IL108085A - History of Ergoline 8 -converted -31) or 41 (-tertbutyl serotonergic energies, their preparation and pharmaceutical preparations containing them - Google Patents
History of Ergoline 8 -converted -31) or 41 (-tertbutyl serotonergic energies, their preparation and pharmaceutical preparations containing themInfo
- Publication number
- IL108085A IL108085A IL10808593A IL10808593A IL108085A IL 108085 A IL108085 A IL 108085A IL 10808593 A IL10808593 A IL 10808593A IL 10808593 A IL10808593 A IL 10808593A IL 108085 A IL108085 A IL 108085A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- formula
- alkyl
- hydrogen
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C07D457/08—Lysergic acid amides in which the amide nitrogen is a member of a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929226967A GB9226967D0 (en) | 1992-12-24 | 1992-12-24 | Serotoninergic ergoline derivatives |
GB939305696A GB9305696D0 (en) | 1993-03-19 | 1993-03-19 | Scrotoninergic ergoline derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
IL108085A0 IL108085A0 (en) | 1994-04-12 |
IL108085A true IL108085A (en) | 1996-10-16 |
Family
ID=26302231
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10808593A IL108085A (en) | 1992-12-24 | 1993-12-20 | History of Ergoline 8 -converted -31) or 41 (-tertbutyl serotonergic energies, their preparation and pharmaceutical preparations containing them |
Country Status (22)
Country | Link |
---|---|
US (1) | US5430031A (el) |
EP (1) | EP0628042B1 (el) |
JP (1) | JP3337688B2 (el) |
KR (1) | KR100325274B1 (el) |
CN (1) | CN1043230C (el) |
AT (1) | ATE204278T1 (el) |
AU (1) | AU669597B2 (el) |
CA (1) | CA2125288C (el) |
DE (1) | DE69330601T2 (el) |
DK (1) | DK0628042T3 (el) |
ES (1) | ES2162856T3 (el) |
FI (1) | FI943839A (el) |
HU (1) | HU220391B (el) |
IL (1) | IL108085A (el) |
MX (1) | MX9400165A (el) |
NZ (1) | NZ258559A (el) |
PL (1) | PL304893A1 (el) |
PT (1) | PT628042E (el) |
RU (1) | RU2131427C1 (el) |
TW (1) | TW252979B (el) |
UA (1) | UA41880C2 (el) |
WO (1) | WO1994014806A1 (el) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9407637D0 (en) | 1994-04-18 | 1994-06-08 | Erba Carlo Spa | Serotoninergic abeo-ergoline derivatives |
EP1685838A1 (en) * | 2000-08-16 | 2006-08-02 | Pharmacia & Upjohn Company LLC | Compounds for the treatment of addictive disorders |
IL154378A0 (en) * | 2000-08-16 | 2003-09-17 | Upjohn Co | Compounds for the treatment of addictive disorders |
ATE424414T1 (de) | 2001-06-08 | 2009-03-15 | Sod Conseils Rech Applic | Chimere somatostatin-dopamin-analoga |
SI21351A (sl) * | 2002-12-17 | 2004-06-30 | LEK farmacevtska dru�ba d.d. | Zdravljenje odvisnosti od psihostimulansov |
JP2016503402A (ja) | 2012-11-01 | 2016-02-04 | イプセン ファルマ ソシエテ パール アクシオン サンプリフィエIpsen Pharma S.A.S. | ソマトスタチン類似体及びそのダイマー |
TWI523863B (zh) | 2012-11-01 | 2016-03-01 | 艾普森藥品公司 | 體抑素-多巴胺嵌合體類似物 |
CN106866656A (zh) * | 2017-02-28 | 2017-06-20 | 西南交通大学 | 一类麦角碱衍生物及其在预防和治疗精神疾病的用途 |
GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
EP3955918A1 (en) | 2019-04-17 | 2022-02-23 | COMPASS Pathfinder Limited | Methods of treating neurocognitive disorders, chronic pain and reducing inflammation |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2802023A1 (de) * | 1977-01-28 | 1978-08-03 | Sandoz Ag | Neue ergotderivate, ihre herstellung und verwendung |
US4382940A (en) * | 1979-12-06 | 1983-05-10 | Farmitalia Carlo Erba S.P.A. | Ercoline derivatives and therapeutic compositions having CNS affecting activity |
GB8714767D0 (en) * | 1987-06-24 | 1987-07-29 | Erba Farmitalia | Egoline derivatives |
FI76085C (fi) * | 1981-07-21 | 1988-09-09 | Erba Farmitalia | Foerfarande foer framstaellning av ergolinderivat. |
CH649300A5 (de) * | 1981-08-07 | 1985-05-15 | Sandoz Ag | Ergopeptinderivate, ihre herstellung und verwendung. |
YU254782A (en) | 1981-12-18 | 1986-10-31 | Schering Ag | Process for making new ergot anilides |
DE3309493A1 (de) * | 1983-03-14 | 1984-09-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel |
PH21123A (en) * | 1983-04-28 | 1987-07-27 | Erba Farmitalia | Ergoline derivatives |
DE3445784A1 (de) * | 1984-12-13 | 1986-06-26 | Schering AG, Berlin und Bergkamen, 1000 Berlin | Verfahren zur herstellung von ergolin-derivaten |
GB8501078D0 (en) * | 1985-01-16 | 1985-02-20 | Erba Farmitalia | Piperazin-1-yl-ergo-line derivatives |
GB8515528D0 (en) * | 1985-06-19 | 1985-07-24 | Erba Farmitalia | Ergoline derivatives |
DE3533672A1 (de) * | 1985-09-19 | 1987-03-26 | Schering Ag | Neue 12- und 13-substituierte ergolinderivate |
US4968802A (en) * | 1985-10-01 | 1990-11-06 | Eli Lilly And Company | Process of making alkoxy cycloalkanol esters of dihydrolysergic acid |
US4939258A (en) * | 1985-10-01 | 1990-07-03 | Eli Lilly And Company | Cycloalkanol esters of dihydrolysergic acid |
DE3535929A1 (de) * | 1985-10-04 | 1987-04-09 | Schering Ag | 1,2-disubstituierte ergolinderivate |
GB8612366D0 (en) * | 1986-05-21 | 1986-06-25 | Erba Farmitalia | Ergoline esters |
DE3620293A1 (de) * | 1986-06-16 | 1987-12-17 | Schering Ag | 1-und/oder 2-substituierte ergolinderivate |
DE3623438C2 (de) * | 1986-07-10 | 1998-04-09 | Schering Ag | In 2-Stellung mit radioaktivem Iod markierte Ergolinylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Diagnostika |
GB8702364D0 (en) * | 1987-02-03 | 1987-03-11 | Erba Farmitalia | Ergolinyl heterocycles |
US4931447A (en) * | 1987-06-15 | 1990-06-05 | Eli Lilly And Company | Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines |
US4843703A (en) * | 1987-07-07 | 1989-07-04 | Truth Incorporated | Method of assembling a window operator |
EP0317269B1 (en) * | 1987-11-20 | 1992-03-04 | FARMITALIA CARLO ERBA S.r.l. | Antiparkinson ergoline derivatives |
DE3824659A1 (de) * | 1988-07-15 | 1990-02-08 | Schering Ag | 2-, 12- oder 13-substituierte 3-(8'(alpha)-ergolinyl)-1,1-diethylharnstoffe, ihre herstellung und verwendung in arzneimitteln |
GB8824744D0 (en) * | 1988-10-21 | 1988-11-30 | Erba Carlo Spa | Antiemesis ergoline derivatives |
US4902691A (en) * | 1988-12-19 | 1990-02-20 | Eli Lilly And Company | Heteroalkylamides of (8-β)-1-alkyl-6-(substituted)ergolines useful for blocking 5HT2 receptors |
DE3913756A1 (de) * | 1989-04-21 | 1990-10-25 | Schering Ag | 8(beta)-substituierte ergoline, verfahren zu ihrer herstellung und ihre verwendung |
ATE131167T1 (de) * | 1990-01-25 | 1995-12-15 | Pharmacia Spa | Verfahren zur herstellung von ergolinderivaten. |
-
1993
- 1993-11-26 PL PL93304893A patent/PL304893A1/xx unknown
- 1993-11-26 DK DK94901903T patent/DK0628042T3/da active
- 1993-11-26 UA UA94085718A patent/UA41880C2/uk unknown
- 1993-11-26 JP JP51472394A patent/JP3337688B2/ja not_active Expired - Fee Related
- 1993-11-26 AT AT94901903T patent/ATE204278T1/de not_active IP Right Cessation
- 1993-11-26 CA CA002125288A patent/CA2125288C/en not_active Expired - Fee Related
- 1993-11-26 RU RU94040382A patent/RU2131427C1/ru not_active IP Right Cessation
- 1993-11-26 NZ NZ258559A patent/NZ258559A/en unknown
- 1993-11-26 KR KR1019940702946A patent/KR100325274B1/ko not_active IP Right Cessation
- 1993-11-26 PT PT94901903T patent/PT628042E/pt unknown
- 1993-11-26 WO PCT/EP1993/003337 patent/WO1994014806A1/en active IP Right Grant
- 1993-11-26 AU AU56286/94A patent/AU669597B2/en not_active Ceased
- 1993-11-26 HU HU9401951A patent/HU220391B/hu not_active IP Right Cessation
- 1993-11-26 TW TW082109975A patent/TW252979B/zh active
- 1993-11-26 DE DE69330601T patent/DE69330601T2/de not_active Expired - Fee Related
- 1993-11-26 ES ES94901903T patent/ES2162856T3/es not_active Expired - Lifetime
- 1993-11-26 EP EP94901903A patent/EP0628042B1/en not_active Expired - Lifetime
- 1993-12-20 IL IL10808593A patent/IL108085A/en not_active IP Right Cessation
- 1993-12-20 US US08/169,177 patent/US5430031A/en not_active Expired - Fee Related
- 1993-12-23 CN CN93112788A patent/CN1043230C/zh not_active Expired - Fee Related
-
1994
- 1994-01-03 MX MX9400165A patent/MX9400165A/es unknown
- 1994-08-19 FI FI943839A patent/FI943839A/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1994014806A1 (en) | 1994-07-07 |
RU94040382A (ru) | 1996-07-10 |
CN1093087A (zh) | 1994-10-05 |
KR100325274B1 (ko) | 2002-08-14 |
NZ258559A (en) | 1996-07-26 |
DE69330601D1 (de) | 2001-09-20 |
CN1043230C (zh) | 1999-05-05 |
IL108085A0 (en) | 1994-04-12 |
TW252979B (el) | 1995-08-01 |
ATE204278T1 (de) | 2001-09-15 |
CA2125288C (en) | 2004-11-23 |
HU220391B (hu) | 2002-01-28 |
RU2131427C1 (ru) | 1999-06-10 |
EP0628042A1 (en) | 1994-12-14 |
AU669597B2 (en) | 1996-06-13 |
FI943839A0 (fi) | 1994-08-19 |
JP3337688B2 (ja) | 2002-10-21 |
DK0628042T3 (da) | 2001-11-12 |
FI943839A (fi) | 1994-08-19 |
CA2125288A1 (en) | 1994-07-07 |
DE69330601T2 (de) | 2002-07-04 |
AU5628694A (en) | 1994-07-19 |
EP0628042B1 (en) | 2001-08-16 |
HU9401951D0 (en) | 1994-09-28 |
HUT68190A (en) | 1995-05-29 |
MX9400165A (es) | 1994-07-29 |
PT628042E (pt) | 2002-01-30 |
JPH07504207A (ja) | 1995-05-11 |
UA41880C2 (uk) | 2001-10-15 |
ES2162856T3 (es) | 2002-01-16 |
US5430031A (en) | 1995-07-04 |
KR950700293A (ko) | 1995-01-16 |
PL304893A1 (en) | 1995-01-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
HC | Change of name of proprietor(s) | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |