IL108607A - הכנה של פוטופרוטאינים צמודים ושיטה לשימוש בהם - Google Patents

הכנה של פוטופרוטאינים צמודים ושיטה לשימוש בהם

Info

Publication number
IL108607A
IL108607A IL10860794A IL10860794A IL108607A IL 108607 A IL108607 A IL 108607A IL 10860794 A IL10860794 A IL 10860794A IL 10860794 A IL10860794 A IL 10860794A IL 108607 A IL108607 A IL 108607A
Authority
IL
Israel
Prior art keywords
photoprotein
sulfhydryl
binding reagent
aequorin
binding
Prior art date
Application number
IL10860794A
Other languages
English (en)
Other versions
IL108607A0 (en
Original Assignee
Sealite Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sealite Sciences Inc filed Critical Sealite Sciences Inc
Publication of IL108607A0 publication Critical patent/IL108607A0/xx
Publication of IL108607A publication Critical patent/IL108607A/he

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL10860794A 1993-02-12 1994-02-09 הכנה של פוטופרוטאינים צמודים ושיטה לשימוש בהם IL108607A (he)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1711693A 1993-02-12 1993-02-12

Publications (2)

Publication Number Publication Date
IL108607A0 IL108607A0 (en) 1994-05-30
IL108607A true IL108607A (he) 1998-12-06

Family

ID=21780817

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10860794A IL108607A (he) 1993-02-12 1994-02-09 הכנה של פוטופרוטאינים צמודים ושיטה לשימוש בהם

Country Status (9)

Country Link
US (1) US5486455A (he)
EP (1) EP0683822B1 (he)
JP (1) JPH08506897A (he)
AT (1) ATE217086T1 (he)
AU (1) AU6171894A (he)
DE (1) DE69430523T2 (he)
IL (1) IL108607A (he)
MX (1) MX9401112A (he)
WO (1) WO1994018342A1 (he)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4438660A1 (de) * 1994-10-28 1996-05-02 Boehringer Mannheim Gmbh Biolumineszenzmarkierte Hapten-Konjugate für den Einsatz in kompetitiven Immunoassays
EP0736770A3 (fr) * 1995-04-05 1997-05-02 Anda Biolog Sa Conjugué immunoréactif, procédé d'obtention de ce conjugué, anticorps dirigés contre ledit conjugué, composition pharmaceutique et dispositif de diagnostic les comprenant
DE19537952A1 (de) * 1995-10-12 1997-04-17 Boehringer Mannheim Gmbh Verfahren zum Nachweis eines Analyten
US5876995A (en) * 1996-02-06 1999-03-02 Bryan; Bruce Bioluminescent novelty items
US5942407A (en) * 1996-06-25 1999-08-24 Immunomatrix, Inc. Light-emitting immunoassay
US6416960B1 (en) 1996-08-08 2002-07-09 Prolume, Ltd. Detection and visualization of neoplastic tissues and other tissues
US6458547B1 (en) 1996-12-12 2002-10-01 Prolume, Ltd. Apparatus and method for detecting and identifying infectious agents
DE19652576A1 (de) * 1996-12-17 1998-06-25 Boehringer Mannheim Gmbh Niedermolekulare Photoprotein-Konjugate
US5876935A (en) * 1997-01-08 1999-03-02 Dade Behring Inc. Luminescent specific binding assay
CA2281648A1 (en) 1997-02-13 1998-08-20 Memorial Sloan-Kettering Cancer Center Hybrid molecules for optically detecting changes in cellular microenvironments
WO1998036099A1 (en) * 1997-02-18 1998-08-20 Oncor, Inc. Detection of targets with green fluorescent protein and fluorescent variants thereof
DE19719465A1 (de) * 1997-05-07 1998-11-12 Boehringer Mannheim Gmbh Konservierung von Aequorin-Reagenzien
AU765703B2 (en) 1998-03-27 2003-09-25 Bruce J. Bryan Luciferases, fluorescent proteins, nucleic acids encoding the luciferases and fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items
EP1925320A3 (en) 1998-03-27 2008-09-03 Prolume, Ltd. Luciferases, fluorescent proteins, nucleic acids encoding the luciferases and fluorescent proteins and the use thereof in diagnostics
ATE356355T1 (de) * 1999-06-18 2007-03-15 Cardiogenics Inc Verfahren zur prozessführung chemilumineszenter bindungstests
US7109315B2 (en) * 2000-03-15 2006-09-19 Bruce J. Bryan Renilla reniformis fluorescent proteins, nucleic acids encoding the fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items
US7659078B1 (en) * 2002-07-17 2010-02-09 University Of Kentucky Research Foundation Method and kit for determination of prostacyclin in plasma
US20080280310A1 (en) * 2007-05-09 2008-11-13 Louis Panagopoulos Testing for Blood Group Immunological Reaction Without the Use of Anti-Human Globulin

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4604364A (en) * 1974-01-04 1986-08-05 Kosak Kenneth M Bioluminescent tracer composition and method of use in immunoassays
GB1578275A (en) * 1977-06-14 1980-11-05 Maier C Procedure for the assay of pharmacologically immunologically and biochemically active compounds in biological fluids
US4396579A (en) * 1981-08-06 1983-08-02 Miles Laboratories, Inc. Luminescence detection device
US4608246A (en) * 1983-03-10 1986-08-26 Immucor, Inc. Testing for a blood group immunological reaction
ES8607563A1 (es) * 1983-10-13 1986-06-01 Univ Georgia Res Found Un metodo para detectar una interaccion ligante
US4665022A (en) * 1984-02-17 1987-05-12 The Regents Of The University Of California Bioluminescent assay reagent and method
US4927916A (en) * 1984-04-23 1990-05-22 The General Hospital Corporation Method of producing fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity using fibrin-specific peptides
US4764368A (en) * 1984-08-29 1988-08-16 Dana-Farber Cancer Institute, Inc. Acid-cleavable compound
US4657853A (en) * 1984-09-14 1987-04-14 E. I. Du Pont De Nemours And Company Immunoassays utilizing covalent conjugates of polymerized enzyme and antibody
US4935339A (en) * 1985-05-07 1990-06-19 Nichols Institute Diagnostics Delayed solid phase immunologic assay
DE3537877A1 (de) * 1985-10-24 1987-04-30 Geiger Reinhard Luciferin-derivate und immunoassays unter einsatz derartiger luciferin-derivate
GB8603537D0 (en) * 1986-02-13 1986-03-19 Parker D Conjugate compound
US4916070A (en) * 1986-04-14 1990-04-10 The General Hospital Corporation Fibrin-specific antibodies and method of screening for the antibodies
DE3714147A1 (de) * 1987-04-28 1988-11-17 Boehringer Mannheim Gmbh Immunchemisches verfahren und reagenz zur bestimmung eines polyvalenten antigens in einer fluessigen probe
JPS6447379A (en) * 1987-08-19 1989-02-21 Chisso Corp Preparation of calcium-dependent oxygenation enzyme
US4981979A (en) * 1987-09-10 1991-01-01 Neorx Corporation Immunoconjugates joined by thioether bonds having reduced toxicity and improved selectivity
US5094939A (en) * 1988-07-19 1992-03-10 Fujirebio, Inc. Chemiluminescence assays using stabilized dioxetane derivatives
US4925648A (en) * 1988-07-29 1990-05-15 Immunomedics, Inc. Detection and treatment of infectious and inflammatory lesions
US5019393A (en) * 1988-08-03 1991-05-28 New England Deaconess Hospital Corporation Biocompatible substance with thromboresistance
US5112615A (en) * 1988-08-03 1992-05-12 New England Deaconess Hospital Corporation Soluble hirudin conjugates
US5135736A (en) * 1988-08-15 1992-08-04 Neorx Corporation Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
US5066789A (en) * 1988-09-30 1991-11-19 Neorx Corporation Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages
JPH02253162A (ja) * 1989-03-27 1990-10-11 Chisso Corp 特異的結合能を有する物質と結合したエクオリンを用いる検出法
JPH04502469A (ja) * 1988-12-22 1992-05-07 ゾマ　コーポレイション ヒンダードカップリング剤および方法
US5134071A (en) * 1989-02-06 1992-07-28 State University Of New York Polymerization and copolymerization of proteins
JPH03153699A (ja) * 1989-11-09 1991-07-01 Chisso Corp 化学結合法により担体に固定化されたエクオリン活性を示す蛋白質
JPH03169897A (ja) * 1989-11-29 1991-07-23 Chisso Corp 化学修飾エクオリンとその調製法
US5116944A (en) * 1989-12-29 1992-05-26 Neorx Corporation Conjugates having improved characteristics for in vivo administration

Also Published As

Publication number Publication date
MX9401112A (es) 1994-08-31
WO1994018342A1 (en) 1994-08-18
ATE217086T1 (de) 2002-05-15
JPH08506897A (ja) 1996-07-23
AU6171894A (en) 1994-08-29
DE69430523D1 (de) 2002-06-06
DE69430523T2 (de) 2002-11-28
EP0683822A4 (en) 1997-11-05
US5486455A (en) 1996-01-23
EP0683822A1 (en) 1995-11-29
EP0683822B1 (en) 2002-05-02
IL108607A0 (en) 1994-05-30

Similar Documents

Publication Publication Date Title
EP0683822B1 (en) Preparation of photoprotein conjugates and methods of use thereof
JP3340434B2 (ja) ジビニルスルホンに由来する成分を含んで成る水溶性ポリマーベース試薬及び抱合体
US4959306A (en) Labeling design for a binding assay reagent
CN101371140A (zh) 抗药物抗体的测定
US5648218A (en) Preparation of photoprotein conjugates and methods of use thereof
JPH10504903A (ja) ルシフェラーゼ標識方法
US7642059B2 (en) Single receptor assays for immunosuppressive drugs
JPH05504481A (ja) 改良された抗体―酵素直接接合体及びその製造方法
Wolf et al. Strategies for Site‐Specific Labeling of Receptor Proteins on the Surfaces of Living Cells by Using Genetically Encoded Peptide Tags
JP3580504B2 (ja) 多相系におけるイムノアッセイの実施方法
JP2006292771A (ja) １０，１０’−置換−９，９’−ビアクリジン誘導体及びシグナル溶液の調製
US5834206A (en) Immunoassays for haptens and hapten tracer-antibody complex which can be used therefor, and process for the preparation thereof
AU2002255117B2 (en) Transcobalamin II assay method
AU2002255117A1 (en) Transcobalamin II assay method
Strasburger et al. [56] Two-site and competitive chemiluminescent immunoassays
JPH032663A (ja) 酵素発光測定法
JPH08211058A (ja) 競合免疫検定における使用のための生物発光標識ハプテン
US5998157A (en) Acylated protein aggregates and their use as signal enhancers in an immunoassay for the detection of antibodies
Anderson et al. Integrating Single Domain Antibodies into Field-Deployable Rapid Assays. Antibodies 2022, 11, 64
CA1335174C (en) Solid-phase non-separation enzyme assay
JPH10239314A (ja) 結合分析の高感度化方法
JPH10251300A (ja) 低分子の発光タンパク質コンジュゲート

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees