AU2884295A (en) Phosphinic acid derivatives with metallopeptidase inhibitory activity
EA200100710A1 (ru) 4-(аминометил)пиперидинбензамиды для лечения желудочно-кишечных расстройств
TR199902495T2 (xx) Bile�imler.
NO915068D0 (no) Fremgangsmaate for fremstilling av nye amino- og nitro-holdige tricykliske forbindelser
GEP19960657B (en) Oxadiazole-alkyl-purine derivatives useful as antitussive agents
MY129176A (en) Tetrahydro gamma-carbolines
BG104717A (en) Water soluble azoles as broad-spectrum antifungals
HUT62563A (en) Process for producing 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydroproin derivatives and pharmaceutical compositions comprising same
BR9307091A (pt) Acido benzenoalcanóicos para doenças cardiovasculares
ATE42747T1 (de) N-(2-(tetrahydro-3,5-dioxo-1h-pyrrolizin-7a(5h) yl)ethyl>aminderivate.
MX9709465A (es) Derivados de bencimidazol 2-sustituidos como inhibidores de la proliferacion de celulas del musculo liso.
NO984921L (no) Tienopyridinderivater og deres anvendelser
DE69503905D1 (de) Peptidderivate mit metallopeptidasehemmender aktivität

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed