IL107712A - A method of producing a polypeptide by fermenting bacteria - Google Patents
A method of producing a polypeptide by fermenting bacteriaInfo
- Publication number
- IL107712A IL107712A IL10771293A IL10771293A IL107712A IL 107712 A IL107712 A IL 107712A IL 10771293 A IL10771293 A IL 10771293A IL 10771293 A IL10771293 A IL 10771293A IL 107712 A IL107712 A IL 107712A
- Authority
- IL
- Israel
- Prior art keywords
- cytochrome
- oxidase
- fermentation
- gene
- dna
- Prior art date
Links
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0053—Oxidoreductases (1.) acting on a heme group of donors (1.9)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/20—Mixing gases with liquids
- B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
- B01F23/233—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements
- B01F23/2331—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the introduction of the gas along the axis of the stirrer or along the stirrer elements
- B01F23/23316—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the introduction of the gas along the axis of the stirrer or along the stirrer elements through a separate hollow guide substantially parallel with the stirrer element
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/20—Mixing gases with liquids
- B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
- B01F23/233—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements
- B01F23/2336—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the location of the place of introduction of the gas relative to the stirrer
- B01F23/23362—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the location of the place of introduction of the gas relative to the stirrer the gas being introduced under the stirrer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/20—Mixing gases with liquids
- B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
- B01F23/237—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids characterised by the physical or chemical properties of gases or vapours introduced in the liquid media
- B01F23/2376—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids characterised by the physical or chemical properties of gases or vapours introduced in the liquid media characterised by the gas being introduced
- B01F23/23761—Aerating, i.e. introducing oxygen containing gas in liquids
- B01F23/237612—Oxygen
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- Engineering & Computer Science (AREA)
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- Diabetes (AREA)
- Endocrinology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/989,844 US5342763A (en) | 1992-11-23 | 1992-11-23 | Method for producing polypeptide via bacterial fermentation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL107712A0 IL107712A0 (en) | 1994-02-27 |
| IL107712A true IL107712A (en) | 2002-09-12 |
Family
ID=25535522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10771293A IL107712A (en) | 1992-11-23 | 1993-11-22 | A method of producing a polypeptide by fermenting bacteria |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US5342763A (de) |
| EP (2) | EP0668906B1 (de) |
| JP (2) | JP3513875B2 (de) |
| AT (2) | ATE432344T1 (de) |
| AU (2) | AU669414B2 (de) |
| CA (1) | CA2147468C (de) |
| DE (2) | DE69334286D1 (de) |
| DK (2) | DK0668906T3 (de) |
| ES (2) | ES2326802T3 (de) |
| IL (1) | IL107712A (de) |
| PT (2) | PT1524316E (de) |
| WO (1) | WO1994012630A2 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5342763A (en) * | 1992-11-23 | 1994-08-30 | Genentech, Inc. | Method for producing polypeptide via bacterial fermentation |
| US6274369B1 (en) * | 1996-02-02 | 2001-08-14 | Invitrogen Corporation | Method capable of increasing competency of bacterial cell transformation |
| WO1997038123A1 (en) * | 1996-04-05 | 1997-10-16 | Board Of Regents, The University Of Texas System | Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells |
| US6114137A (en) * | 1996-10-31 | 2000-09-05 | Genentech Inc | Assay using marked microbial host cell strains |
| ZA979496B (en) * | 1996-10-31 | 1999-04-23 | Genentech Inc | Assay using marked microbial host cell strains |
| US6117651A (en) * | 1996-11-08 | 2000-09-12 | Neose Technologies, Inc. | Expression vectors |
| US6083715A (en) * | 1997-06-09 | 2000-07-04 | Board Of Regents, The University Of Texas System | Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells |
| PT1141014E (pt) * | 1999-01-06 | 2005-04-29 | Genentech Inc | Variante mutante do factor de crescimento semelhante a insulina (igf-i) |
| JP2002535967A (ja) * | 1999-01-06 | 2002-10-29 | ジェネンテック・インコーポレーテッド | インシュリン様成長因子（ｉｇｆ）ｉ変異体 |
| AU2001263215A1 (en) | 2000-05-16 | 2001-11-26 | Genentech Inc. | Method for treating cartilage disorders |
| SE0003958D0 (sv) | 2000-10-31 | 2000-10-31 | Biogaia Fermentation Ab | Method for growth of microorganisms |
| PT1332222E (pt) | 2000-11-03 | 2009-06-30 | Genentech Inc | Desvios de taxas metabólicas em fermentações expressando proteínas recombinantes |
| US7071300B2 (en) * | 2001-03-14 | 2006-07-04 | Genentech, Inc. | IGF antagonist peptides |
| EP1590445A4 (de) * | 2003-01-16 | 2006-02-01 | Fredric R Bloom | Bakterien für hochleistungsklonen |
| US7249880B2 (en) | 2003-10-14 | 2007-07-31 | Advanced Technology Materials, Inc. | Flexible mixing bag for mixing solids, liquids and gases |
| JP5014116B2 (ja) * | 2004-03-11 | 2012-08-29 | ジェネンテック， インコーポレイテッド | ポリペプチドの精製 |
| US7078201B2 (en) * | 2004-12-01 | 2006-07-18 | Burmaster Brian M | Ethanol fermentation using oxidation reduction potential |
| WO2006069403A2 (en) | 2004-12-22 | 2006-06-29 | Genentech, Inc. | Methods for producing soluble multi-membrane-spanning proteins |
| CA2836713A1 (en) * | 2005-04-15 | 2006-10-26 | Garrett W. Brown | Equipoising support apparatus |
| JP4358785B2 (ja) * | 2005-05-27 | 2009-11-04 | 麒麟麦酒株式会社 | 密封容器内の酸素量の測定方法及びこれに用いる密封容器のピアス装置 |
| JP2009513140A (ja) * | 2005-10-26 | 2009-04-02 | リーブテック，インコーポレイテッド | ミキサーとスパージャーを備えたバイオリアクター |
| WO2007130154A2 (en) | 2005-12-22 | 2007-11-15 | Genentech, Inc. | Recombinant production of heparin binding proteins |
| DE102006001623B4 (de) * | 2006-01-11 | 2009-05-07 | Sartorius Stedim Biotech Gmbh | Behälter und Verfahren zum Mischen von Medien |
| US8366311B2 (en) | 2006-04-21 | 2013-02-05 | Atmi Bvba | Systems and devices for mixing substances and methods of making same |
| WO2007134267A2 (en) * | 2006-05-13 | 2007-11-22 | Advanced Technology Materials, Inc. | Disposable bioreactor |
| JP2009072133A (ja) * | 2007-09-21 | 2009-04-09 | Hitachi Plant Technologies Ltd | 培養槽装置、細胞培養方法及び物質生産方法 |
| EP2216395A1 (de) * | 2009-02-09 | 2010-08-11 | Lonza Biologics plc. | Bioreaktor zur Kultivierung von Säugetierzellen |
| SI2437874T1 (sl) * | 2009-06-05 | 2015-08-31 | F. Hoffmann-La Roche Ag | Naprava za gojenje celic |
| AU2010275687A1 (en) * | 2009-07-24 | 2012-01-12 | F. Hoffmann-La Roche Ag | Stirrer system |
| US20140024090A1 (en) * | 2011-12-19 | 2014-01-23 | Shell Oil Company | Method and apparatus for converting a carbon source into a hydrocarbon or hydrocarbon precursor |
| BR112022008083A2 (pt) * | 2019-10-30 | 2022-07-12 | Genomatica Inc | Microrganismos e métodos para reduzir subprodutos |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3384553A (en) * | 1965-04-08 | 1968-05-21 | Ceskoslovenska Akademie Ved | Method and equipment for aerobic fermentation on liquid culture mediums |
| US3445342A (en) * | 1966-02-11 | 1969-05-20 | New Brunswick Scientific Co | Fermentation apparatus |
| US3445341A (en) * | 1966-06-17 | 1969-05-20 | New Brunswick Scientific Co | Fermentation apparatus with sterilization capabilities |
| US4116778A (en) * | 1974-01-10 | 1978-09-26 | Viktor Vasilievich Belousov | Plant for continuous cultivation of microorganisms |
| US4064015A (en) * | 1975-05-12 | 1977-12-20 | New Brunswick Scientific Co., Inc. | Control of biosynthesis in submerged culture |
| US4468455A (en) * | 1980-12-02 | 1984-08-28 | Phillips Petroleum Company | Cell culture control |
| US4476224A (en) * | 1982-05-10 | 1984-10-09 | Adler Howard I | Material and method for promoting the growth of anaerobic bacteria |
| US4762784A (en) * | 1985-07-15 | 1988-08-09 | International Minerals & Chemical Corp. | Fermemtation process for the high level production of bovine growth hormone |
| US5049493A (en) * | 1987-10-23 | 1991-09-17 | California Institute Of Technology | Enhancement of cell growth by expression of a cloned hemoglobin gene |
| US4882283A (en) * | 1987-11-17 | 1989-11-21 | Phillips Petroleum Company | Heat exchange apparatus |
| US5182195A (en) * | 1987-11-13 | 1993-01-26 | Takeda Chemical Industries, Ltd. | Method for increasing gene expression using protease deficient yeasts |
| FR2669935B1 (fr) * | 1990-11-30 | 1996-08-02 | Ajinomoto Kk | Procede et appareil pour la regulation de la concentration de source de carbone dans la culture aerobie d'un micro-organisme. |
| US5342763A (en) * | 1992-11-23 | 1994-08-30 | Genentech, Inc. | Method for producing polypeptide via bacterial fermentation |
-
1992
- 1992-11-23 US US07/989,844 patent/US5342763A/en not_active Expired - Lifetime
-
1993
- 1993-11-19 EP EP94901628A patent/EP0668906B1/de not_active Expired - Lifetime
- 1993-11-19 WO PCT/US1993/011297 patent/WO1994012630A2/en active IP Right Grant
- 1993-11-19 AU AU56150/94A patent/AU669414B2/en not_active Ceased
- 1993-11-19 CA CA002147468A patent/CA2147468C/en not_active Expired - Fee Related
- 1993-11-19 ES ES04017942T patent/ES2326802T3/es not_active Expired - Lifetime
- 1993-11-19 AT AT04017942T patent/ATE432344T1/de active
- 1993-11-19 ES ES94901628T patent/ES2231771T3/es not_active Expired - Lifetime
- 1993-11-19 DE DE69334286T patent/DE69334286D1/de not_active Expired - Lifetime
- 1993-11-19 DE DE69333671T patent/DE69333671T2/de not_active Expired - Lifetime
- 1993-11-19 AT AT94901628T patent/ATE280223T1/de active
- 1993-11-19 DK DK94901628T patent/DK0668906T3/da active
- 1993-11-19 EP EP04017942A patent/EP1524316B1/de not_active Expired - Lifetime
- 1993-11-19 PT PT04017942T patent/PT1524316E/pt unknown
- 1993-11-19 DK DK04017942T patent/DK1524316T3/da active
- 1993-11-19 PT PT94901628T patent/PT668906E/pt unknown
- 1993-11-19 JP JP51329394A patent/JP3513875B2/ja not_active Expired - Fee Related
- 1993-11-22 IL IL10771293A patent/IL107712A/en not_active IP Right Cessation
-
1994
- 1994-05-09 US US08/240,121 patent/US5487980A/en not_active Expired - Lifetime
-
1995
- 1995-05-25 US US08/451,241 patent/US5633165A/en not_active Expired - Lifetime
-
1996
- 1996-07-12 AU AU59461/96A patent/AU679880B2/en not_active Ceased
-
2003
- 2003-10-23 JP JP2003362819A patent/JP3674705B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004121256A (ja) | 2004-04-22 |
| EP0668906A1 (de) | 1995-08-30 |
| US5633165A (en) | 1997-05-27 |
| EP0668906B1 (de) | 2004-10-20 |
| PT668906E (pt) | 2005-02-28 |
| WO1994012630A3 (en) | 1994-10-13 |
| AU5615094A (en) | 1994-06-22 |
| ATE432344T1 (de) | 2009-06-15 |
| CA2147468A1 (en) | 1994-06-09 |
| JP3674705B2 (ja) | 2005-07-20 |
| CA2147468C (en) | 2006-05-16 |
| US5487980A (en) | 1996-01-30 |
| ES2231771T3 (es) | 2005-05-16 |
| ATE280223T1 (de) | 2004-11-15 |
| EP1524316A2 (de) | 2005-04-20 |
| AU5946196A (en) | 1996-09-05 |
| DK1524316T3 (da) | 2009-09-07 |
| US5342763A (en) | 1994-08-30 |
| JP3513875B2 (ja) | 2004-03-31 |
| DK0668906T3 (da) | 2005-02-07 |
| DE69334286D1 (de) | 2009-07-09 |
| IL107712A0 (en) | 1994-02-27 |
| DE69333671T2 (de) | 2006-01-19 |
| DE69333671D1 (de) | 2004-11-25 |
| EP1524316B1 (de) | 2009-05-27 |
| AU669414B2 (en) | 1996-06-06 |
| ES2326802T3 (es) | 2009-10-20 |
| AU679880B2 (en) | 1997-07-10 |
| WO1994012630A2 (en) | 1994-06-09 |
| PT1524316E (pt) | 2009-08-13 |
| EP1524316A3 (de) | 2005-04-27 |
| JPH08503611A (ja) | 1996-04-23 |
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