IL108247A - Pharmaceutical compositions containing dextrorotatory o-aryl ethers of morphinans for reducing adverse effects of neurotoxic injury, certain such novel compounds and their preparation - Google Patents
Pharmaceutical compositions containing dextrorotatory o-aryl ethers of morphinans for reducing adverse effects of neurotoxic injury, certain such novel compounds and their preparationInfo
- Publication number
- IL108247A IL108247A IL108247A IL10824793A IL108247A IL 108247 A IL108247 A IL 108247A IL 108247 A IL108247 A IL 108247A IL 10824793 A IL10824793 A IL 10824793A IL 108247 A IL108247 A IL 108247A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- morphinan
- methyl
- oxy
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US113593A | 1993-01-06 | 1993-01-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL108247A0 IL108247A0 (en) | 1994-04-12 |
| IL108247A true IL108247A (en) | 1998-02-22 |
Family
ID=21694554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL108247A IL108247A (en) | 1993-01-06 | 1993-12-31 | Pharmaceutical compositions containing dextrorotatory o-aryl ethers of morphinans for reducing adverse effects of neurotoxic injury, certain such novel compounds and their preparation |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0612730B1 (OSRAM) |
| JP (1) | JP2501298B2 (OSRAM) |
| KR (1) | KR940018094A (OSRAM) |
| CN (1) | CN1097006A (OSRAM) |
| AT (1) | ATE154931T1 (OSRAM) |
| AU (1) | AU681601B2 (OSRAM) |
| BR (1) | BR9400021A (OSRAM) |
| CA (1) | CA2110337A1 (OSRAM) |
| CZ (1) | CZ2294A3 (OSRAM) |
| DE (1) | DE69311887T2 (OSRAM) |
| DK (1) | DK0612730T3 (OSRAM) |
| ES (1) | ES2105061T3 (OSRAM) |
| FI (1) | FI940041A7 (OSRAM) |
| GR (1) | GR3024891T3 (OSRAM) |
| HU (2) | HUT66061A (OSRAM) |
| IL (1) | IL108247A (OSRAM) |
| MX (1) | MX9400177A (OSRAM) |
| NO (1) | NO940028D0 (OSRAM) |
| NZ (1) | NZ250580A (OSRAM) |
| PL (1) | PL175365B1 (OSRAM) |
| TW (1) | TW264473B (OSRAM) |
| UY (1) | UY23706A1 (OSRAM) |
| ZA (1) | ZA939806B (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9522176D0 (en) * | 1995-10-30 | 1996-01-03 | Iaf Biochem Int | Morphinan derivatives having neuroprotective activity |
| EP1394160A1 (en) * | 1996-06-13 | 2004-03-03 | SUMIKA FINE CHEMICALS Co., Ltd. | Process for preparing crystalline paroxetin hydrochloride |
| FR2752163B1 (fr) * | 1996-08-12 | 1998-10-30 | Pf Medicament | Utilisation de l'efaroxan pour la fabricaton de medicament destine au traitement de la maladie de huntington |
| GB9706753D0 (en) * | 1997-04-03 | 1997-05-21 | Pharmacia & Upjohn Spa | Aralkoxy-morphinan derivatives |
| KR100425881B1 (ko) * | 2001-03-14 | 2004-04-03 | 고광호 | 신규한 몰피난 유도체 |
| CN1653050B (zh) * | 2002-05-17 | 2013-04-24 | 詹肯生物科学公司 | 阿片和阿片样化合物及其用途 |
| DE10229842A1 (de) * | 2002-07-03 | 2004-02-05 | Helmut Prof. Dr. Schmidhammer | Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung |
| US20040204862A1 (en) | 2003-04-11 | 2004-10-14 | Wainer Irving W. | Computer-based model for identification and characterization for non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| WO2010096788A1 (en) * | 2009-02-23 | 2010-08-26 | Mallinckrodt Inc. | (+)-morphinanium quaternary salts and processes for their production |
| CN103044327B (zh) * | 2013-01-07 | 2014-12-17 | 苏州立新制药有限公司 | 一种右美沙芬的制备方法 |
| TWI869633B (zh) * | 2014-09-14 | 2025-01-11 | 美商阿瓦尼爾製藥股份有限公司 | 用於治療失智症中躁動行為之包含右旋美索芬(dextromethorphan)化合物及奎尼丁(quinidine)的藥學組成物 |
| WO2016138103A1 (en) * | 2015-02-25 | 2016-09-01 | Alkermes, Inc. | Treatments for alzheimer's related diseases and disorders |
| WO2022045301A1 (ja) * | 2020-08-28 | 2022-03-03 | 日本ケミファ株式会社 | 新規銅触媒を用いたジアリールエーテル骨格を有するモルヒナン誘導体の製造方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI773636A7 (fi) * | 1976-12-06 | 1978-06-07 | Hoffmann La Roche | Nya fenylderivat |
| US4113729A (en) * | 1976-12-06 | 1978-09-12 | Hoffmann-La Roche Inc. | 3-Phenoxymorphinans and derivatives thereof |
| US4806543A (en) * | 1986-11-25 | 1989-02-21 | Board Of Trustees Of The Leland Stanford Junior University | Method and compositions for reducing neurotoxic injury |
-
1993
- 1993-11-25 TW TW082109942A patent/TW264473B/zh active
- 1993-11-30 CA CA002110337A patent/CA2110337A1/en not_active Abandoned
- 1993-12-20 DE DE69311887T patent/DE69311887T2/de not_active Expired - Fee Related
- 1993-12-20 AT AT93120498T patent/ATE154931T1/de not_active IP Right Cessation
- 1993-12-20 EP EP93120498A patent/EP0612730B1/en not_active Expired - Lifetime
- 1993-12-20 ES ES93120498T patent/ES2105061T3/es not_active Expired - Lifetime
- 1993-12-20 DK DK93120498.6T patent/DK0612730T3/da active
- 1993-12-23 NZ NZ250580A patent/NZ250580A/en unknown
- 1993-12-30 JP JP5354172A patent/JP2501298B2/ja not_active Expired - Lifetime
- 1993-12-30 ZA ZA939806A patent/ZA939806B/xx unknown
- 1993-12-31 UY UY23706A patent/UY23706A1/es unknown
- 1993-12-31 AU AU52807/93A patent/AU681601B2/en not_active Ceased
- 1993-12-31 IL IL108247A patent/IL108247A/en not_active IP Right Cessation
-
1994
- 1994-01-03 MX MX9400177A patent/MX9400177A/es not_active IP Right Cessation
- 1994-01-03 HU HU9400002A patent/HUT66061A/hu unknown
- 1994-01-04 KR KR1019940000067A patent/KR940018094A/ko not_active Ceased
- 1994-01-04 NO NO940028A patent/NO940028D0/no unknown
- 1994-01-05 FI FI940041A patent/FI940041A7/fi unknown
- 1994-01-05 BR BR9400021A patent/BR9400021A/pt not_active Application Discontinuation
- 1994-01-05 CZ CZ9422A patent/CZ2294A3/cs unknown
- 1994-01-05 PL PL94301784A patent/PL175365B1/pl unknown
- 1994-01-05 CN CN94100181A patent/CN1097006A/zh active Pending
-
1995
- 1995-06-19 HU HU95P/P00253P patent/HU211290A9/hu unknown
-
1997
- 1997-09-30 GR GR970402538T patent/GR3024891T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU5280793A (en) | 1994-07-14 |
| TW264473B (OSRAM) | 1995-12-01 |
| CZ2294A3 (en) | 1994-07-13 |
| KR940018094A (ko) | 1994-08-16 |
| EP0612730A1 (en) | 1994-08-31 |
| UY23706A1 (es) | 1994-06-05 |
| CA2110337A1 (en) | 1994-07-07 |
| CN1097006A (zh) | 1995-01-04 |
| NO940028L (OSRAM) | 1994-07-07 |
| AU681601B2 (en) | 1997-09-04 |
| GR3024891T3 (en) | 1998-01-30 |
| JP2501298B2 (ja) | 1996-05-29 |
| FI940041L (fi) | 1994-07-07 |
| DK0612730T3 (da) | 1998-02-02 |
| FI940041A0 (fi) | 1994-01-05 |
| NO940028D0 (no) | 1994-01-04 |
| ZA939806B (en) | 1994-07-06 |
| NZ250580A (en) | 1996-07-26 |
| PL301784A1 (en) | 1994-07-11 |
| EP0612730B1 (en) | 1997-07-02 |
| ATE154931T1 (de) | 1997-07-15 |
| IL108247A0 (en) | 1994-04-12 |
| DE69311887T2 (de) | 1998-01-15 |
| BR9400021A (pt) | 1994-07-26 |
| MX9400177A (es) | 1994-07-29 |
| HU211290A9 (en) | 1995-11-28 |
| ES2105061T3 (es) | 1997-10-16 |
| HU9400002D0 (en) | 1994-05-30 |
| DE69311887D1 (de) | 1997-08-07 |
| FI940041A7 (fi) | 1994-07-07 |
| PL175365B1 (pl) | 1998-12-31 |
| HUT66061A (en) | 1994-09-28 |
| JPH06316564A (ja) | 1994-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| RH | Patent void |