FI940041A7 - Morfinaanien o-aryylieettereitä - Google Patents

Morfinaanien o-aryylieettereitä Download PDF

Info

Publication number
FI940041A7
FI940041A7 FI940041A FI940041A FI940041A7 FI 940041 A7 FI940041 A7 FI 940041A7 FI 940041 A FI940041 A FI 940041A FI 940041 A FI940041 A FI 940041A FI 940041 A7 FI940041 A7 FI 940041A7
Authority
FI
Finland
Prior art keywords
morphinans
aryl ethers
ethers
aryl
Prior art date
Application number
FI940041A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI940041L (fi
FI940041A0 (fi
Inventor
Erno Mohacsi
Jay Philip O'brien
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI940041A0 publication Critical patent/FI940041A0/fi
Publication of FI940041L publication Critical patent/FI940041L/fi
Publication of FI940041A7 publication Critical patent/FI940041A7/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI940041A 1993-01-06 1994-01-05 Morfinaanien o-aryylieettereitä FI940041A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US113593A 1993-01-06 1993-01-06

Publications (3)

Publication Number Publication Date
FI940041A0 FI940041A0 (fi) 1994-01-05
FI940041L FI940041L (fi) 1994-07-07
FI940041A7 true FI940041A7 (fi) 1994-07-07

Family

ID=21694554

Family Applications (1)

Application Number Title Priority Date Filing Date
FI940041A FI940041A7 (fi) 1993-01-06 1994-01-05 Morfinaanien o-aryylieettereitä

Country Status (23)

Country Link
EP (1) EP0612730B1 (OSRAM)
JP (1) JP2501298B2 (OSRAM)
KR (1) KR940018094A (OSRAM)
CN (1) CN1097006A (OSRAM)
AT (1) ATE154931T1 (OSRAM)
AU (1) AU681601B2 (OSRAM)
BR (1) BR9400021A (OSRAM)
CA (1) CA2110337A1 (OSRAM)
CZ (1) CZ2294A3 (OSRAM)
DE (1) DE69311887T2 (OSRAM)
DK (1) DK0612730T3 (OSRAM)
ES (1) ES2105061T3 (OSRAM)
FI (1) FI940041A7 (OSRAM)
GR (1) GR3024891T3 (OSRAM)
HU (2) HUT66061A (OSRAM)
IL (1) IL108247A (OSRAM)
MX (1) MX9400177A (OSRAM)
NO (1) NO940028D0 (OSRAM)
NZ (1) NZ250580A (OSRAM)
PL (1) PL175365B1 (OSRAM)
TW (1) TW264473B (OSRAM)
UY (1) UY23706A1 (OSRAM)
ZA (1) ZA939806B (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9522176D0 (en) * 1995-10-30 1996-01-03 Iaf Biochem Int Morphinan derivatives having neuroprotective activity
EP1394160A1 (en) * 1996-06-13 2004-03-03 SUMIKA FINE CHEMICALS Co., Ltd. Process for preparing crystalline paroxetin hydrochloride
FR2752163B1 (fr) * 1996-08-12 1998-10-30 Pf Medicament Utilisation de l'efaroxan pour la fabricaton de medicament destine au traitement de la maladie de huntington
GB9706753D0 (en) * 1997-04-03 1997-05-21 Pharmacia & Upjohn Spa Aralkoxy-morphinan derivatives
KR100425881B1 (ko) * 2001-03-14 2004-04-03 고광호 신규한 몰피난 유도체
AU2003234621A1 (en) * 2002-05-17 2003-12-02 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
DE10229842A1 (de) * 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
US20040204862A1 (en) 2003-04-11 2004-10-14 Wainer Irving W. Computer-based model for identification and characterization for non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US8436174B2 (en) * 2009-02-23 2013-05-07 Mallinckrodt Llc (+)-morphinanium quaternary salts and processes for their production
CN103044327B (zh) * 2013-01-07 2014-12-17 苏州立新制药有限公司 一种右美沙芬的制备方法
EP4166141A1 (en) * 2014-09-14 2023-04-19 Avanir Pharmaceuticals, Inc. Combinations of deuterated dextromethorphan and quinidine for the treatment of agitation and aggression in alzheimer's dementia
WO2016138103A1 (en) * 2015-02-25 2016-09-01 Alkermes, Inc. Treatments for alzheimer's related diseases and disorders
AU2021332768B2 (en) * 2020-08-28 2024-04-18 Nippon Chemiphar Co., Ltd. Method for preparing morphinan derivative having diaryl ether skeleton using novel copper catalyst

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI773636A7 (fi) * 1976-12-06 1978-06-07 Hoffmann La Roche Nya fenylderivat
US4113729A (en) * 1976-12-06 1978-09-12 Hoffmann-La Roche Inc. 3-Phenoxymorphinans and derivatives thereof
US4806543A (en) * 1986-11-25 1989-02-21 Board Of Trustees Of The Leland Stanford Junior University Method and compositions for reducing neurotoxic injury

Also Published As

Publication number Publication date
BR9400021A (pt) 1994-07-26
AU5280793A (en) 1994-07-14
ATE154931T1 (de) 1997-07-15
GR3024891T3 (en) 1998-01-30
TW264473B (OSRAM) 1995-12-01
DE69311887T2 (de) 1998-01-15
ES2105061T3 (es) 1997-10-16
CN1097006A (zh) 1995-01-04
NZ250580A (en) 1996-07-26
EP0612730B1 (en) 1997-07-02
FI940041L (fi) 1994-07-07
HU211290A9 (en) 1995-11-28
DK0612730T3 (da) 1998-02-02
FI940041A0 (fi) 1994-01-05
PL301784A1 (en) 1994-07-11
MX9400177A (es) 1994-07-29
NO940028D0 (no) 1994-01-04
CA2110337A1 (en) 1994-07-07
JP2501298B2 (ja) 1996-05-29
NO940028L (OSRAM) 1994-07-07
HUT66061A (en) 1994-09-28
EP0612730A1 (en) 1994-08-31
IL108247A (en) 1998-02-22
CZ2294A3 (en) 1994-07-13
KR940018094A (ko) 1994-08-16
PL175365B1 (pl) 1998-12-31
IL108247A0 (en) 1994-04-12
AU681601B2 (en) 1997-09-04
DE69311887D1 (de) 1997-08-07
ZA939806B (en) 1994-07-06
UY23706A1 (es) 1994-06-05
HU9400002D0 (en) 1994-05-30
JPH06316564A (ja) 1994-11-15

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