UA41880C2 - Серотонінергічні похідні ерголіну і фармацевтична композиція - Google Patents

Серотонінергічні похідні ерголіну і фармацевтична композиція

Info

Publication number
UA41880C2
UA41880C2 UA94085718A UA94085718A UA41880C2 UA 41880 C2 UA41880 C2 UA 41880C2 UA 94085718 A UA94085718 A UA 94085718A UA 94085718 A UA94085718 A UA 94085718A UA 41880 C2 UA41880 C2 UA 41880C2
Authority
UA
Ukraine
Prior art keywords
pharmaceutical composition
derivatives
ergolin
serotoninergic
active agent
Prior art date
Application number
UA94085718A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Серджіо МАНТЕГАНІ
Серджио Мантегани
Ензо БРАМБІЛЛА
Энзо БРАМБИЛЛА
Карла Качча
Нікола КАРФАНЬЯ
Никола КАРФАНЬЯ
Original Assignee
Фармація Енд Апджон С.П.А.
Фармация Энд Апджон С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929226967A external-priority patent/GB9226967D0/en
Priority claimed from GB939305696A external-priority patent/GB9305696D0/en
Application filed by Фармація Енд Апджон С.П.А., Фармация Энд Апджон С.П.А. filed Critical Фармація Енд Апджон С.П.А.
Publication of UA41880C2 publication Critical patent/UA41880C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C07D457/08—Lysergic acid amides in which the amide nitrogen is a member of a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
UA94085718A 1992-12-24 1993-11-26 Серотонінергічні похідні ерголіну і фармацевтична композиція UA41880C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929226967A GB9226967D0 (en) 1992-12-24 1992-12-24 Serotoninergic ergoline derivatives
GB939305696A GB9305696D0 (en) 1993-03-19 1993-03-19 Scrotoninergic ergoline derivatives
PCT/EP1993/003337 WO1994014806A1 (en) 1992-12-24 1993-11-26 Serotoninergic ergoline derivatives

Publications (1)

Publication Number Publication Date
UA41880C2 true UA41880C2 (uk) 2001-10-15

Family

ID=26302231

Family Applications (1)

Application Number Title Priority Date Filing Date
UA94085718A UA41880C2 (uk) 1992-12-24 1993-11-26 Серотонінергічні похідні ерголіну і фармацевтична композиція

Country Status (22)

Country Link
US (1) US5430031A (el)
EP (1) EP0628042B1 (el)
JP (1) JP3337688B2 (el)
KR (1) KR100325274B1 (el)
CN (1) CN1043230C (el)
AT (1) ATE204278T1 (el)
AU (1) AU669597B2 (el)
CA (1) CA2125288C (el)
DE (1) DE69330601T2 (el)
DK (1) DK0628042T3 (el)
ES (1) ES2162856T3 (el)
FI (1) FI943839A0 (el)
HU (1) HU220391B (el)
IL (1) IL108085A (el)
MX (1) MX9400165A (el)
NZ (1) NZ258559A (el)
PL (1) PL304893A1 (el)
PT (1) PT628042E (el)
RU (1) RU2131427C1 (el)
TW (1) TW252979B (el)
UA (1) UA41880C2 (el)
WO (1) WO1994014806A1 (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9407637D0 (en) 1994-04-18 1994-06-08 Erba Carlo Spa Serotoninergic abeo-ergoline derivatives
AU2001283393B2 (en) * 2000-08-16 2005-09-22 Pharmacia & Upjohn Company Compounds for the treatment of addictive disorders
EP1685838A1 (en) * 2000-08-16 2006-08-02 Pharmacia & Upjohn Company LLC Compounds for the treatment of addictive disorders
BR0210915A (pt) 2001-06-08 2004-06-08 Sod Conseils Rech Applic Análogos quiméricos de somatostatina-dopamina
SI21351A (sl) * 2002-12-17 2004-06-30 LEK farmacevtska dru�ba d.d. Zdravljenje odvisnosti od psihostimulansov
WO2014070965A2 (en) 2012-11-01 2014-05-08 Ipsen Pharma S.A.S Somatostatin analogs and dimers thereof
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
CN106866656A (zh) * 2017-02-28 2017-06-20 西南交通大学 一类麦角碱衍生物及其在预防和治疗精神疾病的用途
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
CA3138094A1 (en) 2019-04-17 2020-10-22 Compass Pathfinder Limited Methods for treating anxiety disorders, headache disorders, and eating disorders with psilocybin

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2802023A1 (de) * 1977-01-28 1978-08-03 Sandoz Ag Neue ergotderivate, ihre herstellung und verwendung
US4382940A (en) * 1979-12-06 1983-05-10 Farmitalia Carlo Erba S.P.A. Ercoline derivatives and therapeutic compositions having CNS affecting activity
GB8714767D0 (en) * 1987-06-24 1987-07-29 Erba Farmitalia Egoline derivatives
AU553809B2 (en) * 1981-07-21 1986-07-31 Farmitalia Carlo Erba S.P.A. Ergoline derivatives
CH649300A5 (de) * 1981-08-07 1985-05-15 Sandoz Ag Ergopeptinderivate, ihre herstellung und verwendung.
YU254782A (en) 1981-12-18 1986-10-31 Schering Ag Process for making new ergot anilides
DE3309493A1 (de) * 1983-03-14 1984-09-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel
PH21123A (en) * 1983-04-28 1987-07-27 Erba Farmitalia Ergoline derivatives
DE3445784A1 (de) * 1984-12-13 1986-06-26 Schering AG, Berlin und Bergkamen, 1000 Berlin Verfahren zur herstellung von ergolin-derivaten
GB8501078D0 (en) * 1985-01-16 1985-02-20 Erba Farmitalia Piperazin-1-yl-ergo-line derivatives
GB8515528D0 (en) * 1985-06-19 1985-07-24 Erba Farmitalia Ergoline derivatives
DE3533672A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-substituierte ergolinderivate
US4968802A (en) * 1985-10-01 1990-11-06 Eli Lilly And Company Process of making alkoxy cycloalkanol esters of dihydrolysergic acid
US4939258A (en) * 1985-10-01 1990-07-03 Eli Lilly And Company Cycloalkanol esters of dihydrolysergic acid
DE3535929A1 (de) * 1985-10-04 1987-04-09 Schering Ag 1,2-disubstituierte ergolinderivate
GB8612366D0 (en) * 1986-05-21 1986-06-25 Erba Farmitalia Ergoline esters
DE3620293A1 (de) * 1986-06-16 1987-12-17 Schering Ag 1-und/oder 2-substituierte ergolinderivate
DE3623438C2 (de) * 1986-07-10 1998-04-09 Schering Ag In 2-Stellung mit radioaktivem Iod markierte Ergolinylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Diagnostika
GB8702364D0 (en) * 1987-02-03 1987-03-11 Erba Farmitalia Ergolinyl heterocycles
US4931447A (en) * 1987-06-15 1990-06-05 Eli Lilly And Company Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines
US4843703A (en) * 1987-07-07 1989-07-04 Truth Incorporated Method of assembling a window operator
EP0317269B1 (en) * 1987-11-20 1992-03-04 FARMITALIA CARLO ERBA S.r.l. Antiparkinson ergoline derivatives
DE3824659A1 (de) * 1988-07-15 1990-02-08 Schering Ag 2-, 12- oder 13-substituierte 3-(8'(alpha)-ergolinyl)-1,1-diethylharnstoffe, ihre herstellung und verwendung in arzneimitteln
GB8824744D0 (en) * 1988-10-21 1988-11-30 Erba Carlo Spa Antiemesis ergoline derivatives
US4902691A (en) * 1988-12-19 1990-02-20 Eli Lilly And Company Heteroalkylamides of (8-β)-1-alkyl-6-(substituted)ergolines useful for blocking 5HT2 receptors
DE3913756A1 (de) * 1989-04-21 1990-10-25 Schering Ag 8(beta)-substituierte ergoline, verfahren zu ihrer herstellung und ihre verwendung
EP0464178B1 (en) * 1990-01-25 1995-12-06 PHARMACIA S.p.A. Process for preparing ergoline derivatives

Also Published As

Publication number Publication date
KR950700293A (ko) 1995-01-16
EP0628042A1 (en) 1994-12-14
KR100325274B1 (ko) 2002-08-14
DE69330601T2 (de) 2002-07-04
DK0628042T3 (da) 2001-11-12
WO1994014806A1 (en) 1994-07-07
CN1093087A (zh) 1994-10-05
FI943839A (fi) 1994-08-19
TW252979B (el) 1995-08-01
CA2125288A1 (en) 1994-07-07
PT628042E (pt) 2002-01-30
ES2162856T3 (es) 2002-01-16
EP0628042B1 (en) 2001-08-16
HUT68190A (en) 1995-05-29
IL108085A0 (en) 1994-04-12
JPH07504207A (ja) 1995-05-11
MX9400165A (es) 1994-07-29
DE69330601D1 (de) 2001-09-20
JP3337688B2 (ja) 2002-10-21
AU669597B2 (en) 1996-06-13
CN1043230C (zh) 1999-05-05
US5430031A (en) 1995-07-04
FI943839A0 (fi) 1994-08-19
ATE204278T1 (de) 2001-09-15
HU220391B (hu) 2002-01-28
RU2131427C1 (ru) 1999-06-10
HU9401951D0 (en) 1994-09-28
NZ258559A (en) 1996-07-26
AU5628694A (en) 1994-07-19
RU94040382A (ru) 1996-07-10
IL108085A (en) 1996-10-16
PL304893A1 (en) 1995-01-09
CA2125288C (en) 2004-11-23

Similar Documents

Publication Publication Date Title
HU9500240D0 (en) New prolin-amide derivatives and pharmaceutical compositions containing them as active component
CA2311742A1 (en) 6-amino-9-benzyl-8-hydroxypurine derivatives
HK1044282A1 (zh) 作為趨化因子受體活性調節劑的n-脲基烷基-哌啶化合物
EP0630898A4 (en) MEDICINE FOR THROMBOZYTOPENIA.
NZ233735A (en) Heterocyclic substituted aminophenol derivatives
EP0144986A3 (en) Indole-3-carboxamide derivatives
EP0437030A3 (en) Use of 4-substituted imidazoles for lowering intraocular pressure
MY117092A (en) Chemotherapeutic pyrrolocarbazole derivatives
TW360652B (en) Acryloyl substituted disstamycin derivatives, process for preparing them, and pharmaceutical composition comprising them
JO1704B1 (en) New potent compounds
UA41880C2 (uk) Серотонінергічні похідні ерголіну і фармацевтична композиція
YU54189A (en) Process for obtaining cephem derivatives and midproducts for the same
UA37311C2 (uk) Засіб для лікування статевої дисфункції і фармацевтичний препарат
AU3626895A (en) Quinazolinone pharmaceuticals and use thereof
MD502G2 (ro) Derivaţi noi ai adenozinei, procedee de preparare a lor, compoziţii farmaceutice ce le conţin
MY103245A (en) Antiarrhythmic agents
WO1999004770A3 (en) A pharmaceutical composition active in reducing production of mcp-1 protein
UA41350C2 (uk) Похідна морфоліну або її фармацевтично прийнятна сіль та фармацевтична композиція на її основі
AU2001261707A1 (en) Pirazino '1$m(1)2$m(1) :1, 6! pyrido '3,4-b! indole derivatives
HRP20010885B1 (en) Ethanesulfonyl-piperidine derivatives
TW349864B (en) Use of N-(pyridinyl)-1H-indol-a-amines for the preparation of a medicament for the treatment of obsessive-compulsive disorders
ZA928876B (en) Thiazole derivatives.
ZA981430B (en) Anticancer composition
AU7935887A (en) Therapeutic agent for the treatment of peptic ulcer disease
EP0997463A4 (en) NAPHTHYRIDINE DERIVATIVES